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The map label for this gene is ctaB [H]

Identifier: 187927335

GI number: 187927335

Start: 241683

End: 242624

Strand: Direct

Name: ctaB [H]

Synonym: Rpic_0228

Alternate gene names: 187927335

Gene position: 241683-242624 (Clockwise)

Preceding gene: 187927334

Following gene: 187927336

Centisome position: 6.13

GC content: 64.01

Gene sequence:

>942_bases
ATGAATACCGTGGCAACCCCAACAACTTCCACTCAACTTCCTGGCTGGCGAACGACCGCATCGCAGTATGCGGCGCTGAC
CAAGCCGCGCGTCACGCAGCTCGCCGTGTTCTGCGCCGTGATCGGCATGTTCCTGGCCACGCCGGGCATGGTCCCGTGGT
CGGTGCTGATCGGCGGCGCGGTCGGCATCTGGCTGTTCGCCGGCGCCGCCTTCGCCATCAACTGCCTGGTCGAGCGCAAG
ATCGATGCAATGATGCGCCGCACGGCCTGGCGCCCGTCGGCAAGCGGTGAACTGGGCACGCGGCAGATCCTGGTGTTCTC
GTTGGTGCTGGGCGGCGCGGGCATGTGGACGCTGCACGTATTCGCCAACGACCTGACGATGTGGCTGACGTTCGCCACCT
TCATCGGCTACGCGATCATCTACACGCTGCTGCTCAAGCCGGCCACACCGCAGAACATCGTGATCGGCGGTCTCTCGGGG
GCGATGCCGCCGGCGCTGGGCTGGGCGGCCGTCGCCAACAGCGTGCCGGCCGAGGCGTGGATCCTGGTGCTGATTATCTT
TACCTGGACGCCGCCGCACTTCTGGGCACTCGCGCTGTACCGCCGCGCAGACTACGCCAAGTCGGGTCTACCGATGCTGC
CGATCACGCACGGCGAGAAATACACGCTGCTGCATATCCTCTTGTACACGCTCATCATGATCGCCGCGACCATCCTGCCG
TTCGTCTACGGCATGAGCGGCTATATCTATCTGGTGACCGCGCTGGTGCTCGGCTTCGGCTTCCTCTCGTATGCCTGGCG
CATGTACCGCAAGTACTCCGACGCGCTGGCGCAGAAGACTTTCCGCTACTCCATCATCTACCTGTCGATCCTGTTTGCCG
CGCTGCTGGTGGACCACTACTTCAAGTTTGGCCCGGCGCTTACGCAAAGCGCGGCGCTGTGA

Upstream 100 bases:

>100_bases
TGCTGATGGTGCGTCTGCATTACCTGATCGGGCTCGCGCAGGCGCGGGCGCCGATGCCTGTGGCGGCTGCCGTCGTCTGA
ATGCCGTCTGACCGTTTTTT

Downstream 100 bases:

>100_bases
CGCACAGGGGCGCCAGCGAGCATGTGCTGTTGGCGGTACGCTAGGCGGTCTGCTTCCAACACAATGACCATGCTCTCTTT
CCGATACTTCCGCGCCGCGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNTVATPTTSTQLPGWRTTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWSVLIGGAVGIWLFAGAAFAINCLVERK
IDAMMRRTAWRPSASGELGTRQILVFSLVLGGAGMWTLHVFANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSG
AMPPALGWAAVANSVPAEAWILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLHILLYTLIMIAATILP
FVYGMSGYIYLVTALVLGFGFLSYAWRMYRKYSDALAQKTFRYSIIYLSILFAALLVDHYFKFGPALTQSAAL

Sequences:

>Translated_313_residues
MNTVATPTTSTQLPGWRTTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWSVLIGGAVGIWLFAGAAFAINCLVERK
IDAMMRRTAWRPSASGELGTRQILVFSLVLGGAGMWTLHVFANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSG
AMPPALGWAAVANSVPAEAWILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLHILLYTLIMIAATILP
FVYGMSGYIYLVTALVLGFGFLSYAWRMYRKYSDALAQKTFRYSIIYLSILFAALLVDHYFKFGPALTQSAAL
>Mature_313_residues
MNTVATPTTSTQLPGWRTTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWSVLIGGAVGIWLFAGAAFAINCLVERK
IDAMMRRTAWRPSASGELGTRQILVFSLVLGGAGMWTLHVFANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSG
AMPPALGWAAVANSVPAEAWILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLHILLYTLIMIAATILP
FVYGMSGYIYLVTALVLGFGFLSYAWRMYRKYSDALAQKTFRYSIIYLSILFAALLVDHYFKFGPALTQSAAL

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=194, Percent_Identity=34.020618556701, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71998235, Length=272, Percent_Identity=27.9411764705882, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=190, Percent_Identity=32.1052631578947, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19921064, Length=287, Percent_Identity=29.9651567944251, Blast_Score=110, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34385; Mature: 34385

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVATPTTSTQLPGWRTTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWSVLIGGA
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGIWLFAGAAFAINCLVERKIDAMMRRTAWRPSASGELGTRQILVFSLVLGGAGMWTLHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHH
FANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSGAMPPALGWAAVANSVPAEAW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHH
ILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLHILLYTLIMIAATILP
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
FVYGMSGYIYLVTALVLGFGFLSYAWRMYRKYSDALAQKTFRYSIIYLSILFAALLVDHY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKFGPALTQSAAL
HHHCHHHHHHCCC
>Mature Secondary Structure
MNTVATPTTSTQLPGWRTTASQYAALTKPRVTQLAVFCAVIGMFLATPGMVPWSVLIGGA
CCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
VGIWLFAGAAFAINCLVERKIDAMMRRTAWRPSASGELGTRQILVFSLVLGGAGMWTLHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEHHH
FANDLTMWLTFATFIGYAIIYTLLLKPATPQNIVIGGLSGAMPPALGWAAVANSVPAEAW
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCHHHH
ILVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGEKYTLLHILLYTLIMIAATILP
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHH
FVYGMSGYIYLVTALVLGFGFLSYAWRMYRKYSDALAQKTFRYSIIYLSILFAALLVDHY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKFGPALTQSAAL
HHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]