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The map label for this gene is pyrD [H]

Identifier: 187933348

GI number: 187933348

Start: 2686889

End: 2687785

Strand: Reverse

Name: pyrD [H]

Synonym: CLL_A2576

Alternate gene names: 187933348

Gene position: 2687785-2686889 (Counterclockwise)

Preceding gene: 187935152

Following gene: 187934364

Centisome position: 70.73

GC content: 31.44

Gene sequence:

>897_bases
ATGTTAAAGGTGAATATAAATGGTGTAGAATTTAAAAATCCAGTTATAGCGGCTTCAGGAACTTTTGGTTTTGGTGCAGA
ATATAACAATTTTTATGATGTAGGGATGTTAGGTGGAATATCATCTAAAGGATTAACGCTGAATGTTAAAGAAGGTAATG
AAGGAATTAGAGTATTCGAAACTTCATCTGGAATGATGAACTCTGTAGGATTACAAAATCCAGGAATAGAGGGATTTATA
AAAAATGAATTACCTAAAATGCAAAAACTAAATACTAACATTTTAGCTAATGTTGGTGGGGGATGCTTTGAAGATTATGC
AGAAGCTATTGAAAAGTTAAATGATACTGAAGTAAATATGATTGAACTTAATATATCATGTCCAAATGTAAAGTGTGGTG
GAATGGCATATGGAATTAAGTCTCAAGTAGCTTATGAATTTGTTAAAGAAATAAAGAAGATTTGCAAAAAACCTCTTATG
GTTAAATTATCACCAAATGCTGAAAATATAGTTGAAATGGCAGCAAAATGTGAAGAAGCAGGAGCAGATTCTTTAAGCTT
AATAAATACATTAAAGGGTTTAGCCATAGATCCATATAAAAGAAAGCCAATATTTAATAATGTATATGCAGGACTTTCAG
GACCAGCAGTAAAACCAGTAGCATTAAGAATGGTTCATGAAGTAAGTAAAGCTGTTAGTATACCAGTAATAGGACTTGGT
GGAATATCTAATGGAATAGATGCAATAGAGTTTATGATGGCAGGGGCAAGAGCAGTTCAAATAGGAACAGTAAATTTTGT
AAATCCAATGGCGGGAAAAGAAATTATAGAAGAAATGGAATCTTTTTGCAAAGAACAAGGCATAAAAGATATAAATGAAA
TTGTTGGTGTAATTTAA

Upstream 100 bases:

>100_bases
TACTTGCAAAACTAAAGGTGGAAATAAGAGAACGTGTAAAGATGGTCCAGTATTTGATGGATATTATGTGGAATTGTAAA
TCAGAGGGGAGAATGAAGTT

Downstream 100 bases:

>100_bases
ATGGCTATTAATATTAAAATATATAGTTTGATGAACAAAGAAATTTAATTATTTAAGATATATTGTTTTTAGATGTGTTT
ATATATGCAATAGGTAAAGT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLKVNINGVEFKNPVIAASGTFGFGAEYNNFYDVGMLGGISSKGLTLNVKEGNEGIRVFETSSGMMNSVGLQNPGIEGFI
KNELPKMQKLNTNILANVGGGCFEDYAEAIEKLNDTEVNMIELNISCPNVKCGGMAYGIKSQVAYEFVKEIKKICKKPLM
VKLSPNAENIVEMAAKCEEAGADSLSLINTLKGLAIDPYKRKPIFNNVYAGLSGPAVKPVALRMVHEVSKAVSIPVIGLG
GISNGIDAIEFMMAGARAVQIGTVNFVNPMAGKEIIEEMESFCKEQGIKDINEIVGVI

Sequences:

>Translated_298_residues
MLKVNINGVEFKNPVIAASGTFGFGAEYNNFYDVGMLGGISSKGLTLNVKEGNEGIRVFETSSGMMNSVGLQNPGIEGFI
KNELPKMQKLNTNILANVGGGCFEDYAEAIEKLNDTEVNMIELNISCPNVKCGGMAYGIKSQVAYEFVKEIKKICKKPLM
VKLSPNAENIVEMAAKCEEAGADSLSLINTLKGLAIDPYKRKPIFNNVYAGLSGPAVKPVALRMVHEVSKAVSIPVIGLG
GISNGIDAIEFMMAGARAVQIGTVNFVNPMAGKEIIEEMESFCKEQGIKDINEIVGVI
>Mature_298_residues
MLKVNINGVEFKNPVIAASGTFGFGAEYNNFYDVGMLGGISSKGLTLNVKEGNEGIRVFETSSGMMNSVGLQNPGIEGFI
KNELPKMQKLNTNILANVGGGCFEDYAEAIEKLNDTEVNMIELNISCPNVKCGGMAYGIKSQVAYEFVKEIKKICKKPLM
VKLSPNAENIVEMAAKCEEAGADSLSLINTLKGLAIDPYKRKPIFNNVYAGLSGPAVKPVALRMVHEVSKAVSIPVIGLG
GISNGIDAIEFMMAGARAVQIGTVNFVNPMAGKEIIEEMESFCKEQGIKDINEIVGVI

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=320, Percent_Identity=26.5625, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI119943098, Length=172, Percent_Identity=29.0697674418605, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082059, Length=326, Percent_Identity=26.3803680981595, Blast_Score=101, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71984108, Length=172, Percent_Identity=27.906976744186, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322633, Length=304, Percent_Identity=32.5657894736842, Blast_Score=96, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24640763, Length=173, Percent_Identity=33.5260115606936, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18858217, Length=173, Percent_Identity=33.5260115606936, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281361352, Length=323, Percent_Identity=26.9349845201238, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137316, Length=323, Percent_Identity=26.9349845201238, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 31912; Mature: 31912

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVNINGVEFKNPVIAASGTFGFGAEYNNFYDVGMLGGISSKGLTLNVKEGNEGIRVFE
CEEEECCCEEECCCEEEECCCCCCCCCCCCEEECCEECCCCCCCEEEEEECCCCCEEEEE
TSSGMMNSVGLQNPGIEGFIKNELPKMQKLNTNILANVGGGCFEDYAEAIEKLNDTEVNM
CCCCCHHHCCCCCCCCCCHHHHCCHHHHHCCCHHEEECCCHHHHHHHHHHHHCCCCCEEE
IELNISCPNVKCGGMAYGIKSQVAYEFVKEIKKICKKPLMVKLSPNAENIVEMAAKCEEA
EEEEEECCCCEECCEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHC
GADSLSLINTLKGLAIDPYKRKPIFNNVYAGLSGPAVKPVALRMVHEVSKAVSIPVIGLG
CCCHHHHHHHHHCCEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEC
GISNGIDAIEFMMAGARAVQIGTVNFVNPMAGKEIIEEMESFCKEQGIKDINEIVGVI
CCCCHHHHHHHHHCCCEEEEEECEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MLKVNINGVEFKNPVIAASGTFGFGAEYNNFYDVGMLGGISSKGLTLNVKEGNEGIRVFE
CEEEECCCEEECCCEEEECCCCCCCCCCCCEEECCEECCCCCCCEEEEEECCCCCEEEEE
TSSGMMNSVGLQNPGIEGFIKNELPKMQKLNTNILANVGGGCFEDYAEAIEKLNDTEVNM
CCCCCHHHCCCCCCCCCCHHHHCCHHHHHCCCHHEEECCCHHHHHHHHHHHHCCCCCEEE
IELNISCPNVKCGGMAYGIKSQVAYEFVKEIKKICKKPLMVKLSPNAENIVEMAAKCEEA
EEEEEECCCCEECCEECCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHC
GADSLSLINTLKGLAIDPYKRKPIFNNVYAGLSGPAVKPVALRMVHEVSKAVSIPVIGLG
CCCHHHHHHHHHCCEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEC
GISNGIDAIEFMMAGARAVQIGTVNFVNPMAGKEIIEEMESFCKEQGIKDINEIVGVI
CCCCHHHHHHHHHCCCEEEEEECEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA