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The map label for this gene is ctaD [H]

Identifier: 187927326

GI number: 187927326

Start: 235070

End: 236674

Strand: Direct

Name: ctaD [H]

Synonym: Rpic_0219

Alternate gene names: 187927326

Gene position: 235070-236674 (Clockwise)

Preceding gene: 187927325

Following gene: 187927327

Centisome position: 5.96

GC content: 62.37

Gene sequence:

>1605_bases
ATGAGCACCGCTGTTACGCACCCGCAAGATCACGCGCACGGTCATGGAGACGACCACGCGCACGACCATCCGCACGGCTG
GCGCCGTTGGCTGTTCGCGACCAACCACAAGGACATCGGTACGCTGTATCTGCTGTTCTCTTTCATGATGCTGCTTTCAG
GCGGCACGCTGGCCCTGCTGATCCGCCTTGAGCTGTTCCAGCCCGGCCTGCAGTTCTTCCATCCGGAGCTGTTCAACCAG
TTCACCACCCTGCATGGCCTGATCATGGTGTTCGGCGCCATCATGCCGGCCTTCGTGGGCTTTGCGAACTGGATGATCCC
GCTGCAGGTTGGCGCGTCCGACATGGCGTTTGCGCGGATGAACAACTTCAGCTTCTGGCTGCTGCCGCCTGCTGCGCTGC
TGCTGGTGGGCTCGTTCTTCGCCCCGGGCGGCGCCACCGCTGCCGGCTGGACGCTCTACGCGCCGCTGTCGGTGCAGATG
GGCCCGGGCATGGACATGGCGATCTTCGCGATCCACATCATGGGCGCATCGTCGATCATGGGCGCGATCAACATCATCGT
GACCATCCTGAACATGCGCGCGCCGGGCATGACGCTGATGAAGATGCCGATGTTCTGCTGGACGTGGCTGATCACGGCGT
ACCTGCTGATCGCCGTGATGCCGGTGCTGGCAGGCGCGATCACCATGGTGCTGACCGACCGCCACTTCGGGACGAGCTTC
TTCTCGGCAGCCGGCGGCGGTGACCCGGTGATGTACCAGCACATCTTCTGGTTCTTCGGGCACCCCGAGGTGTACATCAT
GATCTTGCCGGCGTTCGGTATCGTCAGCCAGATCGTGCCGGCCTTTGCGCGCAAGCCGCTGTTCGGCTACAGCTCGATGG
TGTATGCCACGGCGTCGATCGCCATCCTGTCGTTCATCGTGTGGGCACACCACATGTTCACGACCGGTATGCCCGTCACC
GGCCAGCTGTTCTTCATGTACGCGACGATGCTGATTGCGGTGCCGACCGGCGTGAAGATCTTCAACTGGGTGGCCACGAT
GTGGCGCGGCTCGATGACGTTCGAGACGCCGATGCTGTTTGCGATCGGCTTCATCTTCGTGTTCACGGTGGGCGGCTTCA
CGGGCCTGATCCTGGCCGTGGCCCCGATCGACATCCAGCTGCAGGACACCTACTACGTGGTGGCGCACTTCCACTACGTG
CTGGTGGCTGGTTCGCTGTTCGCGCTGTTCGCGGGCTTCTACTACTGGGGCCCGAAGTGGTCGGGCTACATGTACAGCGA
GACGCGCGGCAAGATCCACTTCTGGGGTTCGATGATCACGTTCAACCTCACGTTCTTCCCGATGCACTTCCTGGGCCTGG
CAGGCATGCCGCGCCGCTATGCGGACTACCCGCAGCAGTTTGCCGATTTCAATGCGATCGCGTCGATCGGAGCTCTGGGC
TTCGGTCTGATGCAAGTGTATTTCTTCTTCTTCGTGGTGCTGCCGTCGTACCGCGGTGGCGAGAAGGCTGCCGACAAGCC
TTGGGATGGCGCGGAAGGCCTGGAGTGGACCGTGCCGTCGCCGGCGCCGTTCCACACCTTTGAAGAACCGCCGCACGTGA
AGTAA

Upstream 100 bases:

>100_bases
TCCGCCGGTAAGGTGGCGTCCAAACAAGCGAATGCGGCCGAAGACCGCAACGCTGGCTGATTGATCGTCTGCGTGACGAA
CCGAACCTAGGAGTTCCTCG

Downstream 100 bases:

>100_bases
TGCAGGTGTTGCGGGGCTGGCGAGTGCCGGCTCCGCGATCCTCCGGACAAACGATGTCGAATCCAGAAAAAAGCCCAACG
CCCGAGCAACGCGCTGCCAA

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MSTAVTHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFMMLLSGGTLALLIRLELFQPGLQFFHPELFNQ
FTTLHGLIMVFGAIMPAFVGFANWMIPLQVGASDMAFARMNNFSFWLLPPAALLLVGSFFAPGGATAAGWTLYAPLSVQM
GPGMDMAIFAIHIMGASSIMGAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVT
GQLFFMYATMLIAVPTGVKIFNWVATMWRGSMTFETPMLFAIGFIFVFTVGGFTGLILAVAPIDIQLQDTYYVVAHFHYV
LVAGSLFALFAGFYYWGPKWSGYMYSETRGKIHFWGSMITFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK

Sequences:

>Translated_534_residues
MSTAVTHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFMMLLSGGTLALLIRLELFQPGLQFFHPELFNQ
FTTLHGLIMVFGAIMPAFVGFANWMIPLQVGASDMAFARMNNFSFWLLPPAALLLVGSFFAPGGATAAGWTLYAPLSVQM
GPGMDMAIFAIHIMGASSIMGAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVT
GQLFFMYATMLIAVPTGVKIFNWVATMWRGSMTFETPMLFAIGFIFVFTVGGFTGLILAVAPIDIQLQDTYYVVAHFHYV
LVAGSLFALFAGFYYWGPKWSGYMYSETRGKIHFWGSMITFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK
>Mature_533_residues
STAVTHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFMMLLSGGTLALLIRLELFQPGLQFFHPELFNQF
TTLHGLIMVFGAIMPAFVGFANWMIPLQVGASDMAFARMNNFSFWLLPPAALLLVGSFFAPGGATAAGWTLYAPLSVQMG
PGMDMAIFAIHIMGASSIMGAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSFF
SAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASIAILSFIVWAHHMFTTGMPVTG
QLFFMYATMLIAVPTGVKIFNWVATMWRGSMTFETPMLFAIGFIFVFTVGGFTGLILAVAPIDIQLQDTYYVVAHFHYVL
VAGSLFALFAGFYYWGPKWSGYMYSETRGKIHFWGSMITFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALGF
GLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=514, Percent_Identity=52.1400778210117, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI1786634, Length=516, Percent_Identity=41.8604651162791, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6226519, Length=530, Percent_Identity=47.1698113207547, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=50.7739938080495, Blast_Score=335, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=47.1774193548387, Blast_Score=221, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59466; Mature: 59334

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVTHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFMMLLSGGTLALL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHCCCHHHHH
IRLELFQPGLQFFHPELFNQFTTLHGLIMVFGAIMPAFVGFANWMIPLQVGASDMAFARM
HHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHH
NNFSFWLLPPAALLLVGSFFAPGGATAAGWTLYAPLSVQMGPGMDMAIFAIHIMGASSIM
CCCEEEECCHHHHHHHHHHCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHH
GAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASI
HHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTGVKIFNWVATMWRGSMTFETPMLF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
AIGFIFVFTVGGFTGLILAVAPIDIQLQDTYYVVAHFHYVLVAGSLFALFAGFYYWGPKW
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGYMYSETRGKIHFWGSMITFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
CCEEEECCCCCEEEEEEEEEEEHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHH
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STAVTHPQDHAHGHGDDHAHDHPHGWRRWLFATNHKDIGTLYLLFSFMMLLSGGTLALL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHCCCHHHHH
IRLELFQPGLQFFHPELFNQFTTLHGLIMVFGAIMPAFVGFANWMIPLQVGASDMAFARM
HHHHHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHHHHH
NNFSFWLLPPAALLLVGSFFAPGGATAAGWTLYAPLSVQMGPGMDMAIFAIHIMGASSIM
CCCEEEECCHHHHHHHHHHCCCCCCCCCCEEEEECEEEECCCCCCHHHHHHHHHHHHHHH
GAINIIVTILNMRAPGMTLMKMPMFCWTWLITAYLLIAVMPVLAGAITMVLTDRHFGTSF
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHH
FSAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSQIVPAFARKPLFGYSSMVYATASI
HHCCCCCCCHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AILSFIVWAHHMFTTGMPVTGQLFFMYATMLIAVPTGVKIFNWVATMWRGSMTFETPMLF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHH
AIGFIFVFTVGGFTGLILAVAPIDIQLQDTYYVVAHFHYVLVAGSLFALFAGFYYWGPKW
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
SGYMYSETRGKIHFWGSMITFNLTFFPMHFLGLAGMPRRYADYPQQFADFNAIASIGALG
CCEEEECCCCCEEEEEEEEEEEHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHH
FGLMQVYFFFFVVLPSYRGGEKAADKPWDGAEGLEWTVPSPAPFHTFEEPPHVK
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]