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The map label for this gene is metH [H]

Identifier: 187736443

GI number: 187736443

Start: 2377647

End: 2381408

Strand: Direct

Name: metH [H]

Synonym: Amuc_1961

Alternate gene names: 187736443

Gene position: 2377647-2381408 (Clockwise)

Preceding gene: 187736442

Following gene: 187736444

Centisome position: 89.25

GC content: 59.36

Gene sequence:

>3762_bases
ATGAGCAGAGCATCCAGAACAGAACGCCTTGATTACCTGAAAGACCAGTTACGTAAAAGGGTTGTCATCCTGGATGGCGC
CATGGGCACCAATATCCAAAAATTCAGGCTGGGAGAGGGAGATTACCGCGGAGAACGTTTTGCGGATGCGGAATGCTATC
CCAACGATTTAAAGAATAATAACGACCTTCTGGTTCTGACCAGGCCGGATATCATTCTTGATATTCACCGCCGCTTTCTT
GACACGGGACGGACGGATATTCTGGAAACCTGCACATTCGGAGCTACCAGCATCGGCCAGCATGATTATTTCTGGCACCG
TCCGGAGGAAGGCAGCCACAAGGACCAGCAGTATTTCCAGGAAGTGGTGGACGCCCCCGAATTGAAGGCCCTTGTCCGGG
AATTGAATTTGGCGGCAGCCGCACTGGCCCGGCAGGCATGCGACGAAGCGGAAGCTGCAGACGGCAAGCCCCGCCTGGTG
GCCGGGTCCATCGGCCCCATGCCCGTCACCTGTTCCCTGTCCCCCGACGTGAATGATCCCGGTTTCCGCGCCGTGAATTT
CCGCCAGCTCAGGCAGGCGTACCGGGATCAGGTGCTGGCCCTGCTGGAAGGGGGGGTGGACATGCTGCTGGTGGAGACGA
TTTTCGACACGCTGAACGCCAAGGCAGCCCTGTTCGCCATTGAAGAAATTTTTGAGGAACAACCGGAAAGCTCTGTTCCG
GTCATGGTATCCGTAACGCTGACGGACAAAGCCGGACGCACGCTGTCCGGCCAGACGATTGAAGCATTCTGGAACTCCAT
CCGCCACGTTCGCCCCTTCTCCGTAGGCATCAATTGCGCCCTGGGGCCGGACCTGATGCGCCCCTTTGCGGAAGAACTGT
CCGGACTGGCAGATTGCCACATGTCCATTTATGCGAATGCCGGGCTTCCCAACCCGCTCAGCCCTACCGGCTACGACCTT
CTGCCGGCGGATATGGCCCGGTTCATGAAGGAATACGCGGAACAGGGCCTGCTGAACATCGTGGGCGGCTGCTGCGGAAC
CACTCCGGAGCATATCGGCGCCATTGCGGCTGCCGTGGAAGGAATGCCTCCGCGCGTTCCGGCTCCCCAAACGCCCGCGC
TTCGCCTGTCCGGATATGAAGCGTACAACCATACGCGGGAAAAAAACACCCTCTTTGTCGGGGAACGCTGCAATGTGGCG
GGTTCCCCCAAATTCGCCCGCCTGATTCGTGAAGGAAATTACGAGGAAGCGGTATCCATTGCCCGGCAGCAGGTGGAAAA
CGGCGCGCTGGTATTGGATTTCTGTTTTGACGACGGCCTGATCGACGGGCCGCAGGCCATGGTCCGCTTCCTGAACCTTG
TTTCCGCAGAGCCGGATATCGCCCGCGTTCCTTTCATGGTGGATTCCTCCAAGTGGGAGGTGCTGGAAGCGGGGCTCCAA
TGCATGCAGGGCAAGGGAATCGTGAATTCCATTTCTCTGAAGGAGGGGGAAGAAGAATTCCTGAAGAAAGCGGCGCTGAT
TAAAAAGTACGGCGCAGCGGTCGTGGTCATGGCGTTTGACGAACAGGGACAGGCCGCCAATTACGAGGACCGCGTCCGCA
TCTCCAGACGGGCCTATGACTTGCTGGTAAACCGGGTGCAGTTTCCTCCGGAAGACATCATTTTTGACCCGAACGTCCTG
ACCGTAGGCACCGGCATTGCGGAACACGCCGATTACGCTCTTGATTTCTTCAAGGCCGCAGGCTGGATCTCCCGGAACCT
GCCGCATGCCCACATTTCCGGCGGCATTTCCAATGTCTCCTTTGCTTTCCGCGGCAACAACCCGGTGCGGGAAGCCATGC
ATTCCGCTTTCCTGTACCACGCTACGCAGCAGGGGCTGGACATGTGCATCGTGAATGCCGGGATGCTGGAGGTGTACGAC
AATATTCCCAAGGACAGGCTGGAGCTGATTGAAGACGTTCTGCTGAACCGGAGGACGGACGCCACGGAACGCCTGACGGA
TTACGCGGAAAAACTGGCTGCGGAAAAAACCGGAGACGGAAAGGAGAAAAAAACCGTACAGGCCTGGAGGGAGCAGGACG
TTGCCAAACGTCTGGAATATTCTCTTATCAAGGGCATTACCGAATTTGTTGACGCGGATACGGAGGAGGCTTTTCAGGAG
CTGGGGTCTCCGCTGAACGTGATTGAAGGCCCTCTGATGGCCGGCATGAAGGTCGTCGGGCAACTGTTCGGGGACGGCAA
AATGTTCCTGCCGCAGGTGGTGAAAAGCGCCCGCGTCATGAAACAGGCTGTAGCCTGGCTCACCCCCTATATAGAAGCGG
ACAGCAAAGGAGCCGCCAAGGCGGGAAAAGCCGTGATCGCCACCGTGAAGGGGGACGTGCATGACATCGGCAAAAATATC
GTCGGCGTGGTGTTGAGCTGCAATGGTTTTGAAATGATTGACCTGGGCGTCATGGTCCATTGCGATACCATTCTGGACCG
GGCGGAAGCGGAACAGGCGGACCTGGTGATGCTTTCCGGGCTGATCACCCCTTCCCTGGAAGAGATGTCCCATGTAGCCG
CGGAGATGGAACGCCGGGGGATGACCATTCCCCTGATGGTGGGGGGAGCTACGACGTCAGCCCTGCATACGGCCCTGAAA
ATAGCCCCCCATTATCAAGGAGCCGTGGTGCATACGGAGGATGCCTCCCAGGTGGTTCCCGCAGCCGCCTCCCTGGTGGG
AGAAAAAAAGGATTCCTACATTGCCGCCGTGAAGGCCCGGCAGGAGGAATTGCGCAACAATCATGAAAACAAACCCGTCC
GGGACCTCCTGCCCCTGGAGAAAGCCAGGGAATTGCGCTGGAAGGGAGCGGAAGGCGGCTATCTCCCCCCCGTTCCCGCC
CGTCTTGGCCCGGTTTCCATCGGCAGCCTGCACAGCTCCGTAAGCTGCGGCTGCTGCAGTGACGATCCACGTTATTACGT
AACTGTTCAGGAGCTTATCGAGCGCATGGACTGGACGCCTTTTTTCCACGCCTGGGAGCTGCACGGCACATGGGACCGCG
CCCGCCGGGAGTTCCGCACCAAAGACCCGTCCAAGGCTGAGGCGGCCGCGGCGCTGTACCAGGACGCCCTCCGCTTGCTG
GAACAGGCCGTGAAGGAAAACCGCTACCAGGCGCGCGGCGTCATAGGCATTTTCCCGGCCAATTCAACAGCCAGCCATGA
CGACATCACCGTCTGGGCTGATGAATCCAGAACCATTCCCCTGGCTACGCTGCTGACGCAGCGCCAGCAACTGGACAAAC
AGGGGAAACCCCGGCTGGCGCTGGCGGACTTCATCGCTCCCGAAGGCGTCAGGGATTACGTGGGGGCCATGGCGGTCAGC
ATCCACGGCTCCCGCCGCTGGGCAAAGGAATGGGAAGCCAGAAACGACTCCTACCGCGCCCTGCTGGTCAGCTCTCTGGC
GGACCGCCTGGTGGAGGCTTTCGCGGCCATCGCCCATGACAAGCTGCGCCTTTTGTGGAATATTCCGGAAGGGTCCGGCG
TGCGACCTGCCTGCGGGTACCCCAGCCAGCCGGACCACCAGGAAAAGGAAACCGTCTTCACCCTGCTCCACGCCCGGGAG
GAAGCGGGCATGAGCCTGACGGAAACATGGATGATGCAGCCCGTTTCTTCCGTCTGCGCCCTCGTCTTCTCCCATCCGGA
AAGCACTTATTTCTCCGTGGGCGTCACCGGGGAAGACCAGCAGGAGGATTACGCCTCCAGAAAACGGGCCTCCCGGCCCT
GA

Upstream 100 bases:

>100_bases
GAAAACAGGTTCCTCCCATTTCCCCGGAGCAATACGGGAAAAACGTGACGACAATTGTCCTTGTTCCAATGACGGACGGA
CGGTAGATTTTCCGCGCCAT

Downstream 100 bases:

>100_bases
CCTCCCCTTTCCCTTTTATGCAGCATACCGACCAGATACAGGCCCTTTCGGAATTCCTGCTGGAATACGCCACCACCCTC
ATGGGCGCGGGGGTGCACAC

Product: methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]

Number of amino acids: Translated: 1253; Mature: 1252

Protein sequence:

>1253_residues
MSRASRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNNNDLLVLTRPDIILDIHRRFL
DTGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQEVVDAPELKALVRELNLAAAALARQACDEAEAADGKPRLV
AGSIGPMPVTCSLSPDVNDPGFRAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVP
VMVSVTLTDKAGRTLSGQTIEAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCHMSIYANAGLPNPLSPTGYDL
LPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAAAVEGMPPRVPAPQTPALRLSGYEAYNHTREKNTLFVGERCNVA
GSPKFARLIREGNYEEAVSIARQQVENGALVLDFCFDDGLIDGPQAMVRFLNLVSAEPDIARVPFMVDSSKWEVLEAGLQ
CMQGKGIVNSISLKEGEEEFLKKAALIKKYGAAVVVMAFDEQGQAANYEDRVRISRRAYDLLVNRVQFPPEDIIFDPNVL
TVGTGIAEHADYALDFFKAAGWISRNLPHAHISGGISNVSFAFRGNNPVREAMHSAFLYHATQQGLDMCIVNAGMLEVYD
NIPKDRLELIEDVLLNRRTDATERLTDYAEKLAAEKTGDGKEKKTVQAWREQDVAKRLEYSLIKGITEFVDADTEEAFQE
LGSPLNVIEGPLMAGMKVVGQLFGDGKMFLPQVVKSARVMKQAVAWLTPYIEADSKGAAKAGKAVIATVKGDVHDIGKNI
VGVVLSCNGFEMIDLGVMVHCDTILDRAEAEQADLVMLSGLITPSLEEMSHVAAEMERRGMTIPLMVGGATTSALHTALK
IAPHYQGAVVHTEDASQVVPAAASLVGEKKDSYIAAVKARQEELRNNHENKPVRDLLPLEKARELRWKGAEGGYLPPVPA
RLGPVSIGSLHSSVSCGCCSDDPRYYVTVQELIERMDWTPFFHAWELHGTWDRARREFRTKDPSKAEAAAALYQDALRLL
EQAVKENRYQARGVIGIFPANSTASHDDITVWADESRTIPLATLLTQRQQLDKQGKPRLALADFIAPEGVRDYVGAMAVS
IHGSRRWAKEWEARNDSYRALLVSSLADRLVEAFAAIAHDKLRLLWNIPEGSGVRPACGYPSQPDHQEKETVFTLLHARE
EAGMSLTETWMMQPVSSVCALVFSHPESTYFSVGVTGEDQQEDYASRKRASRP

Sequences:

>Translated_1253_residues
MSRASRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNNNDLLVLTRPDIILDIHRRFL
DTGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQEVVDAPELKALVRELNLAAAALARQACDEAEAADGKPRLV
AGSIGPMPVTCSLSPDVNDPGFRAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVP
VMVSVTLTDKAGRTLSGQTIEAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCHMSIYANAGLPNPLSPTGYDL
LPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAAAVEGMPPRVPAPQTPALRLSGYEAYNHTREKNTLFVGERCNVA
GSPKFARLIREGNYEEAVSIARQQVENGALVLDFCFDDGLIDGPQAMVRFLNLVSAEPDIARVPFMVDSSKWEVLEAGLQ
CMQGKGIVNSISLKEGEEEFLKKAALIKKYGAAVVVMAFDEQGQAANYEDRVRISRRAYDLLVNRVQFPPEDIIFDPNVL
TVGTGIAEHADYALDFFKAAGWISRNLPHAHISGGISNVSFAFRGNNPVREAMHSAFLYHATQQGLDMCIVNAGMLEVYD
NIPKDRLELIEDVLLNRRTDATERLTDYAEKLAAEKTGDGKEKKTVQAWREQDVAKRLEYSLIKGITEFVDADTEEAFQE
LGSPLNVIEGPLMAGMKVVGQLFGDGKMFLPQVVKSARVMKQAVAWLTPYIEADSKGAAKAGKAVIATVKGDVHDIGKNI
VGVVLSCNGFEMIDLGVMVHCDTILDRAEAEQADLVMLSGLITPSLEEMSHVAAEMERRGMTIPLMVGGATTSALHTALK
IAPHYQGAVVHTEDASQVVPAAASLVGEKKDSYIAAVKARQEELRNNHENKPVRDLLPLEKARELRWKGAEGGYLPPVPA
RLGPVSIGSLHSSVSCGCCSDDPRYYVTVQELIERMDWTPFFHAWELHGTWDRARREFRTKDPSKAEAAAALYQDALRLL
EQAVKENRYQARGVIGIFPANSTASHDDITVWADESRTIPLATLLTQRQQLDKQGKPRLALADFIAPEGVRDYVGAMAVS
IHGSRRWAKEWEARNDSYRALLVSSLADRLVEAFAAIAHDKLRLLWNIPEGSGVRPACGYPSQPDHQEKETVFTLLHARE
EAGMSLTETWMMQPVSSVCALVFSHPESTYFSVGVTGEDQQEDYASRKRASRP
>Mature_1252_residues
SRASRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNNNDLLVLTRPDIILDIHRRFLD
TGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQEVVDAPELKALVRELNLAAAALARQACDEAEAADGKPRLVA
GSIGPMPVTCSLSPDVNDPGFRAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVPV
MVSVTLTDKAGRTLSGQTIEAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCHMSIYANAGLPNPLSPTGYDLL
PADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAAAVEGMPPRVPAPQTPALRLSGYEAYNHTREKNTLFVGERCNVAG
SPKFARLIREGNYEEAVSIARQQVENGALVLDFCFDDGLIDGPQAMVRFLNLVSAEPDIARVPFMVDSSKWEVLEAGLQC
MQGKGIVNSISLKEGEEEFLKKAALIKKYGAAVVVMAFDEQGQAANYEDRVRISRRAYDLLVNRVQFPPEDIIFDPNVLT
VGTGIAEHADYALDFFKAAGWISRNLPHAHISGGISNVSFAFRGNNPVREAMHSAFLYHATQQGLDMCIVNAGMLEVYDN
IPKDRLELIEDVLLNRRTDATERLTDYAEKLAAEKTGDGKEKKTVQAWREQDVAKRLEYSLIKGITEFVDADTEEAFQEL
GSPLNVIEGPLMAGMKVVGQLFGDGKMFLPQVVKSARVMKQAVAWLTPYIEADSKGAAKAGKAVIATVKGDVHDIGKNIV
GVVLSCNGFEMIDLGVMVHCDTILDRAEAEQADLVMLSGLITPSLEEMSHVAAEMERRGMTIPLMVGGATTSALHTALKI
APHYQGAVVHTEDASQVVPAAASLVGEKKDSYIAAVKARQEELRNNHENKPVRDLLPLEKARELRWKGAEGGYLPPVPAR
LGPVSIGSLHSSVSCGCCSDDPRYYVTVQELIERMDWTPFFHAWELHGTWDRARREFRTKDPSKAEAAAALYQDALRLLE
QAVKENRYQARGVIGIFPANSTASHDDITVWADESRTIPLATLLTQRQQLDKQGKPRLALADFIAPEGVRDYVGAMAVSI
HGSRRWAKEWEARNDSYRALLVSSLADRLVEAFAAIAHDKLRLLWNIPEGSGVRPACGYPSQPDHQEKETVFTLLHAREE
AGMSLTETWMMQPVSSVCALVFSHPESTYFSVGVTGEDQQEDYASRKRASRP

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1282, Percent_Identity=46.9578783151326, Blast_Score=1084, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1268, Percent_Identity=49.8422712933754, Blast_Score=1181, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535405, Length=1286, Percent_Identity=45.6454121306376, Blast_Score=1042, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 138236; Mature: 138104

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRASRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNN
CCCCHHHHHHHHHHHHHHCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
NDLLVLTRPDIILDIHRRFLDTGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQ
CCEEEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EVVDAPELKALVRELNLAAAALARQACDEAEAADGKPRLVAGSIGPMPVTCSLSPDVNDP
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCCCCCC
GFRAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVP
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
VMVSVTLTDKAGRTLSGQTIEAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCH
EEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECEEECCCHHHHHHHHHHHHHHHHHH
MSIYANAGLPNPLSPTGYDLLPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAAAVE
HHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHC
GMPPRVPAPQTPALRLSGYEAYNHTREKNTLFVGERCNVAGSPKFARLIREGNYEEAVSI
CCCCCCCCCCCCCEEECCCHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHH
ARQQVENGALVLDFCFDDGLIDGPQAMVRFLNLVSAEPDIARVPFMVDSSKWEVLEAGLQ
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEECCEEECCCHHHHHHHHHH
CMQGKGIVNSISLKEGEEEFLKKAALIKKYGAAVVVMAFDEQGQAANYEDRVRISRRAYD
HHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
LLVNRVQFPPEDIIFDPNVLTVGTGIAEHADYALDFFKAAGWISRNLPHAHISGGISNVS
HHHHHHCCCCHHEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEE
FAFRGNNPVREAMHSAFLYHATQQGLDMCIVNAGMLEVYDNIPKDRLELIEDVLLNRRTD
EEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCC
ATERLTDYAEKLAAEKTGDGKEKKTVQAWREQDVAKRLEYSLIKGITEFVDADTEEAFQE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGSPLNVIEGPLMAGMKVVGQLFGDGKMFLPQVVKSARVMKQAVAWLTPYIEADSKGAAK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AGKAVIATVKGDVHDIGKNIVGVVLSCNGFEMIDLGVMVHCDTILDRAEAEQADLVMLSG
CCCEEEEEECCCHHHHHHHHEEEEEECCCCEEEECCCEEEHHHHHHHHCCHHHCCHHHHH
LITPSLEEMSHVAAEMERRGMTIPLMVGGATTSALHTALKIAPHYQGAVVHTEDASQVVP
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
AAASLVGEKKDSYIAAVKARQEELRNNHENKPVRDLLPLEKARELRWKGAEGGYLPPVPA
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHCCCCCCCCCCCCCCC
RLGPVSIGSLHSSVSCGCCSDDPRYYVTVQELIERMDWTPFFHAWELHGTWDRARREFRT
CCCCCCHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCC
KDPSKAEAAAALYQDALRLLEQAVKENRYQARGVIGIFPANSTASHDDITVWADESRTIP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCCCCCCEEEEECCCCCCH
LATLLTQRQQLDKQGKPRLALADFIAPEGVRDYVGAMAVSIHGSRRWAKEWEARNDSYRA
HHHHHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHEEEEECCCHHHHHHHHCCCCHHHH
LLVSSLADRLVEAFAAIAHDKLRLLWNIPEGSGVRPACGYPSQPDHQEKETVFTLLHARE
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EAGMSLTETWMMQPVSSVCALVFSHPESTYFSVGVTGEDQQEDYASRKRASRP
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRASRTERLDYLKDQLRKRVVILDGAMGTNIQKFRLGEGDYRGERFADAECYPNDLKNN
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
NDLLVLTRPDIILDIHRRFLDTGRTDILETCTFGATSIGQHDYFWHRPEEGSHKDQQYFQ
CCEEEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EVVDAPELKALVRELNLAAAALARQACDEAEAADGKPRLVAGSIGPMPVTCSLSPDVNDP
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCCCCCC
GFRAVNFRQLRQAYRDQVLALLEGGVDMLLVETIFDTLNAKAALFAIEEIFEEQPESSVP
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
VMVSVTLTDKAGRTLSGQTIEAFWNSIRHVRPFSVGINCALGPDLMRPFAEELSGLADCH
EEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEECEEECCCHHHHHHHHHHHHHHHHHH
MSIYANAGLPNPLSPTGYDLLPADMARFMKEYAEQGLLNIVGGCCGTTPEHIGAIAAAVE
HHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHC
GMPPRVPAPQTPALRLSGYEAYNHTREKNTLFVGERCNVAGSPKFARLIREGNYEEAVSI
CCCCCCCCCCCCCEEECCCHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCHHHHHHH
ARQQVENGALVLDFCFDDGLIDGPQAMVRFLNLVSAEPDIARVPFMVDSSKWEVLEAGLQ
HHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEECCEEECCCHHHHHHHHHH
CMQGKGIVNSISLKEGEEEFLKKAALIKKYGAAVVVMAFDEQGQAANYEDRVRISRRAYD
HHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
LLVNRVQFPPEDIIFDPNVLTVGTGIAEHADYALDFFKAAGWISRNLPHAHISGGISNVS
HHHHHHCCCCHHEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEE
FAFRGNNPVREAMHSAFLYHATQQGLDMCIVNAGMLEVYDNIPKDRLELIEDVLLNRRTD
EEEECCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCC
ATERLTDYAEKLAAEKTGDGKEKKTVQAWREQDVAKRLEYSLIKGITEFVDADTEEAFQE
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGSPLNVIEGPLMAGMKVVGQLFGDGKMFLPQVVKSARVMKQAVAWLTPYIEADSKGAAK
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AGKAVIATVKGDVHDIGKNIVGVVLSCNGFEMIDLGVMVHCDTILDRAEAEQADLVMLSG
CCCEEEEEECCCHHHHHHHHEEEEEECCCCEEEECCCEEEHHHHHHHHCCHHHCCHHHHH
LITPSLEEMSHVAAEMERRGMTIPLMVGGATTSALHTALKIAPHYQGAVVHTEDASQVVP
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
AAASLVGEKKDSYIAAVKARQEELRNNHENKPVRDLLPLEKARELRWKGAEGGYLPPVPA
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHCCCCCCCCCCCCCCC
RLGPVSIGSLHSSVSCGCCSDDPRYYVTVQELIERMDWTPFFHAWELHGTWDRARREFRT
CCCCCCHHHHHCCCCCCCCCCCCCEEEEHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCC
KDPSKAEAAAALYQDALRLLEQAVKENRYQARGVIGIFPANSTASHDDITVWADESRTIP
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEECCCCCCCCCCEEEEECCCCCCH
LATLLTQRQQLDKQGKPRLALADFIAPEGVRDYVGAMAVSIHGSRRWAKEWEARNDSYRA
HHHHHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHEEEEECCCHHHHHHHHCCCCHHHH
LLVSSLADRLVEAFAAIAHDKLRLLWNIPEGSGVRPACGYPSQPDHQEKETVFTLLHARE
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
EAGMSLTETWMMQPVSSVCALVFSHPESTYFSVGVTGEDQQEDYASRKRASRP
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]