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The map label for this gene is hupB [H]

Identifier: 187736379

GI number: 187736379

Start: 2303420

End: 2303689

Strand: Direct

Name: hupB [H]

Synonym: Amuc_1896

Alternate gene names: 187736379

Gene position: 2303420-2303689 (Clockwise)

Preceding gene: 187736378

Following gene: 187736380

Centisome position: 86.46

GC content: 53.33

Gene sequence:

>270_bases
ATGAACAAGGCTCAACTGATCGAACTGATTCAAAGCAAGCTGGGTGCTGATACGACCAAGAAGCACGCTGAAGAAGCTCT
GGCCGCTGTGCTGGAATCCATCAAGGAAGGCGTGAAGGAATCCGGCAAGGTGCAGATCATTGGCTTTGGTACGTTTGCTA
CCAAGACCCGTGAAGCCCGTACCGGCCGCAACCCGAAGACCGGCAACACGATTAATATTCCCGCCTCCAAGACGGTTGCT
TTCAAGGCCTCTTCCGCCTTGAAGGACTAA

Upstream 100 bases:

>100_bases
GCCGGATGACGACAATTAACGCCGTTTTAGGTCCTGATTTTCCTTCACACCGCATTTTTTCTTTACTGTCAGGGCTCCAT
ATGCTATTCACCGAAGTCCT

Downstream 100 bases:

>100_bases
GACGGCAACTCCTTCTCAAGGGAGTACTTTTCTTTCAGCACCCCCGTCCTTTGAGGACAGGGGTGTTTTTTATGTCCCGG
TGCGGATGCACACGGCTTGA

Product: histone family protein DNA-binding protein

Products: NA

Alternate protein names: HU-1; NS1 [H]

Number of amino acids: Translated: 89; Mature: 89

Protein sequence:

>89_residues
MNKAQLIELIQSKLGADTTKKHAEEALAAVLESIKEGVKESGKVQIIGFGTFATKTREARTGRNPKTGNTINIPASKTVA
FKASSALKD

Sequences:

>Translated_89_residues
MNKAQLIELIQSKLGADTTKKHAEEALAAVLESIKEGVKESGKVQIIGFGTFATKTREARTGRNPKTGNTINIPASKTVA
FKASSALKD
>Mature_89_residues
MNKAQLIELIQSKLGADTTKKHAEEALAAVLESIKEGVKESGKVQIIGFGTFATKTREARTGRNPKTGNTINIPASKTVA
FKASSALKD

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=52.8089887640449, Blast_Score=90, Evalue=3e-20,
Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=48.314606741573, Blast_Score=79, Evalue=6e-17,
Organism=Escherichia coli, GI1788005, Length=88, Percent_Identity=35.2272727272727, Blast_Score=61, Evalue=1e-11,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9456; Mature: 9456

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAQLIELIQSKLGADTTKKHAEEALAAVLESIKEGVKESGKVQIIGFGTFATKTREAR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
TGRNPKTGNTINIPASKTVAFKASSALKD
CCCCCCCCCEEECCCCCEEEEECCCCCCC
>Mature Secondary Structure
MNKAQLIELIQSKLGADTTKKHAEEALAAVLESIKEGVKESGKVQIIGFGTFATKTREAR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
TGRNPKTGNTINIPASKTVAFKASSALKD
CCCCCCCCCEEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]