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The map label for this gene is serS

Identifier: 188584655

GI number: 188584655

Start: 22970

End: 24238

Strand: Direct

Name: serS

Synonym: Nther_0013

Alternate gene names: 188584655

Gene position: 22970-24238 (Clockwise)

Preceding gene: 188584654

Following gene: 188584656

Centisome position: 0.73

GC content: 36.25

Gene sequence:

>1269_bases
ATGCTAGATGTCAAGTATATTCGAAACAATCCTGATGAGGCAAGGAAAGCTTGTGTCCAAAAAGGTGAAGATGATCATGT
TGATGAAATTTTGAAATATGATGAACAGCGTAGGAAGATATTAACAGATTTAGAAGTATTAAAAAATAAGCGTAATACTG
TTTCCAAAGAAATAGGTCAATTGAAAAAAGAGGGACACGATGCACAAGACAAAATTGCTGAAATGAAAGAGGTATCTGAT
AAAGTAAAAGAAATGGACGATGAACTGAAAAAAGTTGATGAACAACTTAATTATCATCTATTATGTATCCCTAATATACC
TAATCCAGATGTGCCTGTTGGGGACGATGACGAAGATAATCAAGTAGTCAAGCAGGTTGGTGAACCAGTTAAAAAGGATT
ACTTTAAACCTCATTGGGAGGTGGCTGAAAACCTGAACTTACTTGATTTTAAGAGAGCTGGCAAAGTTACTGGTACAAGA
TTTGTAAATTATGTAGGTGATGCTGCTCGTTTAGAAAGGGCCTTGATTGATTTCATGATTGATGTACATGTAACAGAACA
TGGTTATGTAGAAATGATGCCTCCTTTTATTGCCAATAGGGACTCAATGACTGGCACAGGGCAACTTCCTAAATTTGAAG
ATGATATGTATAAATTGGAAGATATGGAATACTTTTTAATTCCCACTGCTGAAGTTACTTTGACCAATTTGTATCGTGAC
GAGATTCTACCTGGAGATTTTTTACCTAGATATTTAGTCGCTTTTACACCATGTTTTCGAAAAGAAGCAGGTGCCCATGG
ACGGGATACTCGAGGTCTTATCAGACAGCATCAATTCAACAAGGTAGAGATGGTAAAATTTGTAGAACCAGAAAAATCAT
ATCAAGAGCTTGATTCACTTGTGGCAAATGCGGAAAGAGTGTTACAATTATTAGAACTACCTTATCAAATATCATTGATG
TGTACTGGTGATTTAGGTTTTGCTGCAGCTAAAAAGTATGACTTAGAGGTTTGGCTACCAAGTTACGACACTTACAGAGA
AATATCATCATGTAGTAATTTCGAAGATTTTCAAGCTAGGAGAGCTAATATAAGATATCGGCCAGAAGAAGGGGAAAAAG
CCAGGTTTGTGCATACTTTAAATGGATCTGGATTAGCTGTTGGAAGAACACTAGCGGCTATATTGGAAAATTATCAAAAT
CCCGATGGAACTGTTACAATTCCTGAAGTGCTTAAGCCTTACTTTAATGGTCGAGACGTGATTTCATAA

Upstream 100 bases:

>100_bases
AACTAGGGTGGCAACGCGAGCAGACCCTCGTCCCTAATTTGGTGACGAGGGTTTTTTGTCTAATTGCTTGGACAATAATA
CATATTAGGGGGGAATAATC

Downstream 100 bases:

>100_bases
ATTTTAAAATTGATTTGACAGTTAAAAGTCCCTGTGTTATACTTTTTAATGTCCTTTGAGAAGTTGGTATAAAAACAAAT
ATCCCAGGAGGGGTGGCCGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLDVKYIRNNPDEARKACVQKGEDDHVDEILKYDEQRRKILTDLEVLKNKRNTVSKEIGQLKKEGHDAQDKIAEMKEVSD
KVKEMDDELKKVDEQLNYHLLCIPNIPNPDVPVGDDDEDNQVVKQVGEPVKKDYFKPHWEVAENLNLLDFKRAGKVTGTR
FVNYVGDAARLERALIDFMIDVHVTEHGYVEMMPPFIANRDSMTGTGQLPKFEDDMYKLEDMEYFLIPTAEVTLTNLYRD
EILPGDFLPRYLVAFTPCFRKEAGAHGRDTRGLIRQHQFNKVEMVKFVEPEKSYQELDSLVANAERVLQLLELPYQISLM
CTGDLGFAAAKKYDLEVWLPSYDTYREISSCSNFEDFQARRANIRYRPEEGEKARFVHTLNGSGLAVGRTLAAILENYQN
PDGTVTIPEVLKPYFNGRDVIS

Sequences:

>Translated_422_residues
MLDVKYIRNNPDEARKACVQKGEDDHVDEILKYDEQRRKILTDLEVLKNKRNTVSKEIGQLKKEGHDAQDKIAEMKEVSD
KVKEMDDELKKVDEQLNYHLLCIPNIPNPDVPVGDDDEDNQVVKQVGEPVKKDYFKPHWEVAENLNLLDFKRAGKVTGTR
FVNYVGDAARLERALIDFMIDVHVTEHGYVEMMPPFIANRDSMTGTGQLPKFEDDMYKLEDMEYFLIPTAEVTLTNLYRD
EILPGDFLPRYLVAFTPCFRKEAGAHGRDTRGLIRQHQFNKVEMVKFVEPEKSYQELDSLVANAERVLQLLELPYQISLM
CTGDLGFAAAKKYDLEVWLPSYDTYREISSCSNFEDFQARRANIRYRPEEGEKARFVHTLNGSGLAVGRTLAAILENYQN
PDGTVTIPEVLKPYFNGRDVIS
>Mature_422_residues
MLDVKYIRNNPDEARKACVQKGEDDHVDEILKYDEQRRKILTDLEVLKNKRNTVSKEIGQLKKEGHDAQDKIAEMKEVSD
KVKEMDDELKKVDEQLNYHLLCIPNIPNPDVPVGDDDEDNQVVKQVGEPVKKDYFKPHWEVAENLNLLDFKRAGKVTGTR
FVNYVGDAARLERALIDFMIDVHVTEHGYVEMMPPFIANRDSMTGTGQLPKFEDDMYKLEDMEYFLIPTAEVTLTNLYRD
EILPGDFLPRYLVAFTPCFRKEAGAHGRDTRGLIRQHQFNKVEMVKFVEPEKSYQELDSLVANAERVLQLLELPYQISLM
CTGDLGFAAAKKYDLEVWLPSYDTYREISSCSNFEDFQARRANIRYRPEEGEKARFVHTLNGSGLAVGRTLAAILENYQN
PDGTVTIPEVLKPYFNGRDVIS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=432, Percent_Identity=32.8703703703704, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI8923421, Length=441, Percent_Identity=30.6122448979592, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI225579074, Length=443, Percent_Identity=29.5711060948081, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=48.1395348837209, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17539260, Length=466, Percent_Identity=32.4034334763949, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=379, Percent_Identity=31.1345646437995, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=34.1628959276018, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6321799, Length=392, Percent_Identity=31.1224489795918, Blast_Score=209, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24581334, Length=356, Percent_Identity=33.4269662921348, Blast_Score=201, Evalue=6e-52,
Organism=Drosophila melanogaster, GI17737985, Length=348, Percent_Identity=33.0459770114943, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_NATTJ (B2A2Z8)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916200.1
- ProteinModelPortal:   B2A2Z8
- SMR:   B2A2Z8
- GeneID:   6314410
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0013
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48569; Mature: 48569

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVKYIRNNPDEARKACVQKGEDDHVDEILKYDEQRRKILTDLEVLKNKRNTVSKEIGQ
CCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKEGHDAQDKIAEMKEVSDKVKEMDDELKKVDEQLNYHLLCIPNIPNPDVPVGDDDEDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHH
QVVKQVGEPVKKDYFKPHWEVAENLNLLDFKRAGKVTGTRFVNYVGDAARLERALIDFMI
HHHHHHCCHHHHHHCCCCHHHHCCCCCEEHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHH
DVHVTEHGYVEMMPPFIANRDSMTGTGQLPKFEDDMYKLEDMEYFLIPTAEVTLTNLYRD
HEEECCCCCCEECCCHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHH
EILPGDFLPRYLVAFTPCFRKEAGAHGRDTRGLIRQHQFNKVEMVKFVEPEKSYQELDSL
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHEECCCCHHHHHHHHH
VANAERVLQLLELPYQISLMCTGDLGFAAAKKYDLEVWLPSYDTYREISSCSNFEDFQAR
HHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHH
RANIRYRPEEGEKARFVHTLNGSGLAVGRTLAAILENYQNPDGTVTIPEVLKPYFNGRDV
HCCCEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCC
IS
CC
>Mature Secondary Structure
MLDVKYIRNNPDEARKACVQKGEDDHVDEILKYDEQRRKILTDLEVLKNKRNTVSKEIGQ
CCCCEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKEGHDAQDKIAEMKEVSDKVKEMDDELKKVDEQLNYHLLCIPNIPNPDVPVGDDDEDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHH
QVVKQVGEPVKKDYFKPHWEVAENLNLLDFKRAGKVTGTRFVNYVGDAARLERALIDFMI
HHHHHHCCHHHHHHCCCCHHHHCCCCCEEHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHH
DVHVTEHGYVEMMPPFIANRDSMTGTGQLPKFEDDMYKLEDMEYFLIPTAEVTLTNLYRD
HEEECCCCCCEECCCHHCCCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHH
EILPGDFLPRYLVAFTPCFRKEAGAHGRDTRGLIRQHQFNKVEMVKFVEPEKSYQELDSL
HCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHEECCCCHHHHHHHHH
VANAERVLQLLELPYQISLMCTGDLGFAAAKKYDLEVWLPSYDTYREISSCSNFEDFQAR
HHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCEEEEECCCCHHHHHHHHCCCCHHHHHH
RANIRYRPEEGEKARFVHTLNGSGLAVGRTLAAILENYQNPDGTVTIPEVLKPYFNGRDV
HCCCEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCC
IS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA