Click here to switch to the map view.

The map label for this gene is murA

Identifier: 187736378

GI number: 187736378

Start: 2302061

End: 2303338

Strand: Direct

Name: murA

Synonym: Amuc_1895

Alternate gene names: 187736378

Gene position: 2302061-2303338 (Clockwise)

Preceding gene: 187736376

Following gene: 187736379

Centisome position: 86.41

GC content: 60.17

Gene sequence:

>1278_bases
ATGGAGAAGCTTGTCGTACATGGAGGTTTTACGCTGAGGGGAGCCGTCAATATCAGCGGGTCCAAAAATGCCTCCCTGCC
TATTTTGGCCGCATCCCTGCTGACGGATGAGCCTGTAGTGGTGCGCCGGGTTCCGGATGTTTCCGATACCAATTTCATGG
TGCAGATCATGGGCCAGCTGGGAGCCTCCGTGGAGCGGTCCAGCGGCAATGTGCGCGTGGAAGCCAGGAACCTGCATTCC
GAAGCCGCTTATGAACAGGTGCGCAAGATGCGCGCCTCCATCTGCCTGATGGGGCCCTTGATGGCCCGCATGCAGCGGTG
CGTGATTCCCCTGCCGGGCGGCTGTGTGATTGGCGACCGTCCTGTGGATCTGCATATCAGGGCCATCCAGGCATTGGGGG
CACAGGTGCAGATTGAGCGTGGCAACCTGATTATTGAAGCTCCCAGGGGGTTGAAAGGAGCCACGGTGGATTTGAGCGGC
GACCACGGCCCCACCGTTCTGGGAACGGACAACCTGATGATGGCCGCCGTATTGGCGGAAGGCACCACCGTTATTGAATC
CGCCGCCTCCGAGCCGGAAGTGGTGGATCTGGCGAACTTTTTAACCAAGATGGGCGCCAATATTCAAGGTGCGGGAACGC
GCCGGATCGTCATTGAGGGAGTGGAAAAGCTCCGCGGCTGCAACCATACCGTTATCCCGGACCGCATTGAGGCCGGCACC
TTTATGGTGGCGGCGGCTATGATGGGGGATGGCGTGACCCTGCGGCGCGTGTGTGAGGAACACATGACTGTGGTGACGGA
TTTGCTCCGGAAGTGCGGCCACCACGTGGAATTCAACGAGCGGGGGGATACGGTCACCATCATTGCCGGGAAAACGCCCA
AATGCGGGGAAATCAAGACAGCCCCGTATCCCGGCTACCCCACGGACATGCAGGCCCAGATGACGGCTCTCTTCGCCACC
ACGCCGGGCATCTCCGTGGTGAAGGATACTATTTTCCCGCAGCGTTTCATGCACTGCTCCGAACTCAAGCGCATGGGGGC
GGACATCAAGGTGGACAACGGCACTGCCGTCATTTCCGGAGTGGAAACGCTCAGCGGCGCCCCCGTCATGGCCTCCGACC
TGCGGGCCTCCGCCGCCCTGGTTCTGGCAGCCCTGAAGGCGGAAGGCACTACGGAAATCCACCGCCTGTACCATATTGAC
CGGGGCTATGAAATGATTGACGAAAAACTCCTGGCCATCGGCGCTGCAGTGGAAAGGCTGCCGGATGACGACAATTAA

Upstream 100 bases:

>100_bases
GGGAAGAGAAACATCCGGGAAATTGTCCCGTTCCGGGGGCTCTTTGGGGTTGCATGGGCGTTTTAAATGTGTAGAATCCG
TCACCTAATTGCAACCCACT

Downstream 100 bases:

>100_bases
CGCCGTTTTAGGTCCTGATTTTCCTTCACACCGCATTTTTTCTTTACTGTCAGGGCTCCATATGCTATTCACCGAAGTCC
TATGAACAAGGCTCAACTGA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MEKLVVHGGFTLRGAVNISGSKNASLPILAASLLTDEPVVVRRVPDVSDTNFMVQIMGQLGASVERSSGNVRVEARNLHS
EAAYEQVRKMRASICLMGPLMARMQRCVIPLPGGCVIGDRPVDLHIRAIQALGAQVQIERGNLIIEAPRGLKGATVDLSG
DHGPTVLGTDNLMMAAVLAEGTTVIESAASEPEVVDLANFLTKMGANIQGAGTRRIVIEGVEKLRGCNHTVIPDRIEAGT
FMVAAAMMGDGVTLRRVCEEHMTVVTDLLRKCGHHVEFNERGDTVTIIAGKTPKCGEIKTAPYPGYPTDMQAQMTALFAT
TPGISVVKDTIFPQRFMHCSELKRMGADIKVDNGTAVISGVETLSGAPVMASDLRASAALVLAALKAEGTTEIHRLYHID
RGYEMIDEKLLAIGAAVERLPDDDN

Sequences:

>Translated_425_residues
MEKLVVHGGFTLRGAVNISGSKNASLPILAASLLTDEPVVVRRVPDVSDTNFMVQIMGQLGASVERSSGNVRVEARNLHS
EAAYEQVRKMRASICLMGPLMARMQRCVIPLPGGCVIGDRPVDLHIRAIQALGAQVQIERGNLIIEAPRGLKGATVDLSG
DHGPTVLGTDNLMMAAVLAEGTTVIESAASEPEVVDLANFLTKMGANIQGAGTRRIVIEGVEKLRGCNHTVIPDRIEAGT
FMVAAAMMGDGVTLRRVCEEHMTVVTDLLRKCGHHVEFNERGDTVTIIAGKTPKCGEIKTAPYPGYPTDMQAQMTALFAT
TPGISVVKDTIFPQRFMHCSELKRMGADIKVDNGTAVISGVETLSGAPVMASDLRASAALVLAALKAEGTTEIHRLYHID
RGYEMIDEKLLAIGAAVERLPDDDN
>Mature_425_residues
MEKLVVHGGFTLRGAVNISGSKNASLPILAASLLTDEPVVVRRVPDVSDTNFMVQIMGQLGASVERSSGNVRVEARNLHS
EAAYEQVRKMRASICLMGPLMARMQRCVIPLPGGCVIGDRPVDLHIRAIQALGAQVQIERGNLIIEAPRGLKGATVDLSG
DHGPTVLGTDNLMMAAVLAEGTTVIESAASEPEVVDLANFLTKMGANIQGAGTRRIVIEGVEKLRGCNHTVIPDRIEAGT
FMVAAAMMGDGVTLRRVCEEHMTVVTDLLRKCGHHVEFNERGDTVTIIAGKTPKCGEIKTAPYPGYPTDMQAQMTALFAT
TPGISVVKDTIFPQRFMHCSELKRMGADIKVDNGTAVISGVETLSGAPVMASDLRASAALVLAALKAEGTTEIHRLYHID
RGYEMIDEKLLAIGAAVERLPDDDN

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=422, Percent_Identity=49.0521327014218, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_AKKM8 (B2UNJ3)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878490.1
- ProteinModelPortal:   B2UNJ3
- SMR:   B2UNJ3
- GeneID:   6273694
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1895
- HOGENOM:   HBG482701
- OMA:   ICGDTDG
- ProtClustDB:   PRK09369
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45409; Mature: 45409

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: ACT_SITE 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLVVHGGFTLRGAVNISGSKNASLPILAASLLTDEPVVVRRVPDVSDTNFMVQIMGQL
CCEEEEECCEEEEEEEEECCCCCCCCCEEEHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
GASVERSSGNVRVEARNLHSEAAYEQVRKMRASICLMGPLMARMQRCVIPLPGGCVIGDR
CCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCEEECCC
PVDLHIRAIQALGAQVQIERGNLIIEAPRGLKGATVDLSGDHGPTVLGTDNLMMAAVLAE
CCEEEHHHHHHCCCEEEEECCCEEEECCCCCCCCEEEECCCCCCEEEECCCHHHHHHHHC
GTTVIESAASEPEVVDLANFLTKMGANIQGAGTRRIVIEGVEKLRGCNHTVIPDRIEAGT
CCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCH
FMVAAAMMGDGVTLRRVCEEHMTVVTDLLRKCGHHVEFNERGDTVTIIAGKTPKCGEIKT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCCCCCC
APYPGYPTDMQAQMTALFATTPGISVVKDTIFPQRFMHCSELKRMGADIKVDNGTAVISG
CCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEC
VETLSGAPVMASDLRASAALVLAALKAEGTTEIHRLYHIDRGYEMIDEKLLAIGAAVERL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PDDDN
CCCCC
>Mature Secondary Structure
MEKLVVHGGFTLRGAVNISGSKNASLPILAASLLTDEPVVVRRVPDVSDTNFMVQIMGQL
CCEEEEECCEEEEEEEEECCCCCCCCCEEEHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
GASVERSSGNVRVEARNLHSEAAYEQVRKMRASICLMGPLMARMQRCVIPLPGGCVIGDR
CCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCEEECCC
PVDLHIRAIQALGAQVQIERGNLIIEAPRGLKGATVDLSGDHGPTVLGTDNLMMAAVLAE
CCEEEHHHHHHCCCEEEEECCCEEEECCCCCCCCEEEECCCCCCEEEECCCHHHHHHHHC
GTTVIESAASEPEVVDLANFLTKMGANIQGAGTRRIVIEGVEKLRGCNHTVIPDRIEAGT
CCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCH
FMVAAAMMGDGVTLRRVCEEHMTVVTDLLRKCGHHVEFNERGDTVTIIAGKTPKCGEIKT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCCCCCC
APYPGYPTDMQAQMTALFATTPGISVVKDTIFPQRFMHCSELKRMGADIKVDNGTAVISG
CCCCCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEC
VETLSGAPVMASDLRASAALVLAALKAEGTTEIHRLYHIDRGYEMIDEKLLAIGAAVERL
HHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PDDDN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA