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The map label for this gene is glmS

Identifier: 189026085

GI number: 189026085

Start: 938722

End: 940629

Strand: Reverse

Name: glmS

Synonym: TPASS_0861

Alternate gene names: 189026085

Gene position: 940629-938722 (Counterclockwise)

Preceding gene: 189026086

Following gene: 189026081

Centisome position: 82.55

GC content: 56.87

Gene sequence:

>1908_bases
ATGTGTGGAATCGTTGGGATGGTGGCGGGGCGTGATGTCTCAGGTCTCTTGCTTGAGGGGCTGCGTCGTCTTGAATACCG
CGGGTATGATTCTGCAGGGATCGCTGTCGTTGGCTCGGACTGTGCGCTCCGCCTTTTACGCTGTGAGGGTCGTGTTCAGT
CGCTCTGCGCGCTATTAGGTCAGAGTCCTCTTTGCGGGACCATGGGCATTGCGCACACCCGGTGGGCAACGCACGGCAAG
CCGTGTGCAGCGAATGCGCATCCGCATTGTTCTGAATCCGTTGCGATAGTTCACAACGGTATTGTTGAAAACCATCGGTC
TTTGCGTGAAATGCTAGTGACCCGTGGCTATTTTTTTCATTCACAAACTGATAGCGAGGTGCTCGCGCATCTTTTGCACT
GGGAGTTGCGGTACACGGCGCACCTCCTGCTTGCGGTAAAAAAAGTGTTGACGCAGGTTCGGGGTACCTACGGGTTACTT
TGCATGGACGCTGCATCTCCTGGGCGGTTGATTGCTGCGCGTTCTGGCAGTCCGTTGGCGGTAGGACTCGGCTGTGGGGA
AAATTTTGTTACGTCAGACCCGCTTGCGCTTGCGCATGTTACGCAGCGTTTTTTGTATCTTGAGGAAGGAGACATCGCAG
ACGTCCACCGAGATAGCGTGTGCGTCCACGACGCGCAGGGAAACGTTGTGGCGCGTCCTGTTGTTACGTATCAGATGCAG
CTTTGTACGCAGGATAAGGGTACGCACCGTCACCATATGCATCAAGAAATATGGCAGCAGCCACACGCTATACGGCATAC
GCTGAATGCCTATATGTCGTTTTCTTCGTCTTCTCGCGCACAGGTGCGGACGTTCGGGGAGGACCGGGTCTTGGACGGTA
CCTCGTGTAAGACGTTTGAGCGGCTGTTTAGACGGATAACACGGGTGCGCATTATCGCGTGTGGTACCTCGTACCATGCA
GGGTTAGTGGCGCGTTACTGGTTTGAGGCATTTGCAGGGGTGGGATGTCAGGTGGAGATTGCCTCAGAGTACCGCTATCG
CACGAGCGTCGTGCACGCGCGTGAAATAGTACTGACGATTTCTCAGTCGGGAGAAACGGCTGACACCATTGCCGCACTGC
GCCTGGCAAAAACGCAAGGGTATCTCTGTGCGATTGCCATTTGCAACGGGGCACGTTCCACGTTGGTGCGTGAGTCGGAC
GCAGTGCTGCTCACCCACGCGGGGTCAGAAATAGGGGTTGCTTCAACGAAGTCTTTTACCACCCAGCTGGTGTGCTTGCT
CGTGCTCACCCGCATGATTGCGCAGGCAAAAAAGATACTCACGCAGGAGCCCGAGGACGCGCTCTCTGCGGCGCTCCAGC
GACTGCCTCAGGATGTGGAGCACGTGCTTGAGTGTGAGGCAGACGTTGCGCGGTGCGCGCGGCATTTTGTGCATGCGCAG
CATGCGCTCTTTTTGGGGCGTGGGGAATTGTATCCGATTGCAATTGAATCGGCGCTCAAGCTGAAAGAAATTTCGTACAT
CCATGCCGAAGCATACGCAGCGGGGGAGCTAAAGCATGGGCCCCTTGCATTAGTGGACGCGCAGATGCCGGTGGTTGCAA
TCGCGCCGGCGTCACCTGGCGTCCTGTTTGAAAAAATGGCCTCAAACATCGAGGAAGTTCGCGCGCGCGGCGGGATGCTC
TACATCTTTACGGACGTGCCGGAGCGTTTTGGCCCGGTATGCACGCCCGAGGCGGACGCGCCGGAAGGGGCGTGCAGTCA
GATAGTCACCGTACCTTCGGTATCTCCCCTTACCGCGCCGATTTTTTACGCCGTACCGCTGCAGCTGTTGGCATACCACA
TTGCCCTGCTCAAGGGGACTGACATTGACCAGCCGCGGAACCTGGCAAAATCGGTGACGGTCGAGTAA

Upstream 100 bases:

>100_bases
CTCGTGGCTTGGTTGAGTCAGAATGGTTCCTACGCGTGCGTGTGTTCTGTGGGTTTGAGTTTAACGTTCTCCCGTGTGCT
TTTGCACTGAAAAGGCGTCT

Downstream 100 bases:

>100_bases
GGGGTCCGCCCCCACTTTCCGCCGGTGCCGGCAGCGTGGCACAGGACGGAGCAGATGATGCCGCGGCGGCGCGGCTAGAA
AATGTTAAAATCGTGAACCT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MCGIVGMVAGRDVSGLLLEGLRRLEYRGYDSAGIAVVGSDCALRLLRCEGRVQSLCALLGQSPLCGTMGIAHTRWATHGK
PCAANAHPHCSESVAIVHNGIVENHRSLREMLVTRGYFFHSQTDSEVLAHLLHWELRYTAHLLLAVKKVLTQVRGTYGLL
CMDAASPGRLIAARSGSPLAVGLGCGENFVTSDPLALAHVTQRFLYLEEGDIADVHRDSVCVHDAQGNVVARPVVTYQMQ
LCTQDKGTHRHHMHQEIWQQPHAIRHTLNAYMSFSSSSRAQVRTFGEDRVLDGTSCKTFERLFRRITRVRIIACGTSYHA
GLVARYWFEAFAGVGCQVEIASEYRYRTSVVHAREIVLTISQSGETADTIAALRLAKTQGYLCAIAICNGARSTLVRESD
AVLLTHAGSEIGVASTKSFTTQLVCLLVLTRMIAQAKKILTQEPEDALSAALQRLPQDVEHVLECEADVARCARHFVHAQ
HALFLGRGELYPIAIESALKLKEISYIHAEAYAAGELKHGPLALVDAQMPVVAIAPASPGVLFEKMASNIEEVRARGGML
YIFTDVPERFGPVCTPEADAPEGACSQIVTVPSVSPLTAPIFYAVPLQLLAYHIALLKGTDIDQPRNLAKSVTVE

Sequences:

>Translated_635_residues
MCGIVGMVAGRDVSGLLLEGLRRLEYRGYDSAGIAVVGSDCALRLLRCEGRVQSLCALLGQSPLCGTMGIAHTRWATHGK
PCAANAHPHCSESVAIVHNGIVENHRSLREMLVTRGYFFHSQTDSEVLAHLLHWELRYTAHLLLAVKKVLTQVRGTYGLL
CMDAASPGRLIAARSGSPLAVGLGCGENFVTSDPLALAHVTQRFLYLEEGDIADVHRDSVCVHDAQGNVVARPVVTYQMQ
LCTQDKGTHRHHMHQEIWQQPHAIRHTLNAYMSFSSSSRAQVRTFGEDRVLDGTSCKTFERLFRRITRVRIIACGTSYHA
GLVARYWFEAFAGVGCQVEIASEYRYRTSVVHAREIVLTISQSGETADTIAALRLAKTQGYLCAIAICNGARSTLVRESD
AVLLTHAGSEIGVASTKSFTTQLVCLLVLTRMIAQAKKILTQEPEDALSAALQRLPQDVEHVLECEADVARCARHFVHAQ
HALFLGRGELYPIAIESALKLKEISYIHAEAYAAGELKHGPLALVDAQMPVVAIAPASPGVLFEKMASNIEEVRARGGML
YIFTDVPERFGPVCTPEADAPEGACSQIVTVPSVSPLTAPIFYAVPLQLLAYHIALLKGTDIDQPRNLAKSVTVE
>Mature_635_residues
MCGIVGMVAGRDVSGLLLEGLRRLEYRGYDSAGIAVVGSDCALRLLRCEGRVQSLCALLGQSPLCGTMGIAHTRWATHGK
PCAANAHPHCSESVAIVHNGIVENHRSLREMLVTRGYFFHSQTDSEVLAHLLHWELRYTAHLLLAVKKVLTQVRGTYGLL
CMDAASPGRLIAARSGSPLAVGLGCGENFVTSDPLALAHVTQRFLYLEEGDIADVHRDSVCVHDAQGNVVARPVVTYQMQ
LCTQDKGTHRHHMHQEIWQQPHAIRHTLNAYMSFSSSSRAQVRTFGEDRVLDGTSCKTFERLFRRITRVRIIACGTSYHA
GLVARYWFEAFAGVGCQVEIASEYRYRTSVVHAREIVLTISQSGETADTIAALRLAKTQGYLCAIAICNGARSTLVRESD
AVLLTHAGSEIGVASTKSFTTQLVCLLVLTRMIAQAKKILTQEPEDALSAALQRLPQDVEHVLECEADVARCARHFVHAQ
HALFLGRGELYPIAIESALKLKEISYIHAEAYAAGELKHGPLALVDAQMPVVAIAPASPGVLFEKMASNIEEVRARGGML
YIFTDVPERFGPVCTPEADAPEGACSQIVTVPSVSPLTAPIFYAVPLQLLAYHIALLKGTDIDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=708, Percent_Identity=33.4745762711864, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI205277386, Length=708, Percent_Identity=33.1920903954802, Blast_Score=371, Evalue=1e-102,
Organism=Escherichia coli, GI1790167, Length=635, Percent_Identity=54.0157480314961, Blast_Score=679, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=29.4797687861272, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=727, Percent_Identity=32.1870701513067, Blast_Score=318, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI17532899, Length=454, Percent_Identity=35.2422907488987, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17532897, Length=454, Percent_Identity=35.2422907488987, Blast_Score=245, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6322745, Length=474, Percent_Identity=33.7552742616034, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6323731, Length=454, Percent_Identity=29.295154185022, Blast_Score=173, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=36.5853658536585, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323958, Length=168, Percent_Identity=30.952380952381, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357745, Length=709, Percent_Identity=33.0042313117066, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI28573187, Length=278, Percent_Identity=25.8992805755396, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_TREPA (O83833)

Other databases:

- EMBL:   AE000520
- PIR:   E71272
- RefSeq:   NP_219297.1
- ProteinModelPortal:   O83833
- SMR:   O83833
- GeneID:   2611074
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0861
- NMPDR:   fig|243276.1.peg.856
- TIGR:   TP_0861
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BioCyc:   TPAL243276:TP_0861-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 69182; Mature: 69182

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 630-630

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGMVAGRDVSGLLLEGLRRLEYRGYDSAGIAVVGSDCALRLLRCEGRVQSLCALLG
CCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHC
QSPLCGTMGIAHTRWATHGKPCAANAHPHCSESVAIVHNGIVENHRSLREMLVTRGYFFH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
SQTDSEVLAHLLHWELRYTAHLLLAVKKVLTQVRGTYGLLCMDAASPGRLIAARSGSPLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCEE
VGLGCGENFVTSDPLALAHVTQRFLYLEEGDIADVHRDSVCVHDAQGNVVARPVVTYQMQ
EEECCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCEEEECCCCCEEECHHHHHHHH
LCTQDKGTHRHHMHQEIWQQPHAIRHTLNAYMSFSSSSRAQVRTFGEDRVLDGTSCKTFE
HHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCHHHHH
RLFRRITRVRIIACGTSYHAGLVARYWFEAFAGVGCQVEIASEYRYRTSVVHAREIVLTI
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHEEEEEEEEE
SQSGETADTIAALRLAKTQGYLCAIAICNGARSTLVRESDAVLLTHAGSEIGVASTKSFT
ECCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHEECCCCEEEEECCCCCCCCCCHHHH
TQLVCLLVLTRMIAQAKKILTQEPEDALSAALQRLPQDVEHVLECEADVARCARHFVHAQ
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHH
HALFLGRGELYPIAIESALKLKEISYIHAEAYAAGELKHGPLALVDAQMPVVAIAPASPG
HHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCC
VLFEKMASNIEEVRARGGMLYIFTDVPERFGPVCTPEADAPEGACSQIVTVPSVSPLTAP
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCCCCCHHHCEEECCCCCCCHHH
IFYAVPLQLLAYHIALLKGTDIDQPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGMVAGRDVSGLLLEGLRRLEYRGYDSAGIAVVGSDCALRLLRCEGRVQSLCALLG
CCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHC
QSPLCGTMGIAHTRWATHGKPCAANAHPHCSESVAIVHNGIVENHRSLREMLVTRGYFFH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
SQTDSEVLAHLLHWELRYTAHLLLAVKKVLTQVRGTYGLLCMDAASPGRLIAARSGSPLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCEE
VGLGCGENFVTSDPLALAHVTQRFLYLEEGDIADVHRDSVCVHDAQGNVVARPVVTYQMQ
EEECCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCCCEEEECCCCCEEECHHHHHHHH
LCTQDKGTHRHHMHQEIWQQPHAIRHTLNAYMSFSSSSRAQVRTFGEDRVLDGTSCKTFE
HHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCHHHHH
RLFRRITRVRIIACGTSYHAGLVARYWFEAFAGVGCQVEIASEYRYRTSVVHAREIVLTI
HHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHEEEEEEEEE
SQSGETADTIAALRLAKTQGYLCAIAICNGARSTLVRESDAVLLTHAGSEIGVASTKSFT
ECCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHEECCCCEEEEECCCCCCCCCCHHHH
TQLVCLLVLTRMIAQAKKILTQEPEDALSAALQRLPQDVEHVLECEADVARCARHFVHAQ
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHH
HALFLGRGELYPIAIESALKLKEISYIHAEAYAAGELKHGPLALVDAQMPVVAIAPASPG
HHEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCC
VLFEKMASNIEEVRARGGMLYIFTDVPERFGPVCTPEADAPEGACSQIVTVPSVSPLTAP
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCCCCCHHHCEEECCCCCCCHHH
IFYAVPLQLLAYHIALLKGTDIDQPRNLAKSVTVE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876