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The map label for this gene is hemA

Identifier: 188585747

GI number: 188585747

Start: 1188376

End: 1189752

Strand: Direct

Name: hemA

Synonym: Nther_1121

Alternate gene names: 188585747

Gene position: 1188376-1189752 (Clockwise)

Preceding gene: 188585746

Following gene: 188585748

Centisome position: 37.54

GC content: 36.96

Gene sequence:

>1377_bases
GTGATTCTAGCAGTTATCGGAATAAATCATGAAACCGCATCAGTAGAAACCAGAGAACAATTAGCTTTCTCTTCTAAACA
GGTAAAAGAACTTGTTCAAAAACTTATTGAAGGTCAACCGATAAAGGAAGCTTCGGTTTTATCAACTTGTAATCGAACAG
AGGTTCACTTTACAGTGAACACAGGGCAAATTGAGGCGGGCAAAAATCATATCATGACATACCTGTCAGATTTTAGTGAT
CTAGACCCCCGGGAGTATGTAGATCATTTATACTTCATTACAGATCAGGAGGCCGTTAGTCATATATTTAAAGTTACTGC
TGGACTGAATTCTTTGGTAACTGGTGAAACAGAAATACTAGGTCAAGTAAAGAAAGCTTATCAGTTGTCTGATGAAGCTG
GTGGAGTTGATTCTATTTTCCATGGGCTATACCAACAAGCCTTAAGGACAGGTAAACGGGTACACAGAGAAACTGGAATT
AACGATAATGCAGCATCTGTCAGTTATGCCAGTGTGGAGCTGGCAACTAAAATATTCGGGAGTTTACAGAACCGGCGTGC
CTTGATTATTGGTGCCGGGAAAATGAGTGAACTGGCTGCAAGGCATTTGTATAGTAACGGTGTCAAAGATGTAATTGTGA
TTAACCGGACTATAGAAAGAGCTAAAAATTTAGCTGATAAATTTGGAGGCCTTTACGCATCTTATGATCAGTTGAGTGAA
TGGCTTAATGAAATTGATATTGTGATCACCAGTACGGGAGCACCACATTTTGTAATTAAAGAAGAACAAATCAAAAGAGC
TATGAAATCAAGAAAATATAGTCCTATGTTTTTAATTGATATCGCTGTACCTAGAGACGTAGAGCCATCTGTCAATAATC
AAGATAATGCTTATTTGTATACCATTGATGATTTAGAAGCAGTTGTGGAATCTAATATGCAAGAAAGACAGGAAGAAGCA
CGAAACGCAGAACTAATAATTAGTGAAGAGGTGGCTGAATTTATGGTTTGGTATAAAACTAGAGATGTAGTGCCTCTGAT
ATCAGCTTTACGAGAAAAAGCTGAAGATGTTAGGAAAATGGAACTTGAAAAGTATCATAAAAAACTTAAAAATCTTAGTC
CAAAGGAGCAAGAAGCCGTAGATAAATTGACTAAGAGTATAGTTAATAAGATATTAAAGGAACCTGTGCTTAGAATAAAA
GAATTTGCTGTTGAAGATAAAAGTGAATTGTATATGGCCACTCTGGCTCAATTATTTGATTTAGAAGATGAAGTTATCCC
CAAGGATGGAGAAGAGCATTCATCTTCAAAGGAAGTTGAGTCCGTTACTCAATCTTCTACAGAGAGGGGTCACCATGAAT
CCGATTTCCATAATTAA

Upstream 100 bases:

>100_bases
CACTTATGTGGGAGTTAATATGTTGCTTCCGAGTGAACACAGTTATTTGTAAATCAGTATTTGTCAGTATTGACTCCTAT
GGTGATTTGGAGGTGTTTTA

Downstream 100 bases:

>100_bases
TCTTATAATAGCTATCAGTTTGCTTGCATCGACAGCCTTATTTATTCTTTCAGTAAAATATTTAGATCAGCCTGGAAATA
ACTATCAAAAAGCTATTTCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MILAVIGINHETASVETREQLAFSSKQVKELVQKLIEGQPIKEASVLSTCNRTEVHFTVNTGQIEAGKNHIMTYLSDFSD
LDPREYVDHLYFITDQEAVSHIFKVTAGLNSLVTGETEILGQVKKAYQLSDEAGGVDSIFHGLYQQALRTGKRVHRETGI
NDNAASVSYASVELATKIFGSLQNRRALIIGAGKMSELAARHLYSNGVKDVIVINRTIERAKNLADKFGGLYASYDQLSE
WLNEIDIVITSTGAPHFVIKEEQIKRAMKSRKYSPMFLIDIAVPRDVEPSVNNQDNAYLYTIDDLEAVVESNMQERQEEA
RNAELIISEEVAEFMVWYKTRDVVPLISALREKAEDVRKMELEKYHKKLKNLSPKEQEAVDKLTKSIVNKILKEPVLRIK
EFAVEDKSELYMATLAQLFDLEDEVIPKDGEEHSSSKEVESVTQSSTERGHHESDFHN

Sequences:

>Translated_458_residues
MILAVIGINHETASVETREQLAFSSKQVKELVQKLIEGQPIKEASVLSTCNRTEVHFTVNTGQIEAGKNHIMTYLSDFSD
LDPREYVDHLYFITDQEAVSHIFKVTAGLNSLVTGETEILGQVKKAYQLSDEAGGVDSIFHGLYQQALRTGKRVHRETGI
NDNAASVSYASVELATKIFGSLQNRRALIIGAGKMSELAARHLYSNGVKDVIVINRTIERAKNLADKFGGLYASYDQLSE
WLNEIDIVITSTGAPHFVIKEEQIKRAMKSRKYSPMFLIDIAVPRDVEPSVNNQDNAYLYTIDDLEAVVESNMQERQEEA
RNAELIISEEVAEFMVWYKTRDVVPLISALREKAEDVRKMELEKYHKKLKNLSPKEQEAVDKLTKSIVNKILKEPVLRIK
EFAVEDKSELYMATLAQLFDLEDEVIPKDGEEHSSSKEVESVTQSSTERGHHESDFHN
>Mature_458_residues
MILAVIGINHETASVETREQLAFSSKQVKELVQKLIEGQPIKEASVLSTCNRTEVHFTVNTGQIEAGKNHIMTYLSDFSD
LDPREYVDHLYFITDQEAVSHIFKVTAGLNSLVTGETEILGQVKKAYQLSDEAGGVDSIFHGLYQQALRTGKRVHRETGI
NDNAASVSYASVELATKIFGSLQNRRALIIGAGKMSELAARHLYSNGVKDVIVINRTIERAKNLADKFGGLYASYDQLSE
WLNEIDIVITSTGAPHFVIKEEQIKRAMKSRKYSPMFLIDIAVPRDVEPSVNNQDNAYLYTIDDLEAVVESNMQERQEEA
RNAELIISEEVAEFMVWYKTRDVVPLISALREKAEDVRKMELEKYHKKLKNLSPKEQEAVDKLTKSIVNKILKEPVLRIK
EFAVEDKSELYMATLAQLFDLEDEVIPKDGEEHSSSKEVESVTQSSTERGHHESDFHN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=411, Percent_Identity=37.712895377129, Blast_Score=271, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_NATTJ (B2A1G4)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917292.1
- ProteinModelPortal:   B2A1G4
- SMR:   B2A1G4
- GeneID:   6315350
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1121
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 51693; Mature: 51693

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 111-111 BINDING 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILAVIGINHETASVETREQLAFSSKQVKELVQKLIEGQPIKEASVLSTCNRTEVHFTVN
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEE
TGQIEAGKNHIMTYLSDFSDLDPREYVDHLYFITDQEAVSHIFKVTAGLNSLVTGETEIL
CCEEECCHHHHHHHHHHHCCCCHHHHHHHHEEEECHHHHHHHHHHHHCHHHHHCCHHHHH
GQVKKAYQLSDEAGGVDSIFHGLYQQALRTGKRVHRETGINDNAASVSYASVELATKIFG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
SLQNRRALIIGAGKMSELAARHLYSNGVKDVIVINRTIERAKNLADKFGGLYASYDQLSE
HHCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHH
WLNEIDIVITSTGAPHFVIKEEQIKRAMKSRKYSPMFLIDIAVPRDVEPSVNNQDNAYLY
HHHHHEEEEECCCCCCEEECHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEE
TIDDLEAVVESNMQERQEEARNAELIISEEVAEFMVWYKTRDVVPLISALREKAEDVRKM
EEHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ELEKYHKKLKNLSPKEQEAVDKLTKSIVNKILKEPVLRIKEFAVEDKSELYMATLAQLFD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
LEDEVIPKDGEEHSSSKEVESVTQSSTERGHHESDFHN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MILAVIGINHETASVETREQLAFSSKQVKELVQKLIEGQPIKEASVLSTCNRTEVHFTVN
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEE
TGQIEAGKNHIMTYLSDFSDLDPREYVDHLYFITDQEAVSHIFKVTAGLNSLVTGETEIL
CCEEECCHHHHHHHHHHHCCCCHHHHHHHHEEEECHHHHHHHHHHHHCHHHHHCCHHHHH
GQVKKAYQLSDEAGGVDSIFHGLYQQALRTGKRVHRETGINDNAASVSYASVELATKIFG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
SLQNRRALIIGAGKMSELAARHLYSNGVKDVIVINRTIERAKNLADKFGGLYASYDQLSE
HHCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHH
WLNEIDIVITSTGAPHFVIKEEQIKRAMKSRKYSPMFLIDIAVPRDVEPSVNNQDNAYLY
HHHHHEEEEECCCCCCEEECHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEE
TIDDLEAVVESNMQERQEEARNAELIISEEVAEFMVWYKTRDVVPLISALREKAEDVRKM
EEHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ELEKYHKKLKNLSPKEQEAVDKLTKSIVNKILKEPVLRIKEFAVEDKSELYMATLAQLFD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
LEDEVIPKDGEEHSSSKEVESVTQSSTERGHHESDFHN
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA