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The map label for this gene is helD [H]

Identifier: 187935712

GI number: 187935712

Start: 3443518

End: 3445629

Strand: Reverse

Name: helD [H]

Synonym: CLL_A3281

Alternate gene names: 187935712

Gene position: 3445629-3443518 (Counterclockwise)

Preceding gene: 187934823

Following gene: 187932424

Centisome position: 90.67

GC content: 25.24

Gene sequence:

>2112_bases
TTGAATCAAAATTTAGATTTTTTAATGGAACAAAATAAGCTAGAAGAAGTTGAAAAAATTTTAAGTGGTGAAATACTTAA
TTATCTAGAAAAAAGAAAAAATATAACTAGTCAAATTCTTCAATCAAGAAAAAAATTTATTGAAGAATATAAAGATGATG
AAGACCAAGTTATAGATTATTTTGATCATGAAAATTACGTAAAAGAAGAAGCTTATAAGACGATAGATAAAAGATTAAAA
GAATTTACTAGTTTAAAAGAAGCACCTTATTTCGGTAAAGTAACATTTATGGAACAGGGGAATTTACCAGAAGAACTTTA
TATAGGTAGATACGGTTTAACTGTAGAAAAAACTTATGAATCTATAATTGTGGACTGGAGGGCTCCCATTGCATCATTAT
TTTATAAGGGTATATTAGGAAAATCTAGTTATACATGTCCAACTGGTGAGATTGATACAGATATACTTTCTAGAAGACAA
ATAATAATTAAAAAAGGTGAACTTAAAGGTATATTTGATTCAGAAGTAGATGTTAAAGATGAAATACTTCAAATGGTTCT
TACTGAAAATTCATCAGATAAACTTAAAGATATAGTAATGTCAATACAATCTGAACAAGATGAAATAATAAGAAGTGATA
AGAATAAAGTTGTAGTAGTAAATGGAGTTGCAGGTTCAGGAAAAACAACTATTGCATTACATAGAATATCTTATCTTCTT
TATAATTATAGAAAACAATTTGGAGATAAAGTTCTTATATTTGGACCGAATGATATATTTATGGATTATATTGCTCAAGT
CCTTCCTTCGTTAGGTGAAGAAGGGATAAAGCAAATGACATTTGAAAACTTTGCTATAAAACAATTAGGCATAGATAATT
TATATATAAAAAGTTTTAGTAAATATATAGAAGAAGCTATGAGTGGAAATAGAACAGCTCTTGCAGAATACCAATATAAA
AGTTCTAAAAAATTCTTAGATTTATTAAATCATGAAATTAATAAATTAAGTCAAAATTACTTTGATATTAAACCAATAAT
TTTTAATGGTGAAGAAATAGTAGGAATTAAAGAGATTAAAGAATTATTTGATATACATTATAAATACATGCCGTTATTTA
GAAGAAGTGAAAAAATAAAAAGAGTTCTTATATCTAAAATAAAAGATAAAAGAGATGCAGAAGTATATAAACTAAATCAA
GAAATGAAAGAAAAATTAGCTTCTTTATCAAGTTATGATTTAGAAATAGAAAAGAATAATTTAGAATATTTAAAGAGAAT
GAAAATTAGGGAAATTGTAAGAAATGTAATTAACTCAAGAAAAGAATTGGATTCTTGGGTAAGTCATGAAGATATAATAA
ATATTTATAAAAATATAACAGATACTAAGCAACTTGGATATATGGACTTAAGTGGAATATTATATTTAATGATTAAATTA
GATGGAAAAAGAATGAAAGAAGAAATTAAGCATATAGTAATAGATGAAGCACAAGATTACAGTGTTATACAATTTGAAGT
AATAAAAGGGCTTACAGGATGTAAAAGTTATACAATCGTTGGAGATTCTAATCAAAGATTAATAAATAATAATGAAGAAC
CAGCTATGTTAAATTTACAACCTTTATTTAATGAGGAAAAGCTGCATGTACAAGTACAAGAGTATGCATTAAATAAAAGT
TATAGATCTACTCAAGAAATAATGGAATATGCAACTAAGTTTTTGGATGACAATAGAATAATTCCATTAGTTAGACATGG
AGAAAAAGTAATAGAAGAAGAGGTATCTTCAGATGATGAATTTGTAGAAACTATTCTTTCGATAATTGAAGATTATGAAG
AAGATGGTCTTGAAAATATAGCTATTATATTTAATGGAAATAAGGATCTTGCTAAATTTTCTCATATTATTAAAGAAAAG
ATCAGTATTCAAAGTTTTGATAGAGAAGATATACTTTATAAAGGTGGAAAAGTTTTAATACCAGCATATTTAGCAAAAGG
ATTAGAATTTGATGGAGTTATAGTAATAGAAAACCATGAAATTGATCCATTGGTAAAATATATTATGTGTACAAGAGCGC
TTCATAGACTTTCATTAATCAAGAAACAATAA

Upstream 100 bases:

>100_bases
GTATGTAACTGATAGAAATATTTCATTTTAATGGCATTAGTCATTTGATAAAAATCATTGATAGAGGAATTTACTTTAAA
AAGCAAAGGGGAAAACTAAT

Downstream 100 bases:

>100_bases
GACATTAATAAATTATAGCAGCTATCAATAGATATGGTAGCTGCTATTTTAATACTTAGATAGGCTAGTAACAGTAAGAA
TTTATGCAAGATAGATATGG

Product: ATP-dependent DNA helicase rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 703

Protein sequence:

>703_residues
MNQNLDFLMEQNKLEEVEKILSGEILNYLEKRKNITSQILQSRKKFIEEYKDDEDQVIDYFDHENYVKEEAYKTIDKRLK
EFTSLKEAPYFGKVTFMEQGNLPEELYIGRYGLTVEKTYESIIVDWRAPIASLFYKGILGKSSYTCPTGEIDTDILSRRQ
IIIKKGELKGIFDSEVDVKDEILQMVLTENSSDKLKDIVMSIQSEQDEIIRSDKNKVVVVNGVAGSGKTTIALHRISYLL
YNYRKQFGDKVLIFGPNDIFMDYIAQVLPSLGEEGIKQMTFENFAIKQLGIDNLYIKSFSKYIEEAMSGNRTALAEYQYK
SSKKFLDLLNHEINKLSQNYFDIKPIIFNGEEIVGIKEIKELFDIHYKYMPLFRRSEKIKRVLISKIKDKRDAEVYKLNQ
EMKEKLASLSSYDLEIEKNNLEYLKRMKIREIVRNVINSRKELDSWVSHEDIINIYKNITDTKQLGYMDLSGILYLMIKL
DGKRMKEEIKHIVIDEAQDYSVIQFEVIKGLTGCKSYTIVGDSNQRLINNNEEPAMLNLQPLFNEEKLHVQVQEYALNKS
YRSTQEIMEYATKFLDDNRIIPLVRHGEKVIEEEVSSDDEFVETILSIIEDYEEDGLENIAIIFNGNKDLAKFSHIIKEK
ISIQSFDREDILYKGGKVLIPAYLAKGLEFDGVIVIENHEIDPLVKYIMCTRALHRLSLIKKQ

Sequences:

>Translated_703_residues
MNQNLDFLMEQNKLEEVEKILSGEILNYLEKRKNITSQILQSRKKFIEEYKDDEDQVIDYFDHENYVKEEAYKTIDKRLK
EFTSLKEAPYFGKVTFMEQGNLPEELYIGRYGLTVEKTYESIIVDWRAPIASLFYKGILGKSSYTCPTGEIDTDILSRRQ
IIIKKGELKGIFDSEVDVKDEILQMVLTENSSDKLKDIVMSIQSEQDEIIRSDKNKVVVVNGVAGSGKTTIALHRISYLL
YNYRKQFGDKVLIFGPNDIFMDYIAQVLPSLGEEGIKQMTFENFAIKQLGIDNLYIKSFSKYIEEAMSGNRTALAEYQYK
SSKKFLDLLNHEINKLSQNYFDIKPIIFNGEEIVGIKEIKELFDIHYKYMPLFRRSEKIKRVLISKIKDKRDAEVYKLNQ
EMKEKLASLSSYDLEIEKNNLEYLKRMKIREIVRNVINSRKELDSWVSHEDIINIYKNITDTKQLGYMDLSGILYLMIKL
DGKRMKEEIKHIVIDEAQDYSVIQFEVIKGLTGCKSYTIVGDSNQRLINNNEEPAMLNLQPLFNEEKLHVQVQEYALNKS
YRSTQEIMEYATKFLDDNRIIPLVRHGEKVIEEEVSSDDEFVETILSIIEDYEEDGLENIAIIFNGNKDLAKFSHIIKEK
ISIQSFDREDILYKGGKVLIPAYLAKGLEFDGVIVIENHEIDPLVKYIMCTRALHRLSLIKKQ
>Mature_703_residues
MNQNLDFLMEQNKLEEVEKILSGEILNYLEKRKNITSQILQSRKKFIEEYKDDEDQVIDYFDHENYVKEEAYKTIDKRLK
EFTSLKEAPYFGKVTFMEQGNLPEELYIGRYGLTVEKTYESIIVDWRAPIASLFYKGILGKSSYTCPTGEIDTDILSRRQ
IIIKKGELKGIFDSEVDVKDEILQMVLTENSSDKLKDIVMSIQSEQDEIIRSDKNKVVVVNGVAGSGKTTIALHRISYLL
YNYRKQFGDKVLIFGPNDIFMDYIAQVLPSLGEEGIKQMTFENFAIKQLGIDNLYIKSFSKYIEEAMSGNRTALAEYQYK
SSKKFLDLLNHEINKLSQNYFDIKPIIFNGEEIVGIKEIKELFDIHYKYMPLFRRSEKIKRVLISKIKDKRDAEVYKLNQ
EMKEKLASLSSYDLEIEKNNLEYLKRMKIREIVRNVINSRKELDSWVSHEDIINIYKNITDTKQLGYMDLSGILYLMIKL
DGKRMKEEIKHIVIDEAQDYSVIQFEVIKGLTGCKSYTIVGDSNQRLINNNEEPAMLNLQPLFNEEKLHVQVQEYALNKS
YRSTQEIMEYATKFLDDNRIIPLVRHGEKVIEEEVSSDDEFVETILSIIEDYEEDGLENIAIIFNGNKDLAKFSHIIKEK
ISIQSFDREDILYKGGKVLIPAYLAKGLEFDGVIVIENHEIDPLVKYIMCTRALHRLSLIKKQ

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81977; Mature: 81977

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNLDFLMEQNKLEEVEKILSGEILNYLEKRKNITSQILQSRKKFIEEYKDDEDQVIDY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FDHENYVKEEAYKTIDKRLKEFTSLKEAPYFGKVTFMEQGNLPEELYIGRYGLTVEKTYE
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHEECCCCCCHHHHHH
SIIVDWRAPIASLFYKGILGKSSYTCPTGEIDTDILSRRQIIIKKGELKGIFDSEVDVKD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHEEEECCCCCCCCCCCCHHH
EILQMVLTENSSDKLKDIVMSIQSEQDEIIRSDKNKVVVVNGVAGSGKTTIALHRISYLL
HHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
YNYRKQFGDKVLIFGPNDIFMDYIAQVLPSLGEEGIKQMTFENFAIKQLGIDNLYIKSFS
HHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KYIEEAMSGNRTALAEYQYKSSKKFLDLLNHEINKLSQNYFDIKPIIFNGEEIVGIKEIK
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECHHHHH
ELFDIHYKYMPLFRRSEKIKRVLISKIKDKRDAEVYKLNQEMKEKLASLSSYDLEIEKNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCC
LEYLKRMKIREIVRNVINSRKELDSWVSHEDIINIYKNITDTKQLGYMDLSGILYLMIKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEHHHHEEEEEEE
DGKRMKEEIKHIVIDEAQDYSVIQFEVIKGLTGCKSYTIVGDSNQRLINNNEEPAMLNLQ
CCHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEC
PLFNEEKLHVQVQEYALNKSYRSTQEIMEYATKFLDDNRIIPLVRHGEKVIEEEVSSDDE
CCCCCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEHHHHCCHHHHHHHHCCCHH
FVETILSIIEDYEEDGLENIAIIFNGNKDLAKFSHIIKEKISIQSFDREDILYKGGKVLI
HHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEE
PAYLAKGLEFDGVIVIENHEIDPLVKYIMCTRALHRLSLIKKQ
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQNLDFLMEQNKLEEVEKILSGEILNYLEKRKNITSQILQSRKKFIEEYKDDEDQVIDY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FDHENYVKEEAYKTIDKRLKEFTSLKEAPYFGKVTFMEQGNLPEELYIGRYGLTVEKTYE
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHEECCCCCCHHHHHH
SIIVDWRAPIASLFYKGILGKSSYTCPTGEIDTDILSRRQIIIKKGELKGIFDSEVDVKD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHEEEECCCCCCCCCCCCHHH
EILQMVLTENSSDKLKDIVMSIQSEQDEIIRSDKNKVVVVNGVAGSGKTTIALHRISYLL
HHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
YNYRKQFGDKVLIFGPNDIFMDYIAQVLPSLGEEGIKQMTFENFAIKQLGIDNLYIKSFS
HHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KYIEEAMSGNRTALAEYQYKSSKKFLDLLNHEINKLSQNYFDIKPIIFNGEEIVGIKEIK
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECHHHHH
ELFDIHYKYMPLFRRSEKIKRVLISKIKDKRDAEVYKLNQEMKEKLASLSSYDLEIEKNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCC
LEYLKRMKIREIVRNVINSRKELDSWVSHEDIINIYKNITDTKQLGYMDLSGILYLMIKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEEHHHHEEEEEEE
DGKRMKEEIKHIVIDEAQDYSVIQFEVIKGLTGCKSYTIVGDSNQRLINNNEEPAMLNLQ
CCHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCEEEEC
PLFNEEKLHVQVQEYALNKSYRSTQEIMEYATKFLDDNRIIPLVRHGEKVIEEEVSSDDE
CCCCCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEHHHHCCHHHHHHHHCCCHH
FVETILSIIEDYEEDGLENIAIIFNGNKDLAKFSHIIKEKISIQSFDREDILYKGGKVLI
HHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEE
PAYLAKGLEFDGVIVIENHEIDPLVKYIMCTRALHRLSLIKKQ
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]