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The map label for this gene is hisD2 [H]

Identifier: 187736201

GI number: 187736201

Start: 2082977

End: 2084275

Strand: Direct

Name: hisD2 [H]

Synonym: Amuc_1714

Alternate gene names: 187736201

Gene position: 2082977-2084275 (Clockwise)

Preceding gene: 187736198

Following gene: 187736202

Centisome position: 78.19

GC content: 60.74

Gene sequence:

>1299_bases
ATGAAAATTTACCGTCCTTCCGATACCTGCTTTGACGAGATGAAGCGCCGGATGAACCGCCGCGCACTCCCGGAGGATTC
CGTAAGGGATACCGTGAACGCTATTATCCGGGATGTTTCCGTGCGCGGAGATGAAGCCCTGTTTGATTATGCCGCCAGAT
TTGACAAGGCGCATCTGGATTCTTCCTCCCTGTTCGTAACGGAGGCAGAACTGGCGGAAGCGGAGGCCATGGTGGAGGAG
TCTGTGAAGGAGGCCATTGCCGTTTCTCTGGCAAACATCCATTATTTTTCAGACCGCAGCCGCAGGCGGGACTGGTCCGG
CGTGAATGCGCAGGGCGTGGAGGTAGCGGAGCGGTTCCTTCCGTACGACCGTGTGGGCATTTATATCCCCGGAGGAAAGG
CTCCCCTGGTATCTACTTCCATCATGACGGGCGGTTTTGCTCAGGCCGCCGGCGTGCGGGAGATTGTGGCCGCCACGCCC
TGCGGGCCGGACGGCCGGGTGAATCCCGCGCTTTTGTATGCGCTGAAAGCCTCCGGCGCAACGGAGATTGTCAAGATAGG
GGGAGCCCAGGCGATAGCCGCCCTTGCGCTGGGGACGGAGAGCGTGAGACCGGTGGAGAAGATTTTTGGCCCCGGCAACC
GTTTTGTGGTGGAGGCCAAGCGTCAGTTGGTGGGGGCCGTTGCCATTGATTTGCTGCCCGGCCCCAGTGAAGTAATGGTG
CTGGCAGATGATACTGCGGATGCGGAGTTCCTTGCTGCCGACCTGCTGGCGCAGGGCGAGCATGGCCCGGACAGCGTAGT
TGTTTTTGTCACCACATCGAAAGCGTTATTGGAGCAGGTGGAGGCGGAAGTGGAACGCCAGGCCGCCCTGCTGAGCCGCG
GGTCCATCATCCGGGAGGTGCTGGACAAGCATGCCTACGGTTTTCTGGTTTCTTCCATTCAGGAAGGGGTGGAACTGGTT
AATGCTTTTGCGCCGGAACATTTGGTGCTCGTCACGAGGGATGAAGAAGCCGTGCTGAATGGCATCAGGACGGCGGGAGC
CATTTACGCAGGCTCCCTTTCTACTGTAGCCTGCGGGGATTTTCTGGCGGGTCCCAGCCATACGCTGCCTACCGGCGGCG
CCGGCAAGTCTTTTTCCGGCTTGCGGGCGGATCAGTTCCAGCGCCGCACCAGCGTGGTGCGCATGGACCGGAATGCCGTG
CTGAACTCCGCCCCGTATGTGGCAGAGTTCGCCCGGGTGGAGGGGCTGGACGCCCACAACCACTCCATTCAGGTTCGCGC
CGCCCGTGTGGACCGGTAA

Upstream 100 bases:

>100_bases
GGCGCCGTGAAGCCCTGTTGGAAATCAAAGAGGACAGAAGGCTTGACTGCGTGCTTAAAGATTGGGAAACTTCCTTTCCG
TTTTTCTGTAGAGACCTTTT

Downstream 100 bases:

>100_bases
TTCCGGATTTTTCCAATTCTCTCCATGATGCAACAGCGGGGAACCAGGGAACGGTTGCCAATTGCAGCAGGTCTCCTTAT
TGCCGGACATGGCGATATGG

Product: Histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKIYRPSDTCFDEMKRRMNRRALPEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHLDSSSLFVTEAELAEAEAMVEE
SVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFLPYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATP
CGPDGRVNPALLYALKASGATEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQLVGAVAIDLLPGPSEVMV
LADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREVLDKHAYGFLVSSIQEGVELV
NAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGDFLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAV
LNSAPYVAEFARVEGLDAHNHSIQVRAARVDR

Sequences:

>Translated_432_residues
MKIYRPSDTCFDEMKRRMNRRALPEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHLDSSSLFVTEAELAEAEAMVEE
SVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFLPYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATP
CGPDGRVNPALLYALKASGATEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQLVGAVAIDLLPGPSEVMV
LADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREVLDKHAYGFLVSSIQEGVELV
NAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGDFLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAV
LNSAPYVAEFARVEGLDAHNHSIQVRAARVDR
>Mature_432_residues
MKIYRPSDTCFDEMKRRMNRRALPEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHLDSSSLFVTEAELAEAEAMVEE
SVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFLPYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATP
CGPDGRVNPALLYALKASGATEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQLVGAVAIDLLPGPSEVMV
LADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREVLDKHAYGFLVSSIQEGVELV
NAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGDFLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAV
LNSAPYVAEFARVEGLDAHNHSIQVRAARVDR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=424, Percent_Identity=37.5, Blast_Score=275, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=36.4928909952607, Blast_Score=256, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46292; Mature: 46292

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYRPSDTCFDEMKRRMNRRALPEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHLD
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
SSSLFVTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFL
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHC
PYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASGA
CCCCEEEEECCCCCCEEEHHHHCCCHHHHCCHHHHHHCCCCCCCCCCCHHEEEEEECCCC
TEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQLVGAVAIDLLPGPSEVMV
CEEEEECCHHHHHHHHHCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHEEECCCCCCEEE
LADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREV
EECCCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDKHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCEEECCCCHHHCCH
FLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGLDAHN
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCCC
HSIQVRAARVDR
CEEEEEEECCCC
>Mature Secondary Structure
MKIYRPSDTCFDEMKRRMNRRALPEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHLD
CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
SSSLFVTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFL
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHC
PYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASGA
CCCCEEEEECCCCCCEEEHHHHCCCHHHHCCHHHHHHCCCCCCCCCCCHHEEEEEECCCC
TEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQLVGAVAIDLLPGPSEVMV
CEEEEECCHHHHHHHHHCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHEEECCCCCCEEE
LADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREV
EECCCCCHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDKHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCEEECCCCHHHCCH
FLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGLDAHN
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCCC
HSIQVRAARVDR
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA