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The map label for this gene is tsaA [H]

Identifier: 187735814

GI number: 187735814

Start: 1599129

End: 1599752

Strand: Reverse

Name: tsaA [H]

Synonym: Amuc_1321

Alternate gene names: 187735814

Gene position: 1599752-1599129 (Counterclockwise)

Preceding gene: 187735818

Following gene: 187735813

Centisome position: 60.05

GC content: 57.85

Gene sequence:

>624_bases
ATGCTTCTCATAGGAAAACCGGCACCTCATTTCAGCGCTAACGCAGTAGTAAACGGTACCATCGTACCGGATTTCAGCCT
TGACCAGTTTAAGGGCAAAAAGTACGTGATCCTGTTCTTCTACCCGAAGGATTTCACCTTCGTGTGCCCTACCGAGCTGA
TCGGCTTCCAGGAAGCCCTGGGCGAATTCGAAAAGCGTGACGTGGCCGTCGTCGGCTGCTCCACAGACAGCGAATTCTCC
CACTGGGCCTGGATCAACACCCCCCGCAGCCAGGGCGGCATTCAGGGCGTGACCTACCCCATCGTTTCCGACATCAACAA
GACCATTTCCGCCGATTACGGCGTGCTGGCCGGAGACGAGGAAATTGACGAAGACGGCAATGTGGAAGTCAACGGGGAAC
TGATCGCCTACCGCGGCCTCTTCCTGATTGACAAAGACGGCATCGTCCGCCACCAGCTCATCAACGACTTCCCGCTGGGC
CGCTCCATTGATGAAGCCATCCGCGTGGTTGACGCCCTCCAGCACTTCGAACTGTACGGGGAAGTCTGCCCTCTTGGCTG
GCACAAGGGAGACGCGGCCATGACCCCGTCCCACGAAGGCGTGGCCTCCTACCTCAGCAAGTAA

Upstream 100 bases:

>100_bases
AGAGAAAACAGGCTCTTTTGGAACGAACGGGATATCATTGCCGCTTGACTTTCGTCCGTTTTTTGGAATCATTCTTTTAG
AACCAAACCAAAAAACAACC

Downstream 100 bases:

>100_bases
GCAGCCCCCCCGGCAATATTTCAAGGCCGCTCCCCTTCCGGGGGAACGGCCTTTTTTCATCCCCGCCTTCCCCTCTTTCC
CAACCAGGCGCCATATCCGG

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MLLIGKPAPHFSANAVVNGTIVPDFSLDQFKGKKYVILFFYPKDFTFVCPTELIGFQEALGEFEKRDVAVVGCSTDSEFS
HWAWINTPRSQGGIQGVTYPIVSDINKTISADYGVLAGDEEIDEDGNVEVNGELIAYRGLFLIDKDGIVRHQLINDFPLG
RSIDEAIRVVDALQHFELYGEVCPLGWHKGDAAMTPSHEGVASYLSK

Sequences:

>Translated_207_residues
MLLIGKPAPHFSANAVVNGTIVPDFSLDQFKGKKYVILFFYPKDFTFVCPTELIGFQEALGEFEKRDVAVVGCSTDSEFS
HWAWINTPRSQGGIQGVTYPIVSDINKTISADYGVLAGDEEIDEDGNVEVNGELIAYRGLFLIDKDGIVRHQLINDFPLG
RSIDEAIRVVDALQHFELYGEVCPLGWHKGDAAMTPSHEGVASYLSK
>Mature_207_residues
MLLIGKPAPHFSANAVVNGTIVPDFSLDQFKGKKYVILFFYPKDFTFVCPTELIGFQEALGEFEKRDVAVVGCSTDSEFS
HWAWINTPRSQGGIQGVTYPIVSDINKTISADYGVLAGDEEIDEDGNVEVNGELIAYRGLFLIDKDGIVRHQLINDFPLG
RSIDEAIRVVDALQHFELYGEVCPLGWHKGDAAMTPSHEGVASYLSK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=204, Percent_Identity=48.0392156862745, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI4505591, Length=204, Percent_Identity=47.5490196078431, Blast_Score=197, Evalue=5e-51,
Organism=Homo sapiens, GI32455266, Length=204, Percent_Identity=47.5490196078431, Blast_Score=197, Evalue=5e-51,
Organism=Homo sapiens, GI32455264, Length=204, Percent_Identity=47.5490196078431, Blast_Score=197, Evalue=5e-51,
Organism=Homo sapiens, GI5802974, Length=204, Percent_Identity=45.5882352941176, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI32483377, Length=200, Percent_Identity=46.5, Blast_Score=188, Evalue=2e-48,
Organism=Homo sapiens, GI5453549, Length=204, Percent_Identity=45.0980392156863, Blast_Score=184, Evalue=3e-47,
Organism=Homo sapiens, GI4758638, Length=196, Percent_Identity=32.6530612244898, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI33188454, Length=81, Percent_Identity=55.5555555555556, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1786822, Length=198, Percent_Identity=29.7979797979798, Blast_Score=94, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193204376, Length=205, Percent_Identity=48.780487804878, Blast_Score=193, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32565831, Length=205, Percent_Identity=48.780487804878, Blast_Score=192, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17554494, Length=201, Percent_Identity=43.7810945273632, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=187, Percent_Identity=26.7379679144385, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323613, Length=202, Percent_Identity=45.049504950495, Blast_Score=175, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320661, Length=203, Percent_Identity=42.3645320197044, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319407, Length=198, Percent_Identity=32.3232323232323, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656348, Length=205, Percent_Identity=48.2926829268293, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17864676, Length=205, Percent_Identity=48.2926829268293, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17157991, Length=194, Percent_Identity=48.4536082474227, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24641739, Length=194, Percent_Identity=48.4536082474227, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17738015, Length=206, Percent_Identity=43.6893203883495, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21357347, Length=206, Percent_Identity=43.2038834951456, Blast_Score=172, Evalue=9e-44,
Organism=Drosophila melanogaster, GI24581278, Length=193, Percent_Identity=29.0155440414508, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17975518, Length=196, Percent_Identity=33.1632653061224, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24652436, Length=196, Percent_Identity=33.1632653061224, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24652434, Length=196, Percent_Identity=33.1632653061224, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22829; Mature: 22829

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIGKPAPHFSANAVVNGTIVPDFSLDQFKGKKYVILFFYPKDFTFVCPTELIGFQEAL
CEEECCCCCCCCCCEEEECEECCCCCHHHHCCCEEEEEEEECCCCEEECCHHHHHHHHHH
GEFEKRDVAVVGCSTDSEFSHWAWINTPRSQGGIQGVTYPIVSDINKTISADYGVLAGDE
HHHHHCCEEEEECCCCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCEEECCC
EIDEDGNVEVNGELIAYRGLFLIDKDGIVRHQLINDFPLGRSIDEAIRVVDALQHFELYG
CCCCCCCEEECCEEEEEEEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EVCPLGWHKGDAAMTPSHEGVASYLSK
CCCCCCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MLLIGKPAPHFSANAVVNGTIVPDFSLDQFKGKKYVILFFYPKDFTFVCPTELIGFQEAL
CEEECCCCCCCCCCEEEECEECCCCCHHHHCCCEEEEEEEECCCCEEECCHHHHHHHHHH
GEFEKRDVAVVGCSTDSEFSHWAWINTPRSQGGIQGVTYPIVSDINKTISADYGVLAGDE
HHHHHCCEEEEECCCCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCEEECCC
EIDEDGNVEVNGELIAYRGLFLIDKDGIVRHQLINDFPLGRSIDEAIRVVDALQHFELYG
CCCCCCCEEECCEEEEEEEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EVCPLGWHKGDAAMTPSHEGVASYLSK
CCCCCCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]