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The map label for this gene is czcR [H]

Identifier: 187928843

GI number: 187928843

Start: 1857060

End: 1857737

Strand: Reverse

Name: czcR [H]

Synonym: Rpic_1760

Alternate gene names: 187928843

Gene position: 1857737-1857060 (Counterclockwise)

Preceding gene: 187928844

Following gene: 187928842

Centisome position: 47.12

GC content: 58.26

Gene sequence:

>678_bases
GTGCGGGTACTTGTTGTAGAAGACGAACCGCGTACTGCGGAGTATTTGCAGAAGGGATTGTCGGAGTCGGGTTTCGTGGT
CGACATCGCGAACAATGGTGGCGATGGGCTCCACATGGCGGAAGAGACCGACTACGACGTCATCATCCTGGACGTCATGC
TGCCAGGTATGGACGGGTGGACGGTCATCAAGTCCATTCGATCCAAGTCCGAGACACCCGTACTGTTTCTGACGGCGCTG
GATGATGTGGCGGATCGTGTCAGAGGCTTCGAGTTGGGGGCAGACGATTACCTGGTCAAGCCCTTCGCCTTTGCCGAGCT
CCTTGCCCGTATCCGGCGTTGCTTGCGCCAAAGCACCTCGAAGGAGTCCGAGCGATTGCGCATTGCCGATCTGGACATCG
ACGTGCTTGGAAGGCGGGTATTCCGGGGAACTACCCGCATTGAATTGACGAATCAGGAGTTCTCGATGTTGCACCTGCTC
ATGCGCCGGAGAGGGGAGGTGCTGTCGCGAACCACGATCGCGTCCCAGGTCTGGGACGTCAACTTCGACACGGATACCAA
TGTCGTTGACGTCGCGATCCGGCGCCTGAGATCCAAGGTGGATGATCCCTTCGATCAAAAGCTGATCCATACCGTACGGG
GAATGGGCTATGTCCTCGACCCAGAGCGCGGCCGGTGA

Upstream 100 bases:

>100_bases
TTCGAACTGGCACCATGCGAACAAGCGGATGCAGCTCAGCATTTCAATGCATCGCCAGCACTGGTCGGATCGAAGTCGCT
TGCTGCAGGAGGAAACTAAG

Downstream 100 bases:

>100_bases
CGGAATGAGGCCCGGGACTTCGATAACCCCGCTGTCACTGACGAGGCGGCTTGGGCTCTTCTTTGCATTGGTACTGTCTA
TCGCGCTGGCCAGCATGGGC

Product: winged helix family two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRVLVVEDEPRTAEYLQKGLSESGFVVDIANNGGDGLHMAEETDYDVIILDVMLPGMDGWTVIKSIRSKSETPVLFLTAL
DDVADRVRGFELGADDYLVKPFAFAELLARIRRCLRQSTSKESERLRIADLDIDVLGRRVFRGTTRIELTNQEFSMLHLL
MRRRGEVLSRTTIASQVWDVNFDTDTNVVDVAIRRLRSKVDDPFDQKLIHTVRGMGYVLDPERGR

Sequences:

>Translated_225_residues
MRVLVVEDEPRTAEYLQKGLSESGFVVDIANNGGDGLHMAEETDYDVIILDVMLPGMDGWTVIKSIRSKSETPVLFLTAL
DDVADRVRGFELGADDYLVKPFAFAELLARIRRCLRQSTSKESERLRIADLDIDVLGRRVFRGTTRIELTNQEFSMLHLL
MRRRGEVLSRTTIASQVWDVNFDTDTNVVDVAIRRLRSKVDDPFDQKLIHTVRGMGYVLDPERGR
>Mature_225_residues
MRVLVVEDEPRTAEYLQKGLSESGFVVDIANNGGDGLHMAEETDYDVIILDVMLPGMDGWTVIKSIRSKSETPVLFLTAL
DDVADRVRGFELGADDYLVKPFAFAELLARIRRCLRQSTSKESERLRIADLDIDVLGRRVFRGTTRIELTNQEFSMLHLL
MRRRGEVLSRTTIASQVWDVNFDTDTNVVDVAIRRLRSKVDDPFDQKLIHTVRGMGYVLDPERGR

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=55.5066079295154, Blast_Score=265, Evalue=1e-72,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=55.2995391705069, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.0909090909091, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=38.1818181818182, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=34.3478260869565, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=37.3873873873874, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=34.4036697247706, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.6742081447964, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=31.8181818181818, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=31.1111111111111, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=29.535864978903, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788550, Length=130, Percent_Identity=36.9230769230769, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790437, Length=137, Percent_Identity=31.3868613138686, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=29.1970802919708, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082052, Length=124, Percent_Identity=33.0645161290323, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=32.6732673267327, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25617; Mature: 25617

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDEPRTAEYLQKGLSESGFVVDIANNGGDGLHMAEETDYDVIILDVMLPGMDGW
CEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCCCEECCCCCCCEEEEEEECCCCCHH
TVIKSIRSKSETPVLFLTALDDVADRVRGFELGADDYLVKPFAFAELLARIRRCLRQSTS
HHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCC
KESERLRIADLDIDVLGRRVFRGTTRIELTNQEFSMLHLLMRRRGEVLSRTTIASQVWDV
CHHHCEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEC
NFDTDTNVVDVAIRRLRSKVDDPFDQKLIHTVRGMGYVLDPERGR
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCC
>Mature Secondary Structure
MRVLVVEDEPRTAEYLQKGLSESGFVVDIANNGGDGLHMAEETDYDVIILDVMLPGMDGW
CEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCCCEECCCCCCCEEEEEEECCCCCHH
TVIKSIRSKSETPVLFLTALDDVADRVRGFELGADDYLVKPFAFAELLARIRRCLRQSTS
HHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCC
KESERLRIADLDIDVLGRRVFRGTTRIELTNQEFSMLHLLMRRRGEVLSRTTIASQVWDV
CHHHCEEEEECCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEC
NFDTDTNVVDVAIRRLRSKVDDPFDQKLIHTVRGMGYVLDPERGR
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]