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The map label for this gene is 187927206

Identifier: 187927206

GI number: 187927206

Start: 113869

End: 114795

Strand: Direct

Name: 187927206

Synonym: Rpic_0098

Alternate gene names: NA

Gene position: 113869-114795 (Clockwise)

Preceding gene: 187927201

Following gene: 187927210

Centisome position: 2.89

GC content: 67.1

Gene sequence:

>927_bases
ATGACCACGCCGCTTTCCATCGATGCCGCCACCGCTGCCGCAGATGCCGCGCTGTTTCCCGGCTTTCGTCCGTTCCGCCA
GATGGCCAACGGGGTGGAGATCGCGGGGGTGATCGGCGGCAGCGGACCGCCGCTGCTGCTGCTGCATGGCCATCCGCAAA
GCCATATGATCTGGCATAAGGTGGCGCGCGAATTGGCGCACGATTACACGGTCGTCGCGACCGATCTGCGCGGCTATGGC
GCCTCGTCCAAGCCGGCTGGCAGCGCCCGGCACGCCGAATACAGCAAGCGCACCATGGCGCAGGACCAGGTGGAGGTGAT
GCGTGCGCTCGGCTTCGGCCGCTTCCGGCTGTGCGCGCATGATCGCGGGGCGCGTGTGGCGCATCGGCTGTGTGTCGATC
ATCCCCTCCACGTCGAGCGCGCCATGCTGCTCGACATCGCCCCCACGCTGGCAATGTACGAGCACACCGACATGGCGTTT
GCGTCCGCCTACTGGCATTGGTTCTTCCTGATCCAGCCGTCGCCGTTTCCCGAGACGCTCATCAACGCCACGCCCGATTT
CTACATCGGCAAGCTGATGGGCCTGCGCCATGCGGGCCTCGAACCGTTCGCCCCGGAGGCCATGGCGACCTACGCCGCCG
CCATGCGCGAACCCGCCTGCGTGCACGCCATGTGCGAGGACTATCGTGCCGCCGCCACCATCGACCTCGAACACGATCGT
GCCGACCGCGATGCCGGCAAGCGCGTGAGCGTGCCGCTTCGTGTGCTGTGGGGCGAGCATGGCGTGATCCAACGCTGCTT
CAAGCCGTTGGAGTTGTGGAAAGCGGTGGCGGACAACGTGAGCGGCGGCACGGTGCCGTGCGGGCACTACGTGCCGGAGG
AAGCCCCGGAGGCCTTGCTCGAGGAGATGCGCGCGTACTTCGCCTGA

Upstream 100 bases:

>100_bases
CGGCAGCGGACGGTTCCGCAACGCACGTGCCCGCTCTGCGCTAGCATGCGGAGCATTCGCCACGCATCACTTCAATCACG
ACCGATCACCGGAGACCCGC

Downstream 100 bases:

>100_bases
GGCGACCGTTCAGGCGTCGGCCCACTCCCGCAGCAGGTTGTGATACGTCCCCGTCAACGCAATGACGGACGGGTCGTCCT
GCCCCAGCAGCCCCATCAGC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTTPLSIDAATAAADAALFPGFRPFRQMANGVEIAGVIGGSGPPLLLLHGHPQSHMIWHKVARELAHDYTVVATDLRGYG
ASSKPAGSARHAEYSKRTMAQDQVEVMRALGFGRFRLCAHDRGARVAHRLCVDHPLHVERAMLLDIAPTLAMYEHTDMAF
ASAYWHWFFLIQPSPFPETLINATPDFYIGKLMGLRHAGLEPFAPEAMATYAAAMREPACVHAMCEDYRAAATIDLEHDR
ADRDAGKRVSVPLRVLWGEHGVIQRCFKPLELWKAVADNVSGGTVPCGHYVPEEAPEALLEEMRAYFA

Sequences:

>Translated_308_residues
MTTPLSIDAATAAADAALFPGFRPFRQMANGVEIAGVIGGSGPPLLLLHGHPQSHMIWHKVARELAHDYTVVATDLRGYG
ASSKPAGSARHAEYSKRTMAQDQVEVMRALGFGRFRLCAHDRGARVAHRLCVDHPLHVERAMLLDIAPTLAMYEHTDMAF
ASAYWHWFFLIQPSPFPETLINATPDFYIGKLMGLRHAGLEPFAPEAMATYAAAMREPACVHAMCEDYRAAATIDLEHDR
ADRDAGKRVSVPLRVLWGEHGVIQRCFKPLELWKAVADNVSGGTVPCGHYVPEEAPEALLEEMRAYFA
>Mature_307_residues
TTPLSIDAATAAADAALFPGFRPFRQMANGVEIAGVIGGSGPPLLLLHGHPQSHMIWHKVARELAHDYTVVATDLRGYGA
SSKPAGSARHAEYSKRTMAQDQVEVMRALGFGRFRLCAHDRGARVAHRLCVDHPLHVERAMLLDIAPTLAMYEHTDMAFA
SAYWHWFFLIQPSPFPETLINATPDFYIGKLMGLRHAGLEPFAPEAMATYAAAMREPACVHAMCEDYRAAATIDLEHDRA
DRDAGKRVSVPLRVLWGEHGVIQRCFKPLELWKAVADNVSGGTVPCGHYVPEEAPEALLEEMRAYFA

Specific function: Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has low activity towards chloroacetate [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI13376164, Length=278, Percent_Identity=27.3381294964029, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI218777837, Length=275, Percent_Identity=24.7272727272727, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562298, Length=226, Percent_Identity=23.8938053097345, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.3 [H]

Molecular weight: Translated: 33938; Mature: 33807

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLSIDAATAAADAALFPGFRPFRQMANGVEIAGVIGGSGPPLLLLHGHPQSHMIWHK
CCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCCCEEEEECCCCHHHHHHH
VARELAHDYTVVATDLRGYGASSKPAGSARHAEYSKRTMAQDQVEVMRALGFGRFRLCAH
HHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DRGARVAHRLCVDHPLHVERAMLLDIAPTLAMYEHTDMAFASAYWHWFFLIQPSPFPETL
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHH
INATPDFYIGKLMGLRHAGLEPFAPEAMATYAAAMREPACVHAMCEDYRAAATIDLEHDR
HCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCC
ADRDAGKRVSVPLRVLWGEHGVIQRCFKPLELWKAVADNVSGGTVPCGHYVPEEAPEALL
CCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EEMRAYFA
HHHHHHCC
>Mature Secondary Structure 
TTPLSIDAATAAADAALFPGFRPFRQMANGVEIAGVIGGSGPPLLLLHGHPQSHMIWHK
CCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCEEEEEECCCCCCEEEEECCCCHHHHHHH
VARELAHDYTVVATDLRGYGASSKPAGSARHAEYSKRTMAQDQVEVMRALGFGRFRLCAH
HHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
DRGARVAHRLCVDHPLHVERAMLLDIAPTLAMYEHTDMAFASAYWHWFFLIQPSPFPETL
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCHHH
INATPDFYIGKLMGLRHAGLEPFAPEAMATYAAAMREPACVHAMCEDYRAAATIDLEHDR
HCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCC
ADRDAGKRVSVPLRVLWGEHGVIQRCFKPLELWKAVADNVSGGTVPCGHYVPEEAPEALL
CCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EEMRAYFA
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA