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The map label for this gene is ziaA [H]

Identifier: 187735590

GI number: 187735590

Start: 1306359

End: 1308284

Strand: Direct

Name: ziaA [H]

Synonym: Amuc_1095

Alternate gene names: 187735590

Gene position: 1306359-1308284 (Clockwise)

Preceding gene: 187735589

Following gene: 187735598

Centisome position: 49.04

GC content: 61.11

Gene sequence:

>1926_bases
ATGAGCACGGAACATTCCCACGAACATTTTCCGGAAGGTGCTTCCTGTTGTTCCGGAAGCTGCGGTTCTGGAAGCTGTTG
CTGCTCCGGAGACGCCATCGGGCCTGTTCCCGCCGTGCTGGGCATTGCCCTGTTCATCAGTGCGCTGGCGGCGGGCGGCG
ATTCCCTGGCCGGTATGGCCGCCTACGTGGGCTCCTACCTGCTGATAGGCTGGGATGTACTGAAGGCCGCCTTTCTGGGG
ATGATGCGCGGCCGCGCCATCAATGAAAATTTTCTGATGAGTATTGCTTCCCTGGGGGCGATGTTCCTGGGGGATTATTC
CGAGGCGGTGGGGGTGATGCTGTTCTACCGCGTGGGAGAGTACCTTCAGGAACGTGCGGTGGGCAGCTCCCGCCGGTCCG
TAAGCGAACTGATGAGTCTGAGGCCTGAGGCCGTCCATGTGAAAAAAGCCGGAGCCGTAGATGACGTTCCTCCTTCCGAG
GTTCTGCCCGGCTCCCTGATTGAAGTGCGCCCCGGCGAACGCGTTCCGTTGGACGGTGTGGTAACGGGAGGCTGCTCCGT
GCTGGATACCTCCGCCATGACCGGGGAATCCCTGCCGGTGGAAGCCGGATCCGGAAGCTCCGTGCTGGCGGGGTACATCA
ACGGGCAGGGTGTGCTGGAAGTGTGTACGGAGCGGGACTGGCGGCATTCCGCCCTGGCGCGGGTCCAGGAACTGGTGGAA
GCCGCATCAGGCCGCAAATCCCCTCTGGAGGGGAGGCTGTCCTCATTTTCCCGCATTTATACGCCGCTGGTGATTTCCAT
AGCCGCTCTGGTATTTTTGCTTTATCCCCTTGTGACGGGCGGAAGCTGGGCGGACGGTCTGTTCCGCGCCCTGGTCCTGC
TGGTGATTTCCTGCCCCTGCGCGCTGGTGCTGTCCATCCCGCTGGGCTTTTTTGCCGGAATAGGGAGAGCGGCGCGGCAG
GGGATTTTGCTGAAAGGGAGCAACTATCTGGATGCCCTGCGGAAGGTGAAGACGGTGGTGTTTGACAAAACCGGAACCTT
GACGGAAGGCGTTTTTTCCGTGGATGAAGTGCTTCCCCGTGACGGCGTTTCCCCGGAGGAACTGCTGTACTGGGCGGCCC
ATGCGGAACTCTCCGCCTCCCATCCGCTGGGGCGTTCCATTGTGAAGGCATATGAAGGGACTCTGTTTCCGGACCGCGTG
GCGGAACTGGTGGAGGTGACGGGCGGCGGCGTTTCAGCCCGCGTGGAAGGGAGACCGGTTCTGGTGGGGAAAAAGTCTTT
TCTTCAAGAGGCCGGCGTAAGGACGGAGGAGGGAGAAGACCGTGGCGTGACCGTTTATGCGGCGTTGGACGGCATACTTC
TGGGATGCCTCCGCCTGTCTGACCGCGTCAAGCCGGGAGCGGAGCGTGCGGTGCGGAAATTGAGGGAACTGGGCGTTTCC
AACCTGGTCATGCTGACGGGGGATTCTTCTTCCGCCGGAACGGAAGTGGGGCTTAAGCTGGGGATGGACGGGGTATTCTG
CGGGCTGATGCCTGCCGGCAAGCTGGAGCATGTGCGCCGGCTGAAACCTGAAACGGGGCTGCTTGCCTTTGTGGGGGACG
GTATGAATGACGCCCCTTCCCTCGCTGCTGCCGACATCGGAATTGCCATGGGCGGCGTAGGGTCCGATACGGCTCTTCAG
GCGGCTGACGTAGTGGTGATGAAGGGAGATCCTTTGGCTGTTCCGCTGGGGATGATGCTTTCCCAAGCCACAGAGCGCAT
CATTGTGCAGAACATCGTTCTTATTTTGGGCGTCAAAATTCTGGTCATGGTGCTGGGTATTCTGGGGCTGGCTGGGATGT
GGGCCGCCGTGATGGCGGATGTGGGCGTCTGCCTGCTTGCGGTGGGCAACTCCATGCGTATTTTCCGGGTGAAGCTGGAC
ATGTGA

Upstream 100 bases:

>100_bases
GAACGGTTTAAGAACCAGAAATCAACGCAGACTTTTTGTTAGTTTGGGCTAATATAGGGCTTGCCATGCCGGAGAGGCAG
GCGTACAAGCGGAACAGGTC

Downstream 100 bases:

>100_bases
CGAAAGGGAACTCTCTTCCTCCCCCTGTTTATGGGAGGATGCCCCCATCCCGATATCCGGATGCTGCCGCGGAATCTTGG
AACAGCGGAAGATATCCTGA

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSTEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMAAYVGSYLLIGWDVLKAAFLG
MMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGEYLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSE
VLPGSLIEVRPGERVPLDGVVTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE
AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPCALVLSIPLGFFAGIGRAARQ
GILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPRDGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRV
AELVEVTGGGVSARVEGRPVLVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS
NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPSLAAADIGIAMGGVGSDTALQ
AADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKILVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLD
M

Sequences:

>Translated_641_residues
MSTEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMAAYVGSYLLIGWDVLKAAFLG
MMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGEYLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSE
VLPGSLIEVRPGERVPLDGVVTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE
AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPCALVLSIPLGFFAGIGRAARQ
GILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPRDGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRV
AELVEVTGGGVSARVEGRPVLVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS
NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPSLAAADIGIAMGGVGSDTALQ
AADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKILVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLD
M
>Mature_640_residues
STEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMAAYVGSYLLIGWDVLKAAFLGM
MRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGEYLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSEV
LPGSLIEVRPGERVPLDGVVTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVEA
ASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPCALVLSIPLGFFAGIGRAARQG
ILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPRDGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRVA
ELVEVTGGGVSARVEGRPVLVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVSN
LVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPSLAAADIGIAMGGVGSDTALQA
ADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKILVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLDM

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=562, Percent_Identity=30.4270462633452, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI115529486, Length=580, Percent_Identity=30, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI55743073, Length=493, Percent_Identity=32.0486815415822, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI237681111, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI237681109, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI21361181, Length=250, Percent_Identity=24, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI22748667, Length=250, Percent_Identity=24.8, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4502271, Length=247, Percent_Identity=24.6963562753036, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI48762689, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI48762685, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI48762691, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI48762687, Length=211, Percent_Identity=27.9620853080569, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1789879, Length=586, Percent_Identity=37.7133105802048, Blast_Score=312, Evalue=5e-86,
Organism=Escherichia coli, GI1786691, Length=503, Percent_Identity=33.3996023856859, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786914, Length=573, Percent_Identity=27.7486910994764, Blast_Score=135, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17556548, Length=590, Percent_Identity=27.9661016949153, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71997262, Length=569, Percent_Identity=22.6713532513181, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32566766, Length=242, Percent_Identity=25.2066115702479, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=494, Percent_Identity=29.1497975708502, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319772, Length=517, Percent_Identity=27.2727272727273, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321430, Length=615, Percent_Identity=26.1788617886179, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325221, Length=632, Percent_Identity=26.5822784810127, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321271, Length=150, Percent_Identity=28, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221329854, Length=310, Percent_Identity=31.6129032258064, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24668696, Length=295, Percent_Identity=23.3898305084746, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281366617, Length=295, Percent_Identity=23.3898305084746, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24668708, Length=295, Percent_Identity=23.3898305084746, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 66870; Mature: 66739

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMA
CCCCCCCCCCCCCHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AYVGSYLLIGWDVLKAAFLGMMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSEVLPGSLIEVRPGERVPLDGV
HHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHCCCCCEEEECCCCCCCCCCE
VTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE
EECCCHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHH
AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPC
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALVLSIPLGFFAGIGRAARQGILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPR
HHHHHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
DGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRVAELVEVTGGGVSARVEGRPV
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCEE
LVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS
EECCHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPS
CEEEEECCCCCCCCHHHHHCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCC
LAAADIGIAMGGVGSDTALQAADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKI
HHHHHHHHEECCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
STEHSHEHFPEGASCCSGSCGSGSCCCSGDAIGPVPAVLGIALFISALAAGGDSLAGMA
CCCCCCCCCCCCHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
AYVGSYLLIGWDVLKAAFLGMMRGRAINENFLMSIASLGAMFLGDYSEAVGVMLFYRVGE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YLQERAVGSSRRSVSELMSLRPEAVHVKKAGAVDDVPPSEVLPGSLIEVRPGERVPLDGV
HHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHCCCCCEEEECCCCCCCCCCE
VTGGCSVLDTSAMTGESLPVEAGSGSSVLAGYINGQGVLEVCTERDWRHSALARVQELVE
EECCCHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHH
AASGRKSPLEGRLSSFSRIYTPLVISIAALVFLLYPLVTGGSWADGLFRALVLLVISCPC
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALVLSIPLGFFAGIGRAARQGILLKGSNYLDALRKVKTVVFDKTGTLTEGVFSVDEVLPR
HHHHHHHHHHHHHCCHHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
DGVSPEELLYWAAHAELSASHPLGRSIVKAYEGTLFPDRVAELVEVTGGGVSARVEGRPV
CCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCEE
LVGKKSFLQEAGVRTEEGEDRGVTVYAALDGILLGCLRLSDRVKPGAERAVRKLRELGVS
EECCHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
NLVMLTGDSSSAGTEVGLKLGMDGVFCGLMPAGKLEHVRRLKPETGLLAFVGDGMNDAPS
CEEEEECCCCCCCCHHHHHCCCCCCEECCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCC
LAAADIGIAMGGVGSDTALQAADVVVMKGDPLAVPLGMMLSQATERIIVQNIVLILGVKI
HHHHHHHHEECCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVMVLGILGLAGMWAAVMADVGVCLLAVGNSMRIFRVKLDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]