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The map label for this gene is uppS [H]

Identifier: 187735687

GI number: 187735687

Start: 1429003

End: 1429719

Strand: Reverse

Name: uppS [H]

Synonym: Amuc_1193

Alternate gene names: 187735687

Gene position: 1429719-1429003 (Counterclockwise)

Preceding gene: 187735688

Following gene: 187735686

Centisome position: 53.67

GC content: 59.41

Gene sequence:

>717_bases
ATGCTTACCATTCCCAAGGAAAAACTGCCGACTCACATCGCCTGCATCATGGACGGCAACGGCCGCTGGGCGAACAGCCG
CCATCTGCCGCGGCAGGCAGGCCACCGGGCGGGAGCGGATACGGTGGAACGCTGTGCGGACTTCTGCATGGCCCATGATA
TCCCCTGGCTCACCCTTTACGCCTTTTCCTCGGAAAACTGGAACCGTCCGAAGACGGAAGTGCGCGCGCTGATGCTCCTT
CTGCACGAATTCCTGAAAAAACGCCTCAACCAAATGATGGAAAAAGGCGTGCGCCTCCACGCCATAGGAGATCTCTCCCG
CATTCCCGCCCGCACCCGGAAACTGCTTCAGAACAGTCTGGAAGCCACTTCGGGAAACACCAGGCTCAACCTGGTTCTGG
CCATTTCCTACGGCAGCCGGGGGGAAATCGCCGCCGCCGCCAGGAAAATAGCGGAAAAAGTCTCCCGCGGAGAACTCCCG
CCGGACGCCGTGACGGAAGACCTGTTCGGCGAGTACCTGGACACCGCCGGCATGCCGGAACCGGATCTGCTTATCCGCAC
CTCTGGAGAAATGCGCGTCTCCAACTTTCTTCTCTGGCAAATCAGCTATGCGGAAATTCATGTGACGGACACGTTGTGGC
CGGACTTTTGCGACCGGGACATGGAAGCTGCTCTGCTGGACTACTCCCGTAGAAAACGCCGTTTCGGCGCTCTCTGA

Upstream 100 bases:

>100_bases
ATGGGCAAAAACACGCGGGAAAGACAGGAATACATCCTGAACAACTTGCGTGTTGAACTGGACCCGGTCATGGACTAGAG
TAACGGAGCGACGCTTATCT

Downstream 100 bases:

>100_bases
CCCTCTTGAACCCCCATTCCTGCGAAACAGCCATGAACCAATACGCTCTTATTCTGGCCGGCGGCAGCGGCACCCGTTTC
TGGCCTCTTTCCCGCGACCA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MLTIPKEKLPTHIACIMDGNGRWANSRHLPRQAGHRAGADTVERCADFCMAHDIPWLTLYAFSSENWNRPKTEVRALMLL
LHEFLKKRLNQMMEKGVRLHAIGDLSRIPARTRKLLQNSLEATSGNTRLNLVLAISYGSRGEIAAAARKIAEKVSRGELP
PDAVTEDLFGEYLDTAGMPEPDLLIRTSGEMRVSNFLLWQISYAEIHVTDTLWPDFCDRDMEAALLDYSRRKRRFGAL

Sequences:

>Translated_238_residues
MLTIPKEKLPTHIACIMDGNGRWANSRHLPRQAGHRAGADTVERCADFCMAHDIPWLTLYAFSSENWNRPKTEVRALMLL
LHEFLKKRLNQMMEKGVRLHAIGDLSRIPARTRKLLQNSLEATSGNTRLNLVLAISYGSRGEIAAAARKIAEKVSRGELP
PDAVTEDLFGEYLDTAGMPEPDLLIRTSGEMRVSNFLLWQISYAEIHVTDTLWPDFCDRDMEAALLDYSRRKRRFGAL
>Mature_238_residues
MLTIPKEKLPTHIACIMDGNGRWANSRHLPRQAGHRAGADTVERCADFCMAHDIPWLTLYAFSSENWNRPKTEVRALMLL
LHEFLKKRLNQMMEKGVRLHAIGDLSRIPARTRKLLQNSLEATSGNTRLNLVLAISYGSRGEIAAAARKIAEKVSRGELP
PDAVTEDLFGEYLDTAGMPEPDLLIRTSGEMRVSNFLLWQISYAEIHVTDTLWPDFCDRDMEAALLDYSRRKRRFGAL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=228, Percent_Identity=35.9649122807018, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI45580742, Length=228, Percent_Identity=35.9649122807018, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1786371, Length=235, Percent_Identity=47.6595744680851, Blast_Score=221, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=36, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319474, Length=233, Percent_Identity=35.6223175965665, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=33.920704845815, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=34.2222222222222, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27004; Mature: 27004

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIPKEKLPTHIACIMDGNGRWANSRHLPRQAGHRAGADTVERCADFCMAHDIPWLTLY
CCCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCEEEEE
AFSSENWNRPKTEVRALMLLLHEFLKKRLNQMMEKGVRLHAIGDLSRIPARTRKLLQNSL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHH
EATSGNTRLNLVLAISYGSRGEIAAAARKIAEKVSRGELPPDAVTEDLFGEYLDTAGMPE
HCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
PDLLIRTSGEMRVSNFLLWQISYAEIHVTDTLWPDFCDRDMEAALLDYSRRKRRFGAL
CCEEEECCCCEEECEEEEEEEEEEEEEEECCCCHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTIPKEKLPTHIACIMDGNGRWANSRHLPRQAGHRAGADTVERCADFCMAHDIPWLTLY
CCCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCEEEEE
AFSSENWNRPKTEVRALMLLLHEFLKKRLNQMMEKGVRLHAIGDLSRIPARTRKLLQNSL
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHHHHHH
EATSGNTRLNLVLAISYGSRGEIAAAARKIAEKVSRGELPPDAVTEDLFGEYLDTAGMPE
HCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
PDLLIRTSGEMRVSNFLLWQISYAEIHVTDTLWPDFCDRDMEAALLDYSRRKRRFGAL
CCEEEECCCCEEECEEEEEEEEEEEEEEECCCCHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12446909 [H]