Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is lutR [H]

Identifier: 187735674

GI number: 187735674

Start: 1414971

End: 1415666

Strand: Direct

Name: lutR [H]

Synonym: Amuc_1180

Alternate gene names: 187735674

Gene position: 1414971-1415666 (Clockwise)

Preceding gene: 187735673

Following gene: 187735675

Centisome position: 53.11

GC content: 57.04

Gene sequence:

>696_bases
ATGAAGCAGTCCAAGACAATGGAGCTGAAGAAACCGGTGCGGGTGTCCCTGGCCCGCCAGGTGCTTACCGCCATGGAATC
CATGATACGGTCCGGCAAATGGAAGGTTGGAGACCGCATTCCCGCGGAAGCGGAACTGGCCCGTGCCTTTTCCGTCAGCC
ACAACACCATCCGCGAAGCCCTTCAATCCCTGATTCACATGGGGATGCTGGAAGCGCGCCCCGGAGACGGCACGTACGTG
ATGGCGTCAGACCGCTTTGCCGTCGCGGTGAGCAACCGCCTCAAGGAATCCGAGCTGCCTCAGATTCTGGAGGCGCGGCT
GGCTTTGGAAAAGGAAATTGCGCGGCTGGCCGCCGTTAAAAGGACGGATGAAGATTTGAAGGAGCTGGAAAATGCCCTGA
AGGACTGCCACGGCAGGGTAAGGCAGGGCATTGAGGATGACATGCTGTTTCATGCCGCCGTGGCCCGCGCCACGCATAAT
CCGGTGCTCTCGGAATTGTATAACGTGGTCATCCGCCATGTGCAGGAGAATCTGGAAAAGCTGCTTCAGGAGAAGCAATA
CGACTCCGGCGCCATGAAGCTGCATGACGACCTTCTCGCAGCCATCAGGAAGCAGGAGGCGGATGAAGCGGAGAACATTA
TTGTAAAGATTGTGGAATTTGACACCGTCAGCATAGGCGGGGCATTCATTTCTTGA

Upstream 100 bases:

>100_bases
GGTGCTGACGGAGGAAAACCTGAAAGACGCCTTTGGGCTGGATATCCAGTTAATCAAGACGGAGAAGGGGCGTCTCTGGA
CCGTTATCCGATAATTTTTC

Downstream 100 bases:

>100_bases
ATTGCCGGCAGGGAAGATGCCGTTGCGGTGGCAGAGTTATTCTTTTTTATTTCCCGGTGCTTTTCTTGCCAGCGGGCTTT
CCGGCAAATAACTGCGTTCT

Product: GntR domain protein

Products: NA

Alternate protein names: L-lactate utilization operon repressor [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKQSKTMELKKPVRVSLARQVLTAMESMIRSGKWKVGDRIPAEAELARAFSVSHNTIREALQSLIHMGMLEARPGDGTYV
MASDRFAVAVSNRLKESELPQILEARLALEKEIARLAAVKRTDEDLKELENALKDCHGRVRQGIEDDMLFHAAVARATHN
PVLSELYNVVIRHVQENLEKLLQEKQYDSGAMKLHDDLLAAIRKQEADEAENIIVKIVEFDTVSIGGAFIS

Sequences:

>Translated_231_residues
MKQSKTMELKKPVRVSLARQVLTAMESMIRSGKWKVGDRIPAEAELARAFSVSHNTIREALQSLIHMGMLEARPGDGTYV
MASDRFAVAVSNRLKESELPQILEARLALEKEIARLAAVKRTDEDLKELENALKDCHGRVRQGIEDDMLFHAAVARATHN
PVLSELYNVVIRHVQENLEKLLQEKQYDSGAMKLHDDLLAAIRKQEADEAENIIVKIVEFDTVSIGGAFIS
>Mature_231_residues
MKQSKTMELKKPVRVSLARQVLTAMESMIRSGKWKVGDRIPAEAELARAFSVSHNTIREALQSLIHMGMLEARPGDGTYV
MASDRFAVAVSNRLKESELPQILEARLALEKEIARLAAVKRTDEDLKELENALKDCHGRVRQGIEDDMLFHAAVARATHN
PVLSELYNVVIRHVQENLEKLLQEKQYDSGAMKLHDDLLAAIRKQEADEAENIIVKIVEFDTVSIGGAFIS

Specific function: Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to lutR, leads to derepression of the operon. Also appears to

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790780, Length=229, Percent_Identity=29.6943231441048, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI48994955, Length=226, Percent_Identity=28.7610619469027, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082208, Length=219, Percent_Identity=27.3972602739726, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786303, Length=177, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 25897; Mature: 25897

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSKTMELKKPVRVSLARQVLTAMESMIRSGKWKVGDRIPAEAELARAFSVSHNTIREA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LQSLIHMGMLEARPGDGTYVMASDRFAVAVSNRLKESELPQILEARLALEKEIARLAAVK
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
RTDEDLKELENALKDCHGRVRQGIEDDMLFHAAVARATHNPVLSELYNVVIRHVQENLEK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLQEKQYDSGAMKLHDDLLAAIRKQEADEAENIIVKIVEFDTVSIGGAFIS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEECCCHHCC
>Mature Secondary Structure
MKQSKTMELKKPVRVSLARQVLTAMESMIRSGKWKVGDRIPAEAELARAFSVSHNTIREA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LQSLIHMGMLEARPGDGTYVMASDRFAVAVSNRLKESELPQILEARLALEKEIARLAAVK
HHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
RTDEDLKELENALKDCHGRVRQGIEDDMLFHAAVARATHNPVLSELYNVVIRHVQENLEK
CCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLQEKQYDSGAMKLHDDLLAAIRKQEADEAENIIVKIVEFDTVSIGGAFIS
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEECCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]