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The map label for this gene is cysK [H]

Identifier: 187935115

GI number: 187935115

Start: 1626425

End: 1627432

Strand: Reverse

Name: cysK [H]

Synonym: CLL_A1571

Alternate gene names: 187935115

Gene position: 1627432-1626425 (Counterclockwise)

Preceding gene: 187933435

Following gene: 187932497

Centisome position: 42.82

GC content: 28.08

Gene sequence:

>1008_bases
ATGAATAATATACTTAATAAAATAAATAACTTAGAAAAGCTTATTGGTAATACCCCTCTTGTCGAAATATTATTTAAATA
TAAAGGGAAAAAATTAAAGGTATATTCAAAACTTGAATATTATAATTACACTGGAAGCATAAAAGATAGAATGGCTTTAT
ATATTTTGAAAAAAGCTTATTTAAATAATTCTATAAAACAAAACTATACTATAGTTGAAACAACTAGTGGAAATACTGGT
ATATCATTTTCAGCTATAGGCTCTTATCTCGGAAATTCTATTGATATTTATATGCCTGATTGGATGAGTGATGAACGAAA
AAAACTTTTATCAAGCTTTAATGCTAACTTAATATTAGTTTCTAAAAAAGAAGGTGGATTTTTAAAATGTTTAGAACTTA
CAGAAAAAAGGAAATTAAGTTCTGATACTGTATTTCTTCCATGTCAATTTTCTAATAACGACAATGCAGAAGCTCACTTT
CTGTCCACAGGACCTGAGATATGGAATGTCTTAAATAATTCAGGTATTATTCCTACTGCTTTTGTTGCTGGTGTTGGAAC
TGGTGGAACAATTATGGGAATAGGTAGATATCTAAAAGCTAATAATGCTAACATGAAAATCTATCCTTTAGAACCATCAA
ACTCCCCTACACTTTCCACTGGCTTTCAAGTAAGTGAACATCGAATTCAAGGAATTGTTGATGAATTTATTCCACCTATA
CTTGACTTAAAAAAATTAAATGAAGTTATAAGTGTTGATGATGGTGATGCTATAATAATGGCACAAAAACTCTCTAGAAT
TTTAGGTTTAGGAGTTGGTATATCATCTGGTGCTAATTTTTTGGGTGCTATAAAAGCGCTTGAATTAAATGGTTACAAAG
GAAATGTAGTAACAATATTTGCTGATGATAATAAAAAGTATTTAAGTACTGATTTAATGAAATTCGAACCAATTAAAGAT
ACCTTTATTTCATCAAATATTGAATTAATAGGTTTAAAACGATTATAA

Upstream 100 bases:

>100_bases
TATATTATAGTATTAATAATTTATCTATATATAAATGAGAACATTATTTTTAAATTACATAGTCTATAATATAAAAATAA
ATTTAGAATAGGAGTTTTTT

Downstream 100 bases:

>100_bases
TATTATGGCTATGTTTTATCGGAATATTTAAATATGCATAAACAAAGTAATTTAAATAATTAAACTTTGCATATTTAAGC
ATATATTTAAAACATAGCAT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNNILNKINNLEKLIGNTPLVEILFKYKGKKLKVYSKLEYYNYTGSIKDRMALYILKKAYLNNSIKQNYTIVETTSGNTG
ISFSAIGSYLGNSIDIYMPDWMSDERKKLLSSFNANLILVSKKEGGFLKCLELTEKRKLSSDTVFLPCQFSNNDNAEAHF
LSTGPEIWNVLNNSGIIPTAFVAGVGTGGTIMGIGRYLKANNANMKIYPLEPSNSPTLSTGFQVSEHRIQGIVDEFIPPI
LDLKKLNEVISVDDGDAIIMAQKLSRILGLGVGISSGANFLGAIKALELNGYKGNVVTIFADDNKKYLSTDLMKFEPIKD
TFISSNIELIGLKRL

Sequences:

>Translated_335_residues
MNNILNKINNLEKLIGNTPLVEILFKYKGKKLKVYSKLEYYNYTGSIKDRMALYILKKAYLNNSIKQNYTIVETTSGNTG
ISFSAIGSYLGNSIDIYMPDWMSDERKKLLSSFNANLILVSKKEGGFLKCLELTEKRKLSSDTVFLPCQFSNNDNAEAHF
LSTGPEIWNVLNNSGIIPTAFVAGVGTGGTIMGIGRYLKANNANMKIYPLEPSNSPTLSTGFQVSEHRIQGIVDEFIPPI
LDLKKLNEVISVDDGDAIIMAQKLSRILGLGVGISSGANFLGAIKALELNGYKGNVVTIFADDNKKYLSTDLMKFEPIKD
TFISSNIELIGLKRL
>Mature_335_residues
MNNILNKINNLEKLIGNTPLVEILFKYKGKKLKVYSKLEYYNYTGSIKDRMALYILKKAYLNNSIKQNYTIVETTSGNTG
ISFSAIGSYLGNSIDIYMPDWMSDERKKLLSSFNANLILVSKKEGGFLKCLELTEKRKLSSDTVFLPCQFSNNDNAEAHF
LSTGPEIWNVLNNSGIIPTAFVAGVGTGGTIMGIGRYLKANNANMKIYPLEPSNSPTLSTGFQVSEHRIQGIVDEFIPPI
LDLKKLNEVISVDDGDAIIMAQKLSRILGLGVGISSGANFLGAIKALELNGYKGNVVTIFADDNKKYLSTDLMKFEPIKD
TFISSNIELIGLKRL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=309, Percent_Identity=29.7734627831715, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI295821200, Length=309, Percent_Identity=29.7734627831715, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4557415, Length=309, Percent_Identity=29.7734627831715, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=33.6538461538462, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=35.6209150326797, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562970, Length=326, Percent_Identity=34.9693251533742, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI32566674, Length=298, Percent_Identity=36.5771812080537, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=36.7213114754098, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI115535073, Length=322, Percent_Identity=35.4037267080745, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17561720, Length=304, Percent_Identity=35.5263157894737, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=242, Percent_Identity=33.8842975206612, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=31.629392971246, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25147552, Length=307, Percent_Identity=30.6188925081433, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561716, Length=120, Percent_Identity=36.6666666666667, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=33.3333333333333, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=33.033033033033, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643623, Length=268, Percent_Identity=29.8507462686567, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129101, Length=268, Percent_Identity=29.8507462686567, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37025; Mature: 37025

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNILNKINNLEKLIGNTPLVEILFKYKGKKLKVYSKLEYYNYTGSIKDRMALYILKKAY
CCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHH
LNNSIKQNYTIVETTSGNTGISFSAIGSYLGNSIDIYMPDWMSDERKKLLSSFNANLILV
HCCCCCCCEEEEEECCCCCCEEHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCEEEE
SKKEGGFLKCLELTEKRKLSSDTVFLPCQFSNNDNAEAHFLSTGPEIWNVLNNSGIIPTA
EECCCCEEEEEHHHHHHCCCCCEEEEEEEECCCCCCCEEEECCCHHHHHHHCCCCCCHHH
FVAGVGTGGTIMGIGRYLKANNANMKIYPLEPSNSPTLSTGFQVSEHRIQGIVDEFIPPI
HHCCCCCCCCEEECCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHH
LDLKKLNEVISVDDGDAIIMAQKLSRILGLGVGISSGANFLGAIKALELNGYKGNVVTIF
HHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECCCCCCEEEEE
ADDNKKYLSTDLMKFEPIKDTFISSNIELIGLKRL
ECCCCCCHHHHCEEECCCHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MNNILNKINNLEKLIGNTPLVEILFKYKGKKLKVYSKLEYYNYTGSIKDRMALYILKKAY
CCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHH
LNNSIKQNYTIVETTSGNTGISFSAIGSYLGNSIDIYMPDWMSDERKKLLSSFNANLILV
HCCCCCCCEEEEEECCCCCCEEHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCCEEEE
SKKEGGFLKCLELTEKRKLSSDTVFLPCQFSNNDNAEAHFLSTGPEIWNVLNNSGIIPTA
EECCCCEEEEEHHHHHHCCCCCEEEEEEEECCCCCCCEEEECCCHHHHHHHCCCCCCHHH
FVAGVGTGGTIMGIGRYLKANNANMKIYPLEPSNSPTLSTGFQVSEHRIQGIVDEFIPPI
HHCCCCCCCCEEECCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCHH
LDLKKLNEVISVDDGDAIIMAQKLSRILGLGVGISSGANFLGAIKALELNGYKGNVVTIF
HHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCCCCCCCCHHEEEEEEEECCCCCCEEEEE
ADDNKKYLSTDLMKFEPIKDTFISSNIELIGLKRL
ECCCCCCHHHHCEEECCCHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA