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The map label for this gene is trxA [H]

Identifier: 188584778

GI number: 188584778

Start: 160475

End: 160798

Strand: Direct

Name: trxA [H]

Synonym: Nther_0136

Alternate gene names: 188584778

Gene position: 160475-160798 (Clockwise)

Preceding gene: 188584777

Following gene: 188584779

Centisome position: 5.07

GC content: 34.88

Gene sequence:

>324_bases
ATGTCAAAAATTTTAGAAGTGAATGATACAAACTTTAAGGAGCAGGTACTGGAAGCTGATAAACCTGTATTAGTTGAGTT
TTGGGCTCCTTGGTGCGGTCCATGTAAAATGGTTGCCCCAGTATTAGAAGAGCTTGCAGAAGAAATGGATGGAAAAATTA
AAATTTGTAAAGTAAATGTTGATGAAAACACAGATACTGCAAGTGATTACGGTGTTATGAGTATTCCAACAATGGTATTG
ATTAAAGATGGAGAAGTTCAGGAACAGGTAGTAGGTTACTTACCACGTGAAGAACTGCAAAACAAAATAGAAGAAAATAT
TTAA

Upstream 100 bases:

>100_bases
AATTGAGACAGATAGTTACTGCTGTCTCTGATGGAGCAATTGCTGCTTTTCACGCTGAAAAATTATTATCATAATTTTAA
AAATGGAAGGAGAGATTAAT

Downstream 100 bases:

>100_bases
TCAATTAATTGACTTACCCGTCTTTAGGACGGGTTTTTTTGTATTATTTTATTAGTTACGTTGAATGCTAACAGTAAGAC
TAAAAAATTGGAGGTTTAAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSKILEVNDTNFKEQVLEADKPVLVEFWAPWCGPCKMVAPVLEELAEEMDGKIKICKVNVDENTDTASDYGVMSIPTMVL
IKDGEVQEQVVGYLPREELQNKIEENI

Sequences:

>Translated_107_residues
MSKILEVNDTNFKEQVLEADKPVLVEFWAPWCGPCKMVAPVLEELAEEMDGKIKICKVNVDENTDTASDYGVMSIPTMVL
IKDGEVQEQVVGYLPREELQNKIEENI
>Mature_106_residues
SKILEVNDTNFKEQVLEADKPVLVEFWAPWCGPCKMVAPVLEELAEEMDGKIKICKVNVDENTDTASDYGVMSIPTMVLI
KDGEVQEQVVGYLPREELQNKIEENI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=40.6976744186046, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI5031973, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI4758304, Length=105, Percent_Identity=35.2380952380952, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI20070125, Length=85, Percent_Identity=38.8235294117647, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=105, Percent_Identity=46.6666666666667, Blast_Score=117, Evalue=1e-28,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=37.2340425531915, Blast_Score=94, Evalue=3e-21,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=33.3333333333333, Blast_Score=60, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI212646193, Length=95, Percent_Identity=38.9473684210526, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980565, Length=106, Percent_Identity=39.622641509434, Blast_Score=78, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71980562, Length=109, Percent_Identity=38.5321100917431, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=93, Percent_Identity=35.4838709677419, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=40.6976744186046, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=86, Percent_Identity=40.6976744186046, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17507915, Length=72, Percent_Identity=44.4444444444444, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=66, Percent_Identity=43.9393939393939, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=82, Percent_Identity=32.9268292682927, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=98, Percent_Identity=36.734693877551, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=91, Percent_Identity=39.5604395604396, Blast_Score=68, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=89, Percent_Identity=37.0786516853933, Blast_Score=67, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=37.1134020618557, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=48.75, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664269, Length=93, Percent_Identity=40.8602150537634, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=39.3258426966292, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=39.3258426966292, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358065, Length=82, Percent_Identity=37.8048780487805, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921434, Length=75, Percent_Identity=36, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639068, Length=105, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12101; Mature: 11970

Theoretical pI: Translated: 3.98; Mature: 3.98

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILEVNDTNFKEQVLEADKPVLVEFWAPWCGPCKMVAPVLEELAEEMDGKIKICKVNV
CCCEECCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEC
DENTDTASDYGVMSIPTMVLIKDGEVQEQVVGYLPREELQNKIEENI
CCCCCCCCCCCEECCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SKILEVNDTNFKEQVLEADKPVLVEFWAPWCGPCKMVAPVLEELAEEMDGKIKICKVNV
CCEECCCCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEC
DENTDTASDYGVMSIPTMVLIKDGEVQEQVVGYLPREELQNKIEENI
CCCCCCCCCCCEECCCEEEEEECCCHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]