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The map label for this gene is dxr [H]

Identifier: 187736224

GI number: 187736224

Start: 2118730

End: 2119905

Strand: Reverse

Name: dxr [H]

Synonym: Amuc_1737

Alternate gene names: 187736224

Gene position: 2119905-2118730 (Counterclockwise)

Preceding gene: 187736226

Following gene: 187736223

Centisome position: 79.57

GC content: 63.35

Gene sequence:

>1176_bases
ATGCAGAAACGACGCGTTGTCATCCTGGGGTCCACAGGTTCCATCGGAACCAGTGCCCTGAAAGTCGCCCGGGACATTCC
GGACAGAATGGAAATCGTGGGGCTGGCCGCAGGAACCAGCGTGGAGGCGCTGGCCCGCCAGGCACGCGAATTCAACGTCC
GCAACGTATGCATTTATGACCCGTCCGGAGCTGCCGGTCTGGCGGCCTCCCTCCCCGGCGCGCAGGTGGAAACGGGAGAA
GAGGGGCTGTGCCGCCTGGCGCAGCTCCCGGAGGCGGACATGGTATTAATCTCCATCGTGGGAACCGCCGGGCTCAAACC
CGCTCTGGCCGCCATTGAAGCAGGCAAGGACCTCGCCATCGCCAGCAAGGAAATCCTGGTCATGGCCGGGCAAATTGTCA
TGGAAAAAACCCGCCGGGCCGGTGTGCAGGTGCTTCCGGTGGACAGCGAGCACAACGCCATTTTCCAATGCCTGAACGGC
AGCCACGGCGGCCCGGAAGCCGTCTCCCGCCTGATTCTGACGGCATCCGGCGGCCCCTTCCGCACCTGGAACAGGGAAGA
TCTGGAACACGTCACGCTGGAACAGGCCCTCAAGCACCCCACCTGGAGCATGGGCCGCAAAATCACCATAGACTCCGCCA
CCCTGTTCAATAAAGGGCTGGAAATGATTGAGGCCCGCTGGCTCTTTGACGTCCCCATGGAAAAAGTGGACGTCATCGTC
CACCCGCAGAGCATCGTGCACTCCATGGTGGAATACCGAGACGGCACGGTGCTGGCCCAGATGAGCAGCTCGGACATGTG
CTTTCCCATCCAGTACGCCGTCACGTGGCCGGACCGCGTTCCCAACTCCCTGAAACAGCTCAATTTCTCGGAAATCGGCC
GGCTGGTGTTCGAGGCCCCCCGCACGGACGTCTTCCCCGCCCTGGACCTGGCGCGCAGGGCCGGAGCCGGCAACAGCACC
CTGGCAGCCGTTTACAACGCCGCCAATGAAGCGGCGGTAAATGCCTTTATCCACGGCCAAATCTCTTTCCCCGGCATCTG
GAAACTGGTGGAGGCCGTCATGGACGACCACACCCCGGCGGATCCCTGCGGGGAACTGGCCCCCATTCTGGAAGCGGACC
AATGGGCCAGGAGGCGCGCGGCGGAGCTGCTCCCATCCTTTTCCCGCCCCTGCTGA

Upstream 100 bases:

>100_bases
GAAGCCGTACTGACGGAAAAAACGGTCCACGCGGCGCGGGGAAGATTTTCATCCCCCGGCTTGTCAAGAGGCCGTATTTT
TTGCATCATGTTTCTCCGTT

Downstream 100 bases:

>100_bases
CGCCATGACCGCCCGGACTCCCGCCGGAACGCCGCCCCCGGCCGCGCGCATCACCATTCTGGATATCCTCCGGGCCCTGG
CCCTGCTGGGCATCGTCATC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQKRRVVILGSTGSIGTSALKVARDIPDRMEIVGLAAGTSVEALARQAREFNVRNVCIYDPSGAAGLAASLPGAQVETGE
EGLCRLAQLPEADMVLISIVGTAGLKPALAAIEAGKDLAIASKEILVMAGQIVMEKTRRAGVQVLPVDSEHNAIFQCLNG
SHGGPEAVSRLILTASGGPFRTWNREDLEHVTLEQALKHPTWSMGRKITIDSATLFNKGLEMIEARWLFDVPMEKVDVIV
HPQSIVHSMVEYRDGTVLAQMSSSDMCFPIQYAVTWPDRVPNSLKQLNFSEIGRLVFEAPRTDVFPALDLARRAGAGNST
LAAVYNAANEAAVNAFIHGQISFPGIWKLVEAVMDDHTPADPCGELAPILEADQWARRRAAELLPSFSRPC

Sequences:

>Translated_391_residues
MQKRRVVILGSTGSIGTSALKVARDIPDRMEIVGLAAGTSVEALARQAREFNVRNVCIYDPSGAAGLAASLPGAQVETGE
EGLCRLAQLPEADMVLISIVGTAGLKPALAAIEAGKDLAIASKEILVMAGQIVMEKTRRAGVQVLPVDSEHNAIFQCLNG
SHGGPEAVSRLILTASGGPFRTWNREDLEHVTLEQALKHPTWSMGRKITIDSATLFNKGLEMIEARWLFDVPMEKVDVIV
HPQSIVHSMVEYRDGTVLAQMSSSDMCFPIQYAVTWPDRVPNSLKQLNFSEIGRLVFEAPRTDVFPALDLARRAGAGNST
LAAVYNAANEAAVNAFIHGQISFPGIWKLVEAVMDDHTPADPCGELAPILEADQWARRRAAELLPSFSRPC
>Mature_391_residues
MQKRRVVILGSTGSIGTSALKVARDIPDRMEIVGLAAGTSVEALARQAREFNVRNVCIYDPSGAAGLAASLPGAQVETGE
EGLCRLAQLPEADMVLISIVGTAGLKPALAAIEAGKDLAIASKEILVMAGQIVMEKTRRAGVQVLPVDSEHNAIFQCLNG
SHGGPEAVSRLILTASGGPFRTWNREDLEHVTLEQALKHPTWSMGRKITIDSATLFNKGLEMIEARWLFDVPMEKVDVIV
HPQSIVHSMVEYRDGTVLAQMSSSDMCFPIQYAVTWPDRVPNSLKQLNFSEIGRLVFEAPRTDVFPALDLARRAGAGNST
LAAVYNAANEAAVNAFIHGQISFPGIWKLVEAVMDDHTPADPCGELAPILEADQWARRRAAELLPSFSRPC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=371, Percent_Identity=43.9353099730458, Blast_Score=293, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42197; Mature: 42197

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRRVVILGSTGSIGTSALKVARDIPDRMEIVGLAAGTSVEALARQAREFNVRNVCIYD
CCCCEEEEEECCCCCCHHHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHHCCCCEEEEEC
PSGAAGLAASLPGAQVETGEEGLCRLAQLPEADMVLISIVGTAGLKPALAAIEAGKDLAI
CCCCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEE
ASKEILVMAGQIVMEKTRRAGVQVLPVDSEHNAIFQCLNGSHGGPEAVSRLILTASGGPF
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCHHHHHHEEEEECCCCC
RTWNREDLEHVTLEQALKHPTWSMGRKITIDSATLFNKGLEMIEARWLFDVPMEKVDVIV
CCCCHHHHHHHHHHHHHCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
HPQSIVHSMVEYRDGTVLAQMSSSDMCFPIQYAVTWPDRVPNSLKQLNFSEIGRLVFEAP
CCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCHHCCHHHHHCCHHHHHHHHHCCC
RTDVFPALDLARRAGAGNSTLAAVYNAANEAAVNAFIHGQISFPGIWKLVEAVMDDHTPA
CCCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHEEEEEEEEECCCHHHHHHHHHHCCCCCC
DPCGELAPILEADQWARRRAAELLPSFSRPC
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQKRRVVILGSTGSIGTSALKVARDIPDRMEIVGLAAGTSVEALARQAREFNVRNVCIYD
CCCCEEEEEECCCCCCHHHHHHHHCCCCHHHEEEEECCCCHHHHHHHHHHCCCCEEEEEC
PSGAAGLAASLPGAQVETGEEGLCRLAQLPEADMVLISIVGTAGLKPALAAIEAGKDLAI
CCCCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEE
ASKEILVMAGQIVMEKTRRAGVQVLPVDSEHNAIFQCLNGSHGGPEAVSRLILTASGGPF
HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCHHHHHHEEEEECCCCC
RTWNREDLEHVTLEQALKHPTWSMGRKITIDSATLFNKGLEMIEARWLFDVPMEKVDVIV
CCCCHHHHHHHHHHHHHCCCCHHCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
HPQSIVHSMVEYRDGTVLAQMSSSDMCFPIQYAVTWPDRVPNSLKQLNFSEIGRLVFEAP
CCHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCHHCCHHHHHCCHHHHHHHHHCCC
RTDVFPALDLARRAGAGNSTLAAVYNAANEAAVNAFIHGQISFPGIWKLVEAVMDDHTPA
CCCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHEEEEEEEEECCCHHHHHHHHHHCCCCCC
DPCGELAPILEADQWARRRAAELLPSFSRPC
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA