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The map label for this gene is gyrA [H]

Identifier: 187735780

GI number: 187735780

Start: 1557384

End: 1560005

Strand: Direct

Name: gyrA [H]

Synonym: Amuc_1286

Alternate gene names: 187735780

Gene position: 1557384-1560005 (Clockwise)

Preceding gene: 187735779

Following gene: 187735781

Centisome position: 58.46

GC content: 58.66

Gene sequence:

>2622_bases
ATGGAAAATAATAGAATCAAACCGGTGGATGTAGCCAGTGAGCTCTCCACTTCTTTCCTGGACTACTCCATGTCCGTCAT
CATCTCCCGCGCCCTGCCGGACGTGAGAGACGGCCTCAAACCTTCCCAGCGGCGCATCCTGTACGCCATGAAGGAACTCA
ATCTGTCCCCTGGGGGCAAGACCCGCAAATGCTCCAAAATCGTGGGCGACACGATGGGTAACTACCACCCTCACGGGGAT
GCCGCCATTTACGGCACCCTGGTGAACATGGCGCAGGACTGGTCCATGCGGGATATTCTCGTGATCGGCCAGGGCAACTT
CGGCACGCCGGATGGAGACCCCCCCGCCGCTGCCCGATACACGGAAGCCAAGCTCTCCGGCATGGGCGTGGCCCTGATGG
CGGATTTGGACAAGGACACCGTGGATTTTGTTCCCACATACGACAATGAACACACGGAACCCACCGTGTTTCCCTCCGCT
TTCCCAAACCTTCTGGTGAACGGCGGCACGGGGATTGCCGTGGGGATGGCCACCAACATGCCTCCGCACAACCTGGGGGA
AGTGGTGGACGGTATCTGCGCCGTGATTGACAATCCCCACATGACTGTGGAAGAGCTGCGCCAGTACATCAAGGGGCCGG
ATTTTCCCACCGGGGGCGACGTGCTGGGCTTTTCAGGCATTGACAACTACTTCCGCACCGGGCGCGGCTCCGTGCGCATC
CGCGGCAAGATAGACATGGAAGTAACGGATTCCGGCAAGGATCTTCTCATCATCCGGGAAGTGCCGTATGGCGTGAACCG
CGCCGCCCTTCAGGAACGCATTGCGGAACTGTACAAGGATAAAATCCTGACGGATATTTCCGGCATCCGTGACCTTTCCG
ATGAGAAAACCTGCATTGAAATCGAGCTGAAGCGGGATGCCCGCCCGCAGGTGGTCATGAACCAGCTTTACAAGCTCACC
TCCATGGAAACTTCCTTTGCGGTGAATATGCTGGCGATTCATGACAACCGCCCCAAGACGCTCGCCATGATGGACGCCAT
CAACTTCTACATCGAGCACCGCCGCGAGGTGGTCGTGCGCCGCACGCGCTATCTGCTGGGGGATGCGGAGAAGGATGCCG
AGCGCCTGGAAGCCTTCCTGCTGGCTCTGCACCACATGGATGACTTCATTTCCATTATCCGGGATTCCAAAAACCGGGAT
GAAGCCCGTGAACGCCTGCAGAATTACACATTCTCCACGCAGACAGCGGAAAGCCTGGGCATCCTGATCCGTTCCCAGGC
CTCCATCCAGGGGGACCGCTACGTCTTCACGGAACGCCAGGTGAACTCCATCCTGGACCTGCGCCTGTACCAGTTGACCG
CCTTGGAAAACGACAAGATTTCCGGGGAATACGCGGAACTGCTGGTCCGCATCAAGGACTACCTGGATATTCTGGCGAAC
GAATCCCGCGTGCTGGGCATTGTAAAGGACGAACTGAAGGCGATTAAGGACAAGTACGCCACGCCGCGCGTCACGCGCAT
CATTCCCTTCTCCGGGGATATGGCCATTGAGGATCTCATCCCGAATGACACGATGATCGTCACCATCACGCACAGCGGCT
ACATCAAGCGCACCAACTCCGCGGAATACCGCGTGCAGGCGCGCGGGGGCAAGGGCGTGAAGGCTGCCACTACCAGGGGA
GCCAAAAAGGATGCGGAAGCGGACTTTATCGAACACCTGTTCGCCGCCCAGAACCACGACTACCTGATGTTCTTTACGAA
CACCGGGCGCGTGTACGTGGACCGCGTGTATGAGATTGACGAAGCGGCGCGCAGCGCGCAGGGTCGCAATATCAAGAATC
TGCTGGATCTCCAGCCGGAAGAAGCCATCGCTGCCATCCTGCGCCTGGAACGCCGGGTGGATGAAAAAGGCAATGACATT
ACCTTTGCGGAAGGCAGCGGCAATGTTGTTTTCGCCACGAAGGACGGCACGGTGAAGAAAACCAGCCTGAACGATTTCGC
CAACTACCGCAAGGCCGGCATCATTGCCATTAATCTGGAGGAAGGCAACAGTCTGGTGAACGCGGAACTTACCAGCGGGG
CCGATGAAATCGTGCTCGTCACGCATGACGGCATGAGCATCCGCTTCCCGGAAGAAGATCTGCGTACGCAGGGCCGCAAC
ACCATCGGTGTTCGCGGCATCCGCCCGCGGGCGGGGGACTACGTTGTGGCCCTGGCCATTGTGGACCCGCAGAAAACCCT
GCTGGTGGCTTCTGAAAACGGCCTCGGCAAGCGCACTTCCTTTGATGAATACCGCACGCAGGGCCGCGGCGGAACCGGCA
TCAAGACCATGAATTGCACGGATAAGACCGGCAAGGTGGTTTCCGCCACGGTCGTGTCTGATGAGGACGAGCTGATGCTG
ATGACCACGGCCGGACAATCCGTCCGCATCAAGGTGGCGACCGTGCGTGAAACGGGCCGCGCCACCCAGGGCGTGAAGCT
CATGACGCTGAATGAGGGCGAATCCATCCAGGACATTTCCATCGTCATTCCTGATGATGAAGATGAAGAAGCCCCGGCGG
AAACGGAAGACGCGGGAGCCGGGGAAGTGTCCGGTGAAATGGAAGCTCCGGCGGAAGAATAA

Upstream 100 bases:

>100_bases
TGATGGGGGATGTGGTGGAACCCCGCAAGAATTACATCGTGGATCATGCCCTCAATGTCCGCAACCTTGACATTTAACCC
CCGCACTCTCTTTCAGCACC

Downstream 100 bases:

>100_bases
AATCCAGGTTTCCCTGCTCCGGCGTCATGCCGGAGCAGGGGGCTTCATGGGCCGTTTTTATGGAAGACCCCCTTTCATTG
GAGCAATGTGCCGGACGTCT

Product: DNA gyrase, A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 873; Mature: 873

Protein sequence:

>873_residues
MENNRIKPVDVASELSTSFLDYSMSVIISRALPDVRDGLKPSQRRILYAMKELNLSPGGKTRKCSKIVGDTMGNYHPHGD
AAIYGTLVNMAQDWSMRDILVIGQGNFGTPDGDPPAAARYTEAKLSGMGVALMADLDKDTVDFVPTYDNEHTEPTVFPSA
FPNLLVNGGTGIAVGMATNMPPHNLGEVVDGICAVIDNPHMTVEELRQYIKGPDFPTGGDVLGFSGIDNYFRTGRGSVRI
RGKIDMEVTDSGKDLLIIREVPYGVNRAALQERIAELYKDKILTDISGIRDLSDEKTCIEIELKRDARPQVVMNQLYKLT
SMETSFAVNMLAIHDNRPKTLAMMDAINFYIEHRREVVVRRTRYLLGDAEKDAERLEAFLLALHHMDDFISIIRDSKNRD
EARERLQNYTFSTQTAESLGILIRSQASIQGDRYVFTERQVNSILDLRLYQLTALENDKISGEYAELLVRIKDYLDILAN
ESRVLGIVKDELKAIKDKYATPRVTRIIPFSGDMAIEDLIPNDTMIVTITHSGYIKRTNSAEYRVQARGGKGVKAATTRG
AKKDAEADFIEHLFAAQNHDYLMFFTNTGRVYVDRVYEIDEAARSAQGRNIKNLLDLQPEEAIAAILRLERRVDEKGNDI
TFAEGSGNVVFATKDGTVKKTSLNDFANYRKAGIIAINLEEGNSLVNAELTSGADEIVLVTHDGMSIRFPEEDLRTQGRN
TIGVRGIRPRAGDYVVALAIVDPQKTLLVASENGLGKRTSFDEYRTQGRGGTGIKTMNCTDKTGKVVSATVVSDEDELML
MTTAGQSVRIKVATVRETGRATQGVKLMTLNEGESIQDISIVIPDDEDEEAPAETEDAGAGEVSGEMEAPAEE

Sequences:

>Translated_873_residues
MENNRIKPVDVASELSTSFLDYSMSVIISRALPDVRDGLKPSQRRILYAMKELNLSPGGKTRKCSKIVGDTMGNYHPHGD
AAIYGTLVNMAQDWSMRDILVIGQGNFGTPDGDPPAAARYTEAKLSGMGVALMADLDKDTVDFVPTYDNEHTEPTVFPSA
FPNLLVNGGTGIAVGMATNMPPHNLGEVVDGICAVIDNPHMTVEELRQYIKGPDFPTGGDVLGFSGIDNYFRTGRGSVRI
RGKIDMEVTDSGKDLLIIREVPYGVNRAALQERIAELYKDKILTDISGIRDLSDEKTCIEIELKRDARPQVVMNQLYKLT
SMETSFAVNMLAIHDNRPKTLAMMDAINFYIEHRREVVVRRTRYLLGDAEKDAERLEAFLLALHHMDDFISIIRDSKNRD
EARERLQNYTFSTQTAESLGILIRSQASIQGDRYVFTERQVNSILDLRLYQLTALENDKISGEYAELLVRIKDYLDILAN
ESRVLGIVKDELKAIKDKYATPRVTRIIPFSGDMAIEDLIPNDTMIVTITHSGYIKRTNSAEYRVQARGGKGVKAATTRG
AKKDAEADFIEHLFAAQNHDYLMFFTNTGRVYVDRVYEIDEAARSAQGRNIKNLLDLQPEEAIAAILRLERRVDEKGNDI
TFAEGSGNVVFATKDGTVKKTSLNDFANYRKAGIIAINLEEGNSLVNAELTSGADEIVLVTHDGMSIRFPEEDLRTQGRN
TIGVRGIRPRAGDYVVALAIVDPQKTLLVASENGLGKRTSFDEYRTQGRGGTGIKTMNCTDKTGKVVSATVVSDEDELML
MTTAGQSVRIKVATVRETGRATQGVKLMTLNEGESIQDISIVIPDDEDEEAPAETEDAGAGEVSGEMEAPAEE
>Mature_873_residues
MENNRIKPVDVASELSTSFLDYSMSVIISRALPDVRDGLKPSQRRILYAMKELNLSPGGKTRKCSKIVGDTMGNYHPHGD
AAIYGTLVNMAQDWSMRDILVIGQGNFGTPDGDPPAAARYTEAKLSGMGVALMADLDKDTVDFVPTYDNEHTEPTVFPSA
FPNLLVNGGTGIAVGMATNMPPHNLGEVVDGICAVIDNPHMTVEELRQYIKGPDFPTGGDVLGFSGIDNYFRTGRGSVRI
RGKIDMEVTDSGKDLLIIREVPYGVNRAALQERIAELYKDKILTDISGIRDLSDEKTCIEIELKRDARPQVVMNQLYKLT
SMETSFAVNMLAIHDNRPKTLAMMDAINFYIEHRREVVVRRTRYLLGDAEKDAERLEAFLLALHHMDDFISIIRDSKNRD
EARERLQNYTFSTQTAESLGILIRSQASIQGDRYVFTERQVNSILDLRLYQLTALENDKISGEYAELLVRIKDYLDILAN
ESRVLGIVKDELKAIKDKYATPRVTRIIPFSGDMAIEDLIPNDTMIVTITHSGYIKRTNSAEYRVQARGGKGVKAATTRG
AKKDAEADFIEHLFAAQNHDYLMFFTNTGRVYVDRVYEIDEAARSAQGRNIKNLLDLQPEEAIAAILRLERRVDEKGNDI
TFAEGSGNVVFATKDGTVKKTSLNDFANYRKAGIIAINLEEGNSLVNAELTSGADEIVLVTHDGMSIRFPEEDLRTQGRN
TIGVRGIRPRAGDYVVALAIVDPQKTLLVASENGLGKRTSFDEYRTQGRGGTGIKTMNCTDKTGKVVSATVVSDEDELML
MTTAGQSVRIKVATVRETGRATQGVKLMTLNEGESIQDISIVIPDDEDEEAPAETEDAGAGEVSGEMEAPAEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=353, Percent_Identity=24.0793201133144, Blast_Score=87, Evalue=9e-17,
Organism=Homo sapiens, GI19913406, Length=174, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1788562, Length=888, Percent_Identity=43.8063063063063, Blast_Score=696, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=759, Percent_Identity=31.6205533596838, Blast_Score=335, Evalue=7e-93,
Organism=Caenorhabditis elegans, GI17535065, Length=383, Percent_Identity=26.8929503916449, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=396, Percent_Identity=26.5151515151515, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115534553, Length=167, Percent_Identity=31.1377245508982, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=414, Percent_Identity=23.1884057971014, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=211, Percent_Identity=27.4881516587678, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136538, Length=364, Percent_Identity=25.2747252747253, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96482; Mature: 96482

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNRIKPVDVASELSTSFLDYSMSVIISRALPDVRDGLKPSQRRILYAMKELNLSPGGK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCCC
TRKCSKIVGDTMGNYHPHGDAAIYGTLVNMAQDWSMRDILVIGQGNFGTPDGDPPAAARY
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCC
TEAKLSGMGVALMADLDKDTVDFVPTYDNEHTEPTVFPSAFPNLLVNGGTGIAVGMATNM
HHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCEECCCCCCCEEEECCCEEEEEEECCC
PPHNLGEVVDGICAVIDNPHMTVEELRQYIKGPDFPTGGDVLGFSGIDNYFRTGRGSVRI
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCHHHHHCCCCCEEE
RGKIDMEVTDSGKDLLIIREVPYGVNRAALQERIAELYKDKILTDISGIRDLSDEKTCIE
EEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
IELKRDARPQVVMNQLYKLTSMETSFAVNMLAIHDNRPKTLAMMDAINFYIEHRREVVVR
EEECCCCCHHHHHHHHHHHHCCCCHHEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
RTRYLLGDAEKDAERLEAFLLALHHMDDFISIIRDSKNRDEARERLQNYTFSTQTAESLG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHC
ILIRSQASIQGDRYVFTERQVNSILDLRLYQLTALENDKISGEYAELLVRIKDYLDILAN
EEEECCCCCCCCEEEEEHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
ESRVLGIVKDELKAIKDKYATPRVTRIIPFSGDMAIEDLIPNDTMIVTITHSGYIKRTNS
CCEEEEEHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCEEEEEEECCCEEEECCC
AEYRVQARGGKGVKAATTRGAKKDAEADFIEHLFAAQNHDYLMFFTNTGRVYVDRVYEID
CEEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEHHHHHH
EAARSAQGRNIKNLLDLQPEEAIAAILRLERRVDEKGNDITFAEGSGNVVFATKDGTVKK
HHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCEEE
TSLNDFANYRKAGIIAINLEEGNSLVNAELTSGADEIVLVTHDGMSIRFPEEDLRTQGRN
CCHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCEEECCHHHHHHCCCC
TIGVRGIRPRAGDYVVALAIVDPQKTLLVASENGLGKRTSFDEYRTQGRGGTGIKTMNCT
EEEEECCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEECCC
DKTGKVVSATVVSDEDELMLMTTAGQSVRIKVATVRETGRATQGVKLMTLNEGESIQDIS
CCCCCEEEEEEECCCCCEEEEEECCCEEEEEEEEEECCCCCCCCEEEEEECCCCCEEEEE
IVIPDDEDEEAPAETEDAGAGEVSGEMEAPAEE
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MENNRIKPVDVASELSTSFLDYSMSVIISRALPDVRDGLKPSQRRILYAMKELNLSPGGK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCCC
TRKCSKIVGDTMGNYHPHGDAAIYGTLVNMAQDWSMRDILVIGQGNFGTPDGDPPAAARY
CHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCC
TEAKLSGMGVALMADLDKDTVDFVPTYDNEHTEPTVFPSAFPNLLVNGGTGIAVGMATNM
HHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCEECCCCCCCEEEECCCEEEEEEECCC
PPHNLGEVVDGICAVIDNPHMTVEELRQYIKGPDFPTGGDVLGFSGIDNYFRTGRGSVRI
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCHHHHHCCCCCEEE
RGKIDMEVTDSGKDLLIIREVPYGVNRAALQERIAELYKDKILTDISGIRDLSDEKTCIE
EEEEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
IELKRDARPQVVMNQLYKLTSMETSFAVNMLAIHDNRPKTLAMMDAINFYIEHRREVVVR
EEECCCCCHHHHHHHHHHHHCCCCHHEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
RTRYLLGDAEKDAERLEAFLLALHHMDDFISIIRDSKNRDEARERLQNYTFSTQTAESLG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHC
ILIRSQASIQGDRYVFTERQVNSILDLRLYQLTALENDKISGEYAELLVRIKDYLDILAN
EEEECCCCCCCCEEEEEHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
ESRVLGIVKDELKAIKDKYATPRVTRIIPFSGDMAIEDLIPNDTMIVTITHSGYIKRTNS
CCEEEEEHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCEEEEEEECCCEEEECCC
AEYRVQARGGKGVKAATTRGAKKDAEADFIEHLFAAQNHDYLMFFTNTGRVYVDRVYEID
CEEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEHHHHHH
EAARSAQGRNIKNLLDLQPEEAIAAILRLERRVDEKGNDITFAEGSGNVVFATKDGTVKK
HHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCEEE
TSLNDFANYRKAGIIAINLEEGNSLVNAELTSGADEIVLVTHDGMSIRFPEEDLRTQGRN
CCHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCEEEEEEECCCEEECCHHHHHHCCCC
TIGVRGIRPRAGDYVVALAIVDPQKTLLVASENGLGKRTSFDEYRTQGRGGTGIKTMNCT
EEEEECCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCEEEECCC
DKTGKVVSATVVSDEDELMLMTTAGQSVRIKVATVRETGRATQGVKLMTLNEGESIQDIS
CCCCCEEEEEEECCCCCEEEEEECCCEEEEEEEEEECCCCCCCCEEEEEECCCCCEEEEE
IVIPDDEDEEAPAETEDAGAGEVSGEMEAPAEE
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]