Click here to switch to the map view.

The map label for this gene is copA [H]

Identifier: 187928921

GI number: 187928921

Start: 1929390

End: 1931204

Strand: Reverse

Name: copA [H]

Synonym: Rpic_1840

Alternate gene names: 187928921

Gene position: 1931204-1929390 (Counterclockwise)

Preceding gene: 187928926

Following gene: 187928920

Centisome position: 48.98

GC content: 60.5

Gene sequence:

>1815_bases
ATGCGCAGCAATCGTGCAATGGGCGTGGTGCTTCCGAACCTTCCGCGGAGGCGATTTGTGCAAGGCTTGGCCGCCGGAGG
GGTGATCGCTGGCCTGGGCTTGGGCGGGATGCCCGCGCGGGCGTCGCAGGCCCAGGGCACAGCCTTTGGCACCGCGCCCG
TGCTGCGGGGCACCGAATTCGATCTGGTGATCGCTGAGACCCCAGTGAACTTTACCGGCAAGCCAGGCATGGCGACTACC
ATCAATGGCATGCTGCCTGGCCCAACGTTGCGGTGGCGTGAAGGTGACACGGTCACCATCCGGGTGACCAACCGTCTGCC
GGAGCCCACGTCAATTCATTGGCACGGCATCATTCTGCCGTTCCAGATGGACGGCGTACCCGGGATCAGCTTTTCCGGCA
TCGCCCCGGGCGAGACATTCACGTATCGTTTCAAGGTCCAGCAGAGTGGCAGTTACTGGTACCACTCGCACTCCGGCTTC
CAGGAAATGACAGGACTATATGGCGGTATCGTTATCGATCCCGCTGGCGAGGACCGCGTGCGGGCCGATCGCGATTACAC
CGTCTTGCTTTCCGACTGGACGGACGAGGATCCGATGCGCGTCCTCACCAAGCTTAAGATCCAAGGCGACTACTACAACT
ATAACCAGCCGACTGTGGTCGATTTCTTTCGCGATGTCTCCCGTGAGGGATGGACATCTGCCATGAACAAACGGCAGATG
TGGAACCAGATGCGCATGAATCCGACCGATTTGGCGGATCTCTCCGGCGCGACGCTGACCTACCTCATGAATGGCGTGAC
GCCAGCGGGGAATTGGACCGGTCTATTTTCTCCAGGCCAGACGGTACGGTTGCGCTTCATCAACGGCGCCGGCAACACGT
TCTATGACGTTCGCGTTCCGGGCTTGAAGATGAAGGTAGTGCAGGTTGACGGACAGGATATCGAACCGGTGTCGGTCGAT
GAGTTCCGCTTTGGCCCTGGCGAGACCTGCGACGTAGTGGTCTCTCCGACGGATGAGGCCCACACAGTGTTCGCGCAGAC
GATGGACCGGACCGGATATGCCCGGGGCACTCTGGCCGTGCGCCAGGGCGTGCAAGCCCCTGTGCCAGCGGTCGACAAGG
CTGAATGGCTGACGATGGCGGATATGATGGGCGACATGGGAGGCATGTCTGGCATGTCTGGCATGTCTGGCATGTCTGGC
ATGTCTGGCATGGACCATGGCGGCATGGCAATGGCTCACAGCCAGCATGGAGCGATGCCGGGCAATGCCGCAAACTCCTT
GAAGGTGCCGAGCAAGAAAGCCCGTCATGCGCGTACAGAGTACGGTCCCAGCACCGACATGCATGTCGATATGGCGCGGA
CCAACCTCGACGATCCCGGCATAGGGCTGCGCAACAATGGGCGACGTGTGCTGGTCCTGCAGGACATGCATACGATCGGC
GGCCCTATGGACGCCCGCAGCCCTCAGCGCGAGGTGGAGTTACATCTGACCGGCAATATGGAGCGCTACGCGTGGTCGCT
CGACGGAGTGGAGTTCGGCAAATCGACCCCCGTTCATTTTCGCTATGGGGAACGTCTTCGCGTCATTCTTCACAACGATA
CGATGATGACGCACCCGATGCACATGCATGGGATGTGGAGCGAACTTGAGGCGCCGGACGGCACATTCTTGGCGCGCCGA
CACACGATTCCGGTGCAGCCCGCGCAGCGCATTAGCTTCCTTGTCACGGCTGACGCTCTTGGCCGATGGGCTTGGCACTG
CCATCTCATGCTTCATATGGATGCAGGTATGTTCCGTGAAGTGATCGTCGCCTAA

Upstream 100 bases:

>100_bases
ACCAATATGTAATGTTTCGGTCAGGTTAAGGTAGCCTTGGAGTGATTAGGCTGCTCCTGCCGTACAAATCTCATCAGGGA
CTTACGCAAGGAATAAAGAG

Downstream 100 bases:

>100_bases
GCCCGGATCGACAAGTCAAATGACCACGCATAAGCACGTTAAGACAGCACTGGCAGTTGCCTTGGCCCTTGTCAGCATCA
GCGCCGCATCTGCACAGGAA

Product: copper-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MRSNRAMGVVLPNLPRRRFVQGLAAGGVIAGLGLGGMPARASQAQGTAFGTAPVLRGTEFDLVIAETPVNFTGKPGMATT
INGMLPGPTLRWREGDTVTIRVTNRLPEPTSIHWHGIILPFQMDGVPGISFSGIAPGETFTYRFKVQQSGSYWYHSHSGF
QEMTGLYGGIVIDPAGEDRVRADRDYTVLLSDWTDEDPMRVLTKLKIQGDYYNYNQPTVVDFFRDVSREGWTSAMNKRQM
WNQMRMNPTDLADLSGATLTYLMNGVTPAGNWTGLFSPGQTVRLRFINGAGNTFYDVRVPGLKMKVVQVDGQDIEPVSVD
EFRFGPGETCDVVVSPTDEAHTVFAQTMDRTGYARGTLAVRQGVQAPVPAVDKAEWLTMADMMGDMGGMSGMSGMSGMSG
MSGMDHGGMAMAHSQHGAMPGNAANSLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLVLQDMHTIG
GPMDARSPQREVELHLTGNMERYAWSLDGVEFGKSTPVHFRYGERLRVILHNDTMMTHPMHMHGMWSELEAPDGTFLARR
HTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVIVA

Sequences:

>Translated_604_residues
MRSNRAMGVVLPNLPRRRFVQGLAAGGVIAGLGLGGMPARASQAQGTAFGTAPVLRGTEFDLVIAETPVNFTGKPGMATT
INGMLPGPTLRWREGDTVTIRVTNRLPEPTSIHWHGIILPFQMDGVPGISFSGIAPGETFTYRFKVQQSGSYWYHSHSGF
QEMTGLYGGIVIDPAGEDRVRADRDYTVLLSDWTDEDPMRVLTKLKIQGDYYNYNQPTVVDFFRDVSREGWTSAMNKRQM
WNQMRMNPTDLADLSGATLTYLMNGVTPAGNWTGLFSPGQTVRLRFINGAGNTFYDVRVPGLKMKVVQVDGQDIEPVSVD
EFRFGPGETCDVVVSPTDEAHTVFAQTMDRTGYARGTLAVRQGVQAPVPAVDKAEWLTMADMMGDMGGMSGMSGMSGMSG
MSGMDHGGMAMAHSQHGAMPGNAANSLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLVLQDMHTIG
GPMDARSPQREVELHLTGNMERYAWSLDGVEFGKSTPVHFRYGERLRVILHNDTMMTHPMHMHGMWSELEAPDGTFLARR
HTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVIVA
>Mature_604_residues
MRSNRAMGVVLPNLPRRRFVQGLAAGGVIAGLGLGGMPARASQAQGTAFGTAPVLRGTEFDLVIAETPVNFTGKPGMATT
INGMLPGPTLRWREGDTVTIRVTNRLPEPTSIHWHGIILPFQMDGVPGISFSGIAPGETFTYRFKVQQSGSYWYHSHSGF
QEMTGLYGGIVIDPAGEDRVRADRDYTVLLSDWTDEDPMRVLTKLKIQGDYYNYNQPTVVDFFRDVSREGWTSAMNKRQM
WNQMRMNPTDLADLSGATLTYLMNGVTPAGNWTGLFSPGQTVRLRFINGAGNTFYDVRVPGLKMKVVQVDGQDIEPVSVD
EFRFGPGETCDVVVSPTDEAHTVFAQTMDRTGYARGTLAVRQGVQAPVPAVDKAEWLTMADMMGDMGGMSGMSGMSGMSG
MSGMDHGGMAMAHSQHGAMPGNAANSLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLVLQDMHTIG
GPMDARSPQREVELHLTGNMERYAWSLDGVEFGKSTPVHFRYGERLRVILHNDTMMTHPMHMHGMWSELEAPDGTFLARR
HTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVIVA

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=449, Percent_Identity=26.5033407572383, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321067, Length=284, Percent_Identity=26.4084507042254, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320714, Length=284, Percent_Identity=23.943661971831, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=134, Percent_Identity=38.8059701492537, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650186, Length=335, Percent_Identity=26.2686567164179, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18859919, Length=564, Percent_Identity=23.0496453900709, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574104, Length=311, Percent_Identity=27.6527331189711, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281360167, Length=269, Percent_Identity=28.6245353159851, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585842, Length=269, Percent_Identity=28.6245353159851, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221330000, Length=269, Percent_Identity=28.6245353159851, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221329998, Length=269, Percent_Identity=28.6245353159851, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 66450; Mature: 66450

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSNRAMGVVLPNLPRRRFVQGLAAGGVIAGLGLGGMPARASQAQGTAFGTAPVLRGTEF
CCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEECCCCE
DLVIAETPVNFTGKPGMATTINGMLPGPTLRWREGDTVTIRVTNRLPEPTSIHWHGIILP
EEEEEECCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEEEEEE
FQMDGVPGISFSGIAPGETFTYRFKVQQSGSYWYHSHSGFQEMTGLYGGIVIDPAGEDRV
EEECCCCCCCCCCCCCCCEEEEEEEEEECCCEEEECCCCHHHHHHHHCCEEECCCCCCCC
RADRDYTVLLSDWTDEDPMRVLTKLKIQGDYYNYNQPTVVDFFRDVSREGWTSAMNKRQM
CCCCCEEEEEECCCCCCHHHEEEEEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
WNQMRMNPTDLADLSGATLTYLMNGVTPAGNWTGLFSPGQTVRLRFINGAGNTFYDVRVP
HHHHCCCCCCHHHCCCCEEEHHHCCCCCCCCEEEECCCCCEEEEEEEECCCCEEEEEECC
GLKMKVVQVDGQDIEPVSVDEFRFGPGETCDVVVSPTDEAHTVFAQTMDRTGYARGTLAV
CEEEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHHH
RQGVQAPVPAVDKAEWLTMADMMGDMGGMSGMSGMSGMSGMSGMDHGGMAMAHSQHGAMP
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
GNAANSLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLVLQDMHTIG
CCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEEEECCHHCC
GPMDARSPQREVELHLTGNMERYAWSLDGVEFGKSTPVHFRYGERLRVILHNDTMMTHPM
CCCCCCCCCCEEEEEEECCCCCEEEEECCEECCCCCCEEEEECCEEEEEEECCEEEECCH
HMHGMWSELEAPDGTFLARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFRE
HHCCCHHHCCCCCCCEEEEECCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEEECCCHHHH
VIVA
HHCC
>Mature Secondary Structure
MRSNRAMGVVLPNLPRRRFVQGLAAGGVIAGLGLGGMPARASQAQGTAFGTAPVLRGTEF
CCCCCEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCEECCCCE
DLVIAETPVNFTGKPGMATTINGMLPGPTLRWREGDTVTIRVTNRLPEPTSIHWHGIILP
EEEEEECCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEEEEEE
FQMDGVPGISFSGIAPGETFTYRFKVQQSGSYWYHSHSGFQEMTGLYGGIVIDPAGEDRV
EEECCCCCCCCCCCCCCCEEEEEEEEEECCCEEEECCCCHHHHHHHHCCEEECCCCCCCC
RADRDYTVLLSDWTDEDPMRVLTKLKIQGDYYNYNQPTVVDFFRDVSREGWTSAMNKRQM
CCCCCEEEEEECCCCCCHHHEEEEEEEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
WNQMRMNPTDLADLSGATLTYLMNGVTPAGNWTGLFSPGQTVRLRFINGAGNTFYDVRVP
HHHHCCCCCCHHHCCCCEEEHHHCCCCCCCCEEEECCCCCEEEEEEEECCCCEEEEEECC
GLKMKVVQVDGQDIEPVSVDEFRFGPGETCDVVVSPTDEAHTVFAQTMDRTGYARGTLAV
CEEEEEEEECCCCCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCHHHH
RQGVQAPVPAVDKAEWLTMADMMGDMGGMSGMSGMSGMSGMSGMDHGGMAMAHSQHGAMP
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
GNAANSLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLVLQDMHTIG
CCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEEEECCHHCC
GPMDARSPQREVELHLTGNMERYAWSLDGVEFGKSTPVHFRYGERLRVILHNDTMMTHPM
CCCCCCCCCCEEEEEEECCCCCEEEEECCEECCCCCCEEEEECCEEEEEEECCEEEECCH
HMHGMWSELEAPDGTFLARRHTIPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFRE
HHCCCHHHCCCCCCCEEEEECCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEEECCCHHHH
VIVA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]