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The map label for this gene is nqo1 [H]

Identifier: 187736101

GI number: 187736101

Start: 1937703

End: 1939103

Strand: Reverse

Name: nqo1 [H]

Synonym: Amuc_1612

Alternate gene names: 187736101

Gene position: 1939103-1937703 (Counterclockwise)

Preceding gene: 187736102

Following gene: 187736100

Centisome position: 72.79

GC content: 58.67

Gene sequence:

>1401_bases
ATGAGCATCACCTATCTTCCCGGTAAAGAACCCCACCCCAGGGAAACGCGCCGCATTCTGAAAAACGTCAACCGCGAGGG
CTGGAATACCTCCATTGACTGCTATCTGGCCGACGGCGGTTATGAAGAACTGAAAAAGGCGCTCGGCATGGAGCCCAGGG
CCGTCATTGACGAGGTGAAAAAATCCGGTCTTCGCGGCCGTGGCGGCGCGGGGTTCCCCACCGGCGTGAAATGGACCTTC
ATTCCGCCGAACAACACGAAGCCTGTTTACCTGGTTTGCAACTGTGACGAATCCGAACCAGGCACGTTCAAGGACCGCTA
CATTGTCCATCAGGATCCCCACCAGCTCATTGAAGGAATGGTCATCTCCAGCTACGCGGTGGGAGCGCATCAGGCTTACA
TCTACATGCGCGAAGAATTTCCCATCGCCGCGGAAATCATGCTCAAAGCCCTTCAGGAAGCTCGCGAACGCGGCTTCCTG
GGCAGCAATATCCAGGGGTCCGGCTATAATCTGGAAATCCACCTGCACCGCGGAGCGGGAGCGTACATTTGCGGTGAGGA
AACGGCCCTGCTCAACTCCCTTGAAGGGGATCGCCCCTATCCCCGCATCAAGCCCCCCTACTTCCCGGCCGCCATCGGCC
TGTACGGATGCCCCACCATTGTCAACAACGTGGAATCCCTCTGCCAGGTGAAACACATCATGGCCATGGGAGGAGAAGCC
TACAGCCAGGAAGGAGCCAAACGTTCCCCCGGCACCCGCATCATCGGGGTTTCCGGCGACGTCAAACGTCCTGGGTTCTA
TGAAATCGTCTCCGGCTCCATGACCTTCGGTGAACTGCTGTATGACGTCTGCGGCGGCCCGCGGGACGGGCGCCAGTTCA
AGGCCGTGATACCCGGAGGCTCCTCCTCCAAGGTCATGCGCACGGATGCGGAATACAAAGTGCAGAATCCGGACGGCACC
ATGGGAAAAATCACCTTTTTCGACATTCCGCTGGATCTGGACAGCATCGCCCGGCACGGCTCCATGTCCGGTTCCGGCGC
GGTCATCGTCATGGACGACTCCCGCTCCATGCCCTGGGCCATGAACAACATCAACCGTTTCTACGCCCATGAATCCTGCG
GGCAGTGCACTCCCTGCCGGGAAGGCTGTCCGTGGATGATGAAACTCAGCACCCGCATCCTGGAAGGAAAAGCCGCCCCG
TCGGATGTGGATCTGCTCATTGAAGTGGCCAACCAGATTGAAGGAAAAACGGTCTGCGCCTTTGGTGAAGCCGCCTCCTG
GCCCACCCAGGCCATGGTCTCCAAATTCAAGGAAGAATTCGTAGCCCTGACGGATCCATTCAACGCCTGTCTGCCCCACA
CGGAGGAAGGCAGGGAGCAAAACCGTTTCCTCACCCGCTAA

Upstream 100 bases:

>100_bases
TCTCCTGTACGAAAAAGTCACTCCGGAAGTGCTGGAAGAAGTGATTGCCAAATATCAGACAGCCTAACCCTTTCCATTTC
CCACGCACCAGATTTTCGCC

Downstream 100 bases:

>100_bases
ACAGCAGCACGCAACACCAGTTCTCAAAACCATCCCTCTCCATCCGTCATCATGAGTGAAGAAGCTTCCAAACTCCCCAA
AGACATTGCCGCCGCGGAAG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I chain 1; NDH-1 subunit 1 [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSITYLPGKEPHPRETRRILKNVNREGWNTSIDCYLADGGYEELKKALGMEPRAVIDEVKKSGLRGRGGAGFPTGVKWTF
IPPNNTKPVYLVCNCDESEPGTFKDRYIVHQDPHQLIEGMVISSYAVGAHQAYIYMREEFPIAAEIMLKALQEARERGFL
GSNIQGSGYNLEIHLHRGAGAYICGEETALLNSLEGDRPYPRIKPPYFPAAIGLYGCPTIVNNVESLCQVKHIMAMGGEA
YSQEGAKRSPGTRIIGVSGDVKRPGFYEIVSGSMTFGELLYDVCGGPRDGRQFKAVIPGGSSSKVMRTDAEYKVQNPDGT
MGKITFFDIPLDLDSIARHGSMSGSGAVIVMDDSRSMPWAMNNINRFYAHESCGQCTPCREGCPWMMKLSTRILEGKAAP
SDVDLLIEVANQIEGKTVCAFGEAASWPTQAMVSKFKEEFVALTDPFNACLPHTEEGREQNRFLTR

Sequences:

>Translated_466_residues
MSITYLPGKEPHPRETRRILKNVNREGWNTSIDCYLADGGYEELKKALGMEPRAVIDEVKKSGLRGRGGAGFPTGVKWTF
IPPNNTKPVYLVCNCDESEPGTFKDRYIVHQDPHQLIEGMVISSYAVGAHQAYIYMREEFPIAAEIMLKALQEARERGFL
GSNIQGSGYNLEIHLHRGAGAYICGEETALLNSLEGDRPYPRIKPPYFPAAIGLYGCPTIVNNVESLCQVKHIMAMGGEA
YSQEGAKRSPGTRIIGVSGDVKRPGFYEIVSGSMTFGELLYDVCGGPRDGRQFKAVIPGGSSSKVMRTDAEYKVQNPDGT
MGKITFFDIPLDLDSIARHGSMSGSGAVIVMDDSRSMPWAMNNINRFYAHESCGQCTPCREGCPWMMKLSTRILEGKAAP
SDVDLLIEVANQIEGKTVCAFGEAASWPTQAMVSKFKEEFVALTDPFNACLPHTEEGREQNRFLTR
>Mature_465_residues
SITYLPGKEPHPRETRRILKNVNREGWNTSIDCYLADGGYEELKKALGMEPRAVIDEVKKSGLRGRGGAGFPTGVKWTFI
PPNNTKPVYLVCNCDESEPGTFKDRYIVHQDPHQLIEGMVISSYAVGAHQAYIYMREEFPIAAEIMLKALQEARERGFLG
SNIQGSGYNLEIHLHRGAGAYICGEETALLNSLEGDRPYPRIKPPYFPAAIGLYGCPTIVNNVESLCQVKHIMAMGGEAY
SQEGAKRSPGTRIIGVSGDVKRPGFYEIVSGSMTFGELLYDVCGGPRDGRQFKAVIPGGSSSKVMRTDAEYKVQNPDGTM
GKITFFDIPLDLDSIARHGSMSGSGAVIVMDDSRSMPWAMNNINRFYAHESCGQCTPCREGCPWMMKLSTRILEGKAAPS
DVDLLIEVANQIEGKTVCAFGEAASWPTQAMVSKFKEEFVALTDPFNACLPHTEEGREQNRFLTR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=430, Percent_Identity=42.7906976744186, Blast_Score=338, Evalue=9e-93,
Organism=Homo sapiens, GI260656005, Length=430, Percent_Identity=42.7906976744186, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1788620, Length=443, Percent_Identity=42.8893905191874, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17531727, Length=407, Percent_Identity=44.7174447174447, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI19920794, Length=426, Percent_Identity=43.4272300469484, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI45550452, Length=424, Percent_Identity=41.0377358490566, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24653819, Length=429, Percent_Identity=32.4009324009324, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24653817, Length=369, Percent_Identity=31.4363143631436, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 51350; Mature: 51219

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITYLPGKEPHPRETRRILKNVNREGWNTSIDCYLADGGYEELKKALGMEPRAVIDEVK
CEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHH
KSGLRGRGGAGFPTGVKWTFIPPNNTKPVYLVCNCDESEPGTFKDRYIVHQDPHQLIEGM
HCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHH
VISSYAVGAHQAYIYMREEFPIAAEIMLKALQEARERGFLGSNIQGSGYNLEIHLHRGAG
HHHHEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCC
AYICGEETALLNSLEGDRPYPRIKPPYFPAAIGLYGCPTIVNNVESLCQVKHIMAMGGEA
EEEECCHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHH
YSQEGAKRSPGTRIIGVSGDVKRPGFYEIVSGSMTFGELLYDVCGGPRDGRQFKAVIPGG
HHHCCCCCCCCCEEEECCCCCCCCCHHEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCC
SSSKVMRTDAEYKVQNPDGTMGKITFFDIPLDLDSIARHGSMSGSGAVIVMDDSRSMPWA
CCCCEEECCCCEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCCCCEEEEEECCCCCCHH
MNNINRFYAHESCGQCTPCREGCPWMMKLSTRILEGKAAPSDVDLLIEVANQIEGKTVCA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEE
FGEAASWPTQAMVSKFKEEFVALTDPFNACLPHTEEGREQNRFLTR
ECCCCCCCHHHHHHHHHHHHEECCCCHHHHCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
SITYLPGKEPHPRETRRILKNVNREGWNTSIDCYLADGGYEELKKALGMEPRAVIDEVK
EEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHH
KSGLRGRGGAGFPTGVKWTFIPPNNTKPVYLVCNCDESEPGTFKDRYIVHQDPHQLIEGM
HCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHH
VISSYAVGAHQAYIYMREEFPIAAEIMLKALQEARERGFLGSNIQGSGYNLEIHLHRGAG
HHHHEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCC
AYICGEETALLNSLEGDRPYPRIKPPYFPAAIGLYGCPTIVNNVESLCQVKHIMAMGGEA
EEEECCHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHH
YSQEGAKRSPGTRIIGVSGDVKRPGFYEIVSGSMTFGELLYDVCGGPRDGRQFKAVIPGG
HHHCCCCCCCCCEEEECCCCCCCCCHHEEECCCCHHHHHHHHHHCCCCCCCEEEEEECCC
SSSKVMRTDAEYKVQNPDGTMGKITFFDIPLDLDSIARHGSMSGSGAVIVMDDSRSMPWA
CCCCEEECCCCEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCCCCEEEEEECCCCCCHH
MNNINRFYAHESCGQCTPCREGCPWMMKLSTRILEGKAAPSDVDLLIEVANQIEGKTVCA
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEE
FGEAASWPTQAMVSKFKEEFVALTDPFNACLPHTEEGREQNRFLTR
ECCCCCCCHHHHHHHHHHHHEECCCCHHHHCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9020134 [H]