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The map label for this gene is merR [H]

Identifier: 187928866

GI number: 187928866

Start: 1880751

End: 1881185

Strand: Reverse

Name: merR [H]

Synonym: Rpic_1783

Alternate gene names: 187928866

Gene position: 1881185-1880751 (Counterclockwise)

Preceding gene: 187928874

Following gene: 187928862

Centisome position: 47.71

GC content: 60.23

Gene sequence:

>435_bases
ATGGAATGCAATCTGATGAATTTGACTATCGGCGCCTTTGCGAAGGCGGCCGAGGTCAATGTGGAGACCATCCGGTTCTA
CCAGCGCAAAGGGTTGTTGTGCGAGCCAGACAAGCCCTATGGCAGCATCCGCCGCTATGGCGAAGCGGATGTGACGCGCG
TGCGGTTCGTGAAATCGGCCCAGCGGCTGGGCTTCAGCCTGGACGAGATTGCCGAGCTGCTGCGGCTGGACGATGGCACC
CATTGCGAGGAGGCCGGCAGCCTAGCCGAGCATAAACTTCAGGATGTGCGAGAGAAGATGGCCGACTTGGCGCGCATGGA
AACCGTGCTATCCAAGCTTGTGTGCGCCTGCCATGCGCGGCAAGGGAACGTTTCCTGTCCGCTGATTGCGTCGCTGCAAG
GGAAGAAAGAACCGCGCAGTACCGACGCGGAGTAG

Upstream 100 bases:

>100_bases
GCACTGCGCCCGTGTTGCGGTTCCGACATGCGCTTGTCCTTTCGAATCGGGAGGGTATAACGTAAGCTTACTTCCGTACT
GTTGTACGGAGTCAAGCAGG

Downstream 100 bases:

>100_bases
CCGGGTAGCTACGCCTTAGCGTGCCTTATTTTCCGTTTTCTGAGACGACCCCATGAAGACGCAATCAGTCATGGCTGCAG
CGCTTGCGCTTGCCCAGCTC

Product: putative transcriptional regulator MerR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MECNLMNLTIGAFAKAAEVNVETIRFYQRKGLLCEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGT
HCEEAGSLAEHKLQDVREKMADLARMETVLSKLVCACHARQGNVSCPLIASLQGKKEPRSTDAE

Sequences:

>Translated_144_residues
MECNLMNLTIGAFAKAAEVNVETIRFYQRKGLLCEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGT
HCEEAGSLAEHKLQDVREKMADLARMETVLSKLVCACHARQGNVSCPLIASLQGKKEPRSTDAE
>Mature_144_residues
MECNLMNLTIGAFAKAAEVNVETIRFYQRKGLLCEPDKPYGSIRRYGEADVTRVRFVKSAQRLGFSLDEIAELLRLDDGT
HCEEAGSLAEHKLQDVREKMADLARMETVLSKLVCACHARQGNVSCPLIASLQGKKEPRSTDAE

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=128, Percent_Identity=35.9375, Blast_Score=85, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16045; Mature: 16045

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECNLMNLTIGAFAKAAEVNVETIRFYQRKGLLCEPDKPYGSIRRYGEADVTRVRFVKSA
CCCCEEEEHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEIAELLRLDDGTHCEEAGSLAEHKLQDVREKMADLARMETVLSKLVCACHAR
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QGNVSCPLIASLQGKKEPRSTDAE
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MECNLMNLTIGAFAKAAEVNVETIRFYQRKGLLCEPDKPYGSIRRYGEADVTRVRFVKSA
CCCCEEEEHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHH
QRLGFSLDEIAELLRLDDGTHCEEAGSLAEHKLQDVREKMADLARMETVLSKLVCACHAR
HHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QGNVSCPLIASLQGKKEPRSTDAE
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2666393 [H]