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The map label for this gene is 187736366

Identifier: 187736366

GI number: 187736366

Start: 2288115

End: 2289485

Strand: Direct

Name: 187736366

Synonym: Amuc_1883

Alternate gene names: NA

Gene position: 2288115-2289485 (Clockwise)

Preceding gene: 187736362

Following gene: 187736367

Centisome position: 85.89

GC content: 57.18

Gene sequence:

>1371_bases
ATGATCAGTTTTACCAATATCAGCGGGGCCGAGGAAATTGGGGCCAATTGCTATTTGCTTGAGATGGACGGCACCAGGAT
TGTGCTTGACAGCGGGATGCACCCCAAGAAGGAGGGGAAGGCGGCCATGCCGGATTTTGATTCCCTGGAACCCAATTCCG
TGGAAGCCGTTTTTTTAAGCCATTCCCACCTGGACCATCTGGGAACGCTGCCTGTGCTTCAGGAGAAACAGCCAGCGGCG
GAGGTGTTCATGACGCCCGCCGCGGCAGCCCTGTCTGAAGTGATGCTGCATAATTCCGTGAATGTGATGAGCGCCAAGAG
GCTGGACCTGGGCATTGTGGAGTATCCTTTTTTCACCCATAATGATCTGGACAGATTGAGCGACGCCTGGCATGCCAAGT
CCTGCAATGAAGTGTTTCGCGTGGGCTTCCGCCAGAACGTGCTGGCCACGTTTTACGATGCCGGGCACATCCTGGGGTCT
GCCGGCGTGATGCTGGAGGGTGAGAGCGGCCATACCGTATTTTATACGGGGGACGTGCAGTTTGAAGACCAGAGCATGAT
TCCCGGGGCTGATTTTCCGGAATCCGGCGTAGATACGCTGGTTATGGAGTGCACGCGCGGCGGTTTCCAGCGCAGCGCCC
ACTATTCCCGGCCGGAAGAGATGGTGAGGTTCGGGAAAGCGATTGCGGAGACGCTGGAACGCGGCGGCGCCGTACTGATT
CCGGTATTCGCCATCGGCAAGAGCCAGGAGATGCTGTTCAACATTCACCGTTTCAAGCAGCAGGGGGTGATTCCCGCCAA
TACTCCCGTGTACTTCGGCGGGCTGAGCGCGAAAGTTTCCCTGTTGTACGACCGTTTTGCCGGGTTGACGCGCAGGCATG
ACCATGAATTCAAGCTGAAGGAGGAGATTCAGACCGTGCCCCTTCCGCGCAAGGGAAAAGCTCCGCTGGTGTGTTCCCCG
GGGAATATTTATGTGGTGTCCAGCGGCATGATGACGGAAAATACGCTTTCCAACGTCATGGCGGAGCAGGTTCTTCCCCA
GGAGAAGAATGCTATTTTGTTCGTAGGATATGCGGATCCTGATTCTCCGGCGGGACTGCTGAAGGCAACTCCTGAAGGGG
AACTGGTGAAAATGAGGCCCAACGGGCAGCCGGTGCGCCGCAAGTGCACCGTGGACTGTTTTGATTTTTCCGGGCATGCC
ACCCGGGACTCCCTGGTTAATTATGCCGTGAAGCTGAACCCCAGGCAGGTGGTTCTGGTGCACGGGGACCCGGATGCCGT
GGAGTGGATGCACCACACGCTATCCGCCAAAATGCCTGATTCCACCATCGTCGTTCCTGAGCCGGGACGCCGCTACACTT
TCGAGCCATGA

Upstream 100 bases:

>100_bases
CTTCTTCCCCATTGGCCTGCGTTCCCTTCCCGGCAGAGGTCCGCTTGGGCTTGCGGCATTGACACGGCGGGAGGCACGGG
GTACTCTCCTGCGGCATATA

Downstream 100 bases:

>100_bases
GTTTTACCGGAGAAAGAAAGGGGAGGCTGATCGTCTTTGAAGGCATTGACGGCACGGGCAAGTCCACCCACATCGGCCAC
TTGCGAAAGTATTTGGAGGA

Product: beta-lactamase domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MISFTNISGAEEIGANCYLLEMDGTRIVLDSGMHPKKEGKAAMPDFDSLEPNSVEAVFLSHSHLDHLGTLPVLQEKQPAA
EVFMTPAAAALSEVMLHNSVNVMSAKRLDLGIVEYPFFTHNDLDRLSDAWHAKSCNEVFRVGFRQNVLATFYDAGHILGS
AGVMLEGESGHTVFYTGDVQFEDQSMIPGADFPESGVDTLVMECTRGGFQRSAHYSRPEEMVRFGKAIAETLERGGAVLI
PVFAIGKSQEMLFNIHRFKQQGVIPANTPVYFGGLSAKVSLLYDRFAGLTRRHDHEFKLKEEIQTVPLPRKGKAPLVCSP
GNIYVVSSGMMTENTLSNVMAEQVLPQEKNAILFVGYADPDSPAGLLKATPEGELVKMRPNGQPVRRKCTVDCFDFSGHA
TRDSLVNYAVKLNPRQVVLVHGDPDAVEWMHHTLSAKMPDSTIVVPEPGRRYTFEP

Sequences:

>Translated_456_residues
MISFTNISGAEEIGANCYLLEMDGTRIVLDSGMHPKKEGKAAMPDFDSLEPNSVEAVFLSHSHLDHLGTLPVLQEKQPAA
EVFMTPAAAALSEVMLHNSVNVMSAKRLDLGIVEYPFFTHNDLDRLSDAWHAKSCNEVFRVGFRQNVLATFYDAGHILGS
AGVMLEGESGHTVFYTGDVQFEDQSMIPGADFPESGVDTLVMECTRGGFQRSAHYSRPEEMVRFGKAIAETLERGGAVLI
PVFAIGKSQEMLFNIHRFKQQGVIPANTPVYFGGLSAKVSLLYDRFAGLTRRHDHEFKLKEEIQTVPLPRKGKAPLVCSP
GNIYVVSSGMMTENTLSNVMAEQVLPQEKNAILFVGYADPDSPAGLLKATPEGELVKMRPNGQPVRRKCTVDCFDFSGHA
TRDSLVNYAVKLNPRQVVLVHGDPDAVEWMHHTLSAKMPDSTIVVPEPGRRYTFEP
>Mature_456_residues
MISFTNISGAEEIGANCYLLEMDGTRIVLDSGMHPKKEGKAAMPDFDSLEPNSVEAVFLSHSHLDHLGTLPVLQEKQPAA
EVFMTPAAAALSEVMLHNSVNVMSAKRLDLGIVEYPFFTHNDLDRLSDAWHAKSCNEVFRVGFRQNVLATFYDAGHILGS
AGVMLEGESGHTVFYTGDVQFEDQSMIPGADFPESGVDTLVMECTRGGFQRSAHYSRPEEMVRFGKAIAETLERGGAVLI
PVFAIGKSQEMLFNIHRFKQQGVIPANTPVYFGGLSAKVSLLYDRFAGLTRRHDHEFKLKEEIQTVPLPRKGKAPLVCSP
GNIYVVSSGMMTENTLSNVMAEQVLPQEKNAILFVGYADPDSPAGLLKATPEGELVKMRPNGQPVRRKCTVDCFDFSGHA
TRDSLVNYAVKLNPRQVVLVHGDPDAVEWMHHTLSAKMPDSTIVVPEPGRRYTFEP

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=443, Percent_Identity=28.6681715575621, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI33300633, Length=449, Percent_Identity=25.1670378619154, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI32566029, Length=450, Percent_Identity=27.1111111111111, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32564696, Length=447, Percent_Identity=25.2796420581655, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323307, Length=446, Percent_Identity=26.0089686098655, Blast_Score=150, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24648013, Length=447, Percent_Identity=26.8456375838926, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21358523, Length=449, Percent_Identity=25.6124721603563, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 50211; Mature: 50211

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISFTNISGAEEIGANCYLLEMDGTRIVLDSGMHPKKEGKAAMPDFDSLEPNSVEAVFLS
CEEECCCCCHHHHCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
HSHLDHLGTLPVLQEKQPAAEVFMTPAAAALSEVMLHNSVNVMSAKRLDLGIVEYPFFTH
CCCHHHHCCCCCCCCCCCHHHEEECHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCC
NDLDRLSDAWHAKSCNEVFRVGFRQNVLATFYDAGHILGSAGVMLEGESGHTVFYTGDVQ
CCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCEE
FEDQSMIPGADFPESGVDTLVMECTRGGFQRSAHYSRPEEMVRFGKAIAETLERGGAVLI
ECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEE
PVFAIGKSQEMLFNIHRFKQQGVIPANTPVYFGGLSAKVSLLYDRFAGLTRRHDHEFKLK
EEEECCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCEEH
EEIQTVPLPRKGKAPLVCSPGNIYVVSSGMMTENTLSNVMAEQVLPQEKNAILFVGYADP
HHHHHCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
DSPAGLLKATPEGELVKMRPNGQPVRRKCTVDCFDFSGHATRDSLVNYAVKLNPRQVVLV
CCCCCEEEECCCCCEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHEEEEEECCEEEEEE
HGDPDAVEWMHHTLSAKMPDSTIVVPEPGRRYTFEP
ECCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MISFTNISGAEEIGANCYLLEMDGTRIVLDSGMHPKKEGKAAMPDFDSLEPNSVEAVFLS
CEEECCCCCHHHHCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
HSHLDHLGTLPVLQEKQPAAEVFMTPAAAALSEVMLHNSVNVMSAKRLDLGIVEYPFFTH
CCCHHHHCCCCCCCCCCCHHHEEECHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCCC
NDLDRLSDAWHAKSCNEVFRVGFRQNVLATFYDAGHILGSAGVMLEGESGHTVFYTGDVQ
CCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEECCEE
FEDQSMIPGADFPESGVDTLVMECTRGGFQRSAHYSRPEEMVRFGKAIAETLERGGAVLI
ECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEE
PVFAIGKSQEMLFNIHRFKQQGVIPANTPVYFGGLSAKVSLLYDRFAGLTRRHDHEFKLK
EEEECCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCCEEH
EEIQTVPLPRKGKAPLVCSPGNIYVVSSGMMTENTLSNVMAEQVLPQEKNAILFVGYADP
HHHHHCCCCCCCCCCEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCC
DSPAGLLKATPEGELVKMRPNGQPVRRKCTVDCFDFSGHATRDSLVNYAVKLNPRQVVLV
CCCCCEEEECCCCCEEEECCCCCCCCEEEEEEEEECCCCCCHHHHHEEEEEECCEEEEEE
HGDPDAVEWMHHTLSAKMPDSTIVVPEPGRRYTFEP
ECCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]