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The map label for this gene is czcS

Identifier: 187928842

GI number: 187928842

Start: 1855625

End: 1857055

Strand: Reverse

Name: czcS

Synonym: Rpic_1759

Alternate gene names: 187928842

Gene position: 1857055-1855625 (Counterclockwise)

Preceding gene: 187928843

Following gene: 187928841

Centisome position: 47.1

GC content: 60.03

Gene sequence:

>1431_bases
ATGAGGCCCGGGACTTCGATAACCCCGCTGTCACTGACGAGGCGGCTTGGGCTCTTCTTTGCATTGGTACTGTCTATCGC
GCTGGCCAGCATGGGCGCCTTTGCTTACTACTCGCTCGCCGCGCAACTCGAGGCCAGAGACGATGAGGTTGTAAAGGGAA
AACTCGAACAGGTCGAGCATTTCTTGCGCGAGGTGGACGGGGTGCAGGGCGTCCCGGCGGCGCAGCATCGCTTCGATGAT
CTGGTGCGAGGTTACTCGGACCTCATCGTTCGCGTCACGGCGCTGGATGGCCGGCTTTTGTTTCGCACGGGCAACGATGC
ATTGCTGGAAGGCACTGACCAAGCGGCGGTCACGGGAAAGTCATCGCTCATGTTCCAGTCCGCCGATGCGGTGTTGGGGC
GAGACGGTACGCGGGCGACGGTGTTCGTGGCGAAGTCTGGCGAGGACAGGAAGCAGGTGACTGCGCGATTCCGGACGACG
CTCGTGCTTGGTACCACCGTCGGTGTGATATTGACGGCCCTGGTGGGGGCGGCCATTACGCGCCGTGAGCTGGAGCCGGC
GCACGTACTTATCAAGCAGATCAACCGGATCAGTGTGGAACGGCTGAGCTACCGGGTGGACATGCCACCCAAGCCCACCG
AAGTGCGTGATATCGCCTCTGCGTTCAATGCGATGCTGCAACGCCTCGAGGATGGTTATCAGAAGCTGTCGCGGTTCTCC
GCCGATCTTGCCCATGATTTGCGCACGCCGCTTAACAACCTCATTGGACATGCCGAGGTCGCCTTGTCACGAGACCGCAC
CGGGCCCGAGTATGTCGCCTTGGTGGAGGAAAGCCTGGTCGAATACCAGCGACTTGCGAGGATGATCGATGCGATGTTGT
TCCTCGCGCGAGCTGACAGTGCCAATGTGGCGCTCGAGTTGACGGAACTCCAGTTGAATGCAGAACTTCGCAAGTTGTCC
GCCTACTTTTCGGTGCTTGCAGAGGAGCGAAGCGTCGTAATCAGGGTAAGCGGGGATGCCACCCTGGTCGCTGATGCCAT
TCTGTTCCAGCGTGCGATCAACAATGTTCTGTCAAATGCGGTCCGTCATGCGTGGCCGAATTCGATGATAGATCTGGTGG
TGCGCCGCGAAGCGGCACATTGTTGCATCGACATCACGAACGTTGGAGACCCAATCCCGGAGCGGGAACTTTCCCTCATC
TTTGATCGGTTCTTCCGTGGGGATAGGGCGAGATCCAACTCGTCACAGTCCACGGGGCTGGGCCTGGCCATCGTCCTGTC
GATCATGGAGCTCCATGGCGGCGACGCGTCAGCCGTGAGCGGCTTGGATGGGAAGACACGCTTTACATTGCGCTTCCCGC
TCAACGGTGCTGAAGCCTCAGCGCGGGTTTCGGTGGGTAGGCCGAGTCAGGACCGACCAGTCGTTGGGTAG

Upstream 100 bases:

>100_bases
CGCCTGAGATCCAAGGTGGATGATCCCTTCGATCAAAAGCTGATCCATACCGTACGGGGAATGGGCTATGTCCTCGACCC
AGAGCGCGGCCGGTGACGGA

Downstream 100 bases:

>100_bases
AGTGGTGCAATGAGCCCGATTGCCTATTTGTAATCGCCGGGCAAGGCTGCAGCATGCGTACAATTTATACACTCGTTTTC
ATAGATCAACGAAGTCTCTA

Product: heavy metal sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRPGTSITPLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEHFLREVDGVQGVPAAQHRFDD
LVRGYSDLIVRVTALDGRLLFRTGNDALLEGTDQAAVTGKSSLMFQSADAVLGRDGTRATVFVAKSGEDRKQVTARFRTT
LVLGTTVGVILTALVGAAITRRELEPAHVLIKQINRISVERLSYRVDMPPKPTEVRDIASAFNAMLQRLEDGYQKLSRFS
ADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLFLARADSANVALELTELQLNAELRKLS
AYFSVLAEERSVVIRVSGDATLVADAILFQRAINNVLSNAVRHAWPNSMIDLVVRREAAHCCIDITNVGDPIPERELSLI
FDRFFRGDRARSNSSQSTGLGLAIVLSIMELHGGDASAVSGLDGKTRFTLRFPLNGAEASARVSVGRPSQDRPVVG

Sequences:

>Translated_476_residues
MRPGTSITPLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEHFLREVDGVQGVPAAQHRFDD
LVRGYSDLIVRVTALDGRLLFRTGNDALLEGTDQAAVTGKSSLMFQSADAVLGRDGTRATVFVAKSGEDRKQVTARFRTT
LVLGTTVGVILTALVGAAITRRELEPAHVLIKQINRISVERLSYRVDMPPKPTEVRDIASAFNAMLQRLEDGYQKLSRFS
ADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLFLARADSANVALELTELQLNAELRKLS
AYFSVLAEERSVVIRVSGDATLVADAILFQRAINNVLSNAVRHAWPNSMIDLVVRREAAHCCIDITNVGDPIPERELSLI
FDRFFRGDRARSNSSQSTGLGLAIVLSIMELHGGDASAVSGLDGKTRFTLRFPLNGAEASARVSVGRPSQDRPVVG
>Mature_476_residues
MRPGTSITPLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEHFLREVDGVQGVPAAQHRFDD
LVRGYSDLIVRVTALDGRLLFRTGNDALLEGTDQAAVTGKSSLMFQSADAVLGRDGTRATVFVAKSGEDRKQVTARFRTT
LVLGTTVGVILTALVGAAITRRELEPAHVLIKQINRISVERLSYRVDMPPKPTEVRDIASAFNAMLQRLEDGYQKLSRFS
ADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLFLARADSANVALELTELQLNAELRKLS
AYFSVLAEERSVVIRVSGDATLVADAILFQRAINNVLSNAVRHAWPNSMIDLVVRREAAHCCIDITNVGDPIPERELSLI
FDRFFRGDRARSNSSQSTGLGLAIVLSIMELHGGDASAVSGLDGKTRFTLRFPLNGAEASARVSVGRPSQDRPVVG

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1786783, Length=476, Percent_Identity=28.5714285714286, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788279, Length=463, Percent_Identity=31.317494600432, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1790861, Length=396, Percent_Identity=25.5050505050505, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=272, Percent_Identity=27.9411764705882, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=27.6679841897233, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1788393, Length=274, Percent_Identity=25.9124087591241, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=29.4930875576037, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=283, Percent_Identity=26.5017667844523, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=27.8026905829596, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=25, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=24.0740740740741, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789403, Length=227, Percent_Identity=29.0748898678414, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CZCS_RALME (Q44007)

Other databases:

- EMBL:   X71400
- EMBL:   X98451
- EMBL:   CP000354
- RefSeq:   YP_145598.1
- RefSeq:   YP_581786.1
- ProteinModelPortal:   Q44007
- SMR:   Q44007
- STRING:   Q44007
- GeneID:   3170507
- GeneID:   4036512
- GenomeReviews:   CP000354_GR
- KEGG:   rme:Rmet_5977
- eggNOG:   COG0642
- HOGENOM:   HBG643531
- OMA:   DSNIEEC
- PhylomeDB:   Q44007
- ProtClustDB:   CLSK758951
- BioCyc:   RMET266264:RMET_5977-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388
- TIGRFAMs:   TIGR01386

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 52010; Mature: 52010

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1640e654)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPGTSITPLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FLREVDGVQGVPAAQHRFDDLVRGYSDLIVRVTALDGRLLFRTGNDALLEGTDQAAVTGK
HHHHHCCCCCCCHHHHHHHHHHHCHHHHEEEEEEECCEEEEEECCCHHCCCCCCHHCCCC
SSLMFQSADAVLGRDGTRATVFVAKSGEDRKQVTARFRTTLVLGTTVGVILTALVGAAIT
CHHEEECCCHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRELEPAHVLIKQINRISVERLSYRVDMPPKPTEVRDIASAFNAMLQRLEDGYQKLSRFS
HHCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLFLARADS
HHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ANVALELTELQLNAELRKLSAYFSVLAEERSVVIRVSGDATLVADAILFQRAINNVLSNA
CCEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VRHAWPNSMIDLVVRREAAHCCIDITNVGDPIPERELSLIFDRFFRGDRARSNSSQSTGL
HHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
GLAIVLSIMELHGGDASAVSGLDGKTRFTLRFPLNGAEASARVSVGRPSQDRPVVG
HHHHHHHHHHHCCCCHHHCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCCH
>Mature Secondary Structure
MRPGTSITPLSLTRRLGLFFALVLSIALASMGAFAYYSLAAQLEARDDEVVKGKLEQVEH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
FLREVDGVQGVPAAQHRFDDLVRGYSDLIVRVTALDGRLLFRTGNDALLEGTDQAAVTGK
HHHHHCCCCCCCHHHHHHHHHHHCHHHHEEEEEEECCEEEEEECCCHHCCCCCCHHCCCC
SSLMFQSADAVLGRDGTRATVFVAKSGEDRKQVTARFRTTLVLGTTVGVILTALVGAAIT
CHHEEECCCHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRELEPAHVLIKQINRISVERLSYRVDMPPKPTEVRDIASAFNAMLQRLEDGYQKLSRFS
HHCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLAHDLRTPLNNLIGHAEVALSRDRTGPEYVALVEESLVEYQRLARMIDAMLFLARADS
HHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ANVALELTELQLNAELRKLSAYFSVLAEERSVVIRVSGDATLVADAILFQRAINNVLSNA
CCEEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
VRHAWPNSMIDLVVRREAAHCCIDITNVGDPIPERELSLIFDRFFRGDRARSNSSQSTGL
HHHHCCHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
GLAIVLSIMELHGGDASAVSGLDGKTRFTLRFPLNGAEASARVSVGRPSQDRPVVG
HHHHHHHHHHHCCCCHHHCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9044283