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The map label for this gene is pcoA [H]

Identifier: 187928862

GI number: 187928862

Start: 1875868

End: 1877706

Strand: Reverse

Name: pcoA [H]

Synonym: Rpic_1779

Alternate gene names: 187928862

Gene position: 1877706-1875868 (Counterclockwise)

Preceding gene: 187928866

Following gene: 187928861

Centisome position: 47.63

GC content: 63.62

Gene sequence:

>1839_bases
ATGCGCAACAATCGTGCATCCGGCCTCGTACTGCCGAATCTGCCGCGACGGCGATTCGTGCAAGGTTTGGCCGCCGGCGG
GGTCATCGCCGGCTTGGGGCTGGCTGGCTTCACTTCGGCGGCACCCGCTGCGTCCACCGCGCTGGGTACCGCCCCAGTGC
TACGCGGCACCGAATTCGACCTGGTGATCGACGAGACGCCGGTGAACTTCACCGGTAAGCCGGCCATGGCGACCACCATC
AACGGCATGCTGCCCGGGCCCACGCTGCGCTGGCGCCAGGGCGACACCGTTACGCTGCGCGTGACCAACCGCTTGCGCGA
GCCGACGTCGATCCACTGGCACGGCATCATCGTGCCGTTTCAGATGGACGGCGTGCCCGGCATCAGCTTTCACGGCATCC
CGCCCGGCGAGACCTTCACGTATCGCTTCAAGGTCCAGCAAAGCGGCAGCTACTGGTATCACTCGCACTCGGGCTTCCAG
GAAATGACCGGGGTCTATGGTGGGCTCATCATCGATGCCGCCGGCGGTGACCCGATCCGCGCGGATCGCGATTACTCGGT
TCTGCTCTCCGACTGGACCGACGAAGATCCGATGCGCGTCCTCTCCAAGCTCAAGAGACAGAGCGACTACTACAACTACC
ACCAGCCCACAGTGGTGGATTTCTTCCGCGACGTCTCCAACGATGGCTGGAAAGCGGCCATGGACAAGCGGAGCATGTGG
AACCAGATGCGCATGAATCCGACTGACCTGGCGGATCTTTCCGGCGCCACACTGACGTACCTGACCAACGGCGTCACACC
TGCCGGCAACTGGACGGGCCTCTTCGCGCCGGGGGAGACCGTGCGGTTGCGCTTTATCAACGGATCGGGCAACACGTTCT
ACGACGTCCGCATCCCGGGGCTAAAGCTCAAGGTAGTGCAGGTCGATGGGCAGAACATCGAGCCCGTCACCGTTGACGAG
TTTCGCTTCGGCCCCGGCGAGACGTGCGACGTGCTCGTTTCACCCAAGGACGATGCCTACACGATCTTCTCGCAGTCGAT
GGATCGTACCGGCTACGCGCGCGGCACGCTGGCAGTTCGCCAAGGCCTGCAGGCTGCAGTTCCCGCGCTCGACAAGGTCG
AGTGGCTTTCGATGGCCGACATGATGGGCGACATGGGCGGAATGGGCCACGCCGGCATGTCGGGCATGGATCATGGTGGC
ATGCAGATGATGGGCGATGGCGGCATGACCACGATGGATTCCGGTGGCATGACGATGATGGGCGATGGCCAGCCTGCGGC
ATCCAGCAGTGCGCCGGACAATCTGAAGGTGCCGAGCAAGAAGGCGCGGCATGCGCGCACGGAATATGGTCCGAGCACCG
ACATGCACGTCGACATGGCTCGCACCAATCTGGACGATCCCGGCATCGGGTTGCGTAACAACGGACGGCGCGTCCTGGTG
CTTGCTGACATGCATACCATCGGCGGCCCCATGGACAAGCGTGGTCCGGGGCGCGAGGTGGAGCTGCACCTCACTGGCAA
CATGGAGCGCTACACGTGGTCGATCGACGGTGTGGAGTTCGGCAAGTCGACGCCGGTGCATTTCCAATATGGCGAAAGGC
TGCGGGTCATCCTCCACAACGACACGATGATGACCCACCCGATGCACTTGCACGGGATGTGGAGCGAGCTGGAAGCACCA
GACGGCACGTTCCTCGCGCGCCGGCACACCCTCCCTGTCCAGCCTGCCCAGCGGATCAGCTTTCTGGTCACAGCAGACGC
GCTGGGTCGCTGGGCGTGGCACTGCCATCTGATGTTGCACATGGACGCGGGTATGTTCCGCGAAGTGGTGGTGGCCTGA

Upstream 100 bases:

>100_bases
ATGACCGATTTGTAATGTTTCGGTCAGGTCGGGGTAGCCTGGCACTGGGTAGCCTGCGCGCAGCTTTCTGAGTCGGACAT
TACGTAAGGAAAACTCGATC

Downstream 100 bases:

>100_bases
TGCTCGACTTCCAACGCAGATCAATCATGCGCAAGCACGCAAGGACATTGTTGACTGTAGCGCTGGCCGCCGCTGGCATC
GGAGCTGCCTCGGCTCAGGA

Product: copper-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MRNNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLAGFTSAAPAASTALGTAPVLRGTEFDLVIDETPVNFTGKPAMATTI
NGMLPGPTLRWRQGDTVTLRVTNRLREPTSIHWHGIIVPFQMDGVPGISFHGIPPGETFTYRFKVQQSGSYWYHSHSGFQ
EMTGVYGGLIIDAAGGDPIRADRDYSVLLSDWTDEDPMRVLSKLKRQSDYYNYHQPTVVDFFRDVSNDGWKAAMDKRSMW
NQMRMNPTDLADLSGATLTYLTNGVTPAGNWTGLFAPGETVRLRFINGSGNTFYDVRIPGLKLKVVQVDGQNIEPVTVDE
FRFGPGETCDVLVSPKDDAYTIFSQSMDRTGYARGTLAVRQGLQAAVPALDKVEWLSMADMMGDMGGMGHAGMSGMDHGG
MQMMGDGGMTTMDSGGMTMMGDGQPAASSSAPDNLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLV
LADMHTIGGPMDKRGPGREVELHLTGNMERYTWSIDGVEFGKSTPVHFQYGERLRVILHNDTMMTHPMHLHGMWSELEAP
DGTFLARRHTLPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVA

Sequences:

>Translated_612_residues
MRNNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLAGFTSAAPAASTALGTAPVLRGTEFDLVIDETPVNFTGKPAMATTI
NGMLPGPTLRWRQGDTVTLRVTNRLREPTSIHWHGIIVPFQMDGVPGISFHGIPPGETFTYRFKVQQSGSYWYHSHSGFQ
EMTGVYGGLIIDAAGGDPIRADRDYSVLLSDWTDEDPMRVLSKLKRQSDYYNYHQPTVVDFFRDVSNDGWKAAMDKRSMW
NQMRMNPTDLADLSGATLTYLTNGVTPAGNWTGLFAPGETVRLRFINGSGNTFYDVRIPGLKLKVVQVDGQNIEPVTVDE
FRFGPGETCDVLVSPKDDAYTIFSQSMDRTGYARGTLAVRQGLQAAVPALDKVEWLSMADMMGDMGGMGHAGMSGMDHGG
MQMMGDGGMTTMDSGGMTMMGDGQPAASSSAPDNLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLV
LADMHTIGGPMDKRGPGREVELHLTGNMERYTWSIDGVEFGKSTPVHFQYGERLRVILHNDTMMTHPMHLHGMWSELEAP
DGTFLARRHTLPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVA
>Mature_612_residues
MRNNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLAGFTSAAPAASTALGTAPVLRGTEFDLVIDETPVNFTGKPAMATTI
NGMLPGPTLRWRQGDTVTLRVTNRLREPTSIHWHGIIVPFQMDGVPGISFHGIPPGETFTYRFKVQQSGSYWYHSHSGFQ
EMTGVYGGLIIDAAGGDPIRADRDYSVLLSDWTDEDPMRVLSKLKRQSDYYNYHQPTVVDFFRDVSNDGWKAAMDKRSMW
NQMRMNPTDLADLSGATLTYLTNGVTPAGNWTGLFAPGETVRLRFINGSGNTFYDVRIPGLKLKVVQVDGQNIEPVTVDE
FRFGPGETCDVLVSPKDDAYTIFSQSMDRTGYARGTLAVRQGLQAAVPALDKVEWLSMADMMGDMGGMGHAGMSGMDHGG
MQMMGDGGMTTMDSGGMTMMGDGQPAASSSAPDNLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLV
LADMHTIGGPMDKRGPGREVELHLTGNMERYTWSIDGVEFGKSTPVHFQYGERLRVILHNDTMMTHPMHLHGMWSELEAP
DGTFLARRHTLPVQPAQRISFLVTADALGRWAWHCHLMLHMDAGMFREVVVA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=448, Percent_Identity=27.4553571428571, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320714, Length=301, Percent_Identity=25.9136212624585, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321067, Length=283, Percent_Identity=27.9151943462898, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=281, Percent_Identity=28.1138790035587, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24650186, Length=580, Percent_Identity=23.448275862069, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI18859919, Length=573, Percent_Identity=21.9895287958115, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574104, Length=98, Percent_Identity=45.9183673469388, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360167, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585842, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330000, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221329998, Length=269, Percent_Identity=27.1375464684015, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67110; Mature: 67110

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLAGFTSAAPAASTALGTAPVLRGTEFD
CCCCCCCEEECCCCCHHHHHHHHHCCCHHHHCCHHCCCCCCCCHHHHCCCCCEECCCEEE
LVIDETPVNFTGKPAMATTINGMLPGPTLRWRQGDTVTLRVTNRLREPTSIHWHGIIVPF
EEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEEE
QMDGVPGISFHGIPPGETFTYRFKVQQSGSYWYHSHSGFQEMTGVYGGLIIDAAGGDPIR
EECCCCCCEECCCCCCCEEEEEEEEEECCCEEEECCCCHHHHHHHHCCEEEECCCCCCCC
ADRDYSVLLSDWTDEDPMRVLSKLKRQSDYYNYHQPTVVDFFRDVSNDGWKAAMDKRSMW
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
NQMRMNPTDLADLSGATLTYLTNGVTPAGNWTGLFAPGETVRLRFINGSGNTFYDVRIPG
HHHCCCCCCHHHCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEEEECCCCEEEEEEECC
LKLKVVQVDGQNIEPVTVDEFRFGPGETCDVLVSPKDDAYTIFSQSMDRTGYARGTLAVR
EEEEEEEECCCCCCCEEECCEECCCCCCEEEEECCCCCEEEEEHHCCCCCCCCCCHHHHH
QGLQAAVPALDKVEWLSMADMMGDMGGMGHAGMSGMDHGGMQMMGDGGMTTMDSGGMTMM
HCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCEEEE
GDGQPAASSSAPDNLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLV
ECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEE
LADMHTIGGPMDKRGPGREVELHLTGNMERYTWSIDGVEFGKSTPVHFQYGERLRVILHN
EEECHHHCCCCCCCCCCCEEEEEEECCCEEEEEEECCEECCCCCCEEEECCCEEEEEEEC
DTMMTHPMHLHGMWSELEAPDGTFLARRHTLPVQPAQRISFLVTADALGRWAWHCHLMLH
CEEEECCEEEECCHHHCCCCCCCEEEEECCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEE
MDAGMFREVVVA
ECCCHHHHHHCC
>Mature Secondary Structure
MRNNRASGLVLPNLPRRRFVQGLAAGGVIAGLGLAGFTSAAPAASTALGTAPVLRGTEFD
CCCCCCCEEECCCCCHHHHHHHHHCCCHHHHCCHHCCCCCCCCHHHHCCCCCEECCCEEE
LVIDETPVNFTGKPAMATTINGMLPGPTLRWRQGDTVTLRVTNRLREPTSIHWHGIIVPF
EEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCEEEEEEEEEE
QMDGVPGISFHGIPPGETFTYRFKVQQSGSYWYHSHSGFQEMTGVYGGLIIDAAGGDPIR
EECCCCCCEECCCCCCCEEEEEEEEEECCCEEEECCCCHHHHHHHHCCEEEECCCCCCCC
ADRDYSVLLSDWTDEDPMRVLSKLKRQSDYYNYHQPTVVDFFRDVSNDGWKAAMDKRSMW
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
NQMRMNPTDLADLSGATLTYLTNGVTPAGNWTGLFAPGETVRLRFINGSGNTFYDVRIPG
HHHCCCCCCHHHCCCCEEEEEECCCCCCCCCEEEECCCCEEEEEEEECCCCEEEEEEECC
LKLKVVQVDGQNIEPVTVDEFRFGPGETCDVLVSPKDDAYTIFSQSMDRTGYARGTLAVR
EEEEEEEECCCCCCCEEECCEECCCCCCEEEEECCCCCEEEEEHHCCCCCCCCCCHHHHH
QGLQAAVPALDKVEWLSMADMMGDMGGMGHAGMSGMDHGGMQMMGDGGMTTMDSGGMTMM
HCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCEEEE
GDGQPAASSSAPDNLKVPSKKARHARTEYGPSTDMHVDMARTNLDDPGIGLRNNGRRVLV
ECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEE
LADMHTIGGPMDKRGPGREVELHLTGNMERYTWSIDGVEFGKSTPVHFQYGERLRVILHN
EEECHHHCCCCCCCCCCCEEEEEEECCCEEEEEEECCEECCCCCCEEEECCCEEEEEEEC
DTMMTHPMHLHGMWSELEAPDGTFLARRHTLPVQPAQRISFLVTADALGRWAWHCHLMLH
CEEEECCEEEECCHHHCCCCCCCEEEEECCCCCCHHHHEEEEEEHHHHCCEEEEEEEEEE
MDAGMFREVVVA
ECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]