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The map label for this gene is patA [H]

Identifier: 188584748

GI number: 188584748

Start: 122363

End: 123745

Strand: Direct

Name: patA [H]

Synonym: Nther_0106

Alternate gene names: 188584748

Gene position: 122363-123745 (Clockwise)

Preceding gene: 188584747

Following gene: 188584749

Centisome position: 3.87

GC content: 38.25

Gene sequence:

>1383_bases
ATGGAGTTAATTAATATTGATGAAACTTTAGAAATGACAAGACAAGAACTGCGTACGAAACATAATAACTATTTAAATCC
GGGATTTATGAAGATGCTAAGCTTACTAGGTTTTGATAAAAAATTTGTCAGGGCTGAAGGTACTAAAGTATGGGATGATA
ATGGTATAGAATATTTAGACTTTTTGGGCGGATATGGTTCTTTAAATTTGGGACATAATCCTGAAGAAGTGTTTAATGCT
CTAGACAAAATAAAAGGTTCACCGAACATTTTACAGGCTGCTCCCGGGACATTTAATGCAGCTTTAGCAGAAAACCTGGC
TGCTATAACACCAGGTAATTTACAGCATTCCTTTTTTTGCAACAGTGGAGCTGAGGCAGTTGAAGGAGCGGTGAAACTTG
CACGAAGAGCAACTGGCAAATCAAAGGTTATTTCAGCCAAGGGATCATTTCATGGAAAGACCATGGGTTCTTTATCTGTA
TCCGGTAGAGATAAATTTAAAGCAGGGTATTTCCCTTTAGTCCCTGAATGTACTCAAATACCCTATGGTGATGATGAAGC
CCTACGAGAAGAAATCGATGAAAATACAGCGGCCGTTATTTTAGAACCTGTTATGGGTGAAGGAGGTGTAATAGTTCCTC
CTGAGGGTTATTTATCAACTGTTAGTGAAATTTGTAGTCAAAACAATATTGTTTTCATTTTAGATGAAATTCAAACAGGT
TTGGGTAGAACTGGTAAAATGCTGGCATGCGAATGGGAGCAAATAACTCCCGACATAATTTGTTTTGCAAAATCCTTGGG
CGGTGGCGTGTTTCCCATTGGTGCCTTTATTACTACTCCTGAACTGTGGAATAAGGCCTATGGTAGAATGGAAGAAGCCC
TGATGCATACATCAACATTTGGCGGTAATGCCTTAGCTACTGGCGCTTCAATAGCGACAATCAACTCTATTTTGGATAAC
AACTTGCCCGAACGTGCAAATGAACATGGTGAATACTTTATAAACTCTTTGAAACAGCTAGATGATAAACACGACATGAT
TAAAGAGGTGCGAGGACAAGGTTTATTAATCGGAATTGAGTTTAACTCTCCGGAAAAAAGTGTCTTAAACAAACTGTCTA
AGGGAATGCTTGAAAAAGTAAGTCAGGAATACACTGGTGCTTTTGTGGCCGAAAAGCTGCAGAATGAATATCAAGTTTTA
ACTGCATTCACCTTGAATAATCCTAATGTTATTAGATTAGAGCCACCATTAATAGTTGACAAGGAACAAATTGACTATGT
TGTGGATTCTCTAGATAAACTGCTAGACCACCATGGTGACTTTTTTAAGCTCGCCTTTTCAAGCGGTAAAAAGGCAGTAT
CATCCTTTTTTAAGCGTGATTAG

Upstream 100 bases:

>100_bases
TGACAGGGATTAAAATAATGACAATGACCTTTCTGGTTTTGTAATTTGTACAGAAACTCCGGACTAAGAATATCCGAAAT
ATCCGAAAGGATGGATTGAA

Downstream 100 bases:

>100_bases
ACGTAATCATAAAAATCTGTCGAGTTTGACGGAATTAAATCTAATTGTTAAAATTGAAAAATGATAACAGTATCAAGTTT
ACTACTGGACAATTTGTCAA

Product: aminotransferase

Products: NA

Alternate protein names: Putrescine--2-oxoglutaric acid transaminase; PAT; PATase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MELINIDETLEMTRQELRTKHNNYLNPGFMKMLSLLGFDKKFVRAEGTKVWDDNGIEYLDFLGGYGSLNLGHNPEEVFNA
LDKIKGSPNILQAAPGTFNAALAENLAAITPGNLQHSFFCNSGAEAVEGAVKLARRATGKSKVISAKGSFHGKTMGSLSV
SGRDKFKAGYFPLVPECTQIPYGDDEALREEIDENTAAVILEPVMGEGGVIVPPEGYLSTVSEICSQNNIVFILDEIQTG
LGRTGKMLACEWEQITPDIICFAKSLGGGVFPIGAFITTPELWNKAYGRMEEALMHTSTFGGNALATGASIATINSILDN
NLPERANEHGEYFINSLKQLDDKHDMIKEVRGQGLLIGIEFNSPEKSVLNKLSKGMLEKVSQEYTGAFVAEKLQNEYQVL
TAFTLNNPNVIRLEPPLIVDKEQIDYVVDSLDKLLDHHGDFFKLAFSSGKKAVSSFFKRD

Sequences:

>Translated_460_residues
MELINIDETLEMTRQELRTKHNNYLNPGFMKMLSLLGFDKKFVRAEGTKVWDDNGIEYLDFLGGYGSLNLGHNPEEVFNA
LDKIKGSPNILQAAPGTFNAALAENLAAITPGNLQHSFFCNSGAEAVEGAVKLARRATGKSKVISAKGSFHGKTMGSLSV
SGRDKFKAGYFPLVPECTQIPYGDDEALREEIDENTAAVILEPVMGEGGVIVPPEGYLSTVSEICSQNNIVFILDEIQTG
LGRTGKMLACEWEQITPDIICFAKSLGGGVFPIGAFITTPELWNKAYGRMEEALMHTSTFGGNALATGASIATINSILDN
NLPERANEHGEYFINSLKQLDDKHDMIKEVRGQGLLIGIEFNSPEKSVLNKLSKGMLEKVSQEYTGAFVAEKLQNEYQVL
TAFTLNNPNVIRLEPPLIVDKEQIDYVVDSLDKLLDHHGDFFKLAFSSGKKAVSSFFKRD
>Mature_460_residues
MELINIDETLEMTRQELRTKHNNYLNPGFMKMLSLLGFDKKFVRAEGTKVWDDNGIEYLDFLGGYGSLNLGHNPEEVFNA
LDKIKGSPNILQAAPGTFNAALAENLAAITPGNLQHSFFCNSGAEAVEGAVKLARRATGKSKVISAKGSFHGKTMGSLSV
SGRDKFKAGYFPLVPECTQIPYGDDEALREEIDENTAAVILEPVMGEGGVIVPPEGYLSTVSEICSQNNIVFILDEIQTG
LGRTGKMLACEWEQITPDIICFAKSLGGGVFPIGAFITTPELWNKAYGRMEEALMHTSTFGGNALATGASIATINSILDN
NLPERANEHGEYFINSLKQLDDKHDMIKEVRGQGLLIGIEFNSPEKSVLNKLSKGMLEKVSQEYTGAFVAEKLQNEYQVL
TAFTLNNPNVIRLEPPLIVDKEQIDYVVDSLDKLLDHHGDFFKLAFSSGKKAVSSFFKRD

Specific function: Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithi

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=31.8407960199005, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=31.7901234567901, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI13994255, Length=464, Percent_Identity=27.3706896551724, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=28.5046728971963, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=28.169014084507, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI226442709, Length=362, Percent_Identity=29.0055248618785, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=27.5294117647059, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=388, Percent_Identity=21.6494845360825, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679950, Length=388, Percent_Identity=21.6494845360825, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI38679946, Length=388, Percent_Identity=21.6494845360825, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI145693181, Length=444, Percent_Identity=40.0900900900901, Blast_Score=324, Evalue=9e-90,
Organism=Escherichia coli, GI1788044, Length=414, Percent_Identity=34.0579710144928, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=33.1619537275064, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=30.4347826086957, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1787560, Length=412, Percent_Identity=31.7961165048544, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786991, Length=324, Percent_Identity=29.9382716049383, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786349, Length=334, Percent_Identity=26.6467065868263, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=401, Percent_Identity=32.6683291770574, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=293, Percent_Identity=33.7883959044369, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI32564660, Length=449, Percent_Identity=27.8396436525612, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=431, Percent_Identity=25.2900232018561, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=463, Percent_Identity=24.1900647948164, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=432, Percent_Identity=33.1018518518519, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324432, Length=421, Percent_Identity=30.166270783848, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=366, Percent_Identity=27.3224043715847, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=412, Percent_Identity=25, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=30.9405940594059, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161085790, Length=475, Percent_Identity=27.7894736842105, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI28574759, Length=468, Percent_Identity=28.2051282051282, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI21356575, Length=464, Percent_Identity=28.6637931034483, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI281366494, Length=164, Percent_Identity=29.8780487804878, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24667139, Length=164, Percent_Identity=29.8780487804878, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24667143, Length=164, Percent_Identity=29.8780487804878, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR017747
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.82 [H]

Molecular weight: Translated: 50447; Mature: 50447

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELINIDETLEMTRQELRTKHNNYLNPGFMKMLSLLGFDKKFVRAEGTKVWDDNGIEYLD
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCEEECCCCCHHHH
FLGGYGSLNLGHNPEEVFNALDKIKGSPNILQAAPGTFNAALAENLAAITPGNLQHSFFC
HHCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHCHHCCCCCCCCEEEEE
NSGAEAVEGAVKLARRATGKSKVISAKGSFHGKTMGSLSVSGRDKFKAGYFPLVPECTQI
CCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
PYGDDEALREEIDENTAAVILEPVMGEGGVIVPPEGYLSTVSEICSQNNIVFILDEIQTG
CCCCHHHHHHHHCCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEHHHHC
LGRTGKMLACEWEQITPDIICFAKSLGGGVFPIGAFITTPELWNKAYGRMEEALMHTSTF
CCCCCCEEEEEHHHCCHHHHHHHHHHCCCEEEHHHHEECHHHHHHHHHHHHHHHHHHCCC
GGNALATGASIATINSILDNNLPERANEHGEYFINSLKQLDDKHDMIKEVRGQGLLIGIE
CCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEEEEE
FNSPEKSVLNKLSKGMLEKVSQEYTGAFVAEKLQNEYQVLTAFTLNNPNVIRLEPPLIVD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEECCCEEEC
KEQIDYVVDSLDKLLDHHGDFFKLAFSSGKKAVSSFFKRD
HHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHCCC
>Mature Secondary Structure
MELINIDETLEMTRQELRTKHNNYLNPGFMKMLSLLGFDKKFVRAEGTKVWDDNGIEYLD
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCEEECCCCCHHHH
FLGGYGSLNLGHNPEEVFNALDKIKGSPNILQAAPGTFNAALAENLAAITPGNLQHSFFC
HHCCCCCCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHCHHCCCCCCCCEEEEE
NSGAEAVEGAVKLARRATGKSKVISAKGSFHGKTMGSLSVSGRDKFKAGYFPLVPECTQI
CCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCC
PYGDDEALREEIDENTAAVILEPVMGEGGVIVPPEGYLSTVSEICSQNNIVFILDEIQTG
CCCCHHHHHHHHCCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHCCCCEEEEEEHHHHC
LGRTGKMLACEWEQITPDIICFAKSLGGGVFPIGAFITTPELWNKAYGRMEEALMHTSTF
CCCCCCEEEEEHHHCCHHHHHHHHHHCCCEEEHHHHEECHHHHHHHHHHHHHHHHHHCCC
GGNALATGASIATINSILDNNLPERANEHGEYFINSLKQLDDKHDMIKEVRGQGLLIGIE
CCCHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCEEEEEEE
FNSPEKSVLNKLSKGMLEKVSQEYTGAFVAEKLQNEYQVLTAFTLNNPNVIRLEPPLIVD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEECCCEEEC
KEQIDYVVDSLDKLLDHHGDFFKLAFSSGKKAVSSFFKRD
HHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA