Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
---|---|
Accession | NC_010655 |
Length | 2,664,102 |
Click here to switch to the map view.
The map label for this gene is thiH [H]
Identifier: 187735612
GI number: 187735612
Start: 1335469
End: 1336605
Strand: Direct
Name: thiH [H]
Synonym: Amuc_1117
Alternate gene names: 187735612
Gene position: 1335469-1336605 (Clockwise)
Preceding gene: 187735610
Following gene: 187735613
Centisome position: 50.13
GC content: 59.45
Gene sequence:
>1137_bases ATGTCTTTTTCTGAAGAATTAAACGGTTTGATGGATTGCCCCACTCCCCTGGTACGCCGTTTCATGGCGTTGCTGGAACC GGTTGACGACGCCCGCCTGGAGGAGATGGCGCAGGAGAGCCGGCGTCTGACGCGGCTGCATTTCGGCCGGACCATCCGCC TGTTCGCCCCCATTTACCTGTCCAACGAATGCATCAATAATTGCAAGTACTGCGGTTTTTCCCGGGATAATCCCATTATC CGCACCACGCTTACGGTGGATGAAGTGGTGCAGGAGGCCCGCTACCTGCACGGCCTGGGGCTGCGCAGCATCCTGCTGGT GGCCGGGGAGCATCCCAAGTTCGTTTCCGACGGGTATATGCAGGAATGCCTGGACGCCCTGCATTCCTTTATTCCATCCC TGGGGCTGGAGATAGGACCGTTGCCGGACGACCGTTATGCGGAGATCGTCCGCCACGGGGCGGAACAATTGGCCGTGTAT CAGGAAACCTATAACCGGGAAGTGTATGAAACCCTGCATACGGCAGGGATGAAGAAAAATTTCAACTGGAGGCTGGACTG CCCGGAACGCGCCTACCAGGGCGGTTTCCGCCGCATTCAGATAGGAGCCTTGTTCGGGCTTTCTCCGTGGCGGCGGGAGG CCATGGCACTTGCCGTCCATCTGGATTACCTGCAGAAGCATTGCTGGAAATCCGCGCTTTCCGTGGCGTTTCCGCGCATG CGTCCCTACGCCGGGAATTACGAGTATGAACCTGATCCGGACTTGATGCTGGATGACCGCCATTTTGTCCAGCTTATGGC CGCCCTGCGCATCTGTTTCCCCAAGATAGGCATGTCCATCAGCACCCGTGAGCCCGCGCCGATGAGGAATGCCCTGATGC ATTTGGGCATGACCCACATGTCCGCCATTGCGCGCACGGAACCGGGGGGCTACACGGGCGTGGGAACGGCTGCCGCCCAT TTGACGGTGCGGGGCAACCGGGTGGATCTTCCCGATGGCCGGAAAGGGAATTGCAAGGCGACGGAGCAGTTTGAGATTTC CGACCAGCGCACACCGGAGCAGGTGGTCGGAGCCATACGGAATGCCGGGCTGGAGCCTGTCTGGAAAGACTGGGATGCCG CTCTGGATGTGGTGTAG
Upstream 100 bases:
>100_bases TAAAAGATGGTATCTTTTGCAAGGGAGGTAGCAAATTGGGGTTTTCCGGTTCAGGAATGGAAATGCAGCCGGCTCTCTCA AAATTTTACTTAGTTTACGT
Downstream 100 bases:
>100_bases GAGAACCTTCTCCCGTCTCATTTCCTTGGAATGACATCCATATCACCGTGATGTTGTGATGGAGCATTGACGGCATGCTC CGGCTGTCATATTTCCGGTA
Product: biotin and thiamin synthesis associated
Products: 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate; 4-hydroxy-benzyl-alcohol; C1 of tyrosine; ThiS protein [C]
Alternate protein names: Dehydroglycine synthase; Tyrosine lyase [H]
Number of amino acids: Translated: 378; Mature: 377
Protein sequence:
>378_residues MSFSEELNGLMDCPTPLVRRFMALLEPVDDARLEEMAQESRRLTRLHFGRTIRLFAPIYLSNECINNCKYCGFSRDNPII RTTLTVDEVVQEARYLHGLGLRSILLVAGEHPKFVSDGYMQECLDALHSFIPSLGLEIGPLPDDRYAEIVRHGAEQLAVY QETYNREVYETLHTAGMKKNFNWRLDCPERAYQGGFRRIQIGALFGLSPWRREAMALAVHLDYLQKHCWKSALSVAFPRM RPYAGNYEYEPDPDLMLDDRHFVQLMAALRICFPKIGMSISTREPAPMRNALMHLGMTHMSAIARTEPGGYTGVGTAAAH LTVRGNRVDLPDGRKGNCKATEQFEISDQRTPEQVVGAIRNAGLEPVWKDWDAALDVV
Sequences:
>Translated_378_residues MSFSEELNGLMDCPTPLVRRFMALLEPVDDARLEEMAQESRRLTRLHFGRTIRLFAPIYLSNECINNCKYCGFSRDNPII RTTLTVDEVVQEARYLHGLGLRSILLVAGEHPKFVSDGYMQECLDALHSFIPSLGLEIGPLPDDRYAEIVRHGAEQLAVY QETYNREVYETLHTAGMKKNFNWRLDCPERAYQGGFRRIQIGALFGLSPWRREAMALAVHLDYLQKHCWKSALSVAFPRM RPYAGNYEYEPDPDLMLDDRHFVQLMAALRICFPKIGMSISTREPAPMRNALMHLGMTHMSAIARTEPGGYTGVGTAAAH LTVRGNRVDLPDGRKGNCKATEQFEISDQRTPEQVVGAIRNAGLEPVWKDWDAALDVV >Mature_377_residues SFSEELNGLMDCPTPLVRRFMALLEPVDDARLEEMAQESRRLTRLHFGRTIRLFAPIYLSNECINNCKYCGFSRDNPIIR TTLTVDEVVQEARYLHGLGLRSILLVAGEHPKFVSDGYMQECLDALHSFIPSLGLEIGPLPDDRYAEIVRHGAEQLAVYQ ETYNREVYETLHTAGMKKNFNWRLDCPERAYQGGFRRIQIGALFGLSPWRREAMALAVHLDYLQKHCWKSALSVAFPRMR PYAGNYEYEPDPDLMLDDRHFVQLMAALRICFPKIGMSISTREPAPMRNALMHLGMTHMSAIARTEPGGYTGVGTAAAHL TVRGNRVDLPDGRKGNCKATEQFEISDQRTPEQVVGAIRNAGLEPVWKDWDAALDVV
Specific function: Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol [H]
COG id: COG1060
COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the radical SAM superfamily. ThiH family [H]
Homologues:
Organism=Escherichia coli, GI1790423, Length=356, Percent_Identity=39.8876404494382, Blast_Score=267, Evalue=1e-72,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013785 - InterPro: IPR010722 - InterPro: IPR007197 - InterPro: IPR012726 [H]
Pfam domain/function: PF06968 BATS; PF04055 Radical_SAM [H]
EC number: NA
Molecular weight: Translated: 42863; Mature: 42732
Theoretical pI: Translated: 6.64; Mature: 6.64
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.4 %Cys (Translated Protein) 4.0 %Met (Translated Protein) 6.3 %Cys+Met (Translated Protein) 2.4 %Cys (Mature Protein) 3.7 %Met (Mature Protein) 6.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSFSEELNGLMDCPTPLVRRFMALLEPVDDARLEEMAQESRRLTRLHFGRTIRLFAPIYL CCCHHHHCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH SNECINNCKYCGFSRDNPIIRTTLTVDEVVQEARYLHGLGLRSILLVAGEHPKFVSDGYM CHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHCCHHH QECLDALHSFIPSLGLEIGPLPDDRYAEIVRHGAEQLAVYQETYNREVYETLHTAGMKKN HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC FNWRLDCPERAYQGGFRRIQIGALFGLSPWRREAMALAVHLDYLQKHCWKSALSVAFPRM CCEEECCHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC RPYAGNYEYEPDPDLMLDDRHFVQLMAALRICFPKIGMSISTREPAPMRNALMHLGMTHM CCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH SAIARTEPGGYTGVGTAAAHLTVRGNRVDLPDGRKGNCKATEQFEISDQRTPEQVVGAIR HHHHHCCCCCCCCCCHHEEEEEEECCEECCCCCCCCCCCCCCEECCCCCCCHHHHHHHHH NAGLEPVWKDWDAALDVV HCCCCCHHHCHHHHHCCC >Mature Secondary Structure SFSEELNGLMDCPTPLVRRFMALLEPVDDARLEEMAQESRRLTRLHFGRTIRLFAPIYL CCHHHHCHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH SNECINNCKYCGFSRDNPIIRTTLTVDEVVQEARYLHGLGLRSILLVAGEHPKFVSDGYM CHHHHCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHCCHHH QECLDALHSFIPSLGLEIGPLPDDRYAEIVRHGAEQLAVYQETYNREVYETLHTAGMKKN HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC FNWRLDCPERAYQGGFRRIQIGALFGLSPWRREAMALAVHLDYLQKHCWKSALSVAFPRM CCEEECCHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC RPYAGNYEYEPDPDLMLDDRHFVQLMAALRICFPKIGMSISTREPAPMRNALMHLGMTHM CCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH SAIARTEPGGYTGVGTAAAHLTVRGNRVDLPDGRKGNCKATEQFEISDQRTPEQVVGAIR HHHHHCCCCCCCCCCHHEEEEEEECCEECCCCCCCCCCCCCCEECCCCCCCHHHHHHHHH NAGLEPVWKDWDAALDVV HCCCCCHHHCHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: deoxyxylulose-5-phosphate; ThiS-COSH; L-tyrosine [C]
Specific reaction: deoxyxylulose-5-phosphate + ThiS-COSH + L-tyrosine = 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate + 4-hydroxy-benzyl-alcohol + C1 of tyrosine + ThiS protein [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8432721; 8265357; 9278503; 10082377 [H]