Click here to switch to the map view.

The map label for this gene is clpP

Identifier: 188585728

GI number: 188585728

Start: 1165095

End: 1165688

Strand: Direct

Name: clpP

Synonym: Nther_1102

Alternate gene names: 188585728

Gene position: 1165095-1165688 (Clockwise)

Preceding gene: 188585727

Following gene: 188585729

Centisome position: 36.81

GC content: 38.22

Gene sequence:

>594_bases
ATGAATTTAATACCCATGGTAATAGAACAAACCAACAGAGGTGAAAGATCCTACGATATATATTCTCGTCTGTTAAAAGA
TCGGATAATATTCATTGGAACAGGCATAAATGATGATATTGCAAACTCAGTAATAGCCCAAATGCTATTTTTAGAATCAG
AGGATCCTGATAAGGATATTCATTTGTATATTAATAGTCCTGGCGGTCATGTGCACGCAGGTTTGGCAATTTATGACACT
ATGCAATATATTCGATCAGATGTTTCAACAATTTGCGTTGGAATGGCTGCAAGCATGGGTGCTGTACTATTAGCTGCTGG
GAATGAAGGTAAGAGATTCTGCTTGCCAAATTCTCGAATCATGTTGCATCAACCTATGGGTGGTGCTCAAGGGCAGGCAG
CTGACGTTGAGATCCATGCTAGAGAAATAATGAAGACAAAAGAGCGCTTGAATCAGATTTTAGCCCACCACACAGGACAG
CCAGTTGAGCAAATAAGTAAAGATACAGATAGAGACTTTTTCATGTCTAGTGAAGAAGCTCAAAAATATGGTGTAATTGA
TGATGTTTTAAAAAGGCCACCTGAAAATAGTTAA

Upstream 100 bases:

>100_bases
AAGGTTTTCAACTATCAGCCAAATTGATAAAAGTTATTAGTTTAAAAAGGGAGACCTAAAGACAGAAATATGTTATTATA
AAGCAAAAGGGGGTTATAAT

Downstream 100 bases:

>100_bases
TTTTTAAAGTGGTATTTAAAGAAAAAGAAGAGGTTACTAGAGAGGTGATTGTGAGTGTTTAAATTAAACGATGAAAAGGG
ACGCTTAAAGTGTTCCTTTT

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MNLIPMVIEQTNRGERSYDIYSRLLKDRIIFIGTGINDDIANSVIAQMLFLESEDPDKDIHLYINSPGGHVHAGLAIYDT
MQYIRSDVSTICVGMAASMGAVLLAAGNEGKRFCLPNSRIMLHQPMGGAQGQAADVEIHAREIMKTKERLNQILAHHTGQ
PVEQISKDTDRDFFMSSEEAQKYGVIDDVLKRPPENS

Sequences:

>Translated_197_residues
MNLIPMVIEQTNRGERSYDIYSRLLKDRIIFIGTGINDDIANSVIAQMLFLESEDPDKDIHLYINSPGGHVHAGLAIYDT
MQYIRSDVSTICVGMAASMGAVLLAAGNEGKRFCLPNSRIMLHQPMGGAQGQAADVEIHAREIMKTKERLNQILAHHTGQ
PVEQISKDTDRDFFMSSEEAQKYGVIDDVLKRPPENS
>Mature_197_residues
MNLIPMVIEQTNRGERSYDIYSRLLKDRIIFIGTGINDDIANSVIAQMLFLESEDPDKDIHLYINSPGGHVHAGLAIYDT
MQYIRSDVSTICVGMAASMGAVLLAAGNEGKRFCLPNSRIMLHQPMGGAQGQAADVEIHAREIMKTKERLNQILAHHTGQ
PVEQISKDTDRDFFMSSEEAQKYGVIDDVLKRPPENS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=59.1836734693878, Blast_Score=243, Evalue=1e-64,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=66.3157894736842, Blast_Score=284, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=57.5268817204301, Blast_Score=226, Evalue=6e-60,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=60.2040816326531, Blast_Score=252, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_NATTJ (B2A158)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917273.1
- ProteinModelPortal:   B2A158
- SMR:   B2A158
- MEROPS:   S14.001
- GeneID:   6314985
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1102
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21916; Mature: 21916

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPMVIEQTNRGERSYDIYSRLLKDRIIFIGTGINDDIANSVIAQMLFLESEDPDKDI
CCCCCHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGHVHAGLAIYDTMQYIRSDVSTICVGMAASMGAVLLAAGNEGKRFCLPNSRI
EEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEECCCCEE
MLHQPMGGAQGQAADVEIHAREIMKTKERLNQILAHHTGQPVEQISKDTDRDFFMSSEEA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHCCCHHH
QKYGVIDDVLKRPPENS
HHCCCHHHHHCCCCCCC
>Mature Secondary Structure
MNLIPMVIEQTNRGERSYDIYSRLLKDRIIFIGTGINDDIANSVIAQMLFLESEDPDKDI
CCCCCHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGHVHAGLAIYDTMQYIRSDVSTICVGMAASMGAVLLAAGNEGKRFCLPNSRI
EEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCEEECCCCEE
MLHQPMGGAQGQAADVEIHAREIMKTKERLNQILAHHTGQPVEQISKDTDRDFFMSSEEA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHCCCHHH
QKYGVIDDVLKRPPENS
HHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA