Click here to switch to the map view.

The map label for this gene is nuoN [H]

Identifier: 188584749

GI number: 188584749

Start: 123981

End: 125483

Strand: Direct

Name: nuoN [H]

Synonym: Nther_0107

Alternate gene names: 188584749

Gene position: 123981-125483 (Clockwise)

Preceding gene: 188584748

Following gene: 188584750

Centisome position: 3.92

GC content: 35.8

Gene sequence:

>1503_bases
GTGTCTTTTACAGATTTAGTATATAGTTTACCGATGTTGATTGTTTTATTCCCCTTAATTATGACTGGGGTTATTTTCTT
AGTTGAACAAAAGTCGATATTTGGTAGGAATTTATTATCGGTGGTTACATCTGCCATAACTTTTTTAATGGTGGCGGCCA
TGTATCCTGTTGTTATAAAAGGTGAGGTTATTTATTATCAATTAGCAAACTTAATACCTCCCTTTGGAATTTCATTTATG
GTTGATACTTTAGGATTCGGTTTGAGTTTGTTGGCTTCTTTTATTTGGATGTTAGTTACTATTTATTCCCTTGAATATAT
GAAAAAAGAGAATTATACAGGTAGGTACTATCCCGCATTGTCTTTGACCTTAAGCGGTTCTATGGGTCTATTTTTAGCGG
GAGATTTATTTACAATGTTCATATTTTTTGAAATTATGTCTCTGGTCTCCTACTTATTAATAATCCATAATGAAACTAAG
GAGGCTCTTAGAGCTGGATATAAATATTTGATTGTAACAATTATAGGTGGATTATTTCTGTTTTTCGGAATCATCATTAC
TTTTGAGTTAAGTCAGACAATTACTTTAAGTGAAATGGGAATAATTTCAACGCCTACTTCCCTAGCTTTTGCAGGTTTTC
TTTCATTTGTGATCGGTTTTGGCATGAAAGCGGGAATGGTTCCGTTGCATATTTGGTTACCTGAAGCTCATCCGGTGGCT
CCCTCTCCTGCAAGTGCTTTGCTATCTGGTATTATGATCAAAACAGGGGCCTATGGATTAATAAGAATCATGTTTCACGT
CTTTGATTACCAAATGATACTAGAGGCGAACTGGCACTTGATTTTAGCAGTAGTTGCAGTCATCACTATTTTCTTAGGTT
CCGCTGTGGCTATTACCCAGGAGGATTTAAAACGTAGGTTAGCGTACTCGAGTATTGGGCAAATGGGTTATATTTTACTA
GGTTTGGCCATATTAACTGAAACTGCGATGACAGGTGATATTTTCCATATATTTAGTCATGCTTTTATGAAAAGCACCCT
CTTTTTAGCCGCTGGCGCCATGATTATGAAAACGGGTAAAAAGAAAATAGCAGATCTAAAAGGTGTAGGTCGTGCCATGC
CTTTAACCATGTTGTCTTTTACAATAGCAGCTTTAGCTATGATTGGTATACCTCCTCTTAATGGATTTATTAGCAAATGG
TCATTGAGCTTAGGAGCTTTAGAAGCGGGACAACCATATTATGTCGTGATTTTATTAATAAGTAGTTTGATGAACAGTGT
CTATTACTTACCTATAATTAACACTGCTTATTTTGGAAAAAGTGAAGAAACTGATGATGACGTAGAATCAAAAGGAGTGA
TTTCAGAAGCTCCTATGAAAATGGTAATGCCCGTTGCGATTTTGGGCTTTAGTTGTTTGATTTTAAGCTTATTCCCGACT
AATATTCCTTATGAATTGGCACAATTGGCTGCAAAAGCCCTGATTAATGGTAATCCTTTCTAG

Upstream 100 bases:

>100_bases
GGGGGTGTTTTATTGGGTAAGCGATGCATTAAAAGAGCAGGTTGGCTATTAATCTATTGCAGATTAAAGTGAACATAATC
ACAATTAGGAGGTTTTAGTA

Downstream 100 bases:

>100_bases
TTTAAGCTATGTAAAATCGAATGGTATAACCGAATGTTGGTAACTTTAAAATATTAATTTAATATCAACAACAAAATATA
ACAACCCTTAGTTAAAAAAC

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MSFTDLVYSLPMLIVLFPLIMTGVIFLVEQKSIFGRNLLSVVTSAITFLMVAAMYPVVIKGEVIYYQLANLIPPFGISFM
VDTLGFGLSLLASFIWMLVTIYSLEYMKKENYTGRYYPALSLTLSGSMGLFLAGDLFTMFIFFEIMSLVSYLLIIHNETK
EALRAGYKYLIVTIIGGLFLFFGIIITFELSQTITLSEMGIISTPTSLAFAGFLSFVIGFGMKAGMVPLHIWLPEAHPVA
PSPASALLSGIMIKTGAYGLIRIMFHVFDYQMILEANWHLILAVVAVITIFLGSAVAITQEDLKRRLAYSSIGQMGYILL
GLAILTETAMTGDIFHIFSHAFMKSTLFLAAGAMIMKTGKKKIADLKGVGRAMPLTMLSFTIAALAMIGIPPLNGFISKW
SLSLGALEAGQPYYVVILLISSLMNSVYYLPIINTAYFGKSEETDDDVESKGVISEAPMKMVMPVAILGFSCLILSLFPT
NIPYELAQLAAKALINGNPF

Sequences:

>Translated_500_residues
MSFTDLVYSLPMLIVLFPLIMTGVIFLVEQKSIFGRNLLSVVTSAITFLMVAAMYPVVIKGEVIYYQLANLIPPFGISFM
VDTLGFGLSLLASFIWMLVTIYSLEYMKKENYTGRYYPALSLTLSGSMGLFLAGDLFTMFIFFEIMSLVSYLLIIHNETK
EALRAGYKYLIVTIIGGLFLFFGIIITFELSQTITLSEMGIISTPTSLAFAGFLSFVIGFGMKAGMVPLHIWLPEAHPVA
PSPASALLSGIMIKTGAYGLIRIMFHVFDYQMILEANWHLILAVVAVITIFLGSAVAITQEDLKRRLAYSSIGQMGYILL
GLAILTETAMTGDIFHIFSHAFMKSTLFLAAGAMIMKTGKKKIADLKGVGRAMPLTMLSFTIAALAMIGIPPLNGFISKW
SLSLGALEAGQPYYVVILLISSLMNSVYYLPIINTAYFGKSEETDDDVESKGVISEAPMKMVMPVAILGFSCLILSLFPT
NIPYELAQLAAKALINGNPF
>Mature_499_residues
SFTDLVYSLPMLIVLFPLIMTGVIFLVEQKSIFGRNLLSVVTSAITFLMVAAMYPVVIKGEVIYYQLANLIPPFGISFMV
DTLGFGLSLLASFIWMLVTIYSLEYMKKENYTGRYYPALSLTLSGSMGLFLAGDLFTMFIFFEIMSLVSYLLIIHNETKE
ALRAGYKYLIVTIIGGLFLFFGIIITFELSQTITLSEMGIISTPTSLAFAGFLSFVIGFGMKAGMVPLHIWLPEAHPVAP
SPASALLSGIMIKTGAYGLIRIMFHVFDYQMILEANWHLILAVVAVITIFLGSAVAITQEDLKRRLAYSSIGQMGYILLG
LAILTETAMTGDIFHIFSHAFMKSTLFLAAGAMIMKTGKKKIADLKGVGRAMPLTMLSFTIAALAMIGIPPLNGFISKWS
LSLGALEAGQPYYVVILLISSLMNSVYYLPIINTAYFGKSEETDDDVESKGVISEAPMKMVMPVAILGFSCLILSLFPTN
IPYELAQLAAKALINGNPF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=327, Percent_Identity=29.3577981651376, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI251831116, Length=274, Percent_Identity=27.7372262773723, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1788827, Length=460, Percent_Identity=29.5652173913043, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1788829, Length=370, Percent_Identity=32.1621621621622, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788613, Length=398, Percent_Identity=29.8994974874372, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788831, Length=395, Percent_Identity=28.8607594936709, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788614, Length=468, Percent_Identity=28.2051282051282, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI2367154, Length=401, Percent_Identity=25.9351620947631, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI145693160, Length=460, Percent_Identity=26.0869565217391, Blast_Score=105, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54779; Mature: 54647

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTDLVYSLPMLIVLFPLIMTGVIFLVEQKSIFGRNLLSVVTSAITFLMVAAMYPVVIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEE
GEVIYYQLANLIPPFGISFMVDTLGFGLSLLASFIWMLVTIYSLEYMKKENYTGRYYPAL
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECEE
SLTLSGSMGLFLAGDLFTMFIFFEIMSLVSYLLIIHNETKEALRAGYKYLIVTIIGGLFL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHH
FFGIIITFELSQTITLSEMGIISTPTSLAFAGFLSFVIGFGMKAGMVPLHIWLPEAHPVA
HHHHHHHHHHCCEEEHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
PSPASALLSGIMIKTGAYGLIRIMFHVFDYQMILEANWHLILAVVAVITIFLGSAVAITQ
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCH
EDLKRRLAYSSIGQMGYILLGLAILTETAMTGDIFHIFSHAFMKSTLFLAAGAMIMKTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KKIADLKGVGRAMPLTMLSFTIAALAMIGIPPLNGFISKWSLSLGALEAGQPYYVVILLI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
SSLMNSVYYLPIINTAYFGKSEETDDDVESKGVISEAPMKMVMPVAILGFSCLILSLFPT
HHHHHCEEEHEEEHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NIPYELAQLAAKALINGNPF
CCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFTDLVYSLPMLIVLFPLIMTGVIFLVEQKSIFGRNLLSVVTSAITFLMVAAMYPVVIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEE
GEVIYYQLANLIPPFGISFMVDTLGFGLSLLASFIWMLVTIYSLEYMKKENYTGRYYPAL
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECEE
SLTLSGSMGLFLAGDLFTMFIFFEIMSLVSYLLIIHNETKEALRAGYKYLIVTIIGGLFL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHH
FFGIIITFELSQTITLSEMGIISTPTSLAFAGFLSFVIGFGMKAGMVPLHIWLPEAHPVA
HHHHHHHHHHCCEEEHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
PSPASALLSGIMIKTGAYGLIRIMFHVFDYQMILEANWHLILAVVAVITIFLGSAVAITQ
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHCCH
EDLKRRLAYSSIGQMGYILLGLAILTETAMTGDIFHIFSHAFMKSTLFLAAGAMIMKTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCH
KKIADLKGVGRAMPLTMLSFTIAALAMIGIPPLNGFISKWSLSLGALEAGQPYYVVILLI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
SSLMNSVYYLPIINTAYFGKSEETDDDVESKGVISEAPMKMVMPVAILGFSCLILSLFPT
HHHHHCEEEHEEEHHHCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
NIPYELAQLAAKALINGNPF
CCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA