Click here to switch to the map view.

The map label for this gene is acxA [H]

Identifier: 188527457

GI number: 188527457

Start: 643188

End: 645329

Strand: Reverse

Name: acxA [H]

Synonym: HPSH_03375

Alternate gene names: 188527457

Gene position: 645329-643188 (Counterclockwise)

Preceding gene: 188527458

Following gene: 188527456

Centisome position: 40.12

GC content: 44.96

Gene sequence:

>2142_bases
ATGAAAGACGCAAAAGTTCAGGTGATGGGTATTGATGCCGGTGGCACCATGACGGACACATTTTTTGTGAAAGAAAATGG
CAGTTTCGTAGTTGGTAAAGCCCAAAGCAACCCAGAAGATGAGAGCTTAGCTATTTACAATAGCTCACAAGATGCTTTAT
CGCACTGGAAATCGGATGTGAATAAGGTTTATCCAGAGTTGGTCACTTGCGTTTACTCAGGCACGGCGATGCTCAATCGG
GTCGTCCAAAGGCGTGGGATGGAAGTGGGCCTAATTTGCAATAAGGGTTTTGAGCAAATGCATTCTATGGGCAGGGCGTT
GCAATCCTACTTGGGGTATGCGCTAGAAGAAAGGTTGCATATCAACACGCACAAGTATGATGATCCGCTGATTCCTTTAA
AAAGGATTAGAGGCGTTACAGAAAGAACCGATGTCAAGGGGCAAGTGGTTATCCCAGTGCGCCTAGAAGAGGTTAAAGTT
GCTGTTAAGGAGCTTTTAGAAGCAGGCGCAAAGGCCATTGTGATTTGCTTGTTGCAATCTCATAAAAACGCTGAAAGCGA
GCGGATCGTTAGAGATATAGCGTTAAAAGAGATTGAAAAATTGGGTAAAAATATTCCTGTATTCGCTTCGGTGGATTACT
ACCCTCAAAGAAAAGAAAGCCACAGAATGAACACCACTATCTTAGAAGCTTATGCGGCTGAGCCAAGCAGGCAAACTCTC
TCTAAAGTCAGCAACCGCTTCAAAGAGCATGGCGCTAAATTTGATCTTAGGGTGATGGCAACACATGGAGGCACTATTAG
TTGGAAGGCTAAAGAGCTTGCCAGAACGATCGTGAGCGGTCCTATTGGAGGCGTGATCGGATCTAAATTGCTAGGCGAAA
CGCTTGGTTATGACAATATTGCATGCAGCGATATTGGCGGCACGAGCTTTGATATGGCGCTTATCGTTAAGAGCAATTTC
AACATCGCTTCTGACCCTGATATGGCGCGCCTTGTTTTATCTCTACCGCTTGTGGCTATGGATTCCGTTGGTGCAGGTGC
GGGGAGTTTTGTGCGCATTGATCCGCACAGCCGATCTGTCAAACTAGGGCCTGACAGCGCGGGGTATAGGGTTGGCACTT
GTTGGAAAGACAGCGGATTAGACACGGTTTCAGTAACCGATTGCCATATTGTTTTAGGCTATTTGAACCCGGATAATTTC
TTAGGCGGTTTAATCAAATTAGATGTGGATAGGGCTAAAAAACACATTAAAGAACAAATCGCTGATCCGCTAGGCATTAG
CGTAGAAGATGCGGCTGCGGGTGTGATTGAGTTGCTTGATTTGGAGCTTAAAGAATACTTGCGATCCAATATTAGCGCTA
AAGGGTATAGCCCGTCTGATTTTGTGTGTTTTTCGTATGGTGGTGCGGGGCCTGTGCATACCTATGGCTATACAGAAGGC
TTAGGGTTTAAGGATGTGGTAGTGCCTGCGTGGGCGGCTGGATTTAGCGCTTTTGGTTGCGCTTGCGCTGATTTTGAATA
CAGATACGATAAGAGCGTGGATATTGCTATTCCGCAGTATTCTTCAGACAAGTCAAAAGTAGAAGCATGCAAAATCATTC
AAGACGCATGGGATGAATTGACCCTCAAAGTGATTGAAGAGTTCAAGATCAATGGATTTTCTCAAAAAGATGTGATCTTA
AGACCTGGATACAGGATGCAGTATATGGGGCAATTGAATGATTTAGAGATCACTTCTCCTGTGTCAAAAGCTGCAAGCGT
GGCTGATTGGGAAGAGATTGTCAAAGAATATGAAAAAACCTACGCTCGTGTTTATTCCGAATCAGCGTGTTCTCCAGAGC
TTGGTTTTAGCGTGACCGGCGTGATCATGCGTGGTGTTGTAGCTACGCAAAAACCTGTGATTCCGGTTGAAAAAGAGCAT
GGCACTACGCCCCCAAAAGAAGCCAAAATAGGCGTTAGAAAATTCTATCGGCATAAAAAATGGGTGGATGCAGATGTGTG
GCAAATGGAAAAATTACTGCCTGGAAATGAAGTCATAGGGCCTGCGATCGTGGAATCAGATGCGACCACTTTCGTGATAC
CCAAAGGCTTTGCGACAAGACTAGACAAACACCGATTGTTCCACTTGAAAGAAATTAAATAA

Upstream 100 bases:

>100_bases
TAAAAAAAATGATTTCCATTTTAAAATTTGTCCTACAATTCAAACAGGTTACCTTGATAGGTTACCTTGAGCAACACTTT
AATACTAAGGAGTCTAAAAA

Downstream 100 bases:

>100_bases
AGGAGTTCAAAATGGCAAATTTATTGAAAAACGGCAAAACTTTAAAACAAGCTAGAGATGAAATCCTAGCCAGGACAGAA
AAAACAGGGCATTATAATGG

Product: hydantoin utilization protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MKDAKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWKSDVNKVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRLEEVKV
AVKELLEAGAKAIVICLLQSHKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVDRAKKHIKEQIADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKVEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GTTPPKEAKIGVRKFYRHKKWVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEIK

Sequences:

>Translated_713_residues
MKDAKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWKSDVNKVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRLEEVKV
AVKELLEAGAKAIVICLLQSHKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVDRAKKHIKEQIADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKVEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GTTPPKEAKIGVRKFYRHKKWVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEIK
>Mature_713_residues
MKDAKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWKSDVNKVYPELVTCVYSGTAMLNR
VVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLHINTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRLEEVKV
AVKELLEAGAKAIVICLLQSHKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNIACSDIGGTSFDMALIVKSNF
NIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSVKLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNF
LGGLIKLDVDRAKKHIKEQIADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKVEACKIIQDAWDELTLKVIEEFKINGFSQKDVIL
RPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKTYARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEH
GTTPPKEAKIGVRKFYRHKKWVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEIK

Specific function: Catalyzes the carboxylation of acetone to form acetoacetate. Has a reduced activity on butanone, and no activity on 2-pentatone, 3-pentatone, 2-hexanone, chloroacetone, pyruvate, phosphoenolpyruvate, acetaldehyde, propionaldehyde and propylene oxide [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=515, Percent_Identity=24.8543689320388, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI133901900, Length=725, Percent_Identity=22.2068965517241, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322634, Length=579, Percent_Identity=24.006908462867, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI45550492, Length=732, Percent_Identity=25.5464480874317, Blast_Score=132, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: =6.4.1.6 [H]

Molecular weight: Translated: 78548; Mature: 78548

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDAKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWKSDV
CCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHH
NKVYPELVTCVYSGTAMLNRVVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLH
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
INTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRLEEVKVAVKELLEAGAKAIVICLLQS
ECCCCCCCCCCCHHHHCCCCHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEHHC
HKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCHHHHH
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNI
HHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ACSDIGGTSFDMALIVKSNFNIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSV
EECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCEE
KLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNFLGGLIKLDVDRAKKHIKEQI
EECCCCCCCEEEEEECCCCCCEEEEEEEEEEEEEECCHHHHCCEEEEEHHHHHHHHHHHH
ADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKVEACKIIQDAWDEL
CCCCHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TLKVIEEFKINGFSQKDVILRPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKT
HHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEHGTTPPKEAKIGVRKFYRHKK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
WVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEIK
CCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCHHHHHHHHHHEEEEECCC
>Mature Secondary Structure
MKDAKVQVMGIDAGGTMTDTFFVKENGSFVVGKAQSNPEDESLAIYNSSQDALSHWKSDV
CCCCEEEEEEECCCCCEEEEEEEECCCCEEEEECCCCCCCCEEEEECCCHHHHHHHHHHH
NKVYPELVTCVYSGTAMLNRVVQRRGMEVGLICNKGFEQMHSMGRALQSYLGYALEERLH
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEE
INTHKYDDPLIPLKRIRGVTERTDVKGQVVIPVRLEEVKVAVKELLEAGAKAIVICLLQS
ECCCCCCCCCCCHHHHCCCCHHCCCCCEEEEEEEHHHHHHHHHHHHHCCCCEEEEEEHHC
HKNAESERIVRDIALKEIEKLGKNIPVFASVDYYPQRKESHRMNTTILEAYAAEPSRQTL
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHCCCCHHHHHHHHCCCHHHHH
SKVSNRFKEHGAKFDLRVMATHGGTISWKAKELARTIVSGPIGGVIGSKLLGETLGYDNI
HHHHHHHHHCCCCEEEEEEEECCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCE
ACSDIGGTSFDMALIVKSNFNIASDPDMARLVLSLPLVAMDSVGAGAGSFVRIDPHSRSV
EECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCEEEECCCCCEE
KLGPDSAGYRVGTCWKDSGLDTVSVTDCHIVLGYLNPDNFLGGLIKLDVDRAKKHIKEQI
EECCCCCCCEEEEEECCCCCCEEEEEEEEEEEEEECCHHHHCCEEEEEHHHHHHHHHHHH
ADPLGISVEDAAAGVIELLDLELKEYLRSNISAKGYSPSDFVCFSYGGAGPVHTYGYTEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCC
LGFKDVVVPAWAAGFSAFGCACADFEYRYDKSVDIAIPQYSSDKSKVEACKIIQDAWDEL
CCCCHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TLKVIEEFKINGFSQKDVILRPGYRMQYMGQLNDLEITSPVSKAASVADWEEIVKEYEKT
HHHHHHHHHCCCCCCCCEEECCCCCEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
YARVYSESACSPELGFSVTGVIMRGVVATQKPVIPVEKEHGTTPPKEAKIGVRKFYRHKK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
WVDADVWQMEKLLPGNEVIGPAIVESDATTFVIPKGFATRLDKHRLFHLKEIK
CCCHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCHHHHHHHHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12003937 [H]