Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is gyrB [H]

Identifier: 187735779

GI number: 187735779

Start: 1554802

End: 1557360

Strand: Direct

Name: gyrB [H]

Synonym: Amuc_1285

Alternate gene names: 187735779

Gene position: 1554802-1557360 (Clockwise)

Preceding gene: 187735778

Following gene: 187735780

Centisome position: 58.36

GC content: 57.76

Gene sequence:

>2559_bases
ATGTCCGAAGATACCAACGAGGTTGTTGAAACCACCGTTTCCACGACGGCGCAGCATGAATACGGCGCCGCGCAGATTGA
CAAACTGGAAGGCCTGGAGGCCGTGCGGAAGCGGCCCGGCATGTACATCGGGGACCCTGACGAACGAGGCTTGCACCATT
GCGTATTTGAAGTGCTCGACAACTCCATTGACGAGCATCTGGCCGGCTATTGCAGCAAGATTGACATTGTCATTCATGTG
GACGGTTCCATTTCCATCGTAGATAACGGGCGCGGCATTCCGGTGGATATCCACCCGAAGTTCGGCATTCCCGCTGTGGA
GCTGGTTCTGACCAACCTGCACGCGGGCGGCAAATTCGGTCAGGGTGCGTACAAGTACTCCGGCGGCCTGCACGGTGTGG
GCGCCAAATGCGTGAATGCCCTGTCCGACTGGTTCAAGGCGGAAGTGCGCCGGGACGGCAAGCGCTATCAGATCAAATTT
GAGCGAGGCAAGACGGTGGAACCCCTCCGCACTGTAGGTTCCTGTGCCTGTGAAGTCACGGGAACCACGATCACGTTTTT
CCCGGATGCCACCATTTTCACGGATACCACGGAGTTCAAGTTTGACCGCCTGACGACGCGCCTGCGGGAACTGGCTTTCC
TGAATCCCGGCCTGGTCATTGAACTGATTGACGAGCGTGAAGCTCCGGCGCGCCGGGAAACGTTCTTCTATAAGGACGGC
ATTGTGGAGTTCGTACGTCAGCTGGGCACGAACAAGGAAGTGATCAACGAGGACCCCATTTCCATTTCCGGCGTCCGGAA
GGTGGAAGTGGAGTACGACGGCAAGAAGATGGAGGACGATGTTCTGGTGGACGTTGTGTTCCAGTACAACAACACGTATG
AAACGAACATCCTTTGCTTTGCCAACTCCATTTACAACGGGGACGGGGGAACGCACCTTTCCGGGTTCCGCGGCGCCCTG
ACGCGCGTCATCAACGGTTACGCAAAGGCCAACGGCCTGTTGAAGGAAAAAGATCCCTCCCTGAGCGGCGAAGATGTTCG
TGAAGGCCTGGTGGCGGTTATTTCCGTCAAGATGCCCAACCCGCGTTTCTCATCCCAGACGAAGGACAAGCTGGTGAATA
CGGAGATTGAAGGCGTGGTGGGCAATGTCGTGTACGAGGAAATCAAGACGTACTTTGAAGAAAACCCGGCGATGGCCAAG
AAGATCATCGAGAAGAGCATCACGGCCGCTCGTGCCCGGGAAGCCGCCCGCAAGGCGCGTGAAACAGTCCGCAAGAGCGC
TCTCTCCATCGGCGGCCTCCCCGGCAAACTGGCGGATTGTTCCGACCGGGATCCCGCGAAGTGCGAGCTGTTCATTGTGG
AAGGTGACTCCGCAGGCGGTTCCGCCAAGATGGGGCGCGACCGCCGCACGCAGGCTATCCTGCCCCTGCGCGGGAAAGTG
CTGAACGTGGAAAAGGCCCGCCTGGACAAAGCCCTGGGGAGCAAGGAAATCCAGAACATGATTACGGCCATCGGCGCCGG
AATCGGGGAAGGGGACGATGAAGCCTCCTTCAAGCTGGACCGCGTGCGCTACCACAAAATCATCATCATGACTGATGCCG
ACGTGGACGGCGCCCACATCCGCACCCTCCTTCTCACTTTCTTCTGCCGCCACATGCCGCAGCTGGTGCGCGCCGGGTAT
CTGTACATCGCTCAGGCGCCCCTGTACCGCATCATCCGCAGGAAAAAGGAAGAGTACGTGCAGGATGACGTGGCCCTGAA
CCGCAAACTGATTGAACTGGCCGTTAATGACGTGACTCTGCGTTTCGCAGACGGCTCCCGTTCCTTCTCTCCCGAAGAAC
TCTCCGCCATTCTGGAAACGCTGGTCAACCTCCAGCGCTATACGGAATCCATGCAGGCGCAGGGCGGTTCCCTGGAAGAC
CTGCTCAGCCATCGGGAGACCAACGGGGAATTCCCGGAATTCCTGGTGAAGGTGCGCTGCGGCAATGAAGAGGAAATACT
CTTCTTCCATGACATGGAGGCCCTGACCGCCTTTTCTGAGGAAAACAGGGACCTTTTCATCTTTGGCACGCCCTCGGAAG
AGGAGTTGCTGGAAAATCCGCTTCCGGAACGGGAGGGGCCCAGCCGCCGCTCCATCACTCATGAACTGCATGAAGCCAAA
GCCATCACGCGGGCCCTGGCCCGGCTGGCGGAACTGGGCATTCCGGGGAATATGATTGTCTCCATGGATACGCCCCTGTT
TGAACTGGTGGAGGGTGAAGGGGATAAGGAAAAAGTAACGCCCCTGTTCTCCGTCATGGACATTCTGGAATCCGTCATCT
CCATCGGCAAGCGCGGGGTGGAAATCACGCGATTCAAAGGGTTGGGTGAAATGGATGCCAAGGACTTGTTCAAGACGACG
ATGGACCCGGAACGGCGCGAGCTGCTCCGCGTCATCCTGAACGATGACAACGCCGTCAGGGCCGATGAAATGTTCACCAT
CCTGATGGGGGATGTGGTGGAACCCCGCAAGAATTACATCGTGGATCATGCCCTCAATGTCCGCAACCTTGACATTTAA

Upstream 100 bases:

>100_bases
GATTTCAGCGGAATTTTGCAAGGCTAGGCCCTACGCGCGCGCACGCGATTTATAACATTAGTCTTGCAAAAAATTAAGAT
AAGCGTAATATATTTCGGTT

Downstream 100 bases:

>100_bases
CCCCCGCACTCTCTTTCAGCACCATGGAAAATAATAGAATCAAACCGGTGGATGTAGCCAGTGAGCTCTCCACTTCTTTC
CTGGACTACTCCATGTCCGT

Product: DNA gyrase, B subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 852; Mature: 851

Protein sequence:

>852_residues
MSEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLDNSIDEHLAGYCSKIDIVIHV
DGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFGQGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKF
ERGKTVEPLRTVGSCACEVTGTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG
IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCFANSIYNGDGGTHLSGFRGAL
TRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPNPRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAK
KIIEKSITAARAREAARKARETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV
LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHIRTLLLTFFCRHMPQLVRAGY
LYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTLRFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLED
LLSHRETNGEFPEFLVKVRCGNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK
AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGVEITRFKGLGEMDAKDLFKTT
MDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYIVDHALNVRNLDI

Sequences:

>Translated_852_residues
MSEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLDNSIDEHLAGYCSKIDIVIHV
DGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFGQGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKF
ERGKTVEPLRTVGSCACEVTGTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG
IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCFANSIYNGDGGTHLSGFRGAL
TRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPNPRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAK
KIIEKSITAARAREAARKARETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV
LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHIRTLLLTFFCRHMPQLVRAGY
LYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTLRFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLED
LLSHRETNGEFPEFLVKVRCGNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK
AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGVEITRFKGLGEMDAKDLFKTT
MDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYIVDHALNVRNLDI
>Mature_851_residues
SEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLDNSIDEHLAGYCSKIDIVIHVD
GSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFGQGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKFE
RGKTVEPLRTVGSCACEVTGTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDGI
VEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCFANSIYNGDGGTHLSGFRGALT
RVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPNPRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAKK
IIEKSITAARAREAARKARETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKVL
NVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHIRTLLLTFFCRHMPQLVRAGYL
YIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTLRFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLEDL
LSHRETNGEFPEFLVKVRCGNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAKA
ITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGVEITRFKGLGEMDAKDLFKTTM
DPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYIVDHALNVRNLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=567, Percent_Identity=26.1022927689594, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI19913408, Length=558, Percent_Identity=27.7777777777778, Blast_Score=129, Evalue=1e-29,
Organism=Escherichia coli, GI48994957, Length=841, Percent_Identity=44.1141498216409, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=552, Percent_Identity=41.1231884057971, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212645845, Length=533, Percent_Identity=25.515947467167, Blast_Score=127, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17535065, Length=547, Percent_Identity=23.400365630713, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI212645657, Length=163, Percent_Identity=30.0613496932515, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=593, Percent_Identity=26.9814502529511, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17136538, Length=561, Percent_Identity=26.7379679144385, Blast_Score=119, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94973; Mature: 94842

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLD
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH
NSIDEHLAGYCSKIDIVIHVDGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFG
HHHHHHHHHHHCEEEEEEEECCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCC
QGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKFERGKTVEPLRTVGSCACEVT
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCEEEEE
GTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG
CCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHEEHHHH
IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCF
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHEEEEEEECCCCCCCEEEEE
ANSIYNGDGGTHLSGFRGALTRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPN
EECEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEECCC
PRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAKKIIEKSITAARAREAARKAR
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCE
LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHI
ECHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHHH
RTLLLTFFCRHMPQLVRAGYLYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTL
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEEE
RFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLEDLLSHRETNGEFPEFLVKVRC
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHEEEEEC
GNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK
CCCCCEEEEECHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGV
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
EITRFKGLGEMDAKDLFKTTMDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYI
EEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHH
VDHALNVRNLDI
HHHCCCCCCCCC
>Mature Secondary Structure 
SEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLD
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH
NSIDEHLAGYCSKIDIVIHVDGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFG
HHHHHHHHHHHCEEEEEEEECCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCC
QGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKFERGKTVEPLRTVGSCACEVT
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCEEEEE
GTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG
CCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHEEHHHH
IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCF
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHEEEEEEECCCCCCCEEEEE
ANSIYNGDGGTHLSGFRGALTRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPN
EECEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEECCC
PRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAKKIIEKSITAARAREAARKAR
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
ETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCE
LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHI
ECHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHHH
RTLLLTFFCRHMPQLVRAGYLYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTL
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEEE
RFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLEDLLSHRETNGEFPEFLVKVRC
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHEEEEEC
GNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK
CCCCCEEEEECHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGV
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
EITRFKGLGEMDAKDLFKTTMDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYI
EEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHH
VDHALNVRNLDI
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226640 [H]