Click here to switch to the map view.

The map label for this gene is tmk

Identifier: 187736367

GI number: 187736367

Start: 2289482

End: 2290102

Strand: Direct

Name: tmk

Synonym: Amuc_1884

Alternate gene names: 187736367

Gene position: 2289482-2290102 (Clockwise)

Preceding gene: 187736366

Following gene: 187736372

Centisome position: 85.94

GC content: 60.23

Gene sequence:

>621_bases
ATGAGTTTTACCGGAGAAAGAAAGGGGAGGCTGATCGTCTTTGAAGGCATTGACGGCACGGGCAAGTCCACCCACATCGG
CCACTTGCGAAAGTATTTGGAGGAGAAGGAGCTGGAAGTGGTGCAGAGTTTTGAGCCCACACGCGGACGGTGGGGCCGGA
TGCTCCGGGACTCCGCCGTGACCGGACGCCTTTCCGTAGAGGAGGAAGTAGCCCTGTTCCTGAAAGACAGGAGGGAACAT
GTGAAGATGCTGATTGCTCCCGCATTGGCGCGGGGGGCATGGGTTCTGCTGGATCGCTACTATCTTTCCATGATGGCTTA
CCAGGGCGCGCGCGGCATAGATCCGGAGGTTATCCGTGCCGCCAATGAAGAATTTGCCCCGGTGCCGGATGCCGTGGTCT
GGCTGGACATTCCCGTTTCCGTGGCGCTGGAACGCATTGGGAACCGCGGGGAACGCGACGCTTTTGAGACGGAAGCGGGC
CTGGCGGCCTGCCGCAGTGTGTTTGCATCCGTCCATGCTCCCTGGATGCTCCGCATAGACGCGGACGCCGGGAAGGAAGA
GGTGGCGGCAAGAGTGCGGAAGGCTCTTTCCATGCGTTTCCCCGATGTCATTGGGGCATAG

Upstream 100 bases:

>100_bases
ACCCGGATGCCGTGGAGTGGATGCACCACACGCTATCCGCCAAAATGCCTGATTCCACCATCGTCGTTCCTGAGCCGGGA
CGCCGCTACACTTTCGAGCC

Downstream 100 bases:

>100_bases
GCATCTCCTTTCGGCCATAGGCCGGGGATTTTTCCTTAGCGTTTCATTCCTGGCATTTGGATGCTATTCCGCAGGCGCAT
AAGCCGTTGGATCCGGAATT

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSFTGERKGRLIVFEGIDGTGKSTHIGHLRKYLEEKELEVVQSFEPTRGRWGRMLRDSAVTGRLSVEEEVALFLKDRREH
VKMLIAPALARGAWVLLDRYYLSMMAYQGARGIDPEVIRAANEEFAPVPDAVVWLDIPVSVALERIGNRGERDAFETEAG
LAACRSVFASVHAPWMLRIDADAGKEEVAARVRKALSMRFPDVIGA

Sequences:

>Translated_206_residues
MSFTGERKGRLIVFEGIDGTGKSTHIGHLRKYLEEKELEVVQSFEPTRGRWGRMLRDSAVTGRLSVEEEVALFLKDRREH
VKMLIAPALARGAWVLLDRYYLSMMAYQGARGIDPEVIRAANEEFAPVPDAVVWLDIPVSVALERIGNRGERDAFETEAG
LAACRSVFASVHAPWMLRIDADAGKEEVAARVRKALSMRFPDVIGA
>Mature_205_residues
SFTGERKGRLIVFEGIDGTGKSTHIGHLRKYLEEKELEVVQSFEPTRGRWGRMLRDSAVTGRLSVEEEVALFLKDRREHV
KMLIAPALARGAWVLLDRYYLSMMAYQGARGIDPEVIRAANEEFAPVPDAVVWLDIPVSVALERIGNRGERDAFETEAGL
AACRSVFASVHAPWMLRIDADAGKEEVAARVRKALSMRFPDVIGA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=164, Percent_Identity=32.9268292682927, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535647, Length=161, Percent_Identity=32.2981366459627, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_AKKM8 (B2UN87)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878479.1
- ProteinModelPortal:   B2UN87
- SMR:   B2UN87
- GeneID:   6274537
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_1884
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23011; Mature: 22880

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTGERKGRLIVFEGIDGTGKSTHIGHLRKYLEEKELEVVQSFEPTRGRWGRMLRDSAV
CCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
TGRLSVEEEVALFLKDRREHVKMLIAPALARGAWVLLDRYYLSMMAYQGARGIDPEVIRA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ANEEFAPVPDAVVWLDIPVSVALERIGNRGERDAFETEAGLAACRSVFASVHAPWMLRID
CCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ADAGKEEVAARVRKALSMRFPDVIGA
CCCCHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure 
SFTGERKGRLIVFEGIDGTGKSTHIGHLRKYLEEKELEVVQSFEPTRGRWGRMLRDSAV
CCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
TGRLSVEEEVALFLKDRREHVKMLIAPALARGAWVLLDRYYLSMMAYQGARGIDPEVIRA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ANEEFAPVPDAVVWLDIPVSVALERIGNRGERDAFETEAGLAACRSVFASVHAPWMLRID
CCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
ADAGKEEVAARVRKALSMRFPDVIGA
CCCCHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA