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The map label for this gene is ahcY [H]

Identifier: 187735564

GI number: 187735564

Start: 1275836

End: 1277251

Strand: Direct

Name: ahcY [H]

Synonym: Amuc_1069

Alternate gene names: 187735564

Gene position: 1275836-1277251 (Clockwise)

Preceding gene: 187735563

Following gene: 187735566

Centisome position: 47.89

GC content: 60.24

Gene sequence:

>1416_bases
ATGTTTTCAGAAACGGAACAATACAAGGTGCGCGATATCGGCCTGGCGGATTTCGGACGCAGGGAACTGGATATTGCGGA
GCATGAGATGCCCGGCCTGATGGCCGTGCGTGAAAAGTACGCTGCAGCCAGGCCCCTGGAGGGCGTGCGCATCATGGGCT
CCCTGCACATGACGGTGCAGACGGCCGTGCTGATAGAAACGCTGACGGCTCTGGGCGCTTCCGTCCGCTGGGCGAGCTGC
AACATTTTCTCCACCCAGGACCACGCCGCCGCCGCCATCGCCAAATCCGGCACCCCCGTTTTCGCCTGGAAGGGGGAAAC
GCTGCGGGAATACTGGGACTGCACGTGGAAGGCCATGAACTTTCCGGACGGGCTGGGGCCGCAGCTGATTGTGGACGACG
GCGGAGACGCCACCCTGCTTATCCACCGCGGGTATGAAATGGAGGAAGGCTCCGACTGGGTGGATACCCCGTCGGAATCG
GAAGAAGAGGAAGTCGTCAAGGCCCTGTTGAAAAAAATTGCCGCGGCGACTCCGGGCATTTTCCATCGCTGGCTTCCCGA
GCTGAAGGGCGTTTCCGAGGAAACGACCACCGGCGTGCACCGCCTGTACCAGATGCAGGCCGCCGGCCGTCTGCTGATTC
CGGCCATCAACGTAAACGATTCCGTAACCAAGTCCAAGTTTGACAACCTGTACGGCTGCCGTGAGTCCCTTGTGGACGGC
ATCAAGCGGGCCACGGACGTGATGGTTGCCGGGAAGGTGGCCGTCGTCTGCGGCTACGGGGACGTAGGCAAAGGCTGCGC
CCAGTCCCTGCGCGGCATGGGAGCCCAGGTGGTCGTGACGGAAATAGACCCCATCTGCGCTCTTCAGGCAGCCATGGAAG
GTTACCGCGTACTGACGGTGGAAGACACGCTGGGCTGGGCGGATATTTACGTGACCACTACGGGAAACTGCAACATCATC
CGCATCGAACACATGGAAAAAATGAAGGACCAGGCCATTGTCTGCAACATCGGCCACTTCGACAATGAAATCCAGGTACA
CAAGCTCCAGACGTATCCCGGCATCAGGCATCTTAACATCAAGCCGCAGGTGGACCGCTACACGTTCCCGTCCGGCAACA
GCCTGTATCTTCTGGCGGAAGGCCGCCTGGTCAACCTGGGCTGCGCTACGGGTCATCCCAGCTTCGTGATGTCCAACAGC
TTCGCCAACCAGGTGCTGGCCCAGCTGGAACTGTGGAATACCCGTAAAGACCGTTCCGTGGGCGTGGAAGTGCTGCCCAA
GGTGCTGGATGAGGAAGTGGCGCGGCTGCACCTCGCCAAGATAGGGTGCAAGCTGACTGTCCTGCGTCCGGAGCAGGCGG
ACTACATCGGCGTTCCGGTGGAAGGTCCTTACAAGCCGGACTTTTACAGGTATTAA

Upstream 100 bases:

>100_bases
ATTTCACCAATCCGGAGCTGCCCTGGGAACAGCTGGACGAAACGCGCCTGGCCTCCCTGAAACAACTTCTTCATTAATTC
CTACGACAACGCTTACAGAC

Downstream 100 bases:

>100_bases
CCTTGTCAAGGTTTTCTTTTCCTGGCCGTTCCGCGCAGGCCTGTCCGGCGGAACGGCTTTTTTGTTTTCCCGATGATGGA
GGGAAGCAGGATAACGGTAC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MFSETEQYKVRDIGLADFGRRELDIAEHEMPGLMAVREKYAAARPLEGVRIMGSLHMTVQTAVLIETLTALGASVRWASC
NIFSTQDHAAAAIAKSGTPVFAWKGETLREYWDCTWKAMNFPDGLGPQLIVDDGGDATLLIHRGYEMEEGSDWVDTPSES
EEEEVVKALLKKIAAATPGIFHRWLPELKGVSEETTTGVHRLYQMQAAGRLLIPAINVNDSVTKSKFDNLYGCRESLVDG
IKRATDVMVAGKVAVVCGYGDVGKGCAQSLRGMGAQVVVTEIDPICALQAAMEGYRVLTVEDTLGWADIYVTTTGNCNII
RIEHMEKMKDQAIVCNIGHFDNEIQVHKLQTYPGIRHLNIKPQVDRYTFPSGNSLYLLAEGRLVNLGCATGHPSFVMSNS
FANQVLAQLELWNTRKDRSVGVEVLPKVLDEEVARLHLAKIGCKLTVLRPEQADYIGVPVEGPYKPDFYRY

Sequences:

>Translated_471_residues
MFSETEQYKVRDIGLADFGRRELDIAEHEMPGLMAVREKYAAARPLEGVRIMGSLHMTVQTAVLIETLTALGASVRWASC
NIFSTQDHAAAAIAKSGTPVFAWKGETLREYWDCTWKAMNFPDGLGPQLIVDDGGDATLLIHRGYEMEEGSDWVDTPSES
EEEEVVKALLKKIAAATPGIFHRWLPELKGVSEETTTGVHRLYQMQAAGRLLIPAINVNDSVTKSKFDNLYGCRESLVDG
IKRATDVMVAGKVAVVCGYGDVGKGCAQSLRGMGAQVVVTEIDPICALQAAMEGYRVLTVEDTLGWADIYVTTTGNCNII
RIEHMEKMKDQAIVCNIGHFDNEIQVHKLQTYPGIRHLNIKPQVDRYTFPSGNSLYLLAEGRLVNLGCATGHPSFVMSNS
FANQVLAQLELWNTRKDRSVGVEVLPKVLDEEVARLHLAKIGCKLTVLRPEQADYIGVPVEGPYKPDFYRY
>Mature_471_residues
MFSETEQYKVRDIGLADFGRRELDIAEHEMPGLMAVREKYAAARPLEGVRIMGSLHMTVQTAVLIETLTALGASVRWASC
NIFSTQDHAAAAIAKSGTPVFAWKGETLREYWDCTWKAMNFPDGLGPQLIVDDGGDATLLIHRGYEMEEGSDWVDTPSES
EEEEVVKALLKKIAAATPGIFHRWLPELKGVSEETTTGVHRLYQMQAAGRLLIPAINVNDSVTKSKFDNLYGCRESLVDG
IKRATDVMVAGKVAVVCGYGDVGKGCAQSLRGMGAQVVVTEIDPICALQAAMEGYRVLTVEDTLGWADIYVTTTGNCNII
RIEHMEKMKDQAIVCNIGHFDNEIQVHKLQTYPGIRHLNIKPQVDRYTFPSGNSLYLLAEGRLVNLGCATGHPSFVMSNS
FANQVLAQLELWNTRKDRSVGVEVLPKVLDEEVARLHLAKIGCKLTVLRPEQADYIGVPVEGPYKPDFYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=470, Percent_Identity=60.6382978723404, Blast_Score=540, Evalue=1e-154,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=60.6334841628959, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=48.0769230769231, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=48.0769230769231, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=48.0769230769231, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI195539349, Length=468, Percent_Identity=48.0769230769231, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=468, Percent_Identity=46.3675213675214, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=474, Percent_Identity=60.337552742616, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320882, Length=487, Percent_Identity=57.4948665297741, Blast_Score=521, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=60.9913793103448, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24656245, Length=469, Percent_Identity=49.2537313432836, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=47.4137931034483, Blast_Score=415, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=47.3002159827214, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52068; Mature: 52068

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSETEQYKVRDIGLADFGRRELDIAEHEMPGLMAVREKYAAARPLEGVRIMGSLHMTVQ
CCCCCCCEEEEECCCHHCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEHHHHH
TAVLIETLTALGASVRWASCNIFSTQDHAAAAIAKSGTPVFAWKGETLREYWDCTWKAMN
HHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHCCCCEEEEECCHHHHHHHCCEEEECC
FPDGLGPQLIVDDGGDATLLIHRGYEMEEGSDWVDTPSESEEEEVVKALLKKIAAATPGI
CCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
FHRWLPELKGVSEETTTGVHRLYQMQAAGRLLIPAINVNDSVTKSKFDNLYGCRESLVDG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IKRATDVMVAGKVAVVCGYGDVGKGCAQSLRGMGAQVVVTEIDPICALQAAMEGYRVLTV
HHHHHHEEEECCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEEE
EDTLGWADIYVTTTGNCNIIRIEHMEKMKDQAIVCNIGHFDNEIQVHKLQTYPGIRHLNI
ECCCCEEEEEEEECCCEEEEEEHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCEEEECC
KPQVDRYTFPSGNSLYLLAEGRLVNLGCATGHPSFVMSNSFANQVLAQLELWNTRKDRSV
CCCCCCEECCCCCEEEEEECCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHCCCCCCCC
GVEVLPKVLDEEVARLHLAKIGCKLTVLRPEQADYIGVPVEGPYKPDFYRY
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MFSETEQYKVRDIGLADFGRRELDIAEHEMPGLMAVREKYAAARPLEGVRIMGSLHMTVQ
CCCCCCCEEEEECCCHHCCCCCCCHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEHHHHH
TAVLIETLTALGASVRWASCNIFSTQDHAAAAIAKSGTPVFAWKGETLREYWDCTWKAMN
HHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHCCCCEEEEECCHHHHHHHCCEEEECC
FPDGLGPQLIVDDGGDATLLIHRGYEMEEGSDWVDTPSESEEEEVVKALLKKIAAATPGI
CCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
FHRWLPELKGVSEETTTGVHRLYQMQAAGRLLIPAINVNDSVTKSKFDNLYGCRESLVDG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
IKRATDVMVAGKVAVVCGYGDVGKGCAQSLRGMGAQVVVTEIDPICALQAAMEGYRVLTV
HHHHHHEEEECCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEEE
EDTLGWADIYVTTTGNCNIIRIEHMEKMKDQAIVCNIGHFDNEIQVHKLQTYPGIRHLNI
ECCCCEEEEEEEECCCEEEEEEHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCEEEECC
KPQVDRYTFPSGNSLYLLAEGRLVNLGCATGHPSFVMSNSFANQVLAQLELWNTRKDRSV
CCCCCCEECCCCCEEEEEECCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHCCCCCCCC
GVEVLPKVLDEEVARLHLAKIGCKLTVLRPEQADYIGVPVEGPYKPDFYRY
CHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA