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The map label for this gene is clpX

Identifier: 188585729

GI number: 188585729

Start: 1165743

End: 1167005

Strand: Direct

Name: clpX

Synonym: Nther_1103

Alternate gene names: 188585729

Gene position: 1165743-1167005 (Clockwise)

Preceding gene: 188585728

Following gene: 188585730

Centisome position: 36.83

GC content: 37.29

Gene sequence:

>1263_bases
GTGTTTAAATTAAACGATGAAAAGGGACGCTTAAAGTGTTCCTTTTGCGGTAAGACCCAAGAACAAGTTAAAAAACTTGT
AGCGGGTCCAGGTGTTTATATTTGCGACGAGTGTATCGAACTATGCAATGAGATAATAGAAGAAGAACTTAATGATGATA
GCGATATGGGCTTTTCTGAAATTCCTAAACCTCAAGAAATATACGAAATTCTCAATGATTATATCATTGGGCAGGAAGAA
GCTAAAAAAGCCCTATCAGTTGCTGTTTATAACCACTATAAACGTGTAAATAACGAAGCCAAAAAGAAAGACGATGTTGA
GATTCAAAAAAGTAATATCTTATTACTTGGTCCAACTGGTGTAGGTAAAACTTTGTTGGCTCAAACCTTGGCAAAAATAT
TAAATGTTCCCTTTGCCATGGCTGATGCTACTTCATTAACCGAAGCTGGTTATGTAGGTGAAGACGTAGAAAATATCCTG
CTAAAATTAATTCAATCAGCGGATTATGATGTTGAAAAAGCTGAAAAAGGGATAGTTTATATCGATGAAATTGATAAGGT
TGCAAGGAAGACTGATAATCCATCTATTACTCGAGATGTTTCAGGAGAAGGGGTACAGCAGGCACTGCTTAGGATTTTAG
AAGGAACAAAAGCAAGTGTACCTCCTCAAGGTGGTAGAAAGCATCCACATCAAGAATTTATCCAAATAGATACCACCAAT
ATCTTGTTCATTTGCGGTGGAGCTTTTGATGGTATTGACAAGATTATTCAGAACAGGATTGGAAAGAAAGGTCTAGGTTT
TGGAGCCGAGGTACAAAGTGCTAAGGATGAAGGTATAGGTGAAATCCTATCAAAAGTTCTACCTCAAGACCTTCTGAAGT
TCGGGTTGATTCCAGAGTTTGTAGGGAGAATTCCTGTAATCTCGTCTTTAGATGCCTTGGATGAAGATGCCTTAGTACGA
ATCCTAGTTGAACCCAAAAATGCTTTAGTTAAGCAGTATCAAAAGCTATTTGAGATAGATGGTGTAGAACTGGAAATGCA
AGAAGATGCACTAAGAGCTATAGCTCGAGAGGCCATTGAGAGAAATACAGGAGCCAGAGGTTTAAGAGCTATAGTTGAAG
AACATCTGAATGATATTATGTACGATCTACCATCTATGGATGATGTCAATAAATGTATCATCACAGAAGAAGTGATTGAA
AAAGATGAAAGACCTATGTTAGTAAAGGATAATCAAGGTGAGAAAAAGCATGAGTCTGCATAG

Upstream 100 bases:

>100_bases
TGGTGTAATTGATGATGTTTTAAAAAGGCCACCTGAAAATAGTTAATTTTTAAAGTGGTATTTAAAGAAAAAGAAGAGGT
TACTAGAGAGGTGATTGTGA

Downstream 100 bases:

>100_bases
AAATATAAAAAATTATTAACTATAATGCCCTGCCTTCGCTTTTAAGTGAAGGCAGGGCATTTTTTCTGTTTTTTGTTGCT
ATTTAGCTCTATTCTCCTCT

Product: ATP-dependent Clp protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFKLNDEKGRLKCSFCGKTQEQVKKLVAGPGVYICDECIELCNEIIEEELNDDSDMGFSEIPKPQEIYEILNDYIIGQEE
AKKALSVAVYNHYKRVNNEAKKKDDVEIQKSNILLLGPTGVGKTLLAQTLAKILNVPFAMADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIVYIDEIDKVARKTDNPSITRDVSGEGVQQALLRILEGTKASVPPQGGRKHPHQEFIQIDTTN
ILFICGGAFDGIDKIIQNRIGKKGLGFGAEVQSAKDEGIGEILSKVLPQDLLKFGLIPEFVGRIPVISSLDALDEDALVR
ILVEPKNALVKQYQKLFEIDGVELEMQEDALRAIAREAIERNTGARGLRAIVEEHLNDIMYDLPSMDDVNKCIITEEVIE
KDERPMLVKDNQGEKKHESA

Sequences:

>Translated_420_residues
MFKLNDEKGRLKCSFCGKTQEQVKKLVAGPGVYICDECIELCNEIIEEELNDDSDMGFSEIPKPQEIYEILNDYIIGQEE
AKKALSVAVYNHYKRVNNEAKKKDDVEIQKSNILLLGPTGVGKTLLAQTLAKILNVPFAMADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIVYIDEIDKVARKTDNPSITRDVSGEGVQQALLRILEGTKASVPPQGGRKHPHQEFIQIDTTN
ILFICGGAFDGIDKIIQNRIGKKGLGFGAEVQSAKDEGIGEILSKVLPQDLLKFGLIPEFVGRIPVISSLDALDEDALVR
ILVEPKNALVKQYQKLFEIDGVELEMQEDALRAIAREAIERNTGARGLRAIVEEHLNDIMYDLPSMDDVNKCIITEEVIE
KDERPMLVKDNQGEKKHESA
>Mature_420_residues
MFKLNDEKGRLKCSFCGKTQEQVKKLVAGPGVYICDECIELCNEIIEEELNDDSDMGFSEIPKPQEIYEILNDYIIGQEE
AKKALSVAVYNHYKRVNNEAKKKDDVEIQKSNILLLGPTGVGKTLLAQTLAKILNVPFAMADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIVYIDEIDKVARKTDNPSITRDVSGEGVQQALLRILEGTKASVPPQGGRKHPHQEFIQIDTTN
ILFICGGAFDGIDKIIQNRIGKKGLGFGAEVQSAKDEGIGEILSKVLPQDLLKFGLIPEFVGRIPVISSLDALDEDALVR
ILVEPKNALVKQYQKLFEIDGVELEMQEDALRAIAREAIERNTGARGLRAIVEEHLNDIMYDLPSMDDVNKCIITEEVIE
KDERPMLVKDNQGEKKHESA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=340, Percent_Identity=50, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1786642, Length=410, Percent_Identity=63.1707317073171, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1790366, Length=106, Percent_Identity=43.3962264150943, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=315, Percent_Identity=45.7142857142857, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71982905, Length=315, Percent_Identity=45.7142857142857, Blast_Score=271, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI71988663, Length=407, Percent_Identity=38.5749385749386, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71988660, Length=254, Percent_Identity=39.7637795275591, Blast_Score=177, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319704, Length=412, Percent_Identity=40.7766990291262, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24648291, Length=327, Percent_Identity=46.4831804281346, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24648289, Length=327, Percent_Identity=46.4831804281346, Blast_Score=295, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_NATTJ (B2A159)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917274.1
- ProteinModelPortal:   B2A159
- GeneID:   6314986
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1103
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46625; Mature: 46625

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKLNDEKGRLKCSFCGKTQEQVKKLVAGPGVYICDECIELCNEIIEEELNDDSDMGFSE
CCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
IPKPQEIYEILNDYIIGQEEAKKALSVAVYNHYKRVNNEAKKKDDVEIQKSNILLLGPTG
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCC
VGKTLLAQTLAKILNVPFAMADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIVY
CCHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCEE
IDEIDKVARKTDNPSITRDVSGEGVQQALLRILEGTKASVPPQGGRKHPHQEFIQIDTTN
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCCE
ILFICGGAFDGIDKIIQNRIGKKGLGFGAEVQSAKDEGIGEILSKVLPQDLLKFGLIPEF
EEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHH
VGRIPVISSLDALDEDALVRILVEPKNALVKQYQKLFEIDGVELEMQEDALRAIAREAIE
HCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
RNTGARGLRAIVEEHLNDIMYDLPSMDDVNKCIITEEVIEKDERPMLVKDNQGEKKHESA
HCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MFKLNDEKGRLKCSFCGKTQEQVKKLVAGPGVYICDECIELCNEIIEEELNDDSDMGFSE
CCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
IPKPQEIYEILNDYIIGQEEAKKALSVAVYNHYKRVNNEAKKKDDVEIQKSNILLLGPTG
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCC
VGKTLLAQTLAKILNVPFAMADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIVY
CCHHHHHHHHHHHHCCCHHHHCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCEE
IDEIDKVARKTDNPSITRDVSGEGVQQALLRILEGTKASVPPQGGRKHPHQEFIQIDTTN
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCCE
ILFICGGAFDGIDKIIQNRIGKKGLGFGAEVQSAKDEGIGEILSKVLPQDLLKFGLIPEF
EEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHH
VGRIPVISSLDALDEDALVRILVEPKNALVKQYQKLFEIDGVELEMQEDALRAIAREAIE
HCCCCHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
RNTGARGLRAIVEEHLNDIMYDLPSMDDVNKCIITEEVIEKDERPMLVKDNQGEKKHESA
HCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA