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The map label for this gene is lpxC/fabZ [H]

Identifier: 187736400

GI number: 187736400

Start: 2328690

End: 2330006

Strand: Reverse

Name: lpxC/fabZ [H]

Synonym: Amuc_1918

Alternate gene names: 187736400

Gene position: 2330006-2328690 (Counterclockwise)

Preceding gene: 187736403

Following gene: 187736398

Centisome position: 87.46

GC content: 58.47

Gene sequence:

>1317_bases
ATGGCATGTGGAAACCAAAGAACTGTCGGCTCTCCGGCCTCCCTGGCCGGTACCTCTTTGCATACGGGACAGCCCGTTAC
CCTGACCCTGAAGCCGGCTCCTGCCGACTTCGGCATTAAATTCCGCCGGGTGGACATTCCGGACCAGCCTTTCATCAGCG
CGGACGTGGAAAAGGTGCAGACTGTGGAACGCGCCACCAGCCTGGCTGAAGGTTCCGTCAAAGTGCATACCGTGGAACAT
ATTCTCTCCGCCCTCACGGGCATGGGCATTGACAACGCCGTCATTGAAATGGACGCCAATGAACCGCCCATCGGGGACGG
GTCCTCAGCCCCCTACGTAGAGCTGATCAAGAGCGCCGGCATCGTGGAACTGGATGTGCCGCGCCGCTATCTGGAAGTGC
GCGAGGCCGTTACCATTGAAACCAAGGGCGGTTCCATCCTGACCATTCTCCCCTCCAAGCAATTCCGCGTTTCCGTCACC
TGCGTGGGGCCGGAAAACCGCATTACCCAGTACTTTGACTCGGTTATCACGCCGGAAACGTATGAAAAGGAACTGGCCCC
GGCTCGCACTTTTACGTTCTACGAAGACATCAAGCCCCTGCTGGAGAAGGGCCTCATCAAGGGCGGCAGCCTGGAAAACG
CCGTGGTCATCCGCGGCGAGGAGCTCATGAGCAAGGAGCCCATGCGTTTCATCAATGAATTTGCCCGCCACAAGGCCATG
GACCTTATTGGAGACCTGACCCTGTGCGGCAAACCCATCCTGGGCCACGTCATCGCCATCAAGCCGGGCCACGGCCCGAA
CACCGAACTTACGGCCAAGCTCAAAAAGGAACACCACCGCAACCAGCAGATGGCCCCCAATCCCGTCAATGTTCCATACG
GAGACGCCGTGCTGGACATCAACGAAGTGATGAGCCTTCTGCCGCACCGCTATCCCTTCCTGATGGTGGACCGCATTATC
GGTTTTGAAGGAGAAACCAAGTGCCGGGGATTGAAGAACCTGACCATGAATGAACTCTTTTTCCAGGGCCACTTCCCGGG
ACATCCGGTCATGCCGGGCGTTCTCCAGGTGGAAGCCATGGCCCAGGTAGCCTCCATCGTCATGCTGCGCCAGCCCGGCA
ATGCCAGCAAGCTCGGCTACTTCATGAGTGCGGACAAGGTTAAATTCCGCCGCGTCGTGGTTCCCGGCGATACGCTCATC
ATTGAAGCGGAACTGACCAAGATGCGCGGAAACATCGGCCAGGCGACGGCTCGTTGTCTGGTGAACGGCCAGGTGGTTTC
GGAAGCCGAGCTTAAATTCGGCCTTCAGGATGCTTGA

Upstream 100 bases:

>100_bases
TCCGGGATGACACGCCGGAATGCCGCCTCTTCCCCGAATTTAAAGGAAAATCCGTGATTTCGTGCTTTCCAAACGGAAGC
TCATTCACTAGCATCCCCGC

Downstream 100 bases:

>100_bases
TCCTGCCGACTGCATCCCCTGTTTTTACGGAAACCCCGGCCGTGCAAGCCACGCCGGGGTTTTTCATGTTCCGCGTCCGG
GCCTTTTTTACCTGGAAATT

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MACGNQRTVGSPASLAGTSLHTGQPVTLTLKPAPADFGIKFRRVDIPDQPFISADVEKVQTVERATSLAEGSVKVHTVEH
ILSALTGMGIDNAVIEMDANEPPIGDGSSAPYVELIKSAGIVELDVPRRYLEVREAVTIETKGGSILTILPSKQFRVSVT
CVGPENRITQYFDSVITPETYEKELAPARTFTFYEDIKPLLEKGLIKGGSLENAVVIRGEELMSKEPMRFINEFARHKAM
DLIGDLTLCGKPILGHVIAIKPGHGPNTELTAKLKKEHHRNQQMAPNPVNVPYGDAVLDINEVMSLLPHRYPFLMVDRII
GFEGETKCRGLKNLTMNELFFQGHFPGHPVMPGVLQVEAMAQVASIVMLRQPGNASKLGYFMSADKVKFRRVVVPGDTLI
IEAELTKMRGNIGQATARCLVNGQVVSEAELKFGLQDA

Sequences:

>Translated_438_residues
MACGNQRTVGSPASLAGTSLHTGQPVTLTLKPAPADFGIKFRRVDIPDQPFISADVEKVQTVERATSLAEGSVKVHTVEH
ILSALTGMGIDNAVIEMDANEPPIGDGSSAPYVELIKSAGIVELDVPRRYLEVREAVTIETKGGSILTILPSKQFRVSVT
CVGPENRITQYFDSVITPETYEKELAPARTFTFYEDIKPLLEKGLIKGGSLENAVVIRGEELMSKEPMRFINEFARHKAM
DLIGDLTLCGKPILGHVIAIKPGHGPNTELTAKLKKEHHRNQQMAPNPVNVPYGDAVLDINEVMSLLPHRYPFLMVDRII
GFEGETKCRGLKNLTMNELFFQGHFPGHPVMPGVLQVEAMAQVASIVMLRQPGNASKLGYFMSADKVKFRRVVVPGDTLI
IEAELTKMRGNIGQATARCLVNGQVVSEAELKFGLQDA
>Mature_437_residues
ACGNQRTVGSPASLAGTSLHTGQPVTLTLKPAPADFGIKFRRVDIPDQPFISADVEKVQTVERATSLAEGSVKVHTVEHI
LSALTGMGIDNAVIEMDANEPPIGDGSSAPYVELIKSAGIVELDVPRRYLEVREAVTIETKGGSILTILPSKQFRVSVTC
VGPENRITQYFDSVITPETYEKELAPARTFTFYEDIKPLLEKGLIKGGSLENAVVIRGEELMSKEPMRFINEFARHKAMD
LIGDLTLCGKPILGHVIAIKPGHGPNTELTAKLKKEHHRNQQMAPNPVNVPYGDAVLDINEVMSLLPHRYPFLMVDRIIG
FEGETKCRGLKNLTMNELFFQGHFPGHPVMPGVLQVEAMAQVASIVMLRQPGNASKLGYFMSADKVKFRRVVVPGDTLII
EAELTKMRGNIGQATARCLVNGQVVSEAELKFGLQDA

Specific function: Involved in saturated fatty acids biosynthesis [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=269, Percent_Identity=38.6617100371747, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786377, Length=136, Percent_Identity=46.3235294117647, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF07977 FabA; PF03331 LpxC [H]

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 47830; Mature: 47699

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACGNQRTVGSPASLAGTSLHTGQPVTLTLKPAPADFGIKFRRVDIPDQPFISADVEKVQ
CCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHH
TVERATSLAEGSVKVHTVEHILSALTGMGIDNAVIEMDANEPPIGDGSSAPYVELIKSAG
HHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHCC
IVELDVPRRYLEVREAVTIETKGGSILTILPSKQFRVSVTCVGPENRITQYFDSVITPET
EEEECCCHHHHHHHHEEEEEECCCEEEEEECCCCEEEEEEEECCHHHHHHHHHHHCCCCH
YEKELAPARTFTFYEDIKPLLEKGLIKGGSLENAVVIRGEELMSKEPMRFINEFARHKAM
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHH
DLIGDLTLCGKPILGHVIAIKPGHGPNTELTAKLKKEHHRNQQMAPNPVNVPYGDAVLDI
HHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECH
NEVMSLLPHRYPFLMVDRIIGFEGETKCRGLKNLTMNELFFQGHFPGHPVMPGVLQVEAM
HHHHHHCCCCCCHHHHHHHHCCCCCHHHCCCCCCCHHHEEEECCCCCCCCCCCHHHHHHH
AQVASIVMLRQPGNASKLGYFMSADKVKFRRVVVPGDTLIIEAELTKMRGNIGQATARCL
HHHHHEEEEECCCCCCCCEEEEECCCEEEEEEEECCCEEEEEEEHHHHCCCHHHHHHHHE
VNGQVVSEAELKFGLQDA
ECCCEEECHHHCCCCCCC
>Mature Secondary Structure 
ACGNQRTVGSPASLAGTSLHTGQPVTLTLKPAPADFGIKFRRVDIPDQPFISADVEKVQ
CCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHH
TVERATSLAEGSVKVHTVEHILSALTGMGIDNAVIEMDANEPPIGDGSSAPYVELIKSAG
HHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHCC
IVELDVPRRYLEVREAVTIETKGGSILTILPSKQFRVSVTCVGPENRITQYFDSVITPET
EEEECCCHHHHHHHHEEEEEECCCEEEEEECCCCEEEEEEEECCHHHHHHHHHHHCCCCH
YEKELAPARTFTFYEDIKPLLEKGLIKGGSLENAVVIRGEELMSKEPMRFINEFARHKAM
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCHHHHHHHHHHHHHH
DLIGDLTLCGKPILGHVIAIKPGHGPNTELTAKLKKEHHRNQQMAPNPVNVPYGDAVLDI
HHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECH
NEVMSLLPHRYPFLMVDRIIGFEGETKCRGLKNLTMNELFFQGHFPGHPVMPGVLQVEAM
HHHHHHCCCCCCHHHHHHHHCCCCCHHHCCCCCCCHHHEEEECCCCCCCCCCCHHHHHHH
AQVASIVMLRQPGNASKLGYFMSADKVKFRRVVVPGDTLIIEAELTKMRGNIGQATARCL
HHHHHEEEEECCCCCCCCEEEEECCCEEEEEEEECCCEEEEEEEHHHHCCCHHHHHHHHE
VNGQVVSEAELKFGLQDA
ECCCEEECHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12949112 [H]