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The map label for this gene is lon2 [H]

Identifier: 188585730

GI number: 188585730

Start: 1167269

End: 1168882

Strand: Direct

Name: lon2 [H]

Synonym: Nther_1104

Alternate gene names: 188585730

Gene position: 1167269-1168882 (Clockwise)

Preceding gene: 188585729

Following gene: 188585731

Centisome position: 36.87

GC content: 40.71

Gene sequence:

>1614_bases
ATGGAAGGAATAGCCGGTCTCTTAGCAATGGTACAATTCTTCTTTGCAGTAGTTATCGGCCTTTATTTTTGGAATCAGTT
AAGAAGCCAGCAGTCAAGTAAAGCTACTGTTGAGCGTGAATCGGAAAAACAAATGGAAAAGCTCAGAAAAATGAGAAGAA
TATCCTTAGCAGAACCTTTAGCAGAAAAAACACGCCCCCAAAAATTTCAAGAAATTGTTGGTCAAAAGGAAGGGTTAAAA
GCACTGAGAGCAGCTCTTTGTGGACCTAATCCACAACATGTGATAATTTATGGTCCACCCGGTATAGGAAAAACTGCAGC
AGCTCGCGTAGTATTAGAGGAAGCTAAAAACAATCCACGTTCCCCTTTTGGTGAGCATTCTGAATTTGTGGAAATTGACT
CCACTACTGCCAGGTTTGATGAAAGAGGGATTGCTGATCCATTAATCGGTACTGTTCATGACCCTATATATCAAGGTGCT
GGAGCCATGGGAATACATGGTATCCCCCAGCCTAAACCTGGAGCAGTAAGTAAAGCCCACGGAGGAGTCTTATTTCTTGA
TGAGATTGGAGAACTTCATCATATACAGATGAATAAACTGTTAAAGGTCCTGGAAGACAGAAAAGTTTTTTTAGAAAGTT
CATATTACAGTTCGGAGGACCCCAACTGTCCCCAGTATATACACGAGATTTTCCAAAAAGGCTTACCTGCAGATTTTCGA
CTTATCGGTGCCACCACTAAAGGACCAGAAAGTATTCCTGAAGCTATTCGAAGTCGTTGTGTTGAAGTATTTTTTAAGGG
TCTAACTCCTGAAGAACTTGTTGGAATAGCGAAACATGCTGTTAAAAGACTGGGATTTGAGGTAGAACAAGGGGCCATTG
AAATAATCAAAAAATATGCTGAAAATGGTAGGGAAGCTGTTAACCTAATTCAAATAGCAGCAGGTCTTGCCCAGACAGAA
AAACGCTCCAATTTAACCCAAAAAGACCTGGAATGGGTTATTAACACAAGCCAAATTTCACCTAGACCAGATAAACTGAT
ACCCGCCAGATCTCAAGTTGGGCTAGCCAATGCATTAGCAGTGCTAGGACCTAGCCGAGGAACACTCTTAGAAATCGAAG
TGTCTTCAATCCCTTGTAAAGAAGGTGAAGGTGAAATAAACGTAACTGGACTTGTGGAAGAAGAGGAAATGGGGGGACAT
TCCCGAGTAGTTCGGCGCAAAAGTATGGCAAAAGGTTCAGTTGATAATGTGTTGACAGTACTAAAGCATTATCTAGACGT
TAATCCTAGGGATTACGACATCCATATAAATTTTCCAGGTTCAATCCCAATAGATGGTCCTTCTGCAGGAGTAGCCATAG
CCACAGCAATATATTCATCTTTATCAAATAAGCCGATTGACCATAAAGTTGCCATGACAGGAGAAGTTTCAATTAGAGGA
GAAATAAAACCTGTAGGAGGCGTTTCCACAAAAATAGAAGCAGCTAAAGAGGCTCAAGCCAGTAAAGTTTTAATTCCTAA
AGAAAACTATCAAAAAACCTTTGAAGATGAAGAGTCTCTAACAGTGTCGCCAGTTGAGGACTTAAAAGAAGTACTAAGAG
AAGTCACCTTGTAG

Upstream 100 bases:

>100_bases
TATAACAGGTCCTTTGTTAAATCTAACAGTTCAGGAATAAAATGCAAGATGCTTCCGCATAATAAGGTTAGGTTGAACTC
TGTAGTGAGAGGGGGATTAC

Downstream 100 bases:

>100_bases
TTTCAAGCTTTGCTTCGCCTCCATTTTTTTTGGCAGGCGAAGTTTTTTTATGTTAGGCGCACCTAAACATCTTTAAGTGA
AATTGAGATTTTATATTATC

Product: ATP-dependent protease LonB

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MEGIAGLLAMVQFFFAVVIGLYFWNQLRSQQSSKATVERESEKQMEKLRKMRRISLAEPLAEKTRPQKFQEIVGQKEGLK
ALRAALCGPNPQHVIIYGPPGIGKTAAARVVLEEAKNNPRSPFGEHSEFVEIDSTTARFDERGIADPLIGTVHDPIYQGA
GAMGIHGIPQPKPGAVSKAHGGVLFLDEIGELHHIQMNKLLKVLEDRKVFLESSYYSSEDPNCPQYIHEIFQKGLPADFR
LIGATTKGPESIPEAIRSRCVEVFFKGLTPEELVGIAKHAVKRLGFEVEQGAIEIIKKYAENGREAVNLIQIAAGLAQTE
KRSNLTQKDLEWVINTSQISPRPDKLIPARSQVGLANALAVLGPSRGTLLEIEVSSIPCKEGEGEINVTGLVEEEEMGGH
SRVVRRKSMAKGSVDNVLTVLKHYLDVNPRDYDIHINFPGSIPIDGPSAGVAIATAIYSSLSNKPIDHKVAMTGEVSIRG
EIKPVGGVSTKIEAAKEAQASKVLIPKENYQKTFEDEESLTVSPVEDLKEVLREVTL

Sequences:

>Translated_537_residues
MEGIAGLLAMVQFFFAVVIGLYFWNQLRSQQSSKATVERESEKQMEKLRKMRRISLAEPLAEKTRPQKFQEIVGQKEGLK
ALRAALCGPNPQHVIIYGPPGIGKTAAARVVLEEAKNNPRSPFGEHSEFVEIDSTTARFDERGIADPLIGTVHDPIYQGA
GAMGIHGIPQPKPGAVSKAHGGVLFLDEIGELHHIQMNKLLKVLEDRKVFLESSYYSSEDPNCPQYIHEIFQKGLPADFR
LIGATTKGPESIPEAIRSRCVEVFFKGLTPEELVGIAKHAVKRLGFEVEQGAIEIIKKYAENGREAVNLIQIAAGLAQTE
KRSNLTQKDLEWVINTSQISPRPDKLIPARSQVGLANALAVLGPSRGTLLEIEVSSIPCKEGEGEINVTGLVEEEEMGGH
SRVVRRKSMAKGSVDNVLTVLKHYLDVNPRDYDIHINFPGSIPIDGPSAGVAIATAIYSSLSNKPIDHKVAMTGEVSIRG
EIKPVGGVSTKIEAAKEAQASKVLIPKENYQKTFEDEESLTVSPVEDLKEVLREVTL
>Mature_537_residues
MEGIAGLLAMVQFFFAVVIGLYFWNQLRSQQSSKATVERESEKQMEKLRKMRRISLAEPLAEKTRPQKFQEIVGQKEGLK
ALRAALCGPNPQHVIIYGPPGIGKTAAARVVLEEAKNNPRSPFGEHSEFVEIDSTTARFDERGIADPLIGTVHDPIYQGA
GAMGIHGIPQPKPGAVSKAHGGVLFLDEIGELHHIQMNKLLKVLEDRKVFLESSYYSSEDPNCPQYIHEIFQKGLPADFR
LIGATTKGPESIPEAIRSRCVEVFFKGLTPEELVGIAKHAVKRLGFEVEQGAIEIIKKYAENGREAVNLIQIAAGLAQTE
KRSNLTQKDLEWVINTSQISPRPDKLIPARSQVGLANALAVLGPSRGTLLEIEVSSIPCKEGEGEINVTGLVEEEEMGGH
SRVVRRKSMAKGSVDNVLTVLKHYLDVNPRDYDIHINFPGSIPIDGPSAGVAIATAIYSSLSNKPIDHKVAMTGEVSIRG
EIKPVGGVSTKIEAAKEAQASKVLIPKENYQKTFEDEESLTVSPVEDLKEVLREVTL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=513, Percent_Identity=25.5360623781676, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI21396489, Length=105, Percent_Identity=43.8095238095238, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786643, Length=474, Percent_Identity=25.9493670886076, Blast_Score=102, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17556486, Length=479, Percent_Identity=22.964509394572, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17505831, Length=467, Percent_Identity=26.338329764454, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319449, Length=77, Percent_Identity=46.7532467532467, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221513036, Length=470, Percent_Identity=25.1063829787234, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666867, Length=470, Percent_Identity=25.1063829787234, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 58807; Mature: 58807

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIAGLLAMVQFFFAVVIGLYFWNQLRSQQSSKATVERESEKQMEKLRKMRRISLAEPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEKTRPQKFQEIVGQKEGLKALRAALCGPNPQHVIIYGPPGIGKTAAARVVLEEAKNNPR
HHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCC
SPFGEHSEFVEIDSTTARFDERGIADPLIGTVHDPIYQGAGAMGIHGIPQPKPGAVSKAH
CCCCCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGVLFLDEIGELHHIQMNKLLKVLEDRKVFLESSYYSSEDPNCPQYIHEIFQKGLPADFR
CCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEE
LIGATTKGPESIPEAIRSRCVEVFFKGLTPEELVGIAKHAVKRLGFEVEQGAIEIIKKYA
EEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ENGREAVNLIQIAAGLAQTEKRSNLTQKDLEWVINTSQISPRPDKLIPARSQVGLANALA
HCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHHHHH
VLGPSRGTLLEIEVSSIPCKEGEGEINVTGLVEEEEMGGHSRVVRRKSMAKGSVDNVLTV
HCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEHHHCCCHHHHHHHHHHHCCCHHHHHHH
LKHYLDVNPRDYDIHINFPGSIPIDGPSAGVAIATAIYSSLSNKPIDHKVAMTGEVSIRG
HHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEE
EIKPVGGVSTKIEAAKEAQASKVLIPKENYQKTFEDEESLTVSPVEDLKEVLREVTL
CCCCCCCCCHHHHHHHHHHHCEEECCCHHHHHHCCCCCCEEECCHHHHHHHHHHHCC
>Mature Secondary Structure
MEGIAGLLAMVQFFFAVVIGLYFWNQLRSQQSSKATVERESEKQMEKLRKMRRISLAEPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEKTRPQKFQEIVGQKEGLKALRAALCGPNPQHVIIYGPPGIGKTAAARVVLEEAKNNPR
HHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCC
SPFGEHSEFVEIDSTTARFDERGIADPLIGTVHDPIYQGAGAMGIHGIPQPKPGAVSKAH
CCCCCCCCEEEECCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGVLFLDEIGELHHIQMNKLLKVLEDRKVFLESSYYSSEDPNCPQYIHEIFQKGLPADFR
CCEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEE
LIGATTKGPESIPEAIRSRCVEVFFKGLTPEELVGIAKHAVKRLGFEVEQGAIEIIKKYA
EEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ENGREAVNLIQIAAGLAQTEKRSNLTQKDLEWVINTSQISPRPDKLIPARSQVGLANALA
HCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHHHHH
VLGPSRGTLLEIEVSSIPCKEGEGEINVTGLVEEEEMGGHSRVVRRKSMAKGSVDNVLTV
HCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEHHHCCCHHHHHHHHHHHCCCHHHHHHH
LKHYLDVNPRDYDIHINFPGSIPIDGPSAGVAIATAIYSSLSNKPIDHKVAMTGEVSIRG
HHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEE
EIKPVGGVSTKIEAAKEAQASKVLIPKENYQKTFEDEESLTVSPVEDLKEVLREVTL
CCCCCCCCCHHHHHHHHHHHCEEECCCHHHHHHCCCCCCEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]