Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is gyrB [H]
Identifier: 187735779
GI number: 187735779
Start: 1554802
End: 1557360
Strand: Direct
Name: gyrB [H]
Synonym: Amuc_1285
Alternate gene names: 187735779
Gene position: 1554802-1557360 (Clockwise)
Preceding gene: 187735778
Following gene: 187735780
Centisome position: 58.36
GC content: 57.76
Gene sequence:
>2559_bases ATGTCCGAAGATACCAACGAGGTTGTTGAAACCACCGTTTCCACGACGGCGCAGCATGAATACGGCGCCGCGCAGATTGA CAAACTGGAAGGCCTGGAGGCCGTGCGGAAGCGGCCCGGCATGTACATCGGGGACCCTGACGAACGAGGCTTGCACCATT GCGTATTTGAAGTGCTCGACAACTCCATTGACGAGCATCTGGCCGGCTATTGCAGCAAGATTGACATTGTCATTCATGTG GACGGTTCCATTTCCATCGTAGATAACGGGCGCGGCATTCCGGTGGATATCCACCCGAAGTTCGGCATTCCCGCTGTGGA GCTGGTTCTGACCAACCTGCACGCGGGCGGCAAATTCGGTCAGGGTGCGTACAAGTACTCCGGCGGCCTGCACGGTGTGG GCGCCAAATGCGTGAATGCCCTGTCCGACTGGTTCAAGGCGGAAGTGCGCCGGGACGGCAAGCGCTATCAGATCAAATTT GAGCGAGGCAAGACGGTGGAACCCCTCCGCACTGTAGGTTCCTGTGCCTGTGAAGTCACGGGAACCACGATCACGTTTTT CCCGGATGCCACCATTTTCACGGATACCACGGAGTTCAAGTTTGACCGCCTGACGACGCGCCTGCGGGAACTGGCTTTCC TGAATCCCGGCCTGGTCATTGAACTGATTGACGAGCGTGAAGCTCCGGCGCGCCGGGAAACGTTCTTCTATAAGGACGGC ATTGTGGAGTTCGTACGTCAGCTGGGCACGAACAAGGAAGTGATCAACGAGGACCCCATTTCCATTTCCGGCGTCCGGAA GGTGGAAGTGGAGTACGACGGCAAGAAGATGGAGGACGATGTTCTGGTGGACGTTGTGTTCCAGTACAACAACACGTATG AAACGAACATCCTTTGCTTTGCCAACTCCATTTACAACGGGGACGGGGGAACGCACCTTTCCGGGTTCCGCGGCGCCCTG ACGCGCGTCATCAACGGTTACGCAAAGGCCAACGGCCTGTTGAAGGAAAAAGATCCCTCCCTGAGCGGCGAAGATGTTCG TGAAGGCCTGGTGGCGGTTATTTCCGTCAAGATGCCCAACCCGCGTTTCTCATCCCAGACGAAGGACAAGCTGGTGAATA CGGAGATTGAAGGCGTGGTGGGCAATGTCGTGTACGAGGAAATCAAGACGTACTTTGAAGAAAACCCGGCGATGGCCAAG AAGATCATCGAGAAGAGCATCACGGCCGCTCGTGCCCGGGAAGCCGCCCGCAAGGCGCGTGAAACAGTCCGCAAGAGCGC TCTCTCCATCGGCGGCCTCCCCGGCAAACTGGCGGATTGTTCCGACCGGGATCCCGCGAAGTGCGAGCTGTTCATTGTGG AAGGTGACTCCGCAGGCGGTTCCGCCAAGATGGGGCGCGACCGCCGCACGCAGGCTATCCTGCCCCTGCGCGGGAAAGTG CTGAACGTGGAAAAGGCCCGCCTGGACAAAGCCCTGGGGAGCAAGGAAATCCAGAACATGATTACGGCCATCGGCGCCGG AATCGGGGAAGGGGACGATGAAGCCTCCTTCAAGCTGGACCGCGTGCGCTACCACAAAATCATCATCATGACTGATGCCG ACGTGGACGGCGCCCACATCCGCACCCTCCTTCTCACTTTCTTCTGCCGCCACATGCCGCAGCTGGTGCGCGCCGGGTAT CTGTACATCGCTCAGGCGCCCCTGTACCGCATCATCCGCAGGAAAAAGGAAGAGTACGTGCAGGATGACGTGGCCCTGAA CCGCAAACTGATTGAACTGGCCGTTAATGACGTGACTCTGCGTTTCGCAGACGGCTCCCGTTCCTTCTCTCCCGAAGAAC TCTCCGCCATTCTGGAAACGCTGGTCAACCTCCAGCGCTATACGGAATCCATGCAGGCGCAGGGCGGTTCCCTGGAAGAC CTGCTCAGCCATCGGGAGACCAACGGGGAATTCCCGGAATTCCTGGTGAAGGTGCGCTGCGGCAATGAAGAGGAAATACT CTTCTTCCATGACATGGAGGCCCTGACCGCCTTTTCTGAGGAAAACAGGGACCTTTTCATCTTTGGCACGCCCTCGGAAG AGGAGTTGCTGGAAAATCCGCTTCCGGAACGGGAGGGGCCCAGCCGCCGCTCCATCACTCATGAACTGCATGAAGCCAAA GCCATCACGCGGGCCCTGGCCCGGCTGGCGGAACTGGGCATTCCGGGGAATATGATTGTCTCCATGGATACGCCCCTGTT TGAACTGGTGGAGGGTGAAGGGGATAAGGAAAAAGTAACGCCCCTGTTCTCCGTCATGGACATTCTGGAATCCGTCATCT CCATCGGCAAGCGCGGGGTGGAAATCACGCGATTCAAAGGGTTGGGTGAAATGGATGCCAAGGACTTGTTCAAGACGACG ATGGACCCGGAACGGCGCGAGCTGCTCCGCGTCATCCTGAACGATGACAACGCCGTCAGGGCCGATGAAATGTTCACCAT CCTGATGGGGGATGTGGTGGAACCCCGCAAGAATTACATCGTGGATCATGCCCTCAATGTCCGCAACCTTGACATTTAA
Upstream 100 bases:
>100_bases GATTTCAGCGGAATTTTGCAAGGCTAGGCCCTACGCGCGCGCACGCGATTTATAACATTAGTCTTGCAAAAAATTAAGAT AAGCGTAATATATTTCGGTT
Downstream 100 bases:
>100_bases CCCCCGCACTCTCTTTCAGCACCATGGAAAATAATAGAATCAAACCGGTGGATGTAGCCAGTGAGCTCTCCACTTCTTTC CTGGACTACTCCATGTCCGT
Product: DNA gyrase, B subunit
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 852; Mature: 851
Protein sequence:
>852_residues MSEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLDNSIDEHLAGYCSKIDIVIHV DGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFGQGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKF ERGKTVEPLRTVGSCACEVTGTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCFANSIYNGDGGTHLSGFRGAL TRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPNPRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAK KIIEKSITAARAREAARKARETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHIRTLLLTFFCRHMPQLVRAGY LYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTLRFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLED LLSHRETNGEFPEFLVKVRCGNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGVEITRFKGLGEMDAKDLFKTT MDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYIVDHALNVRNLDI
Sequences:
>Translated_852_residues MSEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLDNSIDEHLAGYCSKIDIVIHV DGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFGQGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKF ERGKTVEPLRTVGSCACEVTGTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCFANSIYNGDGGTHLSGFRGAL TRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPNPRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAK KIIEKSITAARAREAARKARETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHIRTLLLTFFCRHMPQLVRAGY LYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTLRFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLED LLSHRETNGEFPEFLVKVRCGNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGVEITRFKGLGEMDAKDLFKTT MDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYIVDHALNVRNLDI >Mature_851_residues SEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLDNSIDEHLAGYCSKIDIVIHVD GSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFGQGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKFE RGKTVEPLRTVGSCACEVTGTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDGI VEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCFANSIYNGDGGTHLSGFRGALT RVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPNPRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAKK IIEKSITAARAREAARKARETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKVL NVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHIRTLLLTFFCRHMPQLVRAGYL YIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTLRFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLEDL LSHRETNGEFPEFLVKVRCGNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAKA ITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGVEITRFKGLGEMDAKDLFKTTM DPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYIVDHALNVRNLDI
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0187
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the type II topoisomerase family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=567, Percent_Identity=26.1022927689594, Blast_Score=129, Evalue=1e-29, Organism=Homo sapiens, GI19913408, Length=558, Percent_Identity=27.7777777777778, Blast_Score=129, Evalue=1e-29, Organism=Escherichia coli, GI48994957, Length=841, Percent_Identity=44.1141498216409, Blast_Score=644, Evalue=0.0, Organism=Escherichia coli, GI1789408, Length=552, Percent_Identity=41.1231884057971, Blast_Score=404, Evalue=1e-113, Organism=Caenorhabditis elegans, GI212645845, Length=533, Percent_Identity=25.515947467167, Blast_Score=127, Evalue=3e-29, Organism=Caenorhabditis elegans, GI17535065, Length=547, Percent_Identity=23.400365630713, Blast_Score=110, Evalue=3e-24, Organism=Caenorhabditis elegans, GI212645657, Length=163, Percent_Identity=30.0613496932515, Blast_Score=70, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=593, Percent_Identity=26.9814502529511, Blast_Score=129, Evalue=2e-30, Organism=Drosophila melanogaster, GI17136538, Length=561, Percent_Identity=26.7379679144385, Blast_Score=119, Evalue=8e-27,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003594 - InterPro: IPR011557 - InterPro: IPR020568 - InterPro: IPR014721 - InterPro: IPR001241 - InterPro: IPR013759 - InterPro: IPR002288 - InterPro: IPR013506 - InterPro: IPR013760 - InterPro: IPR018522 [H]
Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 94973; Mature: 94842
Theoretical pI: Translated: 5.03; Mature: 5.03
Prosite motif: PS00177 TOPOISOMERASE_II
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLD CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH NSIDEHLAGYCSKIDIVIHVDGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFG HHHHHHHHHHHCEEEEEEEECCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCC QGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKFERGKTVEPLRTVGSCACEVT CCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCEEEEE GTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG CCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHEEHHHH IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCF HHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHEEEEEEECCCCCCCEEEEE ANSIYNGDGGTHLSGFRGALTRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPN EECEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEECCC PRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAKKIIEKSITAARAREAARKAR CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH ETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCE LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHI ECHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHHH RTLLLTFFCRHMPQLVRAGYLYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTL HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEEE RFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLEDLLSHRETNGEFPEFLVKVRC EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHEEEEEC GNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK CCCCCEEEEECHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHH AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGV HHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC EITRFKGLGEMDAKDLFKTTMDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYI EEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHH VDHALNVRNLDI HHHCCCCCCCCC >Mature Secondary Structure SEDTNEVVETTVSTTAQHEYGAAQIDKLEGLEAVRKRPGMYIGDPDERGLHHCVFEVLD CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHH NSIDEHLAGYCSKIDIVIHVDGSISIVDNGRGIPVDIHPKFGIPAVELVLTNLHAGGKFG HHHHHHHHHHHCEEEEEEEECCEEEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCC QGAYKYSGGLHGVGAKCVNALSDWFKAEVRRDGKRYQIKFERGKTVEPLRTVGSCACEVT CCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCEEEEE GTTITFFPDATIFTDTTEFKFDRLTTRLRELAFLNPGLVIELIDEREAPARRETFFYKDG CCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHEEHHHH IVEFVRQLGTNKEVINEDPISISGVRKVEVEYDGKKMEDDVLVDVVFQYNNTYETNILCF HHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCHHEEEEEEECCCCCCCEEEEE ANSIYNGDGGTHLSGFRGALTRVINGYAKANGLLKEKDPSLSGEDVREGLVAVISVKMPN EECEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEECCC PRFSSQTKDKLVNTEIEGVVGNVVYEEIKTYFEENPAMAKKIIEKSITAARAREAARKAR CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH ETVRKSALSIGGLPGKLADCSDRDPAKCELFIVEGDSAGGSAKMGRDRRTQAILPLRGKV HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCE LNVEKARLDKALGSKEIQNMITAIGAGIGEGDDEASFKLDRVRYHKIIIMTDADVDGAHI ECHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHHH RTLLLTFFCRHMPQLVRAGYLYIAQAPLYRIIRRKKEEYVQDDVALNRKLIELAVNDVTL HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECEEEE RFADGSRSFSPEELSAILETLVNLQRYTESMQAQGGSLEDLLSHRETNGEFPEFLVKVRC EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHEEEEEC GNEEEILFFHDMEALTAFSEENRDLFIFGTPSEEELLENPLPEREGPSRRSITHELHEAK CCCCCEEEEECHHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHH AITRALARLAELGIPGNMIVSMDTPLFELVEGEGDKEKVTPLFSVMDILESVISIGKRGV HHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC EITRFKGLGEMDAKDLFKTTMDPERRELLRVILNDDNAVRADEMFTILMGDVVEPRKNYI EEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHH VDHALNVRNLDI HHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8226640 [H]