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The map label for this gene is ppnK

Identifier: 188586309

GI number: 188586309

Start: 1768021

End: 1768881

Strand: Reverse

Name: ppnK

Synonym: Nther_1692

Alternate gene names: 188586309

Gene position: 1768881-1768021 (Counterclockwise)

Preceding gene: 188586310

Following gene: 188586308

Centisome position: 55.88

GC content: 36.47

Gene sequence:

>861_bases
ATGAGGAGTGTAGGTTTAATACCCAACATTCAAAAAGATCAAGTAGCGGAAATTACAAGTAGAATGTATAAAATCCTATC
AGAACACGATATTGATGTGTACTTGACCCATGAAGGTGCAGATTTAATTGGGACTGAAAGTGCCGGAGTTTCCTCTGATG
TCATGGGAGAAGTGGCGGAAATGATTATCATTCTGGGAGGAGACGGTACAATACTAAAGGCAGCTCGAGAGTATGCCCCT
TATGATATTCCTTTATTAGGTATTAATTTAGGGAAGATGGGTTTTCTAGCGGAAATTGAAGCTAATGAGGTTATGGCATA
TTTAGAAAGCCTTTTAACAGGTAATTATACAATTGAAGAGCGCATGATGTTAGATGCTACTGTGTTAAGAGATCGTAAAG
AAATCACAACTTTTAGTGCTTTAAATGATGTTATCATTGCTAAGGGGCCATTTTCTAGAATAATTGAAGTTGAAACTAAA
GTGGGCGGTAATTATCTGGAAACGTATCCGGGAGATGGTTTGATAGTTACTAGCCCAACAGGTTCAACGGGATATTCTTT
TTCAGCTGGAGGTCCTATTATTAGTTCCAATTTGGAGGTCATGATGATTACCCCGATATGTCCTCATCTCATGCATAATA
GATCTGTAATAATATCATCTGATGAGGTGGTAACTGCTAAGATGAAAACCAATTACGCTGTAGTAGTTTTAACTGTAGAC
GGTCAACAGGGTTTCACTTTACAAGATGGCGATGAAATAAAGGTTAAAAAATCTAACTATAAGACTAAATTAGTTAAATT
ACGGCGAAGAAGTTTTTATCAGTTATTAAATGAAAAATTGACAGGAGGTCAAGAAGTATAA

Upstream 100 bases:

>100_bases
TTTTAAGTCAGGGTTCACAGAGTACTTCGAACACTTCAATGGATCAAATAGTAACACAAGTTGTAAAAAATGCCCATGAA
TACTTTAAAGGAGGCTCTTT

Downstream 100 bases:

>100_bases
TGATTAGGGAGCTGCTGATTAGAGAAGGAGGGCTCGAATGCTAGTACATCTAAATATTAAAGATTTTGCCCTGATTGATC
ACCTTATCCTGGAGCCTGGT

Product: ATP-NAD/AcoX kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MRSVGLIPNIQKDQVAEITSRMYKILSEHDIDVYLTHEGADLIGTESAGVSSDVMGEVAEMIIILGGDGTILKAAREYAP
YDIPLLGINLGKMGFLAEIEANEVMAYLESLLTGNYTIEERMMLDATVLRDRKEITTFSALNDVIIAKGPFSRIIEVETK
VGGNYLETYPGDGLIVTSPTGSTGYSFSAGGPIISSNLEVMMITPICPHLMHNRSVIISSDEVVTAKMKTNYAVVVLTVD
GQQGFTLQDGDEIKVKKSNYKTKLVKLRRRSFYQLLNEKLTGGQEV

Sequences:

>Translated_286_residues
MRSVGLIPNIQKDQVAEITSRMYKILSEHDIDVYLTHEGADLIGTESAGVSSDVMGEVAEMIIILGGDGTILKAAREYAP
YDIPLLGINLGKMGFLAEIEANEVMAYLESLLTGNYTIEERMMLDATVLRDRKEITTFSALNDVIIAKGPFSRIIEVETK
VGGNYLETYPGDGLIVTSPTGSTGYSFSAGGPIISSNLEVMMITPICPHLMHNRSVIISSDEVVTAKMKTNYAVVVLTVD
GQQGFTLQDGDEIKVKKSNYKTKLVKLRRRSFYQLLNEKLTGGQEV
>Mature_286_residues
MRSVGLIPNIQKDQVAEITSRMYKILSEHDIDVYLTHEGADLIGTESAGVSSDVMGEVAEMIIILGGDGTILKAAREYAP
YDIPLLGINLGKMGFLAEIEANEVMAYLESLLTGNYTIEERMMLDATVLRDRKEITTFSALNDVIIAKGPFSRIIEVETK
VGGNYLETYPGDGLIVTSPTGSTGYSFSAGGPIISSNLEVMMITPICPHLMHNRSVIISSDEVVTAKMKTNYAVVVLTVD
GQQGFTLQDGDEIKVKKSNYKTKLVKLRRRSFYQLLNEKLTGGQEV

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family

Homologues:

Organism=Homo sapiens, GI55743112, Length=238, Percent_Identity=28.1512605042017, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1788968, Length=232, Percent_Identity=30.6034482758621, Blast_Score=157, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6320794, Length=240, Percent_Identity=29.1666666666667, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322509, Length=242, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6325068, Length=216, Percent_Identity=29.1666666666667, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161077047, Length=232, Percent_Identity=29.7413793103448, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28573828, Length=232, Percent_Identity=29.7413793103448, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28573830, Length=232, Percent_Identity=29.7413793103448, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI28573832, Length=232, Percent_Identity=29.7413793103448, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573826, Length=232, Percent_Identity=29.7413793103448, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653422, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI281363323, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI20129957, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI281363321, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24653424, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PPNK_NATTJ (B2A524)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917854.1
- ProteinModelPortal:   B2A524
- SMR:   B2A524
- GeneID:   6314335
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1692
- HOGENOM:   HBG713904
- OMA:   LNEMVLH
- GO:   GO:0005737
- HAMAP:   MF_00361
- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504
- Gene3D:   G3DSA:2.60.200.30
- Gene3D:   G3DSA:3.40.50.10330
- PANTHER:   PTHR20275

Pfam domain/function: PF01513 NAD_kinase; SSF111331 ATP-NAD_kinase_PpnK-typ

EC number: =2.7.1.23

Molecular weight: Translated: 31324; Mature: 31324

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVGLIPNIQKDQVAEITSRMYKILSEHDIDVYLTHEGADLIGTESAGVSSDVMGEVAE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCHHHHHHHEE
MIIILGGDGTILKAAREYAPYDIPLLGINLGKMGFLAEIEANEVMAYLESLLTGNYTIEE
EEEEECCCCCEEHHHHHCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCCEEHH
RMMLDATVLRDRKEITTFSALNDVIIAKGPFSRIIEVETKVGGNYLETYPGDGLIVTSPT
HHHHHHHHHHCHHHHHHHHHHCCEEEECCCCHHEEEEEECCCCCEEEECCCCCEEEECCC
GSTGYSFSAGGPIISSNLEVMMITPICPHLMHNRSVIISSDEVVTAKMKTNYAVVVLTVD
CCCCCEECCCCCEEECCCCEEEECCCCHHHHCCCEEEEECCCEEEEEEECCEEEEEEEEC
GQQGFTLQDGDEIKVKKSNYKTKLVKLRRRSFYQLLNEKLTGGQEV
CCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRSVGLIPNIQKDQVAEITSRMYKILSEHDIDVYLTHEGADLIGTESAGVSSDVMGEVAE
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCHHHHHHHEE
MIIILGGDGTILKAAREYAPYDIPLLGINLGKMGFLAEIEANEVMAYLESLLTGNYTIEE
EEEEECCCCCEEHHHHHCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHCCCCEEHH
RMMLDATVLRDRKEITTFSALNDVIIAKGPFSRIIEVETKVGGNYLETYPGDGLIVTSPT
HHHHHHHHHHCHHHHHHHHHHCCEEEECCCCHHEEEEEECCCCCEEEECCCCCEEEECCC
GSTGYSFSAGGPIISSNLEVMMITPICPHLMHNRSVIISSDEVVTAKMKTNYAVVVLTVD
CCCCCEECCCCCEEECCCCEEEECCCCHHHHCCCEEEEECCCEEEEEEECCEEEEEEEEC
GQQGFTLQDGDEIKVKKSNYKTKLVKLRRRSFYQLLNEKLTGGQEV
CCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA