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The map label for this gene is icd [H]

Identifier: 187933271

GI number: 187933271

Start: 2765246

End: 2766454

Strand: Reverse

Name: icd [H]

Synonym: CLL_A2649

Alternate gene names: 187933271

Gene position: 2766454-2765246 (Counterclockwise)

Preceding gene: 187935144

Following gene: 187934830

Centisome position: 72.8

GC content: 29.36

Gene sequence:

>1209_bases
ATGGAAAAAATAAAAATGTCTAATCCATTAGTTGAAATTGATGGAGATGAAATGACAAGAATAGTTTGGGGAATGATAAA
GGACGAGTTATTAAATCCATTTATCGAATTAAATACAGAATATTATGATCTAGGTTTAGAAAATAGAAATGCAACAGATG
ATAATATTACTGTACAAGCAGCAGAAGCAATAAAAAAACACAAAGTAGGGGTTAAATGTGCAACAATAACTCCAAATAGC
GCAAGAGTAAAAGAATATAATCTTAAAAAAATGTGGAAAAGTCCAAATGGAACTATTAGAGCTATTTTAGATGGAACAGT
ATTTAGAGCGCCAATTATAGTTGATGTAGTTAAACCTTATGTTAGGACTTGGAGTAAGCCAATAACAATAGCTAGACATG
CTTATGGTGATATATACAAAGCATCTGAAATGAAAATAGAAGGTAAAGGTAAATGCGAACTTGTATTTACAGCAGAAAAT
GGACAAGAAAAGAGAGAACTAATACATAACTTTAATGATGATGGTGTTGTTATGGGCATGCATAATATAAATAAATCAAT
TGAAAGCTTTGCAAGAAGCTGTTTTAATTATTCAATAGATTTAAAACAAGATTTATGGTTTGGAGCTAAAGATACAATCT
CAAAAAAATATGACCATACTTTTAAAGATATATTTGAAGAGATTTATGAAAATGAATATAAAGAAAAGTTTGAAGCACTA
GGTATAAAATATACTTATATGCTTATAGATTCAGCAGTAGCAAATGTAATAAAATCACATGGTGGAATGATTTGGGCTTG
CAAAAATTATGATGGTGATGTTATGAGTGATATGATTGCAGCAGCATTTGGTTCAATAGCTATGATGACATCAGTTTTAG
TTTCACCAGATGGAAATTATGAATATGAGGCGGCTCATGGAACAGTTCAAGATCAATATTATGATCACTTGAAGGGTAAA
GAAACTTCAACTAATTCTATAGCAACAATATTTGCATGGAGTGGCGCACTTAGAAAAAGAGGAGAGCTAGATAATAATAA
AGAGTTAATTGATTTTGCAAATAACCTTGAAATTGCATCTTTAAAAACAATAGAAAACGGAATAATGACAGGTGATTTAG
CAGCAATTGCAATTCATGATAATATAAAAAAGGTTAATACATTTGAATTTATAAAAGAAATAAGAAAGAACTTAGAAGTA
AGTTTATAA

Upstream 100 bases:

>100_bases
GTCAATAATGTATAATATGTATAAAATTTCTTTAGAGAAAAGGGTTAAAAATACTATGAAAAATTATAATGTTTTTAATC
TAAAACAAGGGGGCAATAAA

Downstream 100 bases:

>100_bases
TAAGTTTAGGGATACATACTCTATAAAGGAGAATGTATCCCTTTATAGTTATAAATAAAAAAATATAATTTCCTAAAAAA
TAAAAATAATATCTAAGGTG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MEKIKMSNPLVEIDGDEMTRIVWGMIKDELLNPFIELNTEYYDLGLENRNATDDNITVQAAEAIKKHKVGVKCATITPNS
ARVKEYNLKKMWKSPNGTIRAILDGTVFRAPIIVDVVKPYVRTWSKPITIARHAYGDIYKASEMKIEGKGKCELVFTAEN
GQEKRELIHNFNDDGVVMGMHNINKSIESFARSCFNYSIDLKQDLWFGAKDTISKKYDHTFKDIFEEIYENEYKEKFEAL
GIKYTYMLIDSAVANVIKSHGGMIWACKNYDGDVMSDMIAAAFGSIAMMTSVLVSPDGNYEYEAAHGTVQDQYYDHLKGK
ETSTNSIATIFAWSGALRKRGELDNNKELIDFANNLEIASLKTIENGIMTGDLAAIAIHDNIKKVNTFEFIKEIRKNLEV
SL

Sequences:

>Translated_402_residues
MEKIKMSNPLVEIDGDEMTRIVWGMIKDELLNPFIELNTEYYDLGLENRNATDDNITVQAAEAIKKHKVGVKCATITPNS
ARVKEYNLKKMWKSPNGTIRAILDGTVFRAPIIVDVVKPYVRTWSKPITIARHAYGDIYKASEMKIEGKGKCELVFTAEN
GQEKRELIHNFNDDGVVMGMHNINKSIESFARSCFNYSIDLKQDLWFGAKDTISKKYDHTFKDIFEEIYENEYKEKFEAL
GIKYTYMLIDSAVANVIKSHGGMIWACKNYDGDVMSDMIAAAFGSIAMMTSVLVSPDGNYEYEAAHGTVQDQYYDHLKGK
ETSTNSIATIFAWSGALRKRGELDNNKELIDFANNLEIASLKTIENGIMTGDLAAIAIHDNIKKVNTFEFIKEIRKNLEV
SL
>Mature_402_residues
MEKIKMSNPLVEIDGDEMTRIVWGMIKDELLNPFIELNTEYYDLGLENRNATDDNITVQAAEAIKKHKVGVKCATITPNS
ARVKEYNLKKMWKSPNGTIRAILDGTVFRAPIIVDVVKPYVRTWSKPITIARHAYGDIYKASEMKIEGKGKCELVFTAEN
GQEKRELIHNFNDDGVVMGMHNINKSIESFARSCFNYSIDLKQDLWFGAKDTISKKYDHTFKDIFEEIYENEYKEKFEAL
GIKYTYMLIDSAVANVIKSHGGMIWACKNYDGDVMSDMIAAAFGSIAMMTSVLVSPDGNYEYEAAHGTVQDQYYDHLKGK
ETSTNSIATIFAWSGALRKRGELDNNKELIDFANNLEIASLKTIENGIMTGDLAAIAIHDNIKKVNTFEFIKEIRKNLEV
SL

Specific function: Catalyzes The Oxidation Of 3-Carboxy-2-Hydroxy-4- Methylpentanoate (3-Isopropylmalate) To 3-Carboxy-4-Methyl-2- Oxopentanoate. The Product Decarboxylates To 4-Methyl-2 Oxopentanoate. [C]

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=409, Percent_Identity=55.0122249388753, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI28178832, Length=409, Percent_Identity=52.3227383863081, Blast_Score=430, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17540874, Length=397, Percent_Identity=53.1486146095718, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17550822, Length=380, Percent_Identity=51.3157894736842, Blast_Score=402, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320137, Length=403, Percent_Identity=55.0868486352357, Blast_Score=441, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6324319, Length=404, Percent_Identity=50, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6323203, Length=404, Percent_Identity=50.7425742574257, Blast_Score=408, Evalue=1e-115,
Organism=Drosophila melanogaster, GI221330987, Length=408, Percent_Identity=52.4509803921569, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221330985, Length=408, Percent_Identity=52.4509803921569, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI28574947, Length=408, Percent_Identity=52.4509803921569, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24660849, Length=408, Percent_Identity=52.4509803921569, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI21356561, Length=408, Percent_Identity=52.4509803921569, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI221330983, Length=408, Percent_Identity=52.4509803921569, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24660856, Length=408, Percent_Identity=52.4509803921569, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24660868, Length=408, Percent_Identity=52.4509803921569, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24660860, Length=408, Percent_Identity=52.4509803921569, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45505; Mature: 45505

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIKMSNPLVEIDGDEMTRIVWGMIKDELLNPFIELNTEYYDLGLENRNATDDNITVQA
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCCCCCCCCCEEEHH
AEAIKKHKVGVKCATITPNSARVKEYNLKKMWKSPNGTIRAILDGTVFRAPIIVDVVKPY
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHCHHHHHHHHHH
VRTWSKPITIARHAYGDIYKASEMKIEGKGKCELVFTAENGQEKRELIHNFNDDGVVMGM
HHHCCCCEEEHHHHCCCCEECCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEH
HNINKSIESFARSCFNYSIDLKQDLWFGAKDTISKKYDHTFKDIFEEIYENEYKEKFEAL
HHHHHHHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHC
GIKYTYMLIDSAVANVIKSHGGMIWACKNYDGDVMSDMIAAAFGSIAMMTSVLVSPDGNY
CCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
EYEAAHGTVQDQYYDHLKGKETSTNSIATIFAWSGALRKRGELDNNKELIDFANNLEIAS
EEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHCCCCCCCCHHHHHCCCCEEEE
LKTIENGIMTGDLAAIAIHDNIKKVNTFEFIKEIRKNLEVSL
EHHHHCCCEECCEEEEEEECCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKIKMSNPLVEIDGDEMTRIVWGMIKDELLNPFIELNTEYYDLGLENRNATDDNITVQA
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHCCCEEEEECCCCCCCCCCCEEEHH
AEAIKKHKVGVKCATITPNSARVKEYNLKKMWKSPNGTIRAILDGTVFRAPIIVDVVKPY
HHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHCHHHHHHHHHH
VRTWSKPITIARHAYGDIYKASEMKIEGKGKCELVFTAENGQEKRELIHNFNDDGVVMGM
HHHCCCCEEEHHHHCCCCEECCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCEEEEH
HNINKSIESFARSCFNYSIDLKQDLWFGAKDTISKKYDHTFKDIFEEIYENEYKEKFEAL
HHHHHHHHHHHHHHHCCCEEEHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHC
GIKYTYMLIDSAVANVIKSHGGMIWACKNYDGDVMSDMIAAAFGSIAMMTSVLVSPDGNY
CCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCE
EYEAAHGTVQDQYYDHLKGKETSTNSIATIFAWSGALRKRGELDNNKELIDFANNLEIAS
EEEECCCCHHHHHHHHHCCCCCCCCCEEEEEEECHHHHHCCCCCCCCHHHHHCCCCEEEE
LKTIENGIMTGDLAAIAIHDNIKKVNTFEFIKEIRKNLEVSL
EHHHHCCCEECCEEEEEEECCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]