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The map label for this gene is hpt [H]

Identifier: 188584722

GI number: 188584722

Start: 96706

End: 97251

Strand: Direct

Name: hpt [H]

Synonym: Nther_0080

Alternate gene names: 188584722

Gene position: 96706-97251 (Clockwise)

Preceding gene: 188584721

Following gene: 188584723

Centisome position: 3.05

GC content: 34.62

Gene sequence:

>546_bases
GTGGAAAGGGCTTATGACAAAGATGCTTTTAAACAATTAATTAGTGAAGAGGAAATAAAAGATAAGGTTAAAGAATTAGG
AGAACAAATTTCGCAAGACTATCAAGGACAAGAAGTGATTGCTGTTGGGGTACTAAAAGGCTCCTTTGTTTTTGCAGCAG
ATTTGTTGAGACAATTAAGCATACCTAATGAAATTGATTTCCTAGCTGTATCAAGCTATGGCGCTAGTACTAAATCAAGT
GGTATAATTAGAATATTGAAAGATTTAGATACTAGTATAGAAAATAAACATGTGCTGATTGTAGAAGATATAGTAGATAC
TGGCTTGACTCTAAATTATTTATTGGAAACCTTATCTACAAGAAAGCCGGCATCACTTAAAATTTGTACTTTATTAGATA
AACCTGATCGCAGAGAGGTGGATCTGACTCCCGATTATATTGGTTTTCAAATACCCGATTTATTCGTGGTAGGATATGGC
CTGGACTATGCAGAATATTATCGGGATTGGCCAGCTATTTATGTTTTACCAGAAGAAGACGAGTAA

Upstream 100 bases:

>100_bases
ATAAAGTTACTAAGGATACTAGAAGATATTTTTGCATTGAAGCTCAACTATCGGAGTATTAATTTAAAAATTCAGGTAAT
GAATAAAAGGAGGGTATACT

Downstream 100 bases:

>100_bases
TAATTATTCTGATTAATGAAAATTTGATTAGTTGTTTTAGAGAATATTTTATGATAAAATACCATGATGCATATATTGTA
GAGTTGTGTGTTTCAAGAGA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MERAYDKDAFKQLISEEEIKDKVKELGEQISQDYQGQEVIAVGVLKGSFVFAADLLRQLSIPNEIDFLAVSSYGASTKSS
GIIRILKDLDTSIENKHVLIVEDIVDTGLTLNYLLETLSTRKPASLKICTLLDKPDRREVDLTPDYIGFQIPDLFVVGYG
LDYAEYYRDWPAIYVLPEEDE

Sequences:

>Translated_181_residues
MERAYDKDAFKQLISEEEIKDKVKELGEQISQDYQGQEVIAVGVLKGSFVFAADLLRQLSIPNEIDFLAVSSYGASTKSS
GIIRILKDLDTSIENKHVLIVEDIVDTGLTLNYLLETLSTRKPASLKICTLLDKPDRREVDLTPDYIGFQIPDLFVVGYG
LDYAEYYRDWPAIYVLPEEDE
>Mature_181_residues
MERAYDKDAFKQLISEEEIKDKVKELGEQISQDYQGQEVIAVGVLKGSFVFAADLLRQLSIPNEIDFLAVSSYGASTKSS
GIIRILKDLDTSIENKHVLIVEDIVDTGLTLNYLLETLSTRKPASLKICTLLDKPDRREVDLTPDYIGFQIPDLFVVGYG
LDYAEYYRDWPAIYVLPEEDE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=184, Percent_Identity=38.0434782608696, Blast_Score=123, Evalue=9e-29,
Organism=Homo sapiens, GI9910262, Length=177, Percent_Identity=37.8531073446328, Blast_Score=114, Evalue=6e-26,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=52.0710059171598, Blast_Score=182, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17510817, Length=182, Percent_Identity=37.3626373626374, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20502; Mature: 20502

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAYDKDAFKQLISEEEIKDKVKELGEQISQDYQGQEVIAVGVLKGSFVFAADLLRQLS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHC
IPNEIDFLAVSSYGASTKSSGIIRILKDLDTSIENKHVLIVEDIVDTGLTLNYLLETLST
CCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHC
RKPASLKICTLLDKPDRREVDLTPDYIGFQIPDLFVVGYGLDYAEYYRDWPAIYVLPEED
CCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCEEEEECCCCHHHHHCCCCEEEEEECCC
E
C
>Mature Secondary Structure
MERAYDKDAFKQLISEEEIKDKVKELGEQISQDYQGQEVIAVGVLKGSFVFAADLLRQLS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHC
IPNEIDFLAVSSYGASTKSSGIIRILKDLDTSIENKHVLIVEDIVDTGLTLNYLLETLST
CCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEHHHHHCCCHHHHHHHHHHC
RKPASLKICTLLDKPDRREVDLTPDYIGFQIPDLFVVGYGLDYAEYYRDWPAIYVLPEED
CCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCEEEEECCCCHHHHHCCCCEEEEEECCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]