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The map label for this gene is phoR [H]

Identifier: 187933470

GI number: 187933470

Start: 2608395

End: 2609927

Strand: Reverse

Name: phoR [H]

Synonym: CLL_A2512

Alternate gene names: 187933470

Gene position: 2609927-2608395 (Counterclockwise)

Preceding gene: 187933809

Following gene: 187935235

Centisome position: 68.68

GC content: 23.29

Gene sequence:

>1533_bases
ATGAATATATTACTAAAAAAGATAGAGGTATTACTAGTAATAATATTAATATGCAATACTTTATTGACTAACTGCTATAA
AAAGGTACAAGCATCTGTAGTTAATTTCAAAAATATTACAATAGAAGATGGGTTACCACAATCTTCTGTAAAAACAAATT
TTCAAGATAGTAAGGAATATATATGTACAGGTACTCATAATGGAGAAATTTTCAATAAAGATGATTCGGCAGAGAACATA
GCTAATAATATAATAATATCTATAAAAGAAGATACGAAAGAAAAGTTATGGGTAGGGACTAATTGTGGAATAAATATATT
TAATTCAAAAGAAATAAATGAGGAAAATTACTGTGAACATGCCATATTTGATAAATTTGAAGTAAAAGGCAAACAATATA
ATGATATAAATGGACTAGAATTTTATCGGTATGAAGATATGATAAAAGCAAGAATACTTATTTCTGATTTTAGAAATGAT
AACAATGTTAAATACTATTATAAATTATCAAGTGTTGATAGTGATTGGACAATTAGTAATGAAAATGAATTTGTATACAA
TAATCTAAAACCAGGAAGACATACATTAAAAGTTAAAGTTATGAATGAAGATGGAAATCTAAGTGAAGAAAATCAAATTA
CTTTTACTATAAAACCACCTCTATGGAAAAGTTCAGGAGCTATATTTGTTTACTTTATCATGATTATTTTAATAATATAT
TTAAGCATTACTAAATTGAAAAATTTAGATAGAATGGTTGAGAAAAGAACAAAACAATTAAGAGATGAAATGGAAAAAAA
CAGAAGATTATTTGACAAAGTAATAGATTTAGAAAGAAGGAAAAATAATTACTTTGTAAATTTATCACATGAACTTAGAA
CACCTTTAAATGTTATTTCATCTACTGAACAACTTATTTCAGAATTAAATAAACAATATGACGGAATAGATAAAGAGAAA
TTAAGTTATTATATGAAAATAATAAAAAGAAATTCAAATAGATTATTAAAATTAATAAACAATATAATAGATACCAATAA
AATTGAAAGTGGAAGATATGAAATGAATTTAAAAGAAAATGATATAGTATACTTAGTTGAAGAAACTTCTTTAAGTTTAA
AAGATTACATTGAAAATAAAGGAATACATTTAATTATAGATCCAGAAATGGAAGAAAAAATTATAATATGTGATAGTTAT
GAAATTGAAAGATGTATAGTTAATTTAGTAAGTAATGCAGCTAAATTTACTCCAGAAGGAGGAGAAATAAAAGTAACATT
AAAAGAATTAAATAATAATGTTATAATTACAGTTAAAGATACTGGTATTGGAATAGATCCTAAATATCATAAAGCAGTAT
TTGATAGATTCAATCAAATTATAGATGCAAATTCTGAATCAAAAGGTGGAAGTGGATTAGGATTAACTATAACTAAACAT
ATTATAGATTTACATAAGGGAAAAATATATGTTAATAGTGATATTGGAAAAGGTTGTGAGTTTGCAATAATACTACCAAG
TAATATAAAGTAG

Upstream 100 bases:

>100_bases
ATATTAAATTATAAATATAATGAATTATAGAAAATATTGTATTAAAAAATAGTATTGTAGTATAATTATGTATATAAATA
TTGTCGAAAAAGGAGAAAAA

Downstream 100 bases:

>100_bases
AATTTATTAGTGGAGTGTTATTAAATTATACATAATTTAATGTAGTATGTTTTTAGGTGTTAAAGTTAAACTTTTAAAGT
TGGGAGACAAGATATGAGAA

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNILLKKIEVLLVIILICNTLLTNCYKKVQASVVNFKNITIEDGLPQSSVKTNFQDSKEYICTGTHNGEIFNKDDSAENI
ANNIIISIKEDTKEKLWVGTNCGINIFNSKEINEENYCEHAIFDKFEVKGKQYNDINGLEFYRYEDMIKARILISDFRND
NNVKYYYKLSSVDSDWTISNENEFVYNNLKPGRHTLKVKVMNEDGNLSEENQITFTIKPPLWKSSGAIFVYFIMIILIIY
LSITKLKNLDRMVEKRTKQLRDEMEKNRRLFDKVIDLERRKNNYFVNLSHELRTPLNVISSTEQLISELNKQYDGIDKEK
LSYYMKIIKRNSNRLLKLINNIIDTNKIESGRYEMNLKENDIVYLVEETSLSLKDYIENKGIHLIIDPEMEEKIIICDSY
EIERCIVNLVSNAAKFTPEGGEIKVTLKELNNNVIITVKDTGIGIDPKYHKAVFDRFNQIIDANSESKGGSGLGLTITKH
IIDLHKGKIYVNSDIGKGCEFAIILPSNIK

Sequences:

>Translated_510_residues
MNILLKKIEVLLVIILICNTLLTNCYKKVQASVVNFKNITIEDGLPQSSVKTNFQDSKEYICTGTHNGEIFNKDDSAENI
ANNIIISIKEDTKEKLWVGTNCGINIFNSKEINEENYCEHAIFDKFEVKGKQYNDINGLEFYRYEDMIKARILISDFRND
NNVKYYYKLSSVDSDWTISNENEFVYNNLKPGRHTLKVKVMNEDGNLSEENQITFTIKPPLWKSSGAIFVYFIMIILIIY
LSITKLKNLDRMVEKRTKQLRDEMEKNRRLFDKVIDLERRKNNYFVNLSHELRTPLNVISSTEQLISELNKQYDGIDKEK
LSYYMKIIKRNSNRLLKLINNIIDTNKIESGRYEMNLKENDIVYLVEETSLSLKDYIENKGIHLIIDPEMEEKIIICDSY
EIERCIVNLVSNAAKFTPEGGEIKVTLKELNNNVIITVKDTGIGIDPKYHKAVFDRFNQIIDANSESKGGSGLGLTITKH
IIDLHKGKIYVNSDIGKGCEFAIILPSNIK
>Mature_510_residues
MNILLKKIEVLLVIILICNTLLTNCYKKVQASVVNFKNITIEDGLPQSSVKTNFQDSKEYICTGTHNGEIFNKDDSAENI
ANNIIISIKEDTKEKLWVGTNCGINIFNSKEINEENYCEHAIFDKFEVKGKQYNDINGLEFYRYEDMIKARILISDFRND
NNVKYYYKLSSVDSDWTISNENEFVYNNLKPGRHTLKVKVMNEDGNLSEENQITFTIKPPLWKSSGAIFVYFIMIILIIY
LSITKLKNLDRMVEKRTKQLRDEMEKNRRLFDKVIDLERRKNNYFVNLSHELRTPLNVISSTEQLISELNKQYDGIDKEK
LSYYMKIIKRNSNRLLKLINNIIDTNKIESGRYEMNLKENDIVYLVEETSLSLKDYIENKGIHLIIDPEMEEKIIICDSY
EIERCIVNLVSNAAKFTPEGGEIKVTLKELNNNVIITVKDTGIGIDPKYHKAVFDRFNQIIDANSESKGGSGLGLTITKH
IIDLHKGKIYVNSDIGKGCEFAIILPSNIK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=29.1139240506329, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788713, Length=252, Percent_Identity=31.3492063492063, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=32.4675324675325, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=28.4644194756554, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=27.0627062706271, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=30.8695652173913, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=30.2127659574468, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI48994928, Length=255, Percent_Identity=28.6274509803922, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI87082128, Length=301, Percent_Identity=25.2491694352159, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=23.6947791164659, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790861, Length=280, Percent_Identity=25.3571428571429, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=281, Percent_Identity=27.0462633451957, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=255, Percent_Identity=25.4901960784314, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=25.6302521008403, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789808, Length=225, Percent_Identity=27.5555555555556, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787374, Length=339, Percent_Identity=21.5339233038348, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58935; Mature: 58935

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLKKIEVLLVIILICNTLLTNCYKKVQASVVNFKNITIEDGLPQSSVKTNFQDSKEY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHCCCCCCCCCE
ICTGTHNGEIFNKDDSAENIANNIIISIKEDTKEKLWVGTNCGINIFNSKEINEENYCEH
EEECCCCCCEECCCCCHHHHHCCEEEEEECCCCCEEEEECCCCEEEECCCCCCCCHHHHH
AIFDKFEVKGKQYNDINGLEFYRYEDMIKARILISDFRNDNNVKYYYKLSSVDSDWTISN
HHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEECC
ENEFVYNNLKPGRHTLKVKVMNEDGNLSEENQITFTIKPPLWKSSGAIFVYFIMIILIIY
CCCEEECCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
LSITKLKNLDRMVEKRTKQLRDEMEKNRRLFDKVIDLERRKNNYFVNLSHELRTPLNVIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHH
STEQLISELNKQYDGIDKEKLSYYMKIIKRNSNRLLKLINNIIDTNKIESGRYEMNLKEN
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
DIVYLVEETSLSLKDYIENKGIHLIIDPEMEEKIIICDSYEIERCIVNLVSNAAKFTPEG
CEEEEEECCCCCHHHHHHCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
GEIKVTLKELNNNVIITVKDTGIGIDPKYHKAVFDRFNQIIDANSESKGGSGLGLTITKH
CEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
IIDLHKGKIYVNSDIGKGCEFAIILPSNIK
HHHHHCCEEEEECCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MNILLKKIEVLLVIILICNTLLTNCYKKVQASVVNFKNITIEDGLPQSSVKTNFQDSKEY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHCCCCCCCCCE
ICTGTHNGEIFNKDDSAENIANNIIISIKEDTKEKLWVGTNCGINIFNSKEINEENYCEH
EEECCCCCCEECCCCCHHHHHCCEEEEEECCCCCEEEEECCCCEEEECCCCCCCCHHHHH
AIFDKFEVKGKQYNDINGLEFYRYEDMIKARILISDFRNDNNVKYYYKLSSVDSDWTISN
HHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEECC
ENEFVYNNLKPGRHTLKVKVMNEDGNLSEENQITFTIKPPLWKSSGAIFVYFIMIILIIY
CCCEEECCCCCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
LSITKLKNLDRMVEKRTKQLRDEMEKNRRLFDKVIDLERRKNNYFVNLSHELRTPLNVIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHH
STEQLISELNKQYDGIDKEKLSYYMKIIKRNSNRLLKLINNIIDTNKIESGRYEMNLKEN
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
DIVYLVEETSLSLKDYIENKGIHLIIDPEMEEKIIICDSYEIERCIVNLVSNAAKFTPEG
CEEEEEECCCCCHHHHHHCCCEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCC
GEIKVTLKELNNNVIITVKDTGIGIDPKYHKAVFDRFNQIIDANSESKGGSGLGLTITKH
CEEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
IIDLHKGKIYVNSDIGKGCEFAIILPSNIK
HHHHHCCEEEEECCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]