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The map label for this gene is 187933176

Identifier: 187933176

GI number: 187933176

Start: 2308053

End: 2309810

Strand: Reverse

Name: 187933176

Synonym: CLL_A2225

Alternate gene names: NA

Gene position: 2309810-2308053 (Counterclockwise)

Preceding gene: 187935340

Following gene: 187934834

Centisome position: 60.78

GC content: 27.76

Gene sequence:

>1758_bases
ATGAAGAAGAATGCAGCGCAAAGAGAATTTAAGAAGTATAAGAGTCAGATAAATCAAATAGAGGAAATAGTAGAGCATTC
AAAACCGGGAGCACTTATAGAACATGAAAGCTCAATTAGAAAGAAAGTAAGGCACCTTAAGGAATTTGAGAATCAAGGGT
TAAAGGATTTCAATGAAGTGTATGAAAAATATGAACAATTATTAGAATATGTTTCAAAGAGAATGCTTGATTATTATAAT
AATAAAAATAATACAGATTTTGATTTTTACCAAGTTGTGCGTGGAAATTATAATAATTTTTTAAATCAAGGTTTAATGAC
TGTATTAACTAAAATGCATATACCAAAATTAATAGCAAAAGAATTTGAAGAAAAATTCCCAACTAACCCAAAAGATGAAT
ATATTCATACTAGACATATGAAAAGGAAATTTTATATTCATTTAGGTGATACGAATACTGGTAAAACCTATAATGCAATA
GAACGCCTTAAAACTGCAAAGAATGGAGTTTATTTATCTCCGCTTAGAATTCTTGCATTAGAAAACTTTGAAAGGCTTAA
TAAAGAAGGCGTAGTTTGTGATTTGTTAACTGGAGAAGAAGAAATAATAAAGGTTGGAGCTACTCATGCTTCATGTACAA
TAGAAAAAGTTAATTTAAAAGAACATTACGATATAGCTGTAATTGATGAGATTCAAATGATTAGCGATACTCATAGGGGC
ATGGCTTGGAGTAAAGCTGTACTTGGATTACAATGTGATGAAATACATATATGTGGAGCATCTAATGCAAAATATATATT
AGAAAAAATGTTAAAAGATTGTAATGATGAATATGAAATAAAAGATTATAAAAGATCTATTCCTCTTGAAGTTGAGTATA
AGAACTTTAATTATAATGATGTTAAGGATGGAGATGCTATTGTAGTTTTTTCAAAAAAGAGAGTATTAGAAATAGCAGAG
GATTATTCACGAGAAGGAATAAAAGCTAGTGTAATATATGGAGATTTACCACCAGAAGTTAGAAGAATGCAATATGAACA
ATTTGTTAATAAAGAAACAAAGGTTCTTGTAACTACAGATGCTATAGGAATGGGAGTTAATTTACCAATAAGAAGAATTA
TTTTTATGAGTATAAGAAAGTTTGATGGAGAAGAGGTAAGAGAATTAACGTCGCAAGAAGTAAAACAAGTTGGTGGGCGT
GCAGGAAGAATAGGAATTTATGATGTAGGATACATTGCTGGCGTAGGTGGTACAGCAGACTTTATTAAATCTAAATTAGA
AGCAGAAGATAATATTATAAGAAAAGCTGTAGTGGGACCATCAGATGCAATACTTAAAATAAAAAGTTTACCTTTGAATG
AAAAGTTAGCATTATGGAGTACTAGAGAAGAAAAATTAGATTATTATACTAAAATGGATATTAGTGAGTATATTTTAATT
TTGGATAAAATAAAGAAATATAAATTAAAAGAAGAGACTGAATGGGATTTATTAAAAGTACCTTTTGATGTTTCAAGAGA
TGACTTAATGGAAACATTCTTAAATTATGTAGATGAATTATTTATTAATAAACAAGATGAATTGTTTATTCCACAGTGTT
ATACAGGTAATTTAGATGAGTTAGAAATATATTATCAAAAGGTAAATATGTATTATTCATTTTCTAAAATATTTAATTTA
AAGTTTGATGCTAAATGGGTTTATGATGAAAGAATGAAAATAAGTGAAGCAATAAATGAAATATTAATAAGAATGTAA

Upstream 100 bases:

>100_bases
AATTATAGACATAGTTTAAAAGTAAGTGGTTTAAACTAGAAGGATATTAAAACACAAGGTAAATAAATTCTTTAGTATTA
TTTATTTGGAGGTTTTGTTA

Downstream 100 bases:

>100_bases
AAAGATTTTTATTTAAGGTTATGTTGATAATATGCCACTTTGTCAATTGTATATATCGGCACATATTTAAAATAAAGTAG
AGTATAATAATAGACCAATA

Product: ATP-dependent RNA helicase, superfamily II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MKKNAAQREFKKYKSQINQIEEIVEHSKPGALIEHESSIRKKVRHLKEFENQGLKDFNEVYEKYEQLLEYVSKRMLDYYN
NKNNTDFDFYQVVRGNYNNFLNQGLMTVLTKMHIPKLIAKEFEEKFPTNPKDEYIHTRHMKRKFYIHLGDTNTGKTYNAI
ERLKTAKNGVYLSPLRILALENFERLNKEGVVCDLLTGEEEIIKVGATHASCTIEKVNLKEHYDIAVIDEIQMISDTHRG
MAWSKAVLGLQCDEIHICGASNAKYILEKMLKDCNDEYEIKDYKRSIPLEVEYKNFNYNDVKDGDAIVVFSKKRVLEIAE
DYSREGIKASVIYGDLPPEVRRMQYEQFVNKETKVLVTTDAIGMGVNLPIRRIIFMSIRKFDGEEVRELTSQEVKQVGGR
AGRIGIYDVGYIAGVGGTADFIKSKLEAEDNIIRKAVVGPSDAILKIKSLPLNEKLALWSTREEKLDYYTKMDISEYILI
LDKIKKYKLKEETEWDLLKVPFDVSRDDLMETFLNYVDELFINKQDELFIPQCYTGNLDELEIYYQKVNMYYSFSKIFNL
KFDAKWVYDERMKISEAINEILIRM

Sequences:

>Translated_585_residues
MKKNAAQREFKKYKSQINQIEEIVEHSKPGALIEHESSIRKKVRHLKEFENQGLKDFNEVYEKYEQLLEYVSKRMLDYYN
NKNNTDFDFYQVVRGNYNNFLNQGLMTVLTKMHIPKLIAKEFEEKFPTNPKDEYIHTRHMKRKFYIHLGDTNTGKTYNAI
ERLKTAKNGVYLSPLRILALENFERLNKEGVVCDLLTGEEEIIKVGATHASCTIEKVNLKEHYDIAVIDEIQMISDTHRG
MAWSKAVLGLQCDEIHICGASNAKYILEKMLKDCNDEYEIKDYKRSIPLEVEYKNFNYNDVKDGDAIVVFSKKRVLEIAE
DYSREGIKASVIYGDLPPEVRRMQYEQFVNKETKVLVTTDAIGMGVNLPIRRIIFMSIRKFDGEEVRELTSQEVKQVGGR
AGRIGIYDVGYIAGVGGTADFIKSKLEAEDNIIRKAVVGPSDAILKIKSLPLNEKLALWSTREEKLDYYTKMDISEYILI
LDKIKKYKLKEETEWDLLKVPFDVSRDDLMETFLNYVDELFINKQDELFIPQCYTGNLDELEIYYQKVNMYYSFSKIFNL
KFDAKWVYDERMKISEAINEILIRM
>Mature_585_residues
MKKNAAQREFKKYKSQINQIEEIVEHSKPGALIEHESSIRKKVRHLKEFENQGLKDFNEVYEKYEQLLEYVSKRMLDYYN
NKNNTDFDFYQVVRGNYNNFLNQGLMTVLTKMHIPKLIAKEFEEKFPTNPKDEYIHTRHMKRKFYIHLGDTNTGKTYNAI
ERLKTAKNGVYLSPLRILALENFERLNKEGVVCDLLTGEEEIIKVGATHASCTIEKVNLKEHYDIAVIDEIQMISDTHRG
MAWSKAVLGLQCDEIHICGASNAKYILEKMLKDCNDEYEIKDYKRSIPLEVEYKNFNYNDVKDGDAIVVFSKKRVLEIAE
DYSREGIKASVIYGDLPPEVRRMQYEQFVNKETKVLVTTDAIGMGVNLPIRRIIFMSIRKFDGEEVRELTSQEVKQVGGR
AGRIGIYDVGYIAGVGGTADFIKSKLEAEDNIIRKAVVGPSDAILKIKSLPLNEKLALWSTREEKLDYYTKMDISEYILI
LDKIKKYKLKEETEWDLLKVPFDVSRDDLMETFLNYVDELFINKQDELFIPQCYTGNLDELEIYYQKVNMYYSFSKIFNL
KFDAKWVYDERMKISEAINEILIRM

Specific function: Unknown

COG id: COG0513

COG function: function code LKJ; Superfamily II DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI31543667, Length=286, Percent_Identity=43.3566433566434, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI115532784, Length=298, Percent_Identity=41.2751677852349, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI115532782, Length=298, Percent_Identity=41.2751677852349, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6325228, Length=447, Percent_Identity=33.1096196868009, Blast_Score=233, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6323430, Length=83, Percent_Identity=44.578313253012, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221329989, Length=298, Percent_Identity=40.2684563758389, Blast_Score=225, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR010995
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: NA

Molecular weight: Translated: 68442; Mature: 68442

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNAAQREFKKYKSQINQIEEIVEHSKPGALIEHESSIRKKVRHLKEFENQGLKDFNEV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCCHHHHHH
YEKYEQLLEYVSKRMLDYYNNKNNTDFDFYQVVRGNYNNFLNQGLMTVLTKMHIPKLIAK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
EFEEKFPTNPKDEYIHTRHMKRKFYIHLGDTNTGKTYNAIERLKTAKNGVYLSPLRILAL
HHHHHCCCCCCHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECHHHHHHH
ENFERLNKEGVVCDLLTGEEEIIKVGATHASCTIEKVNLKEHYDIAVIDEIQMISDTHRG
HHHHHHCCCCCEEEEECCCHHHHEECCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHCC
MAWSKAVLGLQCDEIHICGASNAKYILEKMLKDCNDEYEIKDYKRSIPLEVEYKNFNYND
HHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCCC
VKDGDAIVVFSKKRVLEIAEDYSREGIKASVIYGDLPPEVRRMQYEQFVNKETKVLVTTD
CCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEC
AIGMGVNLPIRRIIFMSIRKFDGEEVRELTSQEVKQVGGRAGRIGIYDVGYIAGVGGTAD
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHCCCCCHHH
FIKSKLEAEDNIIRKAVVGPSDAILKIKSLPLNEKLALWSTREEKLDYYTKMDISEYILI
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHCCHHHHHHH
LDKIKKYKLKEETEWDLLKVPFDVSRDDLMETFLNYVDELFINKQDELFIPQCYTGNLDE
HHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHH
LEIYYQKVNMYYSFSKIFNLKFDAKWVYDERMKISEAINEILIRM
HHHHHHHHHHHEEEHHHEEEEECCEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKNAAQREFKKYKSQINQIEEIVEHSKPGALIEHESSIRKKVRHLKEFENQGLKDFNEV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHCCCHHHHHH
YEKYEQLLEYVSKRMLDYYNNKNNTDFDFYQVVRGNYNNFLNQGLMTVLTKMHIPKLIAK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
EFEEKFPTNPKDEYIHTRHMKRKFYIHLGDTNTGKTYNAIERLKTAKNGVYLSPLRILAL
HHHHHCCCCCCHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEECHHHHHHH
ENFERLNKEGVVCDLLTGEEEIIKVGATHASCTIEKVNLKEHYDIAVIDEIQMISDTHRG
HHHHHHCCCCCEEEEECCCHHHHEECCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHCC
MAWSKAVLGLQCDEIHICGASNAKYILEKMLKDCNDEYEIKDYKRSIPLEVEYKNFNYND
HHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCCC
VKDGDAIVVFSKKRVLEIAEDYSREGIKASVIYGDLPPEVRRMQYEQFVNKETKVLVTTD
CCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEC
AIGMGVNLPIRRIIFMSIRKFDGEEVRELTSQEVKQVGGRAGRIGIYDVGYIAGVGGTAD
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEECHHHCCCCCHHH
FIKSKLEAEDNIIRKAVVGPSDAILKIKSLPLNEKLALWSTREEKLDYYTKMDISEYILI
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHCCHHHHHHH
LDKIKKYKLKEETEWDLLKVPFDVSRDDLMETFLNYVDELFINKQDELFIPQCYTGNLDE
HHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHH
LEIYYQKVNMYYSFSKIFNLKFDAKWVYDERMKISEAINEILIRM
HHHHHHHHHHHEEEHHHEEEEECCEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11121031 [H]