Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is lipA [H]

Identifier: 187735587

GI number: 187735587

Start: 1303611

End: 1304549

Strand: Reverse

Name: lipA [H]

Synonym: Amuc_1092

Alternate gene names: 187735587

Gene position: 1304549-1303611 (Counterclockwise)

Preceding gene: 187735588

Following gene: 187735586

Centisome position: 48.97

GC content: 60.17

Gene sequence:

>939_bases
ATGGAACGCCGGAACGACAATGAGACTGCGGAAGGAACGGAACGCAAACCGTCGTGGATCAAGGTTCGTCTGCCCAACGG
CCGGGAATTCTGGGACGTCAAGCAGCTTGTGGAAGGCAAAAACCTCTTCACCGTCTGTGAAGAAGCACACTGCCCCAACC
GTTATGAATGTTGGAACCAGGGTACGGCCACGTTCATGATTGCCGGAGAACGGTGCACGCGCGCCTGCGGATTCTGCGCC
ACCCGCACGGCCAAGCCCGGCCCGCTGGATCCTGAAGAACCGCAGCACGTGGCGGAAGCCGTCGTGCACATGAAGCTGCG
CCACGCCGTGATTACCATGGTCACCCGGGATGATTTGCCGGACGGCGCCGCCGCGCATTTCGCCCAGGTAATTAGGGCCG
TCAGAAAAGCCAGCCCTTCCACGATCATTGAAGTGCTTGCCTCGGACTTGAATGAGAAGCCCTCCTCCATCCAGACGCTC
ATGGCGGCCCGTCCGCATATTTTCGGACACAATCTGGAGACGGTGGAACGCCTCACGCCCATTGTCCGCTTCCGCGCCCA
GTACCGGCGGTCCCTGCGCGTTCTCCGGATGGCTCTGGAGTGCGTGGACGGCAAAGTGTCTACAAAGAGCGGCATCATGC
TGGGCCTGGGGGAAACGGAAGAAGAGCTTTTCCGCTCCATGGACGATTTGCTGGAGCACGGCGTCACGGTCCTGACGTTG
GGGCAATACCTGCGCCCCTCCCGCAACCATCTTCCGGTGGTCAAATACGTCCATCCGGATGATTTCGCCCGGTATGAGGA
AGTTGCGCGCTCCAAAGGCTTCAGGCACGTGGCATCCGGGCCGTTGGTCCGCAGCTCCTACCATGCCGCCAATTTCACCC
CGGAAGCGGATGTTCTGGAAGCCATTAACGAAGACCTGAGAAAGGCCGGCGAACTTTAG

Upstream 100 bases:

>100_bases
CGCGTCTTTCTTCCCCTCCGGATGAAAACGGGGAATGAAGTCCGGAATAAAACACTTTGCATTTGCCAAAGCAGCAGAGT
CACGGCAAGCTAGCGGGACT

Downstream 100 bases:

>100_bases
AATAAATCTTGATTTTTTATCCTTCCCCTTTTACCATCCGGGCAATTCCACGTCATTGAGAATCTCATGAGCAAAACATG
TTCCTTCATCAAGGCAGGAG

Product: lipoyl synthase

Products: NA

Alternate protein names: Lip-syn; LS; Lipoate synthase; Lipoic acid synthase; Sulfur insertion protein lipA [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQGTATFMIAGERCTRACGFCA
TRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLPDGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTL
MAARPHIFGHNLETVERLTPIVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL
GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLEAINEDLRKAGEL

Sequences:

>Translated_312_residues
MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQGTATFMIAGERCTRACGFCA
TRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLPDGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTL
MAARPHIFGHNLETVERLTPIVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL
GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLEAINEDLRKAGEL
>Mature_312_residues
MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQGTATFMIAGERCTRACGFCA
TRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLPDGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTL
MAARPHIFGHNLETVERLTPIVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL
GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLEAINEDLRKAGEL

Specific function: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives [H]

COG id: COG0320

COG function: function code H; Lipoate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Lipoyl synthase family [H]

Homologues:

Organism=Homo sapiens, GI37577166, Length=299, Percent_Identity=41.8060200668896, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI37577164, Length=246, Percent_Identity=41.869918699187, Blast_Score=199, Evalue=2e-51,
Organism=Escherichia coli, GI1786846, Length=281, Percent_Identity=48.3985765124555, Blast_Score=257, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI32564533, Length=256, Percent_Identity=45.703125, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6324770, Length=290, Percent_Identity=43.1034482758621, Blast_Score=243, Evalue=4e-65,
Organism=Drosophila melanogaster, GI221513272, Length=285, Percent_Identity=44.5614035087719, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR003698
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =2.8.1.8 [H]

Molecular weight: Translated: 35140; Mature: 35140

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQ
CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCC
GTATFMIAGERCTRACGFCATRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLP
CCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTLMAARPHIFGHNLETVERLTP
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH
IVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEH
GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLE
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHCCCCEECCCCCCCCCCHHHHHH
AINEDLRKAGEL
HHHHHHHHHCCC
>Mature Secondary Structure
MERRNDNETAEGTERKPSWIKVRLPNGREFWDVKQLVEGKNLFTVCEEAHCPNRYECWNQ
CCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHCC
GTATFMIAGERCTRACGFCATRTAKPGPLDPEEPQHVAEAVVHMKLRHAVITMVTRDDLP
CCEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGAAAHFAQVIRAVRKASPSTIIEVLASDLNEKPSSIQTLMAARPHIFGHNLETVERLTP
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH
IVRFRAQYRRSLRVLRMALECVDGKVSTKSGIMLGLGETEEELFRSMDDLLEHGVTVLTL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEH
GQYLRPSRNHLPVVKYVHPDDFARYEEVARSKGFRHVASGPLVRSSYHAANFTPEADVLE
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHCCCCEECCCCCCCCCCHHHHHH
AINEDLRKAGEL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA