Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

Click here to switch to the map view.

The map label for this gene is nuoI [H]

Identifier: 187736098

GI number: 187736098

Start: 1934013

End: 1934576

Strand: Reverse

Name: nuoI [H]

Synonym: Amuc_1609

Alternate gene names: 187736098

Gene position: 1934576-1934013 (Counterclockwise)

Preceding gene: 187736099

Following gene: 187736097

Centisome position: 72.62

GC content: 55.85

Gene sequence:

>564_bases
ATGGCCTTCAAAACGATCAAGCGTCCGAAGATTTCCCTTGGAGAGCGGTTCTATCTGCAATCCATTCTTGGCGGTCTTTG
GCTCACTATCAGGCATCTCGTTCTGGCTCTGCTGGGCAAATCCCGCAACAAAAAAGAACTGGCCGGTTCCGGCATCGGCG
TTACGATGCAATATCCGGAAGCCAGATGGGACAAACATCTGCCGAAATATTACCGCGGAGCTCCCGTGCTGGTGAAAGGC
GAAGACGGCCGTGAACGCTGCGTTTCCTGCCAGCTCTGCGAATTCATCTGCCCGGCCCGCGCCATCACCATCACCCCCGG
CCCCATACAGGAAGGACCGTGGGGCAAAGTGGAAAAAGCCCCCAGGGAATTTCAGATTGACATGCTGCGCTGCATCTACT
GCGGCATGTGCGAGGAAGCCTGCCCGGAACAGGCCATCTTCATGAGCCATAACTACCTGTTCACCCCCACGGATAAAACC
CAGGCCATCCACAACAAGGCCAAGCTCTACGAACTGGGCGGCACCCGCAAGGGGCTGGTCAACAAGTGGAACCAATACAA
ATAA

Upstream 100 bases:

>100_bases
GTCTTCTTTGAACTGGCCGTCATCAACATCTTCCTTACAGCCGCCATCCTGTACTTCGTCAAGTAATCCCCCCCTTCTTC
ATTCCGACAACATTACTATT

Downstream 100 bases:

>100_bases
CCCCCGAACACTCCATTTCCCGTACGTTATGAACATCTTTGCCAGCGACATACTTTTTTACGTTTTCGGGGCCCTGGCCG
TGGTCCTGTCCCTGATGGTC

Product: 4Fe-4S ferredoxin iron-sulfur binding domain protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MAFKTIKRPKISLGERFYLQSILGGLWLTIRHLVLALLGKSRNKKELAGSGIGVTMQYPEARWDKHLPKYYRGAPVLVKG
EDGRERCVSCQLCEFICPARAITITPGPIQEGPWGKVEKAPREFQIDMLRCIYCGMCEEACPEQAIFMSHNYLFTPTDKT
QAIHNKAKLYELGGTRKGLVNKWNQYK

Sequences:

>Translated_187_residues
MAFKTIKRPKISLGERFYLQSILGGLWLTIRHLVLALLGKSRNKKELAGSGIGVTMQYPEARWDKHLPKYYRGAPVLVKG
EDGRERCVSCQLCEFICPARAITITPGPIQEGPWGKVEKAPREFQIDMLRCIYCGMCEEACPEQAIFMSHNYLFTPTDKT
QAIHNKAKLYELGGTRKGLVNKWNQYK
>Mature_186_residues
AFKTIKRPKISLGERFYLQSILGGLWLTIRHLVLALLGKSRNKKELAGSGIGVTMQYPEARWDKHLPKYYRGAPVLVKGE
DGRERCVSCQLCEFICPARAITITPGPIQEGPWGKVEKAPREFQIDMLRCIYCGMCEEACPEQAIFMSHNYLFTPTDKTQ
AIHNKAKLYELGGTRKGLVNKWNQYK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=120, Percent_Identity=39.1666666666667, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1788617, Length=133, Percent_Identity=35.3383458646617, Blast_Score=84, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17555194, Length=123, Percent_Identity=38.2113821138211, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17864306, Length=116, Percent_Identity=38.7931034482759, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 21294; Mature: 21163

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFKTIKRPKISLGERFYLQSILGGLWLTIRHLVLALLGKSRNKKELAGSGIGVTMQYPE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCH
ARWDKHLPKYYRGAPVLVKGEDGRERCVSCQLCEFICPARAITITPGPIQEGPWGKVEKA
HHHHHCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCC
PREFQIDMLRCIYCGMCEEACPEQAIFMSHNYLFTPTDKTQAIHNKAKLYELGGTRKGLV
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCCHHH
NKWNQYK
HHHCCCC
>Mature Secondary Structure 
AFKTIKRPKISLGERFYLQSILGGLWLTIRHLVLALLGKSRNKKELAGSGIGVTMQYPE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCH
ARWDKHLPKYYRGAPVLVKGEDGRERCVSCQLCEFICPARAITITPGPIQEGPWGKVEKA
HHHHHCCHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCC
PREFQIDMLRCIYCGMCEEACPEQAIFMSHNYLFTPTDKTQAIHNKAKLYELGGTRKGLV
CHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCCHHH
NKWNQYK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA