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The map label for this gene is acxB [H]

Identifier: 188527456

GI number: 188527456

Start: 640879

End: 643176

Strand: Reverse

Name: acxB [H]

Synonym: HPSH_03370

Alternate gene names: 188527456

Gene position: 643176-640879 (Counterclockwise)

Preceding gene: 188527457

Following gene: 188527455

Centisome position: 39.98

GC content: 43.73

Gene sequence:

>2298_bases
ATGGCAAATTTATTGAAAAACGGCAAAACTTTAAAACAAGCTAGAGATGAAATCCTAGCCAGGACAGAAAAAACAGGGCA
TTATAATGGTCTCAAAAAACTAGAGTTTAAAGAAAGAGATCCGATCGGTTATGAGAAGATGTTCTCTAAACTAAGGGGCG
GTATCGTGCATGCCAGAGAAACAGCTAAAAGGATTGCGGCAAGCCCTATTGTTGAGCAAGAGGGGGAATTGTGCTTCACG
CTTTATAACGCTGTGGGCGATAGCGTGCTGACTTCTACGGGCATCATTATCCATGTAGGCACTATGGGATCAGCTATCAA
ATACATGGTAGAGAATAATTGGGAAGATAACCCCGGTATCAATGACAAGGATATTTTCACCAATAACGACTGTGCGATTG
GGAATGTGCACCCATGCGATATTATGACTCTTGTGCCTATTTTCCACGATGAAAAATTGATTGGGTGGGTAGGCGGCGTT
ACGCATGTGATTGATACCGGTTCGGTTACTCCAGGATCAATGAGCACTGGACAGGTTCAAAGATTTGGGGATGGATACAT
GATCACTTGCCGTAAGACAGGAGCGAACGATGAAAGCTTTAAAGATTGGTTGCATGAATCTCAAAGATCGGTTCGCACGC
CTAAATATTGGATTCTAGATGAAAGGACTAGGATTGCAGGATGCCACATGATTAGGGATTTAGTGATGGAAGTCATTAAA
GAAGATGGCATTGATTCTTACATGCGATTCATTGATGAGGTGATTGAAGAGGGCAGAAGAGGTCTTATCTCTAGAATCAA
ATCCATGACCATACCAGGCAAGTATAGAAAGGTAGCGTTTGTGGATGTGCCTTATGCACATAAAGATATTGGCGTGTGCT
CTGAATTTGCTAAGCTAGACACGATCATGCACTCTCCTGTGGAAATCACTATCAATAAAGACGCTACATGGAAATTAGAT
TTTGAAGGCGCATCTAGGTGGGGATGGCACTCTTTCAATTGCAACCAAGTGTCTTTCACTAGCGGTATTTGGGTGATGAT
GACTCAAACGCTGATACCCACTTCTCGCATCAATGATGGCGCTTATTTCGCTACGCAGTTCAGGCTCAAAAAAGGGACTT
GGATGAATCCAGATGACAGGCGCACCGGGCATGCTTATGCGTGGCATTTCTTGGTATCAGGCTGGAGCGCTTTGTGGAGA
GGCTTATCTCAAGCGTATTACAGCCGAGGGTATTTAGAAGAGGTCAATTCCGGAAACGCTAACACTTCCAATTGGCTGCA
AGGCGGTGGTATCAACCAGGATGGAGAAATCCATGCGGTGAATAGCTTTGAGACGAGTTCTTGTGGGACTGGAGCTTGCG
CGATAAAAGACGGCTTGAATCACGCAGCGGCTATTTGGAATCCAGAAGGCGATATGGGCGATGTTGAAATTTGGGAAATG
GCAGAGCCTCTTCTTTATCTAGGCAGGAATGTCAAAGCCAATACCGGTGGGTATGGAAAATATCGAGGCGGTAACGGGTT
TGAAACCTTAAGAATGGTGTGGGGCGCGCATGATTGGACCATGTTCTTTATGGGTAATGGCTATATGAATAGCGATTGGG
GTATGATGGGGGGCTATCCAGCGGCTAGTGGCTATAGGTTTGAAGCGCACAACACCGATTTAAAAAACAGGATTAAAAAT
AACGCCAGCTTGCCTTTGGGGGGCGATTTTAACCCGACTGATCGAGATTATGAAAAGCACATTTCTCATGCGTCTCAAGT
TAAAAGGGATAAGCAATGCATCACCACTGAGAACTGCTTTGATAATTATGACTTGTATTTGAATTACATCAAAGGCGGTC
CTGGATTTGGCGATCCGATTGAAAGGGATTTGAATGCGATTTTAGAAGATCTCAACAGCAAACAGCTATTGCCAGAATAC
GCTTACAAGGTTTATGGTGCGGTGGTGAGTCAAAATAAAGACGGTGTGTGGGTCGGCGATGAAGCCAAAACTAAGGCTAG
AAGAAAAGAAATTCTTGAAAACAGAAAGGCTAGATCCATACCGGTAAAACAATGGATGGAGCAAGAAAGAAACGCTATCC
TTGAAAAAGAGGCTTCCAAACAGGTTAAGCACATGTATGCGACTAGTTTTGATCTTTCGCCTAAGTTTTTAAACGATTTT
AAAACATTCTGGAACTTGCCAAAGAGCTGGAGCGTGAAAGAAGATGAGCTTGGCGTATTCACCTATGGGTCTAAATACAG
GATGGATTTGAATAAATTGCCTGATGTGCGCACGGTTGTGTTGGTTGATGAGAAATAA

Upstream 100 bases:

>100_bases
AATCAGATGCGACCACTTTCGTGATACCCAAAGGCTTTGCGACAAGACTAGACAAACACCGATTGTTCCACTTGAAAGAA
ATTAAATAAAGGAGTTCAAA

Downstream 100 bases:

>100_bases
AGAAAGGAGAATGGTTATGTCAAAATACACACAAGAACAAATTAAAAATTTGGTAGAGGGGAACTTGGATTGGAACACTG
TCTTAAAAATGCTTAGCATG

Product: N-methylhydantoinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 764

Protein sequence:

>765_residues
MANLLKNGKTLKQARDEILARTEKTGHYNGLKKLEFKERDPIGYEKMFSKLRGGIVHARETAKRIAASPIVEQEGELCFT
LYNAVGDSVLTSTGIIIHVGTMGSAIKYMVENNWEDNPGINDKDIFTNNDCAIGNVHPCDIMTLVPIFHDEKLIGWVGGV
THVIDTGSVTPGSMSTGQVQRFGDGYMITCRKTGANDESFKDWLHESQRSVRTPKYWILDERTRIAGCHMIRDLVMEVIK
EDGIDSYMRFIDEVIEEGRRGLISRIKSMTIPGKYRKVAFVDVPYAHKDIGVCSEFAKLDTIMHSPVEITINKDATWKLD
FEGASRWGWHSFNCNQVSFTSGIWVMMTQTLIPTSRINDGAYFATQFRLKKGTWMNPDDRRTGHAYAWHFLVSGWSALWR
GLSQAYYSRGYLEEVNSGNANTSNWLQGGGINQDGEIHAVNSFETSSCGTGACAIKDGLNHAAAIWNPEGDMGDVEIWEM
AEPLLYLGRNVKANTGGYGKYRGGNGFETLRMVWGAHDWTMFFMGNGYMNSDWGMMGGYPAASGYRFEAHNTDLKNRIKN
NASLPLGGDFNPTDRDYEKHISHASQVKRDKQCITTENCFDNYDLYLNYIKGGPGFGDPIERDLNAILEDLNSKQLLPEY
AYKVYGAVVSQNKDGVWVGDEAKTKARRKEILENRKARSIPVKQWMEQERNAILEKEASKQVKHMYATSFDLSPKFLNDF
KTFWNLPKSWSVKEDELGVFTYGSKYRMDLNKLPDVRTVVLVDEK

Sequences:

>Translated_765_residues
MANLLKNGKTLKQARDEILARTEKTGHYNGLKKLEFKERDPIGYEKMFSKLRGGIVHARETAKRIAASPIVEQEGELCFT
LYNAVGDSVLTSTGIIIHVGTMGSAIKYMVENNWEDNPGINDKDIFTNNDCAIGNVHPCDIMTLVPIFHDEKLIGWVGGV
THVIDTGSVTPGSMSTGQVQRFGDGYMITCRKTGANDESFKDWLHESQRSVRTPKYWILDERTRIAGCHMIRDLVMEVIK
EDGIDSYMRFIDEVIEEGRRGLISRIKSMTIPGKYRKVAFVDVPYAHKDIGVCSEFAKLDTIMHSPVEITINKDATWKLD
FEGASRWGWHSFNCNQVSFTSGIWVMMTQTLIPTSRINDGAYFATQFRLKKGTWMNPDDRRTGHAYAWHFLVSGWSALWR
GLSQAYYSRGYLEEVNSGNANTSNWLQGGGINQDGEIHAVNSFETSSCGTGACAIKDGLNHAAAIWNPEGDMGDVEIWEM
AEPLLYLGRNVKANTGGYGKYRGGNGFETLRMVWGAHDWTMFFMGNGYMNSDWGMMGGYPAASGYRFEAHNTDLKNRIKN
NASLPLGGDFNPTDRDYEKHISHASQVKRDKQCITTENCFDNYDLYLNYIKGGPGFGDPIERDLNAILEDLNSKQLLPEY
AYKVYGAVVSQNKDGVWVGDEAKTKARRKEILENRKARSIPVKQWMEQERNAILEKEASKQVKHMYATSFDLSPKFLNDF
KTFWNLPKSWSVKEDELGVFTYGSKYRMDLNKLPDVRTVVLVDEK
>Mature_764_residues
ANLLKNGKTLKQARDEILARTEKTGHYNGLKKLEFKERDPIGYEKMFSKLRGGIVHARETAKRIAASPIVEQEGELCFTL
YNAVGDSVLTSTGIIIHVGTMGSAIKYMVENNWEDNPGINDKDIFTNNDCAIGNVHPCDIMTLVPIFHDEKLIGWVGGVT
HVIDTGSVTPGSMSTGQVQRFGDGYMITCRKTGANDESFKDWLHESQRSVRTPKYWILDERTRIAGCHMIRDLVMEVIKE
DGIDSYMRFIDEVIEEGRRGLISRIKSMTIPGKYRKVAFVDVPYAHKDIGVCSEFAKLDTIMHSPVEITINKDATWKLDF
EGASRWGWHSFNCNQVSFTSGIWVMMTQTLIPTSRINDGAYFATQFRLKKGTWMNPDDRRTGHAYAWHFLVSGWSALWRG
LSQAYYSRGYLEEVNSGNANTSNWLQGGGINQDGEIHAVNSFETSSCGTGACAIKDGLNHAAAIWNPEGDMGDVEIWEMA
EPLLYLGRNVKANTGGYGKYRGGNGFETLRMVWGAHDWTMFFMGNGYMNSDWGMMGGYPAASGYRFEAHNTDLKNRIKNN
ASLPLGGDFNPTDRDYEKHISHASQVKRDKQCITTENCFDNYDLYLNYIKGGPGFGDPIERDLNAILEDLNSKQLLPEYA
YKVYGAVVSQNKDGVWVGDEAKTKARRKEILENRKARSIPVKQWMEQERNAILEKEASKQVKHMYATSFDLSPKFLNDFK
TFWNLPKSWSVKEDELGVFTYGSKYRMDLNKLPDVRTVVLVDEK

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 86513; Mature: 86382

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLLKNGKTLKQARDEILARTEKTGHYNGLKKLEFKERDPIGYEKMFSKLRGGIVHARE
CCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEHHHH
TAKRIAASPIVEQEGELCFTLYNAVGDSVLTSTGIIIHVGTMGSAIKYMVENNWEDNPGI
HHHHHHHCCCHHCCCCEEEEHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCC
NDKDIFTNNDCAIGNVHPCDIMTLVPIFHDEKLIGWVGGVTHVIDTGSVTPGSMSTGQVQ
CCCCCEECCCCCCCCCCCCCCEEEEHHHCCCHHHHHHCCHHHHEECCCCCCCCCCCCCHH
RFGDGYMITCRKTGANDESFKDWLHESQRSVRTPKYWILDERTRIAGCHMIRDLVMEVIK
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
EDGIDSYMRFIDEVIEEGRRGLISRIKSMTIPGKYRKVAFVDVPYAHKDIGVCSEFAKLD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
TIMHSPVEITINKDATWKLDFEGASRWGWHSFNCNQVSFTSGIWVMMTQTLIPTSRINDG
HHHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEEHHHHHCCCCCCCCC
AYFATQFRLKKGTWMNPDDRRTGHAYAWHFLVSGWSALWRGLSQAYYSRGYLEEVNSGNA
EEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
NTSNWLQGGGINQDGEIHAVNSFETSSCGTGACAIKDGLNHAAAIWNPEGDMGDVEIWEM
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEHHHCCCCCEEEECCCCCCCCCHHHHH
AEPLLYLGRNVKANTGGYGKYRGGNGFETLRMVWGAHDWTMFFMGNGYMNSDWGMMGGYP
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEECCCCCCCCCCC
AASGYRFEAHNTDLKNRIKNNASLPLGGDFNPTDRDYEKHISHASQVKRDKQCITTENCF
CCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCC
DNYDLYLNYIKGGPGFGDPIERDLNAILEDLNSKQLLPEYAYKVYGAVVSQNKDGVWVGD
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEECC
EAKTKARRKEILENRKARSIPVKQWMEQERNAILEKEASKQVKHMYATSFDLSPKFLNDF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KTFWNLPKSWSVKEDELGVFTYGSKYRMDLNKLPDVRTVVLVDEK
HHHHCCCCCCCCCCCCCEEEECCCEEEECHHCCCCCEEEEEEECC
>Mature Secondary Structure 
ANLLKNGKTLKQARDEILARTEKTGHYNGLKKLEFKERDPIGYEKMFSKLRGGIVHARE
CCCHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEHHHH
TAKRIAASPIVEQEGELCFTLYNAVGDSVLTSTGIIIHVGTMGSAIKYMVENNWEDNPGI
HHHHHHHCCCHHCCCCEEEEHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCC
NDKDIFTNNDCAIGNVHPCDIMTLVPIFHDEKLIGWVGGVTHVIDTGSVTPGSMSTGQVQ
CCCCCEECCCCCCCCCCCCCCEEEEHHHCCCHHHHHHCCHHHHEECCCCCCCCCCCCCHH
RFGDGYMITCRKTGANDESFKDWLHESQRSVRTPKYWILDERTRIAGCHMIRDLVMEVIK
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
EDGIDSYMRFIDEVIEEGRRGLISRIKSMTIPGKYRKVAFVDVPYAHKDIGVCSEFAKLD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
TIMHSPVEITINKDATWKLDFEGASRWGWHSFNCNQVSFTSGIWVMMTQTLIPTSRINDG
HHHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEEHHHHHCCCCCCCCC
AYFATQFRLKKGTWMNPDDRRTGHAYAWHFLVSGWSALWRGLSQAYYSRGYLEEVNSGNA
EEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCC
NTSNWLQGGGINQDGEIHAVNSFETSSCGTGACAIKDGLNHAAAIWNPEGDMGDVEIWEM
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEEHHHCCCCCEEEECCCCCCCCCHHHHH
AEPLLYLGRNVKANTGGYGKYRGGNGFETLRMVWGAHDWTMFFMGNGYMNSDWGMMGGYP
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCEECCCCCCCCCCC
AASGYRFEAHNTDLKNRIKNNASLPLGGDFNPTDRDYEKHISHASQVKRDKQCITTENCF
CCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCC
DNYDLYLNYIKGGPGFGDPIERDLNAILEDLNSKQLLPEYAYKVYGAVVSQNKDGVWVGD
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEECC
EAKTKARRKEILENRKARSIPVKQWMEQERNAILEKEASKQVKHMYATSFDLSPKFLNDF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
KTFWNLPKSWSVKEDELGVFTYGSKYRMDLNKLPDVRTVVLVDEK
HHHHCCCCCCCCCCCCCEEEECCCEEEECHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]