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The map label for this gene is ctaC [H]

Identifier: 187927325

GI number: 187927325

Start: 233773

End: 235029

Strand: Direct

Name: ctaC [H]

Synonym: Rpic_0218

Alternate gene names: 187927325

Gene position: 233773-235029 (Clockwise)

Preceding gene: 187927324

Following gene: 187927326

Centisome position: 5.93

GC content: 61.34

Gene sequence:

>1257_bases
ATGAAAATGTTGAATAAGACATTGGCAAGTTTGCTGGCGGCAGGCTCCCTCCTCGCCCTCAGTCAAACGGCCCTGGCAGT
GGAAGACATGCCAGGCGGCCCCGCAGTGCGGCAGCTTAATCTCGCGCCTCCGGTCACCAAGATCGCCGCCGAGATCCATT
GGCTGCACTGGATGATGCTGATCATCTGTATCGTGATCTTCATCGGTGTTTTCGGGGTGATGTTCTACTCCATTTTCAAG
CACCGTAAGTCGGTCGGTCACAAACCGGCGACGTTCCATGAAAGCACCACGGTCGAAATCATCTGGACCATCGTGCCGTT
CCTGATCGTGATCGGGATGGCGCTGCCGGCCACCAAGGCCGTGGTCGCCATGAAGGACACCACCAACTCCGACCTCACCA
TCAAGGCCACCGGCTACCAGTGGAAGTGGGGTTACGACTACCTGAAGGGCGAAGGCGAGGGCATCTCGTTCCTCTCCACG
CTCACCACGCCGCGCGACCAGATCAACAACCAGGCGCCCAAGTCGAACACGTACCTGATCGAGGTCGACAACGAGCTGGT
CGTGCCGGTCAACCGCAAGGTGCGCATCGTCACGACCGCCAACGACGTGATCCACTCGTGGATGATCCCGGCGTTCGGCG
TGAAGCAGGATGCGATTCCGGGCTTCGTGCGCGACGCATGGTTCAAGGCAGAGAAGGTCGGCGTCTATCGCGGCCAGTGC
GCCGAGCTTTGCGGCAAGGAACACGCCTTCATGCCGATCGTCGTGCGCGTGCTCTCGCAGGACGACTACACCAAGTGGGT
CGACGGCAAGAAGAAGGAAATGGCCGCCAAGGCCGATGATCCGAACAAGACCTACACGCTGGAAGAGCTGAAGTCGCGCG
GCGAGAAGGTCTACACCGCCAACTGCGCGGTCTGCCACCAGCCGAACGGTAAGGGCGGTGGCCCGTTCCCGGCCCTTGAT
GGCTCGAAGATCGCCAATGGCCCGCTGGCCGACCACGTTGGCATCGTGCTGCACGGCAAGGGCGCGATGCCGCCCTGGGC
TTCGGCGCTGAACGATGTCGAAATCGCTGCCGTCGTCACTTACGAGCGCAACAACTGGGGTAACCATACCGGTGACCTGC
TGCAGCCGACGCAAGTGAAGGATGCGCGCGGCGGCAAGATGCCCGAAGGTGGGGCTGCCAAGACCGCTACAACTGAATCC
GCCGGTAAGGTGGCGTCCAAACAAGCGAATGCGGCCGAAGACCGCAACGCTGGCTGA

Upstream 100 bases:

>100_bases
CGGACGAGCTTTCCCGGTGTTTGGGACACGGGCAACCAACCCAGGTCTCATGAGCCGCGCACCGGGGCAGAGTGGAATCT
GTCAATTGGGTAGATAAAAA

Downstream 100 bases:

>100_bases
TTGATCGTCTGCGTGACGAACCGAACCTAGGAGTTCCTCGATGAGCACCGCTGTTACGCACCCGCAAGATCACGCGCACG
GTCATGGAGACGACCACGCG

Product: cytochrome c oxidase subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II; Oxidase aa(3) subunit 2 [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKMLNKTLASLLAAGSLLALSQTALAVEDMPGGPAVRQLNLAPPVTKIAAEIHWLHWMMLIICIVIFIGVFGVMFYSIFK
HRKSVGHKPATFHESTTVEIIWTIVPFLIVIGMALPATKAVVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLST
LTTPRDQINNQAPKSNTYLIEVDNELVVPVNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDAWFKAEKVGVYRGQC
AELCGKEHAFMPIVVRVLSQDDYTKWVDGKKKEMAAKADDPNKTYTLEELKSRGEKVYTANCAVCHQPNGKGGGPFPALD
GSKIANGPLADHVGIVLHGKGAMPPWASALNDVEIAAVVTYERNNWGNHTGDLLQPTQVKDARGGKMPEGGAAKTATTES
AGKVASKQANAAEDRNAG

Sequences:

>Translated_418_residues
MKMLNKTLASLLAAGSLLALSQTALAVEDMPGGPAVRQLNLAPPVTKIAAEIHWLHWMMLIICIVIFIGVFGVMFYSIFK
HRKSVGHKPATFHESTTVEIIWTIVPFLIVIGMALPATKAVVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLST
LTTPRDQINNQAPKSNTYLIEVDNELVVPVNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDAWFKAEKVGVYRGQC
AELCGKEHAFMPIVVRVLSQDDYTKWVDGKKKEMAAKADDPNKTYTLEELKSRGEKVYTANCAVCHQPNGKGGGPFPALD
GSKIANGPLADHVGIVLHGKGAMPPWASALNDVEIAAVVTYERNNWGNHTGDLLQPTQVKDARGGKMPEGGAAKTATTES
AGKVASKQANAAEDRNAG
>Mature_418_residues
MKMLNKTLASLLAAGSLLALSQTALAVEDMPGGPAVRQLNLAPPVTKIAAEIHWLHWMMLIICIVIFIGVFGVMFYSIFK
HRKSVGHKPATFHESTTVEIIWTIVPFLIVIGMALPATKAVVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLST
LTTPRDQINNQAPKSNTYLIEVDNELVVPVNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDAWFKAEKVGVYRGQC
AELCGKEHAFMPIVVRVLSQDDYTKWVDGKKKEMAAKADDPNKTYTLEELKSRGEKVYTANCAVCHQPNGKGGGPFPALD
GSKIANGPLADHVGIVLHGKGAMPPWASALNDVEIAAVVTYERNNWGNHTGDLLQPTQVKDARGGKMPEGGAAKTATTES
AGKVASKQANAAEDRNAG

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome c oxidase subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=165, Percent_Identity=36.969696969697, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6226540, Length=259, Percent_Identity=30.8880308880309, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 45337; Mature: 45337

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA ; PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMLNKTLASLLAAGSLLALSQTALAVEDMPGGPAVRQLNLAPPVTKIAAEIHWLHWMML
CCHHHHHHHHHHHHCHHHHHHHHHHEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
IICIVIFIGVFGVMFYSIFKHRKSVGHKPATFHESTTVEIIWTIVPFLIVIGMALPATKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
VVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLSTLTTPRDQINNQAPKSNTYLI
EEEEECCCCCCEEEEECCEEEECCCHHHCCCCCCEEHHHHHCCCHHHHCCCCCCCCEEEE
EVDNELVVPVNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDAWFKAEKVGVYRGQC
EECCEEEEECCCEEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
AELCGKEHAFMPIVVRVLSQDDYTKWVDGKKKEMAAKADDPNKTYTLEELKSRGEKVYTA
HHHCCCCCCHHHHHHHHHCCCCCHHHCCCCHHHHHCCCCCCCCEEEHHHHHHCCCEEEEE
NCAVCHQPNGKGGGPFPALDGSKIANGPLADHVGIVLHGKGAMPPWASALNDVEIAAVVT
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCEEEEEEEE
YERNNWGNHTGDLLQPTQVKDARGGKMPEGGAAKTATTESAGKVASKQANAAEDRNAG
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKMLNKTLASLLAAGSLLALSQTALAVEDMPGGPAVRQLNLAPPVTKIAAEIHWLHWMML
CCHHHHHHHHHHHHCHHHHHHHHHHEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHH
IICIVIFIGVFGVMFYSIFKHRKSVGHKPATFHESTTVEIIWTIVPFLIVIGMALPATKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
VVAMKDTTNSDLTIKATGYQWKWGYDYLKGEGEGISFLSTLTTPRDQINNQAPKSNTYLI
EEEEECCCCCCEEEEECCEEEECCCHHHCCCCCCEEHHHHHCCCHHHHCCCCCCCCEEEE
EVDNELVVPVNRKVRIVTTANDVIHSWMIPAFGVKQDAIPGFVRDAWFKAEKVGVYRGQC
EECCEEEEECCCEEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHH
AELCGKEHAFMPIVVRVLSQDDYTKWVDGKKKEMAAKADDPNKTYTLEELKSRGEKVYTA
HHHCCCCCCHHHHHHHHHCCCCCHHHCCCCHHHHHCCCCCCCCEEEHHHHHHCCCEEEEE
NCAVCHQPNGKGGGPFPALDGSKIANGPLADHVGIVLHGKGAMPPWASALNDVEIAAVVT
CEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHCCCEEEEEEEE
YERNNWGNHTGDLLQPTQVKDARGGKMPEGGAAKTATTESAGKVASKQANAAEDRNAG
EECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2820725; 7651515; 9380672 [H]