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The map label for this gene is prs [H]

Identifier: 187934834

GI number: 187934834

Start: 2304927

End: 2306018

Strand: Reverse

Name: prs [H]

Synonym: CLL_A2222

Alternate gene names: 187934834

Gene position: 2306018-2304927 (Counterclockwise)

Preceding gene: 187933176

Following gene: 187935246

Centisome position: 60.68

GC content: 29.4

Gene sequence:

>1092_bases
ATGACTGAATTAAATCATGAACTTGGAATAATAGCATTAGAAAGCTGTAAAGAATTAGGTAAGGCAATAGATGACTTTAT
AAGAACTACTAGAAAACAAGAAGAGTCGTTTTTAATACCGATTAATGAAATAAGATTTTCTAATGGTGAAGGAAAGGTTA
AGATTTCTGAAACAGTAAGAGGAAAAGATATTTACATATTATGTGACGTTGGAAATTATAGTTGCACATATAAAATGTTT
GGTTTCAAAAATCATAAAGGTCCAGATGAACATTTCCAAGACATTAAAAGAACAGTTTCAGCTATTAGAGGAAAAGCTGC
TAGAATTACTGTAATAATGCCACTTCTTTATGAATCAAGACAACATAGACGTAAAGGAAGAGAATCTTTAGACTGCGCTT
TAGCACTTCAAGAACTAGAAAGATTAGGAGTAGATGAAATTCTTACATTTGATGTTCATGATCCTAATATTCAAAATGCT
ATTCCATTATTATCTTTTGAAAATATTTATCCAACTTATGATATAGTAAAATCAATTATATTAAATGAAAAATCATTAGA
ACTAGATAAAGAAAAATTACTAGTAATAAGTCCGGATACTGGAGCAATGGACAGGGCTATATATTATTCAAGCGTACTAG
GTGTTGATGTTGGTTTATTCTATAAGAGAAGAGATCATACAACTATAGTAAATGGAAAAAATCCTATAGTACAACATGAG
TATATGGGAAGAGATGTTACTGGAAGAGATGTTTTAATTGTTGATGATATGATAGCATCTGGTGAATCTGTTCTTGATAT
AGCAAAGGAATTAAAAAGCAGAGGTGCTAGAAATGTATATGTAGCTGCAACATTTGCATTCTTTACTGAAGGTCTTAATA
AGTTTAATAAAGCTTACGAAGAAGGATTAATAAAGAGAATTTACTCTACTAATTTAACATACATACCGCAATCATTAAAA
GATGCAGAGTGGTTTACAAGTGCTGATATGTCAGAATTTGTATCTAGAGTAATAAATAGATTGAATCATGGAAAATCAAT
TGCTAAATATATGGATGCAACAAGAATAATACATACGTTATTAAATGAATAA

Upstream 100 bases:

>100_bases
TTATGATAACATATTTATAAATATGTATTTTTAGTATATACTGTTACTAGGTAATATATTTAAAATAAAAGATAAATTAT
AAATAAAGGGAGAGAAACTA

Downstream 100 bases:

>100_bases
TATTTAAGGCATTAAGAAATTTTATTTAATTAAAAATAAGCTATATTATTGTTTTTTTCAATAATATAGCTTATTTTAGT
ATAATAAATTATATTATCTT

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTELNHELGIIALESCKELGKAIDDFIRTTRKQEESFLIPINEIRFSNGEGKVKISETVRGKDIYILCDVGNYSCTYKMF
GFKNHKGPDEHFQDIKRTVSAIRGKAARITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEILTFDVHDPNIQNA
IPLLSFENIYPTYDIVKSIILNEKSLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHTTIVNGKNPIVQHE
YMGRDVTGRDVLIVDDMIASGESVLDIAKELKSRGARNVYVAATFAFFTEGLNKFNKAYEEGLIKRIYSTNLTYIPQSLK
DAEWFTSADMSEFVSRVINRLNHGKSIAKYMDATRIIHTLLNE

Sequences:

>Translated_363_residues
MTELNHELGIIALESCKELGKAIDDFIRTTRKQEESFLIPINEIRFSNGEGKVKISETVRGKDIYILCDVGNYSCTYKMF
GFKNHKGPDEHFQDIKRTVSAIRGKAARITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEILTFDVHDPNIQNA
IPLLSFENIYPTYDIVKSIILNEKSLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHTTIVNGKNPIVQHE
YMGRDVTGRDVLIVDDMIASGESVLDIAKELKSRGARNVYVAATFAFFTEGLNKFNKAYEEGLIKRIYSTNLTYIPQSLK
DAEWFTSADMSEFVSRVINRLNHGKSIAKYMDATRIIHTLLNE
>Mature_362_residues
TELNHELGIIALESCKELGKAIDDFIRTTRKQEESFLIPINEIRFSNGEGKVKISETVRGKDIYILCDVGNYSCTYKMFG
FKNHKGPDEHFQDIKRTVSAIRGKAARITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEILTFDVHDPNIQNAI
PLLSFENIYPTYDIVKSIILNEKSLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHTTIVNGKNPIVQHEY
MGRDVTGRDVLIVDDMIASGESVLDIAKELKSRGARNVYVAATFAFFTEGLNKFNKAYEEGLIKRIYSTNLTYIPQSLKD
AEWFTSADMSEFVSRVINRLNHGKSIAKYMDATRIIHTLLNE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=311, Percent_Identity=27.6527331189711, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI28557709, Length=309, Percent_Identity=27.1844660194175, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=26.6881028938907, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=26.1146496815287, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=28.525641025641, Blast_Score=111, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=24.5161290322581, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=24.5161290322581, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17554702, Length=309, Percent_Identity=24.2718446601942, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71989924, Length=309, Percent_Identity=24.2718446601942, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17570245, Length=328, Percent_Identity=22.8658536585366, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320946, Length=320, Percent_Identity=25.625, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321776, Length=308, Percent_Identity=25.6493506493506, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=23.8993710691824, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=25.6410256410256, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45551540, Length=335, Percent_Identity=23.5820895522388, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 41332; Mature: 41201

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELNHELGIIALESCKELGKAIDDFIRTTRKQEESFLIPINEIRFSNGEGKVKISETVR
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHEEECCCCCCEEEECCCC
GKDIYILCDVGNYSCTYKMFGFKNHKGPDEHFQDIKRTVSAIRGKAARITVIMPLLYESR
CCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHH
QHRRKGRESLDCALALQELERLGVDEILTFDVHDPNIQNAIPLLSFENIYPTYDIVKSII
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHCCCCEEECCCCCHHHHHHHHH
LNEKSLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHTTIVNGKNPIVQHE
HCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCCEEHH
YMGRDVTGRDVLIVDDMIASGESVLDIAKELKSRGARNVYVAATFAFFTEGLNKFNKAYE
HCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHH
EGLIKRIYSTNLTYIPQSLKDAEWFTSADMSEFVSRVINRLNHGKSIAKYMDATRIIHTL
HHHHHHHHHCCCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LNE
HCC
>Mature Secondary Structure 
TELNHELGIIALESCKELGKAIDDFIRTTRKQEESFLIPINEIRFSNGEGKVKISETVR
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHEEECCCCCCEEEECCCC
GKDIYILCDVGNYSCTYKMFGFKNHKGPDEHFQDIKRTVSAIRGKAARITVIMPLLYESR
CCEEEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHH
QHRRKGRESLDCALALQELERLGVDEILTFDVHDPNIQNAIPLLSFENIYPTYDIVKSII
HHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHCCCCEEECCCCCHHHHHHHHH
LNEKSLELDKEKLLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHTTIVNGKNPIVQHE
HCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCCEEHH
YMGRDVTGRDVLIVDDMIASGESVLDIAKELKSRGARNVYVAATFAFFTEGLNKFNKAYE
HCCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHH
EGLIKRIYSTNLTYIPQSLKDAEWFTSADMSEFVSRVINRLNHGKSIAKYMDATRIIHTL
HHHHHHHHHCCCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LNE
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]