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The map label for this gene is lytC [H]

Identifier: 188585704

GI number: 188585704

Start: 1134318

End: 1136291

Strand: Direct

Name: lytC [H]

Synonym: Nther_1077

Alternate gene names: 188585704

Gene position: 1134318-1136291 (Clockwise)

Preceding gene: 188585702

Following gene: 188585705

Centisome position: 35.83

GC content: 36.98

Gene sequence:

>1974_bases
TTGAAAAAAGTTGTAACTTTAGTTATTGTTGTTTTCATGCTAGTAATAACAACGAACTATGCAGCTGGTCAAGAAAATGT
TGATGTTTTTGTAGACGAGGATCTGGTGAATTTTCCTGACCAAGAACCTTACATAGACGAAAACAGCAGAGTTCAAGTAC
CAGTACGTTTTGTCAGTGAAGCCCTCGGAGGTTATGTGGAATGGGATGGCAGTACTCAAACAGTCAATATTAAACTGGAT
AAAAAGGAACTATCCTTAGAAGTGGGACAAGAAATTTACTTAATTGATAATAGTGAAAAAGAAATGGATACAGTTCCACA
AGTTTCACAACAGGGCCGAACCATGGTACCTCTGAGATTTGTAAGTGAAGGTTTGGGTGCTGAAGTAGATTGGCTAGGAG
AGGAAGAGTCTGTTTATATTAATACAAAAGAGAGTCAAGAAGAAAAAGAGAATGAAAATAACGAGAATAATCCGTCTGAT
GTTCCTTCACAAGAAGAATTGGAGAACAGTGAAGCTATGGCTGAAATTAAAGCGAGCAATCTAAATGTAAGAACAGGACC
AGGAATGGACTATTCAGTAGTTGATAATTTACAGGCAGGAGATTCCTTTCCTATTTTGGACAAGCACCATAATGAAAATG
AGGAAGAATATCAAGACTGGCTGAAAATTGATTTAGAGGATGAACAAGATGATGTTTGGGTTAGTGCAGATTTTATAGAG
ATTAGTTTTCTAGAAGAAAGTGAAGAAGATGAAGACAAGGAACAAAAAGACGAAGAAAAAGAAGAAATAGAAGAACCAGA
AGAAGATGAAAGAGATAGACCGGAAATACCACAAGAATACGATGATATTTTAGGTGAGATAGTTATAGATGCCGACAATT
TAAATGTTAGGACAGGGCCAGGGTTGGACTATGATAGTATCACCCAAGTTGATGAGGGTGAAGACTATGACATCATAACT
ATGGCAGCTATGGAAAATCATCCCACCTATGAAGAGTGGTTTAAAATCGACTTAGATAAAAGAAACTTAGATGTGGAAGA
CAGAAATGAAGCCAAGGGTTGGGTTGCTGCAGAGTATGTCAAAAGAGATAATATAGATTTGATGAATAATTTAGAGGAAA
TAAATTATATAAATTGGACCGAGAACTCTAACAACACTGAAATCACCCTGGGACCAGTACAAAGGATTCCCTTGGAGTCC
TTTACGAGAGAAGACCCTGATAGACTTGTTCTAGACTTTGAAGGAATAGCTCTAGCTACTGATGAGACTGCTTGGCAAGT
CGAAACATCTACTTTGCAAGGTATAAGGGCTCATGAACACAATGGAATGACAAGGGTTGTTTTTGATTTGAATTCCAAGG
AACACTACTCTATAGATTGGGAAGATGCTCATTTAAATGTCAGATTATATGACGATAATCCATTATCTGGTAAGAAAATA
TTTATAGATCCAGGACATGGAGGTAGTAATAGTGGAGCTATTGGACAAAATGGTCTTAAAGAAAAGGAAGTGGCTCTAGA
CGTCTCTTTAAGAACTAGGGATATGTTGGAGGAATTAGGTGCTGATATCTATATGAGCCGCGAATCGGATATTCAAGTTT
CTCTGGACGAGCGAGTTGAAATGGCAACTGATTCAAATGCTGATATTTTTGTAAGTGTCCATGCTAACGCTCATCCCAAT
AATGATATTCACGGTACAGAAACCTTTTATTCTTCAGAACGGAGTCCTTTAGATTTTGAATTAGCTGAAGCCTTACAGAA
TAGCTTATTACACAGTCTTCAAAGAAATAATAGAGGGGTGAAAGATAGCAGTTTTAGAGTACTAAGAAATGCTACTATGC
CTGCAGCTTTAGTTGAATTGGCCTTTTTATCCCATGAAAAAGAAGAAGAATTACTTAAAAAGGATGAATTCCGCGAAAAG
GCTGCTGAAGCAATTGTAGAGGGTATTTTAAATTATGATAAAACTGTCCGTTAA

Upstream 100 bases:

>100_bases
TGCTCGTCTATTATATAAAAGCTAATCCAAAAAAATCTATCATTTTGTGAAATCTGTAAAATGTACCAAATTTAAGCACT
AATCAAGGGGGCGAAATTAA

Downstream 100 bases:

>100_bases
TATGAACTAGTTAATATGAATTTTATTAAAAAGGCAACCGAAGCCTATAGATTTTTAAGGCTTTCGGTTGCCTTTTTTCT
TGCTACAACTCCCAATTAAT

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MKKVVTLVIVVFMLVITTNYAAGQENVDVFVDEDLVNFPDQEPYIDENSRVQVPVRFVSEALGGYVEWDGSTQTVNIKLD
KKELSLEVGQEIYLIDNSEKEMDTVPQVSQQGRTMVPLRFVSEGLGAEVDWLGEEESVYINTKESQEEKENENNENNPSD
VPSQEELENSEAMAEIKASNLNVRTGPGMDYSVVDNLQAGDSFPILDKHHNENEEEYQDWLKIDLEDEQDDVWVSADFIE
ISFLEESEEDEDKEQKDEEKEEIEEPEEDERDRPEIPQEYDDILGEIVIDADNLNVRTGPGLDYDSITQVDEGEDYDIIT
MAAMENHPTYEEWFKIDLDKRNLDVEDRNEAKGWVAAEYVKRDNIDLMNNLEEINYINWTENSNNTEITLGPVQRIPLES
FTREDPDRLVLDFEGIALATDETAWQVETSTLQGIRAHEHNGMTRVVFDLNSKEHYSIDWEDAHLNVRLYDDNPLSGKKI
FIDPGHGGSNSGAIGQNGLKEKEVALDVSLRTRDMLEELGADIYMSRESDIQVSLDERVEMATDSNADIFVSVHANAHPN
NDIHGTETFYSSERSPLDFELAEALQNSLLHSLQRNNRGVKDSSFRVLRNATMPAALVELAFLSHEKEEELLKKDEFREK
AAEAIVEGILNYDKTVR

Sequences:

>Translated_657_residues
MKKVVTLVIVVFMLVITTNYAAGQENVDVFVDEDLVNFPDQEPYIDENSRVQVPVRFVSEALGGYVEWDGSTQTVNIKLD
KKELSLEVGQEIYLIDNSEKEMDTVPQVSQQGRTMVPLRFVSEGLGAEVDWLGEEESVYINTKESQEEKENENNENNPSD
VPSQEELENSEAMAEIKASNLNVRTGPGMDYSVVDNLQAGDSFPILDKHHNENEEEYQDWLKIDLEDEQDDVWVSADFIE
ISFLEESEEDEDKEQKDEEKEEIEEPEEDERDRPEIPQEYDDILGEIVIDADNLNVRTGPGLDYDSITQVDEGEDYDIIT
MAAMENHPTYEEWFKIDLDKRNLDVEDRNEAKGWVAAEYVKRDNIDLMNNLEEINYINWTENSNNTEITLGPVQRIPLES
FTREDPDRLVLDFEGIALATDETAWQVETSTLQGIRAHEHNGMTRVVFDLNSKEHYSIDWEDAHLNVRLYDDNPLSGKKI
FIDPGHGGSNSGAIGQNGLKEKEVALDVSLRTRDMLEELGADIYMSRESDIQVSLDERVEMATDSNADIFVSVHANAHPN
NDIHGTETFYSSERSPLDFELAEALQNSLLHSLQRNNRGVKDSSFRVLRNATMPAALVELAFLSHEKEEELLKKDEFREK
AAEAIVEGILNYDKTVR
>Mature_657_residues
MKKVVTLVIVVFMLVITTNYAAGQENVDVFVDEDLVNFPDQEPYIDENSRVQVPVRFVSEALGGYVEWDGSTQTVNIKLD
KKELSLEVGQEIYLIDNSEKEMDTVPQVSQQGRTMVPLRFVSEGLGAEVDWLGEEESVYINTKESQEEKENENNENNPSD
VPSQEELENSEAMAEIKASNLNVRTGPGMDYSVVDNLQAGDSFPILDKHHNENEEEYQDWLKIDLEDEQDDVWVSADFIE
ISFLEESEEDEDKEQKDEEKEEIEEPEEDERDRPEIPQEYDDILGEIVIDADNLNVRTGPGLDYDSITQVDEGEDYDIIT
MAAMENHPTYEEWFKIDLDKRNLDVEDRNEAKGWVAAEYVKRDNIDLMNNLEEINYINWTENSNNTEITLGPVQRIPLES
FTREDPDRLVLDFEGIALATDETAWQVETSTLQGIRAHEHNGMTRVVFDLNSKEHYSIDWEDAHLNVRLYDDNPLSGKKI
FIDPGHGGSNSGAIGQNGLKEKEVALDVSLRTRDMLEELGADIYMSRESDIQVSLDERVEMATDSNADIFVSVHANAHPN
NDIHGTETFYSSERSPLDFELAEALQNSLLHSLQRNNRGVKDSSFRVLRNATMPAALVELAFLSHEKEEELLKKDEFREK
AAEAIVEGILNYDKTVR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=221, Percent_Identity=31.2217194570136, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI87082163, Length=217, Percent_Identity=30.4147465437788, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790611, Length=222, Percent_Identity=28.3783783783784, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 74951; Mature: 74951

Theoretical pI: Translated: 3.94; Mature: 3.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVVTLVIVVFMLVITTNYAAGQENVDVFVDEDLVNFPDQEPYIDENSRVQVPVRFVSE
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCCEEEEHHHHHHH
ALGGYVEWDGSTQTVNIKLDKKELSLEVGQEIYLIDNSEKEMDTVPQVSQQGRTMVPLRF
HHCCEEEECCCEEEEEEEECHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEHHH
VSEGLGAEVDWLGEEESVYINTKESQEEKENENNENNPSDVPSQEELENSEAMAEIKASN
HHHCCCCCEEECCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHCC
LNVRTGPGMDYSVVDNLQAGDSFPILDKHHNENEEEYQDWLKIDLEDEQDDVWVSADFIE
CEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCCCCCEEEEEEEEE
ISFLEESEEDEDKEQKDEEKEEIEEPEEDERDRPEIPQEYDDILGEIVIDADNLNVRTGP
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCEEECCC
GLDYDSITQVDEGEDYDIITMAAMENHPTYEEWFKIDLDKRNLDVEDRNEAKGWVAAEYV
CCCHHHCCCCCCCCCCEEEEEEEECCCCCHHHHEEEECCCCCCCCCCCCCCCCCCEEHHH
KRDNIDLMNNLEEINYINWTENSNNTEITLGPVQRIPLESFTREDPDRLVLDFEGIALAT
HCCCCHHHHCHHHCCEEEECCCCCCCEEEECCCCCCCHHHHCCCCCCEEEEEECCEEEEC
DETAWQVETSTLQGIRAHEHNGMTRVVFDLNSKEHYSIDWEDAHLNVRLYDDNPLSGKKI
CCCCEEEEHHHHHCHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCEE
FIDPGHGGSNSGAIGQNGLKEKEVALDVSLRTRDMLEELGADIYMSRESDIQVSLDERVE
EEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCEEEECCCCEEEEHHHHEE
MATDSNADIFVSVHANAHPNNDIHGTETFYSSERSPLDFELAEALQNSLLHSLQRNNRGV
CCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
KDSSFRVLRNATMPAALVELAFLSHEKEEELLKKDEFREKAAEAIVEGILNYDKTVR
CCCHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKVVTLVIVVFMLVITTNYAAGQENVDVFVDEDLVNFPDQEPYIDENSRVQVPVRFVSE
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCCEEEEHHHHHHH
ALGGYVEWDGSTQTVNIKLDKKELSLEVGQEIYLIDNSEKEMDTVPQVSQQGRTMVPLRF
HHCCEEEECCCEEEEEEEECHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEHHH
VSEGLGAEVDWLGEEESVYINTKESQEEKENENNENNPSDVPSQEELENSEAMAEIKASN
HHHCCCCCEEECCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHCC
LNVRTGPGMDYSVVDNLQAGDSFPILDKHHNENEEEYQDWLKIDLEDEQDDVWVSADFIE
CEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCCCCCEEEEEEEEE
ISFLEESEEDEDKEQKDEEKEEIEEPEEDERDRPEIPQEYDDILGEIVIDADNLNVRTGP
EEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHEEEEECCCCEEECCC
GLDYDSITQVDEGEDYDIITMAAMENHPTYEEWFKIDLDKRNLDVEDRNEAKGWVAAEYV
CCCHHHCCCCCCCCCCEEEEEEEECCCCCHHHHEEEECCCCCCCCCCCCCCCCCCEEHHH
KRDNIDLMNNLEEINYINWTENSNNTEITLGPVQRIPLESFTREDPDRLVLDFEGIALAT
HCCCCHHHHCHHHCCEEEECCCCCCCEEEECCCCCCCHHHHCCCCCCEEEEEECCEEEEC
DETAWQVETSTLQGIRAHEHNGMTRVVFDLNSKEHYSIDWEDAHLNVRLYDDNPLSGKKI
CCCCEEEEHHHHHCHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEEECCCCCCCCEE
FIDPGHGGSNSGAIGQNGLKEKEVALDVSLRTRDMLEELGADIYMSRESDIQVSLDERVE
EEECCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHCCCCEEEECCCCEEEEHHHHEE
MATDSNADIFVSVHANAHPNNDIHGTETFYSSERSPLDFELAEALQNSLLHSLQRNNRGV
CCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
KDSSFRVLRNATMPAALVELAFLSHEKEEELLKKDEFREKAAEAIVEGILNYDKTVR
CCCHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]