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The map label for this gene is rmlD [H]

Identifier: 187736304

GI number: 187736304

Start: 2205553

End: 2206458

Strand: Direct

Name: rmlD [H]

Synonym: Amuc_1817

Alternate gene names: 187736304

Gene position: 2205553-2206458 (Clockwise)

Preceding gene: 187736302

Following gene: 187736305

Centisome position: 82.79

GC content: 58.83

Gene sequence:

>906_bases
ATGTACAGAACATTGGTGTTCGGGGCGGACGGCCGGGTGGGAAGCCGTCTGGCAGCGTATCTGGAAGAACATGGCCTGGA
GGTGGTGAAGTGCGGACGGGGCTTTTGTGATTTGAAGGATTTAAGCGCTTTGAAACGTGTTCTGCTTTCTTCCGGAGCCA
CTCATGTGGTGAATTGCGCCGCTGTGAGCGGATTGGAAGCCTGCCTGGATGATCCGGAGACGGCCCACTGCGTCAACGCC
ATGGCTCCGGAGATGATGGCGCGCATTTGCCGCCTGGAGGGCATGCGCTTTATCCATTTGAGTACGGATTATGTGCTGGA
CGGCAGGAGGAGAGGTTTGAAAACGGAGGAGGGGAAGTGCCGCCCCGTAAATGTGTACGGAGAGTCCAAGCTGGAGGCGG
AATTCCGTGTGCGGGAGGAGATGCCGGACGCTCTGATAGCCCGCGTTTCCTGGGTATTCGGCAATCCGGAACGGCCCTCA
TTCCCGGAAATGGTGCTGCGGCGGGCGATGAAAAGGGAGCCCCTGGCCGCTGTGGCGGATAAATGGTCCATGCCTACATG
GGTGGAAGATTTATGTGCATGGCTCCGTTTTCTGGCTTATGAGAGCGGGGCGTCCGGCGTGCTGCATCTGTGTCAGTCCG
GAGAGCCTGTTTCCTGGCACAGTTATGCCGTGGCCGTGCTGAAATGCGCCGTGAAGCACGGGTTACTGCCTTCTTTGCCG
CCTGTGGCGGAACAAAAGCTCGACGAACAGGCCGGTTTCAGGGATGCTCGGCCCCGGCATACCGCCATGTCCAGCGAACG
CCTCTCTTCCCTGATGAAGCAGCCCGTGAGGGCGTATGAAGAGGCCATTGACATGGCCGTGGCCCGCTATGCCGCAGATC
CAACCTTTCTCTCCAGCATTTCATGA

Upstream 100 bases:

>100_bases
GTAAAACACAACTTTAATTCAAACAACCTTTCCTTCTTTTGTCACGATGAAAAAAGGTTTTCATTGGATTTTGGAGGGTG
AAACGTCTAAGCTCTGCGTC

Downstream 100 bases:

>100_bases
ATGATTTCCACAATTCCCGTGATTCCCGCCCCAGGCCCGTTTACCGGGACCGCCGTTCCCAGCCGGGCCGCCCGCGCACA
GCTCCCAAAAAGAACCTTTT

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MYRTLVFGADGRVGSRLAAYLEEHGLEVVKCGRGFCDLKDLSALKRVLLSSGATHVVNCAAVSGLEACLDDPETAHCVNA
MAPEMMARICRLEGMRFIHLSTDYVLDGRRRGLKTEEGKCRPVNVYGESKLEAEFRVREEMPDALIARVSWVFGNPERPS
FPEMVLRRAMKREPLAAVADKWSMPTWVEDLCAWLRFLAYESGASGVLHLCQSGEPVSWHSYAVAVLKCAVKHGLLPSLP
PVAEQKLDEQAGFRDARPRHTAMSSERLSSLMKQPVRAYEEAIDMAVARYAADPTFLSSIS

Sequences:

>Translated_301_residues
MYRTLVFGADGRVGSRLAAYLEEHGLEVVKCGRGFCDLKDLSALKRVLLSSGATHVVNCAAVSGLEACLDDPETAHCVNA
MAPEMMARICRLEGMRFIHLSTDYVLDGRRRGLKTEEGKCRPVNVYGESKLEAEFRVREEMPDALIARVSWVFGNPERPS
FPEMVLRRAMKREPLAAVADKWSMPTWVEDLCAWLRFLAYESGASGVLHLCQSGEPVSWHSYAVAVLKCAVKHGLLPSLP
PVAEQKLDEQAGFRDARPRHTAMSSERLSSLMKQPVRAYEEAIDMAVARYAADPTFLSSIS
>Mature_301_residues
MYRTLVFGADGRVGSRLAAYLEEHGLEVVKCGRGFCDLKDLSALKRVLLSSGATHVVNCAAVSGLEACLDDPETAHCVNA
MAPEMMARICRLEGMRFIHLSTDYVLDGRRRGLKTEEGKCRPVNVYGESKLEAEFRVREEMPDALIARVSWVFGNPERPS
FPEMVLRRAMKREPLAAVADKWSMPTWVEDLCAWLRFLAYESGASGVLHLCQSGEPVSWHSYAVAVLKCAVKHGLLPSLP
PVAEQKLDEQAGFRDARPRHTAMSSERLSSLMKQPVRAYEEAIDMAVARYAADPTFLSSIS

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=283, Percent_Identity=23.6749116607774, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI11034825, Length=283, Percent_Identity=23.6749116607774, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1788352, Length=251, Percent_Identity=31.4741035856574, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 33391; Mature: 33391

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRTLVFGADGRVGSRLAAYLEEHGLEVVKCGRGFCDLKDLSALKRVLLSSGATHVVNCA
CCEEEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
AVSGLEACLDDPETAHCVNAMAPEMMARICRLEGMRFIHLSTDYVLDGRRRGLKTEEGKC
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCHHCCCCCCCCCC
RPVNVYGESKLEAEFRVREEMPDALIARVSWVFGNPERPSFPEMVLRRAMKREPLAAVAD
EEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHH
KWSMPTWVEDLCAWLRFLAYESGASGVLHLCQSGEPVSWHSYAVAVLKCAVKHGLLPSLP
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
PVAEQKLDEQAGFRDARPRHTAMSSERLSSLMKQPVRAYEEAIDMAVARYAADPTFLSSI
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
S
C
>Mature Secondary Structure
MYRTLVFGADGRVGSRLAAYLEEHGLEVVKCGRGFCDLKDLSALKRVLLSSGATHVVNCA
CCEEEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
AVSGLEACLDDPETAHCVNAMAPEMMARICRLEGMRFIHLSTDYVLDGRRRGLKTEEGKC
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEECCHHCCCCCCCCCC
RPVNVYGESKLEAEFRVREEMPDALIARVSWVFGNPERPSFPEMVLRRAMKREPLAAVAD
EEEEECCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHH
KWSMPTWVEDLCAWLRFLAYESGASGVLHLCQSGEPVSWHSYAVAVLKCAVKHGLLPSLP
CCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
PVAEQKLDEQAGFRDARPRHTAMSSERLSSLMKQPVRAYEEAIDMAVARYAADPTFLSSI
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA